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| 1 | TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells显示文摘免疫疗法和化疗的联合为癌症的某些类型的治疗被认为是一条有希望的途径。然而,内在的机制需要充分被调查为癌症 chemoimmunotherapy 指导更有效的协议的设计。联系危险的分子的模式(阻尼) 能激活有免疫力的房间,是众所周知的,包括树枝状的房间(DC ) ,经由像使用费的受体(TLR ) ;然而,在有免疫力的反应的激活免除化学对待药的肿瘤房间的阻尼的角色需要进一步被阐明。这里,我们发现那 colorectal 与 oxaliplatin (OXA ) 对待的癌症(CRC ) 房间或 5 氟尿嘧啶(5-Fu ) 释放了高活动性的组盒子 1 的高水平(HMGB1 ) 和热吃惊蛋白质 70 (HSP70 ) 。在 OXA/5-Fu 治疗以后,也展出的 CRC 病人的 sera 增加了 HMGB1 和 HSP70 的层次,哪个是著名阻尼。与 OXA/5-Fu 对待的垂死的 CRC 房间的上层清液支持了老鼠和人的 DC 成熟,与 HLA 医生, CD80 和 CD86 表示和 IL-1β 的改进的 upregulation;, TNF-α, MIP-1α, MIP-1β, RANTES 和 IP-10 生产。由 DC 组成的疫苗与导致的化学上强调的 CRC 房间的上层清液搏动了更重要的 IFN-γ在 vitro 并且在 vivo 生产 Th1 反应。然而,化学上强调的 CRC 房间的上层清液没能在 TLR4 缺乏的 DC 导致 phenotypic 成熟和 cytokine 生产,显示在导致阻尼的 DC 成熟和激活的 TLR4 的一个必要角色。而且,有化学上强调的 CRC 房间的上层清液的 pulsing 高效地没导致 IFN-γ在 TLR4 缺乏的 DC 生产 Th1 反应。一起,这些结果证明免除化学上强调的癌症房间的阻尼能经由 TLR4 激活 DC 并且提高反肿瘤 T 房间有免疫力的回答的正式就职,描出一条临床上相关的免疫助手小径由阻尼被触发。 | Hongliang Fang Bing Ang Xinyun Xu Xiaohui Huang Yanfeng Wu Yanping Sun Wenying Wang Nan Li Xuetao Cao Tao Wan | 2014 | Cellular & Molecular Immunology2014，11，2： | 11 |
| 2 | Precision forging technology for aluminum alloy显示文摘 | Lei DENG Xinyun WANG Junsong JIN Juchen XIA | 2018 | Frontiers of Mechanical Engineering2018，13，1： | 6 |
| 3 | Modelling of dynamic recrystallization kinetics of 300M steel at high strain rates during hot deformation显示文摘The flow curves of 300M steel exhibit a transition from stress peak presence to stress peak absence as the strain rate increases. It is difficult to establish dynamic recrystallization(DRX) kinetics models suitable for strain rates where there are no stress peaks in the flow curves using the existing Avrami equation, and the optimal processing parameters for forging can be scarcely acquired.In this study, the high-temperature flow and DRX behavior of 300M steel are investigated by performing isothermal compression tests at temperatures between 1173–1423K with strain rates between 0.001–50 s-1. Distinct stress peaks can be found in the flow curves at low strain rates, and the average grain size decreases with the increase in the strain rate at the same temperature. The DRX mechanism is a discontinuous DRX, and the grain boundary migration plays an important role in the DRX process. In contrast, no stress peak is observed in the flow curves at high strain rates, and the average grain size no longer decreases with the strain rate increase at the same temperature. The DRX mechanism in this case is a continuous DRX. The demarcated strain rate is calculated based on the characteristics of the obtained flow curves and grain sizes. The recrystallization volume fraction model and prediction grain size model at high strain rates are established. In combination with the existing DRX kinetics models at low strain rates, the processing parameters can be optimized to produce components with excellent mechanical properties. | GUO Peng DENG Lei WANG XinYun LI JianJun | 2019 | Science China(Technological Sciences)2019，62，9： | 5 |
| 4 | MULTIPOINT BLANK HOLDER FORCE CONTROL IN HYDROFORMING OF FUEL TANK显示文摘力量(BHF ) 控制的多点的空白的持有者的学习外面被得到 forhydroforming 一辆复杂形状摩托车燃料坦克。由有限元素方法(女性) 模拟,多点的空白的持有者柱体的配置和本地 BHF 的设置被优化,并且多点的 BHF 在上的影响流体力学的深绘画和 conventionalhydroforming 进程被学习。需要的液体压力和整个 BHF 为流体力学的深绘画过程被预言。最后,模拟结果被形成实验证明,并且他们在同意很好。 | WU Yousheng WANG Xinyun XIA Juchen HU Guoan SUN Yousong YANG Lin | 2006 | Chinese Journal of Mechanical Engineering2006，19，2： | 4 |
| 5 | HDL impairs osteoclastogenesis and induces osteoclast apoptosis via upregulation of ABCG1 expression显示文摘 | Xinyun Huang Yuan Lv Panpan He Zongbao Wang Fang Xiong Linhao He Xilong Zheng Dawei Zhang Qi Cao Chaoke Tang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 6 | Thermoplastic micro-formability of TiZrHfNiCuBe high entropy metallic glass显示文摘High entropy metallic glasses(MGs) have attracted tremendous attentions owing to high entropy that benefits the probing of new MG-forming systems. However, the micro-formability of high entropy MGs is lack of investigation in comparison with these conventional MG counterparts, which is crucial to the development of this kind of metallic alloys. In this work, the thermoplastic mciro-formability of TiZrHfNiCuBe high entropy MG was systemically investigated. Time-Temperature-Transformation(TTT)curve was first constructed based on isothermal crystallization experiments, which provides thermoplastic processing time of the supercooled high entropy MGs. By comparison with the deformation map,Newtonian flow was found beneficial to the thermoplastic formability. While the thermoplastic forming becomes arduous with reducing mould size to tens micrometer, because of the strong supercooled TiZrHfNiCuBe high entropy MG(fragility = 27). Fortunately, the micro-formability of TiZrHfNiCuBe high entropy MG could be improved by vibration loading, as demonstrated by finite-element-method simulation. Our findings not only systemically evaluate the thermoplastic micro-formability of high entropy MG, but also provide fundamental understanding of the phenomenon. | Xinyun Wang Wenlei Dai Mao Zhang Pan Gong Ning Li | 2018 | Journal of Materials Science & Technology2018，34，11： | 3 |
| 7 | The advancements,challenges,and future implications of the CRISPR/Cas9 system in swine research显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(CRISPR/Cas9)genome editing technology has dramatically influenced swine research by enabling the production of high-quality disease-resistant pig breeds,thus improving yields.In addition,CRISPR/Cas9 has been used extensively in pigs as one of the tools in biomedical research.In this review,we present the advancements of the CRISPR/Cas9 system in swine research,such as animal breeding,vaccine development,xenotransplantation,and disease modeling.We also highlight the current challenges and some potential applications of the CRISPR/Cas9 technologies. | Jinfu Zhang Emmanuel M.Khazalwa Hussein M.Abkallo Yuan Zhou Xiongwei Nie Jinxue Ruan Changzhi Zhao Jieru Wang Jing Xu Xinyun Li Shuhong Zhao Erwei Zuo Lucilla Steinaa Shengsong Xie | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 8 | A pH Model for Calculating the pH Value of Mixed–Acid–Base Equilibria of Overhead Condensing Systems in Crude Distillation显示文摘A pH predictive model based on acid–base equilibria and ion equilibria was proposed to calculate the pH value of the overhead condensing system of crude distillation unit. The pH model could be used to predict the appropriate amounts of neutralizers by measuring the Cl-ion concentration of the overhead knockout drum. The pH values of various neutralized streams were estimated by this model. The results showed that the predicted pH values were in good agreement with the experimental ones. The trend of the corrosion inhibition efficiency decreases in the following order: ethylenediamine > N,Ndimethylethanolamine> triethylamine > 3-methoxypropylamine > morpholine. The difficulty in the accurate control of corrosion was solved, and a good instruction was provided for mitigating corrosion in refinery. | Wang Haibo Li Yun Cheng Guangxu Wu Wei Chen Xuan Zhang Yaoheng Li Xinyun | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，4： | 2 |
| 9 | SnRK1 Phosphorylates and Destabilizes WRKY3 to Enhance Barley Immunity to Powdery Mildew显示文摘Plants recognize pathogens and activate immune responses,which usually involve massive transcriptional reprogramming.The evolutionarily conserved kinase,Sucrose non-fermenting-related kinase 1(SnRK1),functions as a metabolic regulator that is essential for plant growth and stress responses.Here,we identify barley SnRK1 and a WRKY3 transcription factor by screening a cDNA library.SnRK1 interacts with WRKY3 in yeast,as confirmed by pull-down and luciferase complementation assays.Förster resonance energy transfer combined with noninvasive fluorescence lifetime imaging analysis indicates that the interaction occurs in the barley nucleus.Transient expression and virus-induced gene silencing analyses indicate that WRKY3 acts as a repressor of disease resistance to the Bgh fungus.Barley plants overexpressing WRKY3 have enhanced fungal microcolony formation and sporulation.Phosphorylation assays show that SnRK1 phosphorylates WRKY3 mainly at Ser83 and Ser112 to destabilize the repressor,and WRKY3 non-phosphorylation-null mutants at these two sites are more stable than the wild-type protein.SnRK1-overexpressing barley plants display enhanced disease resistance to Bgh.Transient expression of SnRK1 reduces fungal haustorium formation in barley cells,which probably requires SnRK1 nuclear localization and kinase activity.Together,these findings suggest that SnRK1 is directly involved in plant immunity through phosphorylation and destabilization of the WRKY3 repressor,revealing a new regulatory mechanism of immune derepression in plants. | Xinyun Han Ling Zhang Lifang Zhao Pengya Xue Ting Qi Chunlei Zhang Hongbo Yuan Lixun Zhou Daowen Wang Jinlong Qiuand Qian-Hua Shen | 2020 | Plant Communications2020，1，4： | 2 |
| 10 | Viscous pressure forming(VPF):state-of-art and future trends显示文摘 | WANG Zhongjin LIU Jianguang WANG Xinyun | 2004 | Journal of Materials Processing Technology2004，151，： | 1 |
| 11 | Modeling of nanoparticle-induced Rayleigh-Gans scattering for nanofiber optical sensing 显示文摘 | Shanshan Wang Xinyun Pan Limin Tong | 2007 | Opt Commun2007，276，2： | 1 |
| 12 | Design and implementation of wireless communication system based on CC1101 显示文摘 | Zi Xinyun Wang Yue Zhao Ling | 2013 | Advanced Materials Research2013，684，： | 1 |
| 13 | Optimization of Ultrasonic Extraction and Clean-up Protocol for the Determination of Polycyclic Aromatic Hydrocarbons in Marine Sediments by High-performance Liquid Chroma-tography Coupled with Fluorescence Detection显示文摘The procedures of ultrasonic extraction and clean-up were optimized for the determination of polycyclic aromatic hydrocarbons (PAHs) in marine sediments. Samples were ultrasonically extracted, and the extracts were purified with a miniaturized silica gel chromatographic column and analyzed with high performance liquid chromatography (HPLC) with a fluorescence detector. Ultrasonication with methanol-dichloromethane (2:1, v/v) mixture gave higher extraction efficiency than that with dichloromethane. Among the three elution solvents used in clean-up step, dichloromethane-hexane (2:3, v/v) mixture was the most satisfactory. Under the optimized conditions, the recoveries in the range of 54.82% to 94.70% with RSDs of 3.02% to 23.22% for a spiked blank, and in the range of 61.20% to 127.08% with RSDs of 7.61% to 26.93% for a spiked matrix, were obtained for the 15 PAHs studied, while the recoveries for a NIST standard reference SRM 1941b were in the range of 50.79% to 83.78% with RSDs of 5.24% to 21.38%. The detection limits were between 0.75 ng L-1 and 10.99 ng L-1for different PAHs. A sample from the Jiaozhou Bay area was examined to test the established methods. | PENG Xuewei YAN Guofang LI Xianguo GUO Xinyun ZHOU Xiao WANG Yan | 2012 | Journal of Ocean University of China2012，11，3： | 1 |
| 14 | Optimization of die profile for improving die life in the hot extrusion process 显示文摘 | ZOU Lin XIA Juchen WANG Xinyun | 2003 | Journal of Material Processing Technology2003，142，3： | 1 |
| 15 | Demonstration program of population‐based lung cancer screening in C hina: Rationale and study design显示文摘 | Qinghua Zhou Yaguang Fan Ning Wu Yunchao Huang Ying Wang Lu Li Jiewei Liu Xinyun Wang Weimin Li Youlin Qiao | 2014 | Thoracic Cancer2014，，3： | 1 |
| 16 | Effect of isothermal extrusion parameters on mechanical properties of Al–Si eutectic alloy显示文摘 | Lei Deng Xinyun Wang Juchen Xia Jianjun Li | 2011 | Materials Science & Engineering A2011，，21： | 1 |
| 17 | Clinical Efficacy Observation of Acupuncture Treatment for Nonarteritic Anterior Ischemic Optic Neuropathy显示文摘 | Yali Qin Wei Yuan Hui Deng Zhanmei Xiang Chao Yang Xinyun Kou Shufei Yang Zhijun Wang Ming Jin Ki-Wan Oh | 2015 | Evidence-Based Complementary and Alternative Medicine2015，，： | 1 |
| 18 | The Improvement of DTC System Performance on Fuzzy Control显示文摘 | Yuan Gao Jinkuan Wang Xinyun Qiu | 2011 | Procedia Environmental Sciences2011，，： | 1 |
| 19 | Path Analysis of Energy-Saving Technology in Yangtze River Basin Based on Multi-Objective and Multi-Parameter Optimisation显示文摘The Yangtze River Basin in China is characterised by hot-and cold-humid climates in summer and winter, respectively. Thus, increased demand for heating and cooling energy according to the season, as well as poor indoor thermal comfort, are inevitable. To overcome this problem, this study focused on the influence of passive design and heating, ventilation, and air conditioning equipment performance on the energy performance of residential buildings, and explored potential energy-saving technology paths involving passive design and improved coefficient of performance through a multi-objective and multi-parameter optimisation technique. A large-scale questionnaire survey covering a typical city was first conducted to identify family lifestyle patterns regarding time spent at home, family type, air conditioner use habits, indoor thermal comfort, etc. Then, the actual heating and cooling energy consumption and information of model building were determined for this region. Subsequently, the design parameters of an individual building were simulated using Energyplus to investigate the cooling and heating energy consumption for a typical residential building with an air conditioner. The results indicated an improvement of approximately 30% in energy efficiency through optimisation of the external-wall insulation thickness and the external-window and shading performance, and through use of appropriate ventilation technology. Thus, a multi-objective and multi-parameter optimisation model was developed to achieve comprehensive optimisation of several design parameters. Experimental results showed that comprehensive optimisation could not only reduce cooling and heating energy consumption, but also improve the thermal comfort level achieved with a non-artificial cooling and heating source. Finally, three energy-saving technology paths were formulated to achieve a balance between indoor thermal comfort improvement and the target energy efficiency(20 kWh/(m2?a)). The findings of this study have implications for the future design of buildings in the Yangtze River Basin, and for modification of existing buildings for improved energy efficiency. | MENG Xiangzhong YU Wei ZHENG Chuyu WANG Di CAO Xinyun | 2019 | Journal of Thermal Science2019，28，6： | 1 |
| 20 | Optimization of die profile for improving die life in the hot extrusion process显示文摘 | Zou Lin Xia Juchen Wang Xinyun | 2003 | Journal of Materials Processing Technology2003，142，3： | 1 |
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