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| 1 | Atg7 is required for acrosome biogenesis during spermatogenesis in mice显示文摘acrosome 是盖住精子原子核的前面的部分并且在授精的过程起一个必要作用的一个专业化细胞器。位于这个 lysosome 相关的细胞器(LRO ) 的生物的续生说下面的分子的机制大部分仍然是未知的。这里,我们显示出房间特定的 Atg7 大美人老鼠是的那个细菌由于在 acrosome 生物的续生说的一个缺点不肥沃并且显示了类似于人的 globozoospermia 的显型;这个繁殖缺点被 intracytoplasmic 精子注射成功地救。而且,在细菌房间的 Atg7 的弄空没影响细菌房间的开发的早阶段,但是精子发生在以后上演,在 Golgi 期间没有通过到保险丝进一个单个 acrosomal 泡的 proacrosomal 泡分阶段执行,它最后导致了不规则或将近 round-headed 精子。Autophagic 流动在弄空 Atg7 的细菌房间被破坏,最后导致 LC3 变化形式的失败到 Golgi 导出仪器的泡。另外, Atg7 部分调整了另一 globozoospermia 相关的蛋白质,联系 Golgi 的 PDZ 卷和卷卷包含主题的蛋白质(GOPC ) ,在 acrosome 生物的续生说期间。最后,任何一个 autophagy 的注射或进睾丸的 lysosome 禁止者导致了类似的显型到细菌的房间特定的 Atg7 大美人老鼠。总的来说,我们的结果揭开为在 acrosome 的生物的续生说的 Atg7 的一个新角色,并且我们提供证据为 acrosome 支持 autolysosome 起源假设。 | Hongna Wang Haifeng Wan Xixia Li Weixiao Liu Qi Chen Yaqing Wang Lin Yang Hongmei Tang Xiujun Zhang Enkui Duan Xiaoyang Zhao Fei Gao Wei Li | 2014 | Cell Research2014，24，7： | 25 |
| 2 | Molecular basis of cryptorchidism-induced infertility显示文摘Artificial cryptorchidism or local testicular heat treatment can induce reversible oligospermia or azoospermia in monkeys and rats via germ cell apoptosis. Local warming of monkey testes in water at 43°C for 2 consecutive days (30 min per day) decreased the number of sperm in the semen by up to 80% on d 28, and the effect was completely reversed on d 144. Germ cells rely heavily on Sertoli cells for structural and nutritional support. Specialized junctions that play a pivotal role in spermatogenesis occur at sites of Sertoli-Sertoli and Sertoli-germ cell contact in the seminiferous epithelium. We demonstrated that expression of tight junction (TJ)-associated molecules, such as occludin and zonula occludens-1 (ZO-1), were greatly reduced 24–48 h after heat treatment, while the permeability of the blood-testis barrier (BTB) was simultaneously increased, but recovered 10 d later. These results indicate a reversible disruption of the BTB associated with transient inductions of transforming growth factor (TGF) β2 and β3 expression, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase activation, and concomitant loss of occludin and ZO-1. This suggests that expression of TJ-associated molecules and the BTB was reversibly perturbed by mild testicular hyperthermia, and that the heat-induced induction of TGF-β might be involved in downregulating TJ-associated proteins, leading to cell junction reduction. This review discusses the changes in total gene expression patterns after experimental cryptorchidism in adult mouse testes, and the cloning of several novel, physiologically significant spermatogenesis-specific genes. | LIU YiXun & LI XiXia State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China | 2010 | Science China(Life Sciences)2010，53，11： | 9 |
| 3 | Cable-like carbon nanotubes decorated metal-organic framework derived ultrathin CoSe2/CNTs nanosheets for electrocatalytic overall water splitting显示文摘The high cost and low reserves of noble metals greatly hinder their practical applications in new energy production and conversion.The exploration of cost-effective alternative electrocatalysts with the ability to drive hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)is extremely significant to promote overall water splitting.Herein,ultrathin CoSe2/CNTs nanocomposites have been synthesized by a facile two-step method,where the ultrathin Co-MOF(metal organic-framework)decorated with cable-like carbon nanotubes(CNTs)(Co-MOF/CNTs)was initially fabricated,and followed a lowtemperature selenization process.The ultrathin CoSe2 nanosheets as well as the superior conductivity of CNTs synergistically resulted in abundant active sites and enhanced conductivity to boost the electrocatalytic activity.The as-prepared CoSe2/CNTs electrocatalysts exhibited an overpotential of190 mV and 300 mV vs.reversible hydrogen electrode(RHE)at a current density of 10 mA/cm^(2) for the HER and OER in alkaline solution,respectively,and demonstrated superior durability.Furthermore,the as-prepared bifunctional CoSe2/CNTs electrocatalysts can act as cathode and anode in an electrolyzer,showing a cell voltage of 1.75 V at 10 mA/cm^(2) for overall water splitting. | Guijuan Wei Kun Du Xixia Zhao Jiayang Wang Wenxiu Yan Chao An Changhua An | 2020 | Chinese Chemical Letters2020，31，10： | 5 |
| 4 | Carbon quantum dot-induced self-assembly of ultrathin Ni(OH)2 nanosheets: A facile method for fabricating three-dimensional porous hierarchical composite micro-nanostructures with excellent supercapacitor performance显示文摘Significant efforts have been directed towards the preparation and applicationof porous hierarchically structured materials owing to their large surface area,rich active sites, and enhanced mass transport and diffusion. In this study, asimple and cost-effective method for the carbon quantum dot (CQD)-inducedassembly of two-dimensional ultrathin Ni(OH)2 nanosheets into a three-dimensional (3D) porous hierarchical structure was developed. The electrostaticforces between the CQDs and cations drove the self-assembly of the 3DCQDs/Ni(OH)2 hierarchical structures. As a new type of structure-directingagent, the CQDs played dual roles in tuning the morphology of the productsand improving the supercapacitor performance. The multilevel CQDs/Ni(OH)2micro-nanostructures had a large specific surface area and rich porosity. Owingto their unique structures and the conductivity of the CQDs, an optimizedasymmetric supercapacitor using the CQDs/Ni(OH)2 exhibited a maximumspecific capacity of 161.3 F.g-1 and a high energy density of 57.4 Wh·kg^-1 Thisstudy introduces a potential method for the fabrication of many other 3Dhierarchical structures with great potential for applications in various fields. | Guijuan Wei Kun Du Xixia Zhao Zhaojie Wang Ming Liu Chuang Li Hui Wang Changhua An Wei Xing | 2017 | Nano Research2017，10，9： | 4 |
| 5 | Molecular-scale integrated multi-functions for organic lightemitting transistors显示文摘Organic light-mitting transistors(OLETs)integrate the functions of light-emitting diodes and field-effect transistors into a unique device,opening a new door for optoelectronics.However,there is still a challenge due to the absence of high quality organic semiconductors for OLETs.Herein,we reported a novel molecule 2,6-di(anthracen-2-yl)naphthalene(2,6-DAN),which exhibited mobility of up to 19 cm2:V'-s'and an absolute fluorescence quantum yield of 37.09%,which are good values for organic semiconductors.Moreover,OLETs based on 2,6-DAN single crystals showed bright yellowish-green emission and well-balanced ambipolar charge transport.The excellent ratio of hole to electron mobilty can reach up to 0.86,which is superior to most single component OL ETs in typical device configurations reported so far. | Lei Zheng Jinfeng Li Ke Zhou Xixia Yu Xiaotao Zhang Huanli Dong Wenping Hu | 2020 | Nano Research2020，13，7： | 4 |
| 6 | Three-dimensional reconstruction of Picea wilsonii Mast. pollen grains using automated electron microscopy显示文摘Three-dimensional electron microscopy(3 D-EM) has attracted considerable attention because of its ability to provide detailed information with respect to developmental analysis. However, large-scale high-resolution 3 D reconstruction of biological samples remains challenging. Herein, we present a 3 D view of a Picea wilsonii Mast. pollen grain with 100 nm axial and38.57 nm lateral resolution using AutoCUTS-SEM(automatic collector of ultrathin sections-scanning electron microscopy). We established a library of 3,127 100 nm thick serial sections of pollen grains for preservation and observation, demonstrating that the protocol can be used to analyze large-volume samples. After obtaining the SEM images, we reconstructed an entire pollen grain comprising 734 serial sections. The images produced by 3D reconstruction clearly revealed the main components of the P.wilsonii pollen grain, i.e., two sacci and pollen corpus, tube cell, generative cell, and two degenerated prothallial cells, and their internal organization. In addition, we performed a quantitative analysis of the different pollen grain cells, including sacci, and found that there were 202 connections within a saccus SEM image. Thus, for the first time, this study provided a global 3D view of the entire pollen grain, which will be useful for analyzing pollen development and growth. | Weiwei Shen Lingyu Ma Xi Zhang Xixia Li Yuanyuan Zhao Yanping Jing Yun Feng Xueke Tan Fei Sun Jinxing Lin | 2020 | Science China(Life Sciences)2020，63，2： | 3 |
| 7 | One-nanometer-thick platinum-based nanowires with controllable surface structures显示文摘Pt-based ultrathin nanowires (NWs) are considered as one of the most intriguing catalysts for fuel cells.However,the delicate controllability of surface structure of ultrathin NWs to regulate their catalytic performances is still a challenge.Here,two kinds of one-nanometer-thick Pt-based NWs with smooth surfaces (S-NWs) and rough surfaces (R-NWs) are demonstrated,in which the combined use of hexadecyltrimethylammonium bromide and oleylamine plays an essential role,as they could form soft-templates to direct the growth of NWs.Due to its high-density of low-coordinated sites on the surface,Pt-based R-NWs exhibit higher oxygen reduction reaction (ORR) activities but lower stabilities than corresponding S-NWs.Notably,Pt0.78Ni0.22 R-NWs possess the highest mass activity (1.07 A-mgpt^-1) and specific activity (1.02 mA·cm^-2) among all Pt-based NWs.After 10,000 sweeping cycles,the mass activity still exhibits 5.7-fold enhancement compared to the corresponding commercial Pt/C.This work presents a new approach to delicately control the surface structure of ultrathin Pt-based NWs as advanced ORR catalysts. | Xiaokun Fan Shuiping Luo Xixia Zhao Xiaotong Wu Zhishan Luo Min Tang Wen Chen Xing Song Zewei Quan | 2019 | Nano Research2019，12，7： | 2 |
| 8 | Study of a pre-treatment process for electroless copper plating on ceramics显示文摘 | Hongfang Ma Zhibao Liu Ling Wu Yihan Wang Xixia Wang | 2011 | Thin Solid Films2011，，22： | 1 |
| 9 | Effective-phonon approximation of polarons in ternary mixed crystals显示文摘 | Liang Xixia Yang Jinsheng | 1996 | Solid State Commun1996，100，： | 1 |
| 10 | Polarons with spatially dependent mass in a finite parabolic quantum well显示文摘 | Zhao Fengqi Liang Xixia | 2002 | Chin Phys Lett2002，19，7： | 1 |
| 11 | SVM-based fuzzy rules acquisition system for pulsed GTAW process显示文摘 | HUANG Xixia SHI Fanhuai GU Wei | 2009 | Engineering Applications of Artificial Intelligence2009，22，8： | 1 |
| 12 | Band structures of two-dimensional magnonic crystals with different shapes and arrangements of scatterers 显示文摘 | Cao Yongjun Yun Guohong Liang Xixia | 2010 | J Phys D: Appl Phys2010，43，30： | 1 |
| 13 | Band structures of two-dimensional magnonic crystals with different shapes and arrangements of scatterers显示文摘 | Cao Yongjun Yun Guohong Liang Xixia | 2010 | J Phys D:Appl Phys2010，43，30： | 1 |
| 14 | SVM-based fuzzy modeling for the arc welding process显示文摘 | Huang Xixia Chen Shanben | 2006 | Materials Science and Engineering2006，427，12： | 1 |
| 15 | Annual Operation Status of SECRAL in 2009显示文摘 | Lu Wang Sun Liangting Feng Yucheng Guo Xiaohong Zhang Xuezheng Li Jingyu Cao Yun Wang Hui Ma Baohua Shang Yong Sha Shan Ma Hongyi Li Xixia Lin Shuhao Zhang Wenhui Jin Tao Zhao Huanyu Zhao Hongwei | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 1 |
| 16 | Operation of LECR3显示文摘 | Feng Yueheng Ma Baohua Wang Hui Li Jinyu Cao Yun Shang Yong Lu Wang Sha Shan Ma Hongyi Zhang Wenhui Lin Shuhao Li Xixia Zhao Huanyu Miao Tingting Guo Xiaohong Zhang Xuezhen Sun Liangting | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 1 |
| 17 | Effect of electron-phonon interaction on surface in zine-blende GaN,AlN and InN under pressure显示文摘 | Yah Zuwei Ban Shiliang Liang Xixia | 2003 | Ear Phys J B2003，，35： | 1 |
| 18 | Binding energies of excitions in GaAs/AlAs quantum wells under pressure 显示文摘 | Zhao Guojun Liang Xixia Ban Shiliang | 2003 | Mod Phys lett B2003，17，16： | 1 |
| 19 | SVM-based fuzzy modeling for the arc welding process显示文摘 | Huang Xixia Chen Shanben | 2006 | Materials Science and Engineering:A2006，427，112： | 1 |
| 20 | Clinical significance of interleukin?6, tumor necrosis factor?α andhigh?sensitivity C?reactive protein in neonates with hypoxic?ischemic encephalopathy显示文摘 | Yun Shang Lina Mu Xixia Guo Yuhua Li Limin Wang Weihong Yang Shujun Li Qiong Shen | 2014 | Experimental and Therapeutic Medicine2014，，4： | 1 |
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