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| 1 | Genetic diversity in Chinese modern wheat varieties revealed by microsatellite markers显示文摘Genetic diversity of 1680 modern varieties in Chinese candidate core collections was analyzed at 78 SSR loci by fluorescence detection system. A total of 1336 alleles were detected, of which 1253 alleles could be annotated into 71 loci. For these 71 loci, the alleles ranged from 4 to 44 with an average of 17.6, and the PIC values changed from 0.19 to 0.89 with an average of 0.69. (1) In the three genomes of wheat, the average genetic richness was B>A>D, and the genetic diversity indexes were B>D>A. (2) Among the seven homoeologous groups, the average genetic richness was 2=7>3>4>6>5>1, and the genetic diversity indexes were 7>3>2>4>6>5>1. As a whole, group 7 possessed the highest genetic diversity, while groups 1 and 5 were the lowest. (3) In the 21 wheat chromosomes, 7A, 3B and 2D possessed much higher genetic diversity, while 2A, 1B, 4D, 5D and 1D were the lowest. (4) The highest average genetic diversity index existed in varieties bred in the 1950s, and then it declined continually. However, the change tendency of genetic diversity among decades was not greatly sharp. This was further illustrated by changes of the average genetic distance between varieties. In the 1950s it was the largest (0.731). Since the 1960s, it has decreased gradually (0.711, 0.706, 0.696, 0.695). The genetic base of modern varieties is becoming narrower and narrower. This should be given enough attention by breeders and policy makers. | HAO Chenyang, WANG Lanfen, ZHANG Xueyong, YOU Guangxia, DONG Yushen, JIA Jizeng, LIU Xu, SHANG Xunwu, LIU Sancai & CAO Yongsheng Key Laboratory of Crop Germplasm & Biotechnology, MOA, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China Agronomy College, Gansu Agricultural University, Lanzhou 730070, China | 2006 | Science China(Life Sciences)2006，49，3： | 19 |
| 2 | Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing显示文摘Many human genetic diseases,including Hutchinson-Gilford progeria syndrome(HGPS),are caused by single point mutations.HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene.Base editors(BEs)composed of a cytidine deaminase fused to CRISPR/Cas9 nickase are highly efficient at inducing C to T base conversions in a programmable manner and can be used to generate animal disease models with single amino-acid substitutions.Here,we generated the first HGPS monkey model by delivering a BE mRNA and guide RNA(gRNA)targeting the LMNA gene via microinjection into monkey zygotes.Five out of six newborn monkeys carried the mutation specifically at the target site.HGPS monkeys expressed the toxic form of lamin A,progerin,and recapitulated the typical HGPS phenotypes including growth retardation,bone alterations,and vascular abnormalities.Thus,this monkey model genetically and clinically mimics HGPS in humans,demonstrating that the BE system can efficiently and accurately generate patient-specific disease models in non-human primates. | Fang Wang Weiqi Zhang Qiaoyan Yang Yu Kang Yanling Fan Jingkuan Wei Zunpeng Liu Shaoxing Dai Hao Li Zifan Li Lizhu Xu Chu Chu Jing Qu Chenyang Si Weizhi Ji Guang-Hui Liu Chengzu Long Yuyu Niu | 2020 | Protein & Cell2020，11，11： | 11 |
| 3 | Rice St#pe Virus Interferes with S-acylation of Remorin and Induces Its Autophagic Degradation to Facilitate Virus Infection显示文摘 | Shuai Fu Yi Xu Chenyang Li Yi Li dianxiang Wu Xueping Zhou | 2018 | Molecular Plant2018，11，2： | 10 |
| 4 | Crustal accretion and reworking processes of micro-continental massifs within orogenic belt:A case study of the Erguna Massif,NE China显示文摘This paper summarizes the geochronological, geochemical and zircon Hf isotopic data for Mesozoic granitoids within the Erguna Massif, NE China, and discusses the spatial-temporal variation of zircon Hf isotopic compositions, with the aim of constraining the accretion and reworking processes of continental crust within the Erguna Massif, and shedding light on the crustal evolution of the eastern segment of the Central Asian Orogenic Belt. Based on the zircon U-Pb dating results, the Mesozoic granitic magmatisms within the Erguna Massif can be subdivided into five stages: Early-Middle Triassic(249–237 Ma), Late Triassic(229–201 Ma), Early-Middle Jurassic(199–171 Ma), Late Jurassic(155–149 Ma), and Early Cretaceous(145–125 Ma).The Triassic to Early-Middle Jurassic granitoids are mainly I-type granites and minor adakitic rocks, whereas the Late Jurassic to Early Cretaceous granitoids are mainly A-type granites. This change in magmatism is consistent with the southward subduction of the Mongol-Okhotsk oceanic plate and subsequent collision and crustal thickening, followed by post-collision extension. Zircon Hf isotopic data indicate that crustal accretion of the Erguna Massif occurred in the Mesoproterozoic and Neoproterozoic. ZirconεHf(t) values increase gradually over time, whereas two-stage model(TDM2) ages decrease throughout the Mesozoic. The latter result indicates a change in the source of granitic magmas from the melting of ancient crust to more juvenile crust. Zircon εHf(t)values also exhibit spatial variations, with values decreasing northwards, whereas TDM2 ages increase. This pattern suggests that,moving from south to north, there is an increasing component of ancient crustal material within the lower continental crust of the Erguna Massif. Even if at the same latitude, the zircon Hf isotopic compositions are also inconsistent. These results reveal lateral and vertical heterogeneities in the lower continental crust of the Erguna Massif during the Mesozoic, which we use as the basis of a structural and tectonic model for this region. | SUN ChenYang TANG Jie XU WenLiang LI Yu ZHAO Shuo | 2017 | Science China Earth Sciences2017，60，7： | 10 |
| 5 | Resequencing of 145 Landmark Cultivars Reveals Asymmetric Sub-genome Selection and Strong Founder Genotype Effects on Wheat Breeding in China显示文摘Controlled pedigrees and the multi-decade timescale of national crop plant breeding programs offer a unique experimental context for examining how selection affects plant genomes.More than 3000 wheat cultivars have been registered,released,and documented since 1949 in China.In this study,a set of 145 elite cultivars selected from historical points of wheat breeding in China were re-sequenced.A total of 43.75 Tb of sequence data were generated with an average read depth of 17.94x for each cultivar,and more than 60.92 million SNPs and 2.54 million InDels were captured,based on the Chinese Spring RefSeq genome v1.0.Seventy years of breeder-driven selection led to dramatic changes in grain yield and related phenotypes,with distinct genomic regions and phenotypes tar-geted by different breeders across the decades.There are very clear instances illustrating how introduced Italian and otherforeign germplasm was integrated into Chinese wheat programs and reshaped the genomic landscape of local modern cultivars.Importantly,the resequencing data also highlighted significant asymmetric breeding selec-tion among the three sub-genomes:this was evident in both the collinear blocks for homeologous chromosomes and among sets of three homeologous genes.Accumulation of more newly assembled genes in newer cultivars implied the potential value of these genes in breeding.Conserved and extended sharing of linkage disequilibrium(LD)blocks was highlighted among pedigree-related cultivars,in which fewer haplotype differences were detected.Fixation or replacement of haplotypes from founder genotypes after generations of breeding was related to their breeding value.Based on the haplotype frequency changes in LD blocks of pedigree-related cultivars,we propose a strategy for evaluating the breeding value of any given line on the basis of the accumulation(pyramiding)of bene-ficial haplotypes.Collectively,our study demonstrates the influence of 'founder genotypes' on the output of breeding efforts over many decades and also suggests that founder genotype perspectives are in fact more dy-namic when applied in the context of modern genomics-informed breeding. | Chenyang Hao Chengzhi Jiao Jian Hou Tian Li Hongxia Liu Yuquan Wang Jun Zheng Hong Liu Zhihong Bi Fengfeng Xu Jing Zhao Lin Ma Yamei Wang Uzma Majeed Xu Liu Rudi Appels Marco Maccaferri Roberto Tuberosa Hongfeng Lu Xueyong Zhang | 2020 | Molecular Plant2020，13，12： | 9 |
| 6 | Wireless whispering-gallery-mode sensor for thermal sensing and aerial mapping显示文摘The Internet of Things(IoT)1,2 employs a large number of spatially distributed wireless sensors to monitor physical environments,e.g.,temperature,humidity,and air pressure,and has many applications,including environmental monitoring3,health care monitoring4,smart cities5,and precision agriculture.A wireless sensor can collect,analyze,and transmit measurements of its environment1,2.Currently,wireless sensors used in the IoT are predominately based on electronic devices that may suffer from electromagnetic interference in many circumstances.Being immune to the electromagnetic interference,optical sensors provide a significant advantage in harsh environments6.Furthermore,by introducing optical resonance to enhance light–matter interactions,optical sensors based on resonators exhibit small footprints,extreme sensitivity,and versatile functionalities7,8,which can significantly enhance the capability and flexibility of wireless sensors.Here we provide the first demonstration of a wireless photonic sensor node based on a whisperinggallery-mode(WGM)optical resonator,in which light propagates along the circular rim of such a structure like a sphere,a disk,or a toroid by continuous total internal reflection.The sensor node is controlled via a customized iOS app.Its performance was studied in two practical scenarios:(1)real-time measurement of the air temperature over 12 h and(2)aerial mapping of the temperature distribution using a sensor node mounted on an unmanned drone.Our work demonstrates the capability of WGM optical sensors in practical applications and may pave the way for the large-scale deployment of WGM sensors in the IoT. | Xiangyi Xu Weijian Chen Guangming Zhao Yihang Li Chenyang Lu Lan Yang | 2018 | Light(Science & Applications)2018，7，1： | 8 |
| 7 | Oryza sativa FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR(OsFIT/OsbHLH156)interacts with OsIRO2 to regulate iron homeostasis显示文摘Iron(Fe)is indispensable for the growth and development of plants.It is well known that FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR(FIT)is a key regulator of Fe uptake in Arabidopsis.Here,we identify the Oryza sativa FIT(also known as Osb HLH156)as the interacting partner of IRON-RELATED BHLH TRANSCRIPTION FACTOR 2(OsIRO2)that is critical for regulating Fe uptake.The OsIRO2 protein is localized in the cytoplasm and nucleus,but OsFIT facilitates the accumulation of OsIRO2 in the nucleus.Loss-of-function mutations of OsFIT result in decreased Fe accumulation,severe Fe-deficiency symptoms,and disrupted expression of Feuptake genes.In contrast,OsFIT overexpression promotes Fe accumulation and the expression of Fe-uptake genes.Genetic analyses indicate that OsFIT and OsIRO2 function in the same genetic node.Further analyses suggest that OsFIT and OsIRO2 form a functional transcription activation complex to initiate the expression of Fe-uptake genes.Our findings provide a mechanism understanding of how rice maintains Fe homeostasis. | Gang Liang Huimin Zhang Yang Li Mengna Pu Yujie Yang Chenyang Li Chengkai Lu Peng Xu Diqiu Yu | 2020 | Journal of Integrative Plant Biology2020，62，5： | 4 |
| 8 | Tailoring the Meso-Structure of Gold Nanoparticles in Keratin-Based Activated Carbon Toward High-Performance Flexible Sensor显示文摘Flexible biosensors with high accuracy and reliable operation in detecting pH and uric acid levels in body fluids are fabricated using well-engineered metaldoped porous carbon as electrode material.The gold nanoparticles@N-doped carbon in situ are prepared using wool keratin as both a novel carbon precursor and a stabilizer.The conducting electrode material is fabricated at 500℃ under customized parameters,which mimics A-B type(two different repeating units) polymeric material and displays excellent deprotonation performance(pH sensitivity).The obtained pH sensor exhibits high pH sensitivity of 57 mV/pH unit and insignificant relative standard deviation of 0.088%.Conversely,the composite carbon material with sp^2 structure prepared at 700℃ is doped with nitrogen and gold nanoparticles,which exhibits good conductivity and electrocatalytic activity for uric acid oxidation.The uric acid sensor has linear response over a range of 1-150 μM and a limit of detection 0.1 μM.These results will provide new avenues where biological material will be the best start,which can be useful to target contradictory applications through molecular engineering at mesoscale. | Aniruddha BPatil Zhaohui Meng Ronghui Wu Liyun Ma Zijie Xu Chenyang Shi Wu Qiu Qiang Liu Yifan Zhang Youhui Lin Naibo Lin Xiang Yang Liu | 2020 | Nano-Micro Letters2020，12，9： | 3 |
| 9 | Crustal Accretion and Reworking within the Khanka Massif: Evidence from Hf Isotopes of Zircons in Phanerozoic Granitoids显示文摘This paper presents a synthesis and analysis of geochronological, geochemical, and zircon Hf isotopic data of Phanerozoic granitoids within the Khanka massif, with the aim of revealing the accretion and reworking processes of continental crust within the massif. Zircon U-Pb dating indicates that Phanerozoic granitic magmatism within the Khanka massif can be subdivided into eight stages: Late Cambrian, Middle–Late Ordovician, Middle Silurian, Late Carboniferous, Early Permian, Middle–Late Permian to Early Triassic, Late Triassic–Early Jurassic, and Early Cretaceous. The zircon Hf isotopic compositions reveal that crustal accretionary events took place mainly in the Mesoproterozoic and Neoproterozoic. Through time, the zircon ε_(Hf)(t) values gradually increase, indicating that the Phanerozoic granitic magmas were derived from the melting of progressively less ancient and more juvenile crust. The zircon ε_(Hf)(t) values exhibit a gradual decrease with the increases in latitude, which implies that the amounts of ancient crustal components within the lower continental crust of the Khanka massif increased from south to north. At the same latitude range, the zircon Hf isotopic compositions also display some variations. We conclude, therefore, that significant horizontal and vertical heterogeneities existed in the lower continental crust of the Khanka massif during the Phanerozoic. | Xiaoming Zhang Wenliang Xu Chenyang Sun Ting Xu Feng Wang | 2018 | Journal of Earth Science2018，29，2： | 3 |
| 10 | Magnetically levitated/piezoelectric/triboelectric hybrid generator as a power supply for the temperature sensor显示文摘The combination of new intelligent materials and structure technology is becoming an effective way in energy havesting and self-powered sensing. In this work, we demonstrate a magnetically levitated/piezoelectric/triboelectric hybrid generator, which does not use complex structure and has high steady output performance. It includes three parts: magnetically levitated generator(MLG), piezoelectric generator(PNG), triboelectric nanogenerator(TENG). The peak power of each is 135 μW, 22 mW and3.6 mW, which are obtained at 1 MΩ, 10 kΩ and 1 kΩ, respectively. The hybrid generator can completely light up light-emitting diodes(LEDs) under the vibration frequency of 20 Hz and the vibration amplitude of 10 mm. It also can charge a 470 μF capacitor.On this basis, we have integrated the hybrid generaor as a power supply into a self-powered tempreature sensing system. The combination of three generators can not only broaden the operating range, but also increase the operating length and sensitivity.This work will extend the application of self-powered sensor in automatic production line and promote the development of industrial control technology. | ZHANG ZengXing HE Jian HAN JianQiang XU HongYan MU JiLiang WEN Tao WANG DaWei TIAN ZhuMei CHEN ZeTian XUE ChenYang | 2017 | Science China(Technological Sciences)2017，60，7： | 3 |
| 11 | Macrophage-mediated tumor-targeted delivery of engineered Salmonella typhimurium VNP20009 in anti-PD1 therapy against melanoma显示文摘Bacterial antitumor therapy has great application potential given its unique characteristics,including genetic manipulation, tumor targeting specificity and immune system modulation. However,the nonnegligible side effects and limited efficacy of clinical treatment limit their biomedical applications. Engineered bacteria for therapeutic applications ideally need to avoid their accumulation in normal organs and possess potent antitumor activity. Here, we show that macrophage-mediated tumor-targeted delivery of Salmonella typhimurium VNP20009 can effectively reduce the toxicity caused by administrating VNP20009 alone in a melanoma mouse model. This benefits from tumor-induced chemotaxis for macrophages combined with their slow release of loaded strains. Inspired by changes in the tumor microenvironment, including a decrease in intratumoral dysfunctional CD8+T cells and an increase in PDL1 on the tumor cell surface, macrophages were loaded with the engineered strain VNP-PD1nb, which can express and secrete anti-PD1 nanoantibodies after they are released from macrophages. This novel triple-combined immunotherapy significantly inhibited melanoma tumors by reactivating the tumor microenvironment by increasing immune cell infiltration, inhibiting tumor cell proliferation, remodeling TAMs to an M1-like phenotype and prominently activating CD8+T cells. These data suggest that novel combination immunotherapy is expected to be a breakthrough relative to single immunotherapy. | Leyang Wu Lin Li Shufeng Li Lina Liu Wenjie Xin Chenyang Li Xingpeng Yin Xuebo Xu Feifei Bao Zichun Hua | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 3 |
| 12 | Targeted therapeutics and novel signaling pathways in nonalcohol-associated fatty liver/steatohepatitis(NAFL/NASH)显示文摘Non-alcohol-associated fatty liver/steatohepatitis(NAFL/NASH)has become the leading cause of liver disease worldwide.NASH,an advanced form of NAFL,can be progressive and more susceptible to developing cirrhosis and hepatocellular carcinoma.Currently,lifestyle interventions are the most essential and effective strategies for preventing and controlling NAFL without the development of fibrosis.While there are stll limited appropriate drugs specifically to treat NAFL/NASH,growing progress is being seen in elucidating the pathogenesis and identifying therapeutic targets.In this review,we discussed recent developments in etiology and prospective therapeutic targets,as well as pharmacological candidates in pre/clinical trials and patents,with a focus on diabetes,hepatic lipid metabolism,inflammation,and fibrosis.Importantly,growing evidence elucidates that the disruption of the gut-liver axis and microbederived metabolites drive the pathogenesis of NAFL/NASH.Extracellular vesicles(EVs)act as a signaling mediator,resulting in lipid accumulation,macrophage and hepatic stellate cell activation,further promoting inflammation and liver fibrosis progression during the development of NAFL/NASH.Targeting gut microbiota or EVs may serve as new strategies for the treatment of NAFL/NASH.Finally,other mechanisms,such as cell therapy and genetic approaches,also have enormous therapeutic potential.Incorporating drugs with different mechanisms and personalized medicine may improve the efficacy to better benefit patients with NAFL/NASH. | Xiaohan Xu Kyle L.Poulsen Ljuan Wu Shan Liu Tatsunori Miyata Qiaoling Song Qingda Wei Chenyang Zhao Chunhua Lin Jinbo Yang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 13 | A branched dihydrophenazine-based polymer as a cathode material to achieve dual-ion batteries with high energy and power density显示文摘Organic electrode materials have exhibited good electrochemical performance in batteries,but their voltages and rate capabilities still require improvement to meet the increasing demand for batteries with high energy and power density.Herein,we design and synthesize a branched dihydrophenazine-based polymer(p-TPPZ)as a cathode material for dual-ion batteries(DIBs)through delicate molecular design.Compared with the linear dihydrophenazine-based polymer(p-DPPZ,with a theoretical capacity of 209 mAh g^(−1)),p-TPPZ possessed a higher theoretical capacity of 233 mAh g^(−1)and lower highest occupied molecular orbital energy levels,which resulted in a high actual capacity(169.3 mAh g^(−1)at 0.5 C),an average discharge voltage of 3.65 V(vs.Li+/Li)and a high energy density(618.2 Wh kg^(−1),based on the cathode materials).The branched structure of p-TPPZ led to a larger specific surface area than that of p-DPPZ,which was beneficial for the electrolyte infiltration and fast ionic transport,contributing to the high power density.Due to the fast reaction kinetics,even at a power density of 23,725 W kg^(−1)(40 C),the energy density still reached 474.5 Wh kg^(−1).We also made a detailed investigation of the p-TPPZ cathode’s charge storage mechanism.This work will stimulate the further molecular design to develop organic batteries with both high energy and power density. | Shuaifei Xu Huichao Dai Shaolong Zhu Yanchao Wu Mingxuan Sun Yuan Chen Kun Fan Chenyang Zhang Chengliang Wang Wenping Hu | 2021 | eScience2021，1，1： | 2 |
| 14 | Multimodal Locomotion and Cargo Transportation of Magnetically Actuated Quadruped Soft Microrobots显示文摘Untethered microrobots have attracted extensive attention due to their potential for biomedical applications and micromanipulation at the small scale.Soft microrobots are of great research importance because of their highly deformable ability to achieve not only multiple locomotion mechanisms but also minimal invasion to the environment.However,the existing microrobots are still limited in their ability to locomote and cross obstacles in unstructured environments compared to conventional legged robots.Nature provides much inspiration for developing miniature robots.Here,we propose a bionic quadruped soft thin-film microrobot with a nonmagnetic soft body and 4 magnetic flexible legs.The quadruped soft microrobot can achieve multiple controllable locomotion modes in the external magnetic field.The experiment demonstrated the robot’s excellent obstacle-crossing ability by walking on the surface with steps and moving in the bottom of a stomach model with gullies.In particular,by controlling the conical angle of the external conical magnetic field,microbeads gripping,transportation,and release of the microrobot were demonstrated.In the future,the quadruped microrobot with excellent obstacle-crossing and gripping capabilities will be relevant for biomedical applications and micromanipulation. | Chenyang Huang Zhengyu Lai Xinyu Wu Tiantian Xu | 2022 | Cyborg and Bionic Systems2022，，1： | 2 |
| 15 | E-Commerce Supply Chain Process Optimization Based on Whole-Process Sharing of Internet of Things Identification Technology显示文摘With in-depth development of the Internet of Things(IoT)in various industries,the informatization process of various industries has also entered the fast lane.This article aims to solve the supply chain process problem in e-commerce,focusing on the specific application of Internet of Things technology in e-commerce.Warehousing logistics is an important link in today’s e-commerce transactions.This article proposes a distributed analysis method for RFID-based e-commerce warehousing process optimization and an e-commerce supply chain management process based on Internet of Things technology.This article first introduces the advantages and disadvantages of shared IoT identification technology and the IoT resource sharing platform based on the three-layer abstract data model and representational state transfer(REST)style.Combining actual IoT applications and the characteristics of an existing platform,a REST-based IoT resource sharing platform is proposed.Combined with actual projects,a REST-based IoT resource sharing platform was built,and key technology experiments were conducted for verification.Finally,optimizing the e-commerce supply chain management process under Internet of Things technology and explaining the advantages of optimized e-commerce supply chain management are discussed.Research on this subject provides a theoretical basis for the application of the Internet of Things in e-commerce and has practical significance and practical value for managing service capabilities and service levels in e-commerce. | Shiyan Xu Jun Chen Maoguo Wu Chenyang Zhao | 2021 | Computer Modeling in Engineering & Sciences2021，，2： | 2 |
| 16 | Evaluation of the weakening behavior of gas on the coal strength and its quantitative influence on the coal deformation显示文摘The coal strength and deformation properties are key factors affecting safe coal mining and highefficiency coalbed methane(CBM)development.In this paper,reconstituted coal samples are chosen to investigate the weakening behavior of gas on coal strength,meanwhile,its effects on coal deformation are quantitatively evaluated.The results indicate that the weakening degree of gas on coal strength is closely related to the confining stress and gas pressure.Compared with non-gas-saturated coals,the maximum weakening ratios of adsorbed gas to coal strength are 10.58%,18.12%,8.55%and 14.65%under the conditions of confining stress CS=3 MPa and gas pressure GP=1 MPa,CS=3 MPa and GP=2 MPa,CS=4 MPa and GP=1 MPa,and CS=4 MPa and GP=2 MPa,respectively.Furthermore,the maximum weakening ratios of free gas to coal strength are 18.27%,36.54%,14.79%and 29.58%,respectively,under above four conditions.The maximum coal bulk strain decreases as particle sizes of coal powders increase,and it has a maximum value of 0.0227 and a minimum value of 0.0191 in particle size ranges of 0.01–0.041 and 0.5–1 mm.Under the same conditions,the coal bulk strain increases with increasing gas pressure,revealing that coal deformation properties can be enhanced by gas. | Haijun Guo Kai Wang Yuchen Wu Hanlu Tang Jianguo Wu Lianhe Guan Chenyang Chang Chao Xu | 2021 | International Journal of Mining Science and Technology2021，31，3： | 2 |
| 17 | Energy-efficient CoMP precoding in heterogeneous networks显示文摘 | Xu Zhikun Yang Chenyang Li Ye G | 2014 | Signal Processing IEEE Transactions on2014，62，4： | 1 |
| 18 | Snakes, shapes, and gradient vector flow 显示文摘 | Xu Chenyang Prince J L | 1998 | IEEE Transactions on Image Processing1998，7，3： | 1 |
| 19 | A rice XANTHINE DEHYDROGENASE gene regulates leaf senescence and response to abiotic stresses显示文摘Xanthine dehydrogenase, a member of the molybdenum enzyme family, participates in purine metabolism and catalyzes the generation of ureides from xanthine and hypoxanthine. However, the mechanisms by which xanthine dehydrogenase affects rice growth and development are poorly understood. In the present study, we identified a mutant with early leaf senescence and reduced tillering that we named early senescence and less-tillering 1(esl1). Map-based cloning revealed that ESL1 encodes a xanthine dehydrogenase, and it was expressed in all tissues. Chlorophyll content was reduced and chloroplast maldevelopment was severe in the esl1 mutant. Mutation of ESL1 led to decreases in allantoin, allantoate, and ABA contents. Further analysis revealed that the accumulation of reactive oxygen species in esl1 resulted in decreased photosynthesis and impaired chloroplast development, along with increased sensitivity to abscisic acid and abiotic stresses. Ttranscriptome analysis showed that the ESL1 mutation altered the expression of genes involved in the photosynthesis process and reactive oxygen species metabolism.Our results suggest that ESL1 is involved in purine metabolism and the induction of leaf senescence.These findings reveal novel molecular mechanisms of ESL1 gene-mediated plant growth and leaf senescence. | Jiangmin Xu Chenyang Pan Han Lin Hanfei Ye Sheng Wang Tao Lu Qianyu Chen Kairu Yang Mei Lu Qian Qian Deyong Ren Yuchun Rao | 2022 | The Crop Journal2022，10，2： | 1 |
| 20 | Gradient Vector Flow:A New External Force for Snakes 显示文摘 | Chenyang Xu Jerry L Prince | 1997 | IEEE Computer Society Conference on Computer Vision and Pattern Recognition1997，2，3： | 1 |
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