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| 1 | Intelligent and connected vehicles: Current status and future perspectives显示文摘Intelligent connected vehicles(ICVs) are believed to change people's life in the near future by making the transportation safer,cleaner and more comfortable. Although many prototypes of ICVs have been developed to prove the concept of autonomous driving and the feasibility of improving traffic efficiency, there still exists a significant gap before achieving mass production of high-level ICVs. The objective of this study is to present an overview of both the state of the art and future perspectives of key technologies that are needed for future ICVs. It is a challenging task to review all related works and predict their future perspectives, especially for such a complex and interdisciplinary area of research. This article is organized to overview the ICV key technologies by answering three questions: what are the milestones in the history of ICVs; what are the electronic components needed for building an ICV platform; and what are the essential algorithms to enable intelligent driving? To answer the first question, the article has reviewed the history and the development milestones of ICVs. For the second question, the recent technology advances in electrical/electronic architecture, sensors, and actuators are presented. For the third question, the article focuses on the algorithms in decision making, as the perception and control algorithm are covered in the development of sensors and actuators. To achieve correct decision-making, there exist two different approaches: the principle-based approach and data-driven approach. The advantages and limitations of both approaches are explained and analyzed. Currently automotive engineers are concerned more with the vehicle platform technology, whereas the academic researchers prefer to focus on theoretical algorithms. However, only by incorporating elements from both worlds can we accelerate the production of high-level ICVs. | YANG DianGe JIANG Kun ZHAO Ding YU ChunLei CAO Zhong XIE ShiChao XIAO ZhongYang JIAO XinYu WANG SiJia ZHANG Kai | 2018 | Science China(Technological Sciences)2018，61，10： | 31 |
| 2 | CMHX008,a PPAR γ partial agonist,enhances insulin sensitivity with minor influences on bone loss显示文摘Traditional thiazolidinediones(TZDs),such as rosiglitazone,are peroxisome proliferator-activated receptor g(PPARg)potent agonists that can be used to treat type 2 diabetes but carry unwanted effects,including increased risk for fracture.The present work aimed to compare the insulin-sensitizing efficacies and bone-loss side effects of CMHX008,a novel TZDs-like PPARg partial agonist,with those of rosiglitazone.A TR-FRET PPARg competitive binding assay was used to compare the binding affinity between CMHX008 and rosiglitazone.Mice were administered vehicle,CMHX008 or rosiglitazone for 16 weeks.Mesenchymal stem cells(MSCs)were used to examine differences in differentiation into osteoblasts after compounds treatment.TR-FRET showed lower affinity to PPARg by CMHX008 compared with rosiglitazone.Mice treated with CMHX008 showed insulin sensitization similar to that of mice treated with rosiglitazone,which was related to the significant inhibition of PPARg Ser273 phosphorylation and improved insulin sensitivity by facilitating the phosphorylation of insulin receptor and Akt in adipose tissues.Micro-CT and histomorphometric analyses demonstrated that the degree of trabecular bone loss after treatment with CMHX008 was weaker than that observed with rosiglitazone,as evidenced by consistent changes in BV/TV,Tb.N,Tb.Th,Tb.Sp,and the mineral apposition rate.MSCs treated with CMHX008 showed higher ALP activity and mRNA levels of bone formation markers than did cells treated with rosiglitazone in the osteoblast differentiation test.Thus,CMHX008 showed insulin-sensitizing effects similar to those of rosiglitazone with a lower risk of bone loss,suggesting that PPARg sparing eliminates the skeletal side effects of TZDs while maintaining their insulin-sensitizing properties. | Yi Hou Xuemei Cao Xiangnan Hu Xinyu Li Xiaoqin Shi Hongying Wang Chuan Peng Jiayu Li Jibin Li Qifu Li Chaodong Wu Xiaoqiu Xiao | 2018 | Genes & Diseases2018，5，3： | 6 |
| 3 | Bifunctional 3D n-doped porous carbon materials derived from paper towel for oxygen reduction reaction and supercapacitor显示文摘Designing and fabricating cheap and active bifunctional materials is crucial for the development of renewable energy technologies.In this article,three-dimensional nitrogen-doped porous carbon materials(NDPC-X,in which X represents the pyrolysis temperature) were fabricated by simultaneous carbonization and activation of polypyrrole-coated paper towel protected by a silica layer followed by acid etching.The material had a high specific surface area(1,123.40 m^2/g).The as-obtained NDPC-900 displayed outstanding activity as a catalyst for the oxygen reduction reaction(ORR) as well as an electrode with a high specific capacitance in a supercapacitor in an alkaline medium.The NDPC-900 catalyst for the ORR exhibited a more positive reduction peak potential of à0.068 V(vs.Hg|HgCl^2) than that of Pt/C(-0.121 V),as well as better cycling stability and stronger methanol tolerance.Moreover,the NDPC-900 had a high specific capacitance of 379.50 F/g at a current density of 1 A/g,with a retention rate of 94.5% after 10,000 cycles in 6 mol/L KOH electrolyte when used as an electrode in a supercapacitor.All these results were attributed to the effect of a large surface area,which provided electrochemically active sites.This work introduces an effective way to use biomass-derived materials for the synthesis of promising bifunctional carbon material for electrochemical energy conversion and storage devices. | Xinyu Gao Xueyan Li Zhuang Kong Guozheng Xiao Ying Zhu | 2018 | Science Bulletin2018，63，10： | 6 |
| 4 | Visible Kerr comb generation in a high-Q silica microdisk resonator with a large wedge angle显示文摘This paper describes the specially designed geometry of a dry-etched large-wedge-angle silica microdisk resonator that enables anomalous dispersion in the 780 nm wavelength regime. This anomalous dispersion occurs naturally without the use of a mode-hybridization technique to control the geometrical dispersion. By fabricating a1-μm-thick silica microdisk with a wedge angle as large as 56° and an optical Q-factor larger than 107, we achieve a visible Kerr comb that covers the wavelength interval of 700–897 nm. The wide optical frequency range and the closeness to the clock transition at 698 nm of 87 Sr atoms make our visible comb a potentially useful tool in optical atomic clock applications. | Jiyang Ma Longfu Xiao Jiaxin Gu Hao Li Xinyu Cheng Guangqiang He Xiaoshun Jiang Min Xiao | 2019 | Photonics Research2019，7，5： | 5 |
| 5 | Modulating the threshold voltage of oxide nanowire field-effect transistors by a Ga^+ ion beam显示文摘在这份报纸,我们报导一个方法改变 SnO 的阀值电压<潜水艇class=“ a-plus-plus ”> 2 并且在里面<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”>由 Ga 的 3 只 nanowire 晶体管<啜class=“ a-plus-plus ”>+离子照耀。不同于在更早的报告的结果, SnO 的阀值电压<潜水艇class=“ a-plus-plus ”> 2 并且在里面<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”>在在 Ga 以后的否定的门电压方向的 3 nanowire 地效果晶体管(联邦货物税)移动<啜class=“ a-plus-plus “>+离子照耀。更小的阀值电压,由 Ga 完成了 < 啜 class= “ a-plus-plus ” >+ 离子照耀,为高效、低电压的操作被要求。阀值电压移动能被归因于 Ga 引起的表面缺点的降级 < 啜 class= “ a-plus-plus ” >+ 离子照耀。在照耀以后,当前的开/关比率稍微衰退,但是离 10 仍然靠近 < 啜 class= “ a-plus-plus ” > 6 。结果显示那 Ga < 啜 class= “ a-plus-plus ” >+ 离子横梁照耀在改进氧化物 nanowire 联邦货物税的表演起一个重要作用。 | Wenqing Li Lei Liao Xiangheng Xiao Xinyue Zhao Zhigao Dai Shishang Guo Wei Wu Ying Shi Jinxia Xu Feng Ren Changzhong Jiang | 2014 | Nano Research2014，7，11： | 5 |
| 6 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 7 | Coriander Genomics Database:a genomic,transcriptomic,and metabolic database for coriander显示文摘Coriander(Coriandrum sativum L.),also known as cilantro,is a globally important vegetable and spice crop.Its genome and that of carrot are models for studying the evolution of the Apiaceae family.Here,we developed the Coriander Genomics Database(CGDB,http://cgdb.bio2db.com/)to collect,store,and integrate the genomic,transcriptomic,metabolic,functional annotation,and repeat sequence data of coriander and carrot to serve as a central online platform for Apiaceae and other related plants.Using these data sets in the CGDB,we intriguingly found that seven transcription factor(TF)families showed significantly greater numbers of members in the coriander genome than in the carrot genome.The highest ratio of the numbers of MADS TFs between coriander and carrot reached 3.15,followed by those for tubby protein(TUB)and heat shock factors.As a demonstration of CGDB applications,we identified 17 TUB family genes and conducted systematic comparative and evolutionary analyses.RNA-seq data deposited in the CGDB also suggest dose compensation effects of gene expression in coriander.CGDB allows bulk downloading,significance searches,genome browser analyses,and BLAST searches for comparisons between coriander and other plants regarding genomics,gene families,gene collinearity,gene expression,and the metabolome.A detailed user manual and contact information are also available to provide support to the scientific research community and address scientific questions.CGDB will be continuously updated,and new data will be integrated for comparative and functional genomic analysis in Apiaceae and other related plants. | Xiaoming Song Fulei Nie Wei Chen Xiao Ma Ke Gong Qihang Yang Jinpeng Wang Nan Li Pengchuan Sun Qiaoying Pei Tong Yu Jingjing Hu Xinyu Li Tong Wu Shuyan Feng Xiu-Qing Li Xiyin Wang | 2020 | Horticulture Research2020，7，1： | 4 |
| 8 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 9 | A paper-based microfluidic biosensor integrating zinc oxide nanowires for electrochemical glucose detection显示文摘This paper reports an electrochemical microfluidic paper-based analytical device(EμPAD)for glucose detection,featuring a highly sensitive working electrode(WE)decorated with zinc oxide nanowires(ZnO NWs).In addition to the common features ofμPADs,such as their low costs,high portability/disposability,and ease of operation,the reported EμPAD has three further advantages.(i)It provides higher sensitivity and a lower limit of detection(LOD)than previously reportedμPADs because of the high surface-to-volume ratio and high enzyme-capturing efficiency of the ZnO NWs.(ii)It does not need any light-sensitive electron mediator(as is usually required in enzymatic glucose sensing),which leads to enhanced biosensing stability.(iii)The ZnO NWs are directly synthesized on the paper substrate via low-temperature hydrothermal growth,representing a simple,low-cost,consistent,and mass-producible process.To achieve superior analytical performance,the on-chip stored enzyme(glucose oxidase)dose and the assay incubation time are tuned.More importantly,the critical design parameters of the EμPAD,including the WE area and the ZnO-NW growth level,are adjusted to yield tunable ranges for the assay sensitivity and LOD.The highest sensitivity that we have achieved is 8.24μA·mM^(−1)·cm^(−2),with a corresponding LOD of 59.5μM.By choosing the right combination of design parameters,we constructed EμPADs that cover the range of clinically relevant glucose concentrations(0−15 mM)and fully calibrated these devices using spiked phosphate-buffered saline and human serum.We believe that the reported approach for integrating ZnO NWs on EμPADs could be well utilized in many other designs of EμPADs and provides a facile and inexpensive paradigm for further enhancing the device performance. | Xiao Li Chen Zhao Xinyu Liu | 2015 | Microsystems & Nanoengineering2015，1，1： | 4 |
| 10 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 11 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 12 | Research progress on aging of organic pollutants in geosorbents:a review显示文摘Geosorbents are the main host of anthropogenic organic pollutants and play a vital role in their fate and transport in the natural environment.Soil and sediment are the most common and abundant geosorbents in the natural environment;their interactions with organic pollutants,especially sorption and desorption processes,have been extensively studied from the perspectives of thermodynamics and kinetics.Recently,the aging of organic pollutants in geosorbents has drawn increased attention,leading to an improved understanding of interactions between organic pollutants and geosorbents and informing remediation criteria.Aging has been deemed important in accurately assessing ecologic and health risks of organic pollutants,and both positive and negative impacts have been reported in studies of natural and artificial sorbents.This paper summarizes recent research progress on organic pollutant aging in geosorbents,including related mechanism research,influence factors,bioavailability assessments,and biological and physicochemical remediation of aged organic pollutants.We also discuss issues in the current research and bring forward suggestions for future study. | Xianjin An Baohua xiao Xinyue Di Hui Dong Haiming Tang | 2017 | Acta Geochimica2017，36，1： | 3 |
| 13 | Iron metabolism,ferroptosis,and lncRNA in cancer: knowns and unknowns显示文摘Cancer cells undergo substantial metabolic alterations to sustain increased energy supply and uncontrolled proliferation.As an essential trace element,iron is vital for many biological processes.Evidence has revealed that cancer cells deploy various mechanisms to elevate the cellular iron concentration to accelerate proliferation.Ferroptosis,a form of cell death caused by iron-catalyzed excessive peroxidation of polyunsaturated fatty acids(PUFAs),is a promising therapeutic target for therapyresistant cancers.Previous studies have reported that long noncoding RNA(lncRNA)is a group of critical regulators involved in modulating cell metabolism,proliferation,apoptosis,and ferroptosis.In this review,we summarize the associations among iron metabolism,ferroptosis,and ferroptosis-related lncRNA in tumorigenesis.This information will help deepen understanding of the role of lncRNA in iron metabolism and raise the possibility of targeting lncRNA and ferroptosis in cancer combination therapy. | Lei QU Xinyu HE Qian TANG Xiao FAN Jian LIU Aifu LIN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，10： | 3 |
| 14 | Effect of an eco-friendly o/w emulsion stabilized with amphiphilic sodium alginate derivatives on lambda-cyhalothrin adsorption-desorption on natural soil minerals显示文摘The effects of amphiphilic O/W emulsions,stabilized by the alkyl polyglycoside(APG)or cholesterol-grafted sodium alginate(CSAD)/APG systems,on lambda-cyhalothrin adsorption/desorption mechanisms on natural soil minerals(i.e.,illite and kaolinite)were investigated.Sorption and desorption of lambda-cyhalothrin onto soil minerals was studied via batch equilibration to give insight into the adsorption equilibrium,kinetics,and thermodynamics of lambda-cyhalothrin adsorption onto minerals.The results indicate the following:(i)The adsorption processes for the APG system and CSAD/APG system include:rapid adsorption,slow adsorption,and adsorption equilibrium.The adsorption kinetics of pesticide on illite and kaolinite are in accordance with the Ho and McKay model,and the adsorption isotherm conforms to the Freundlich model.In addition,the adsorption processes of pesticide for the two systems on minerals were spontaneous and feasible(ΔG^0<0),endothermic(ΔH^0>0),and mainly involved chemical bonding(ΔH^0>60).(ii)The equilibrium adsorption percentages of the pesticide on illite for the APG system and CSAD/APG system were 42.4%and 64.8%,and the corresponding equilibrium adsorption percentages on kaolinite were 40.8%and 61.8%,respectively.Moreover,the pesticide adsorption rate K_(2-CSAD/APG)was faster than K_(2-APG),and its adsorption capacity K_(f-CSAD/APG )was greater than K_(f-APG).Meanwhile,the pesticide desorption K_(fd)in the CSAD/APG system was smaller than that in the APG system.As a result,this eco-friendly O/W emulsion based on amphiphilic sodium alginate derivatives might provide a green pesticide formulation,since it could reduce the amount of lambda-cyhalothrin entering aquatic systems to threaten non-target fish and invertebrate species. | Yang Peng Dunchao Xiao Gaobo Yu Yuhong Feng Jiacheng Li Xinyu Zhao Yiyuan Tang Longzheng Wang Quan Zhang | 2019 | Journal of Environmental Sciences2019，31，4： | 3 |
| 15 | Experimental study of mean overtopping discharge at perforated caissons for non-impulsive waves显示文摘In this study, hydraulic model tests are carried out to investigate the mean overtopping discharge at perforated caisson breakwaters for non-impulsive waves. Based on the experimental data, the mean overtopping discharges of perforated and nonperforated caissons are compared. It is found that when the relative crest freeboard is smaller than 1.6, the mean overtopping discharge of a breakwater can be reduced by at least half by using perforated caissons with 35% porosity instead of nonperforated caissons. The effects of the relative crest freeboard, the caisson porosity and perforation shape, the relative wave chamber width and the relative water depth on the mean overtopping discharge at perforated caissons are clarified. Then,predictive formulas for the mean overtopping discharge at perforated caissons are developed. The predictive formulas based on the experimental data are valid in a wide range of the relative crest freeboard and involve the effects of the caisson porosity and the relative water depth. The predictive formulas developed in this study are of significance for the hydraulic design of perforated caissons. | LIU Xiao LIU Yong LI HuaJun WANG XinYu ZHAO Yang | 2018 | Science China(Technological Sciences)2018，61，5： | 3 |
| 16 | Autophagy mediates the secretion of macrophage migration inhibitory factor from cardiomyocytes upon serum-starvation显示文摘Macrophage migration inhibitory factor(MIF) is an inflammatory cytokine. It is elevated early in the blood of acute myocardial infarction patients. However, it is unclear whether and how MIF is released. This study investigated the cellular source and mechanism of MIF release from hearts. An ischemia-mimic treatment induced the secretion of MIF from neonatal rat cardiomyocytes but not from fibroblasts. The treatment did not cause significant leakage of lactate dehydrogenase, suggesting that ischemia induced the MIF secretion without causing severe cell damage. Plasma samples from patients with acute chest pain at the emergency department were collected for the detection of MIF. MIF levels in patients with acute coronary syndrome(ACS)increased early, when cardiac injury markers were not yet elevated, suggesting that ischemia can induce MIF secretion before the occurrence of severe myocardial damage. Serum-starvation caused MIF secretion from rat cardiomyocytes and Langendorffperfused rat hearts. The secretion was suppressed by the inhibition of autophagy by inhibitors or by silencing of Atg5. In conclusion, serum-starvation induces the secretion of MIF from cardiomyocytes via autophagy dependent pathway. Clarifying the mechanism of MIF secretion will be helpful for its application in the early diagnosis and treatment of ACS. | Jimin Wu Xiangning Deng Juan Gao Wei Gao Han Xiao Xinyu Wang Youyi Zhang | 2019 | Science China(Life Sciences)2019，62，8： | 2 |
| 17 | Image acquisition system for agricultural context-aware computing显示文摘Context-aware computing is a new mode originated from ubiquitous computing.Its emergence brings a substantial change to traditional computing and related service.Image is a pervasive tool for context awareness.A large number of applications are developed based on images analysis.In this paper,an image acquisition system is presented for agricultural context-aware computing.The potential use of the system includes production evaluation,precise management and assistant control.The system includes four modules:the camera system,the control system,mechanism,and communication.The system can be easily installed in target crop fields.The camera system is composed of a binocular stereo camera and a color camera.Two cubic images and a corresponding texture image are collected for each plant in the process of data acquisition.An accessorial software system is developed to control and manage the capture system.Experiments show that the presented system is effective for image acquisition of agricultural context-aware computing. | Xiao Boxiang Wang Chuanyu Guo Xinyu Wu Sheng | 2014 | International Journal of Agricultural and Biological Engineering2014，7，4： | 2 |
| 18 | The mechanism of dentine hypersensitivity:Stimuli-induced directional cation transport through dentinal tubules显示文摘Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains unclear.The long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain processes.However,no experimental evidence supports the statements.Here,we demonstrate that stimuli-induced directional cation transport,rather than fluid-flow,through dentinal tubules actually leads to dentine hypersensitivity.The in vitro/in vivo electro-chemical and electro-neurophysiological approaches reveal the cation current through the nanoconfined negatively charged dentinal tubules coming from external stimuli(pressure,pH,and temperature)on dentin surface and further triggering the nerve impulses causing the dentine hypersensitivity.Furthermore,the cationic-hydrogels blocked dentinal tubules could significantly reduce the stimuli-triggered nerve action potentials and the anionhydrogels counterpart enhances those,supporting the cation-flow transducing dentine hypersensitivity.Therefore,the inspired ion-blocking desensitizing therapies have achieved remarkable pain relief in clinical applications.The proposed mechanism would enrich the basic knowledge of dentistry and further foster breakthrough initiatives in hypersensitivity mitigation and cure. | Nuo Chen Jingjing Deng Shengjie Jiang Xiang-Yu Kong Teng Zhou Kai Zhao Zuohui Xiao Huimin Zheng Weipeng Chen Congcong Zhu Xinyu Liu Liping Wen Yan Wei Xuliang Deng Lei Jiang | 2023 | Nano Research2023，16，1： | 2 |
| 19 | Aerothermal characteristics of bleed slot in hypersonic flows显示文摘Two types of flow configurations with bleed in two-dimensional hypersonic flows are numerically examined to investigate their aerodynamic thermal loads and related flow structures at choked conditions. One is a turbulent boundary layer flow without shock impingement where the effects of the slot angle are discussed, and the other is shock wave boundary layer interactions where the effects of slot angle and slot location relative to shock impingement point are surveyed. A key separation is induced by bleed barrier shock on the upstream slot wall, resulting in a localized maximum heat flux at the reattachment point. For slanted slots, the dominating flow patterns are not much affected by the change in slot angle, but vary dramatically with slot location relative to the shock impingement point. Different flow structures are found in the case of normal slot, such as a flow pattern similar to typical Laval nozzle flow, the largest separation bubble which is almost independent of the shock position. Its larger detached distance results in 20% lower stagnation heat flux on the downstream slot corner, but with much wider area suffering from severe thermal loads. In spite of the complexity of the flow patterns, it is clearly revealed that the heat flux generally rises with the slot location moving downstream, and an increase in slot angle from 20° to 40° reduces 50% the heat flux peak at the reattachment point in the slot passage. The results further indicate that the bleed does not raise the heat flux around the slot for all cases except for the area around the downstream slot corner. Among all bleed configurations, the slot angle of 40° located slightly upstream of the incident shock is regarded as the best. | YUE LianJie LU HongBo XU Xiao CHANG XinYu | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，10： | 2 |
| 20 | Characteristics and distributions of humic acids in two soil profiles of the southwest China Karst area显示文摘Characteristics and distributions of humic acid(HA) and soil organic matter(SOM) in a yellow soil profile and a limestone soil profile of the southwest China Karst area were systematically investigated to reveal their evolutions in different soils of the study area. The results showed that characteristics and distribution of SOM along the two soil profiles were notably different. Total organic carbon(TOC) contents of soil samples decreased just slightly along the limestone soil profile but sharply along the yellow soil profile. TOCs of the limestone soils were significantly higher than those of the corresponding yellow soils, and C/N ratios of SOMs showed a similar variation trend to that of TOCs, indicating that SOM can be better conserved in the limestone soil than in the yellow soil. The soil humic acids were exhaustively extracted and further fractionated according to their apparent molecular weights using ultrafiltration techniques to explore underlying conservation mechanisms. The result showed that C/N ratios of HAs from different limestone soil layers were relatively stable and that large molecular HA fractions predominated the bulk HA of the top soil, indicating that HA in the limestone profile was protected while bio and chemical degradations were retarded. Combined with organic elements contents and mineral contents of two soils, weconcluded that high calcium contents in limestone soils may play a key role in SOM conservation by forming complexation compounds with HAs or/and enclosing SOMs with hypergene CaCO_3 precipitation. | Liangang Ma Baohua Xiao Xinyue Di Weilin Huang Shijie Wang | 2016 | Acta Geochimica2016，35，1： | 2 |
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