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| 1 | Upregulation of Chemokine CXCL12 in the Dorsal Root Ganglia and Spinal Cord Contributes to the Development and Maintenance of Neuropathic Pain Following Spared Nerve Injury in Rats显示文摘Emerging evidence indicates that CXCL12/CXCR4 signaling is involved in chronic pain. However, few studies have systemically assessed its role in direct nerve injury-induced neuropathic pain and the underlying mechanism. Here, we determined that spared nerve injury(SNI)increased the expression of CXCL12 and its cognate receptor CXCR4 in lumbar 5 dorsal root ganglia(DRG)neurons and satellite glial cells. SNI also induced longlasting upregulation of CXCL12 and CXCR4 in the ipsilateral L4–5 spinal cord dorsal horn, characterized by CXCL12 expression in neurons and microglia, and CXCR4 expression in neurons and astrocytes. Moreover, SNIinduced a sustained increase in TNF-a expression in the DRG and spinal cord. Intraperitoneal injection(i.p.) of the TNF-a synthesis inhibitor thalidomide reduced the SNI-induced mechanical hypersensitivity and inhibited the expression of CXCL12 in the DRG and spinal cord.Intrathecal injection(i.t.) of the CXCR4 antagonist AMD3100, both 30 min before and 7 days after SNI,reduced the behavioral signs of allodynia. Rats given an i.t.or i.p. bolus of AMD3100 on day 8 of SNI exhibited attenuated abnormal pain behaviors. The neuropathic pain established following SNI was also impaired by i.t. administration of a CXCL12-neutralizing antibody. Moreover,repetitive i.t. AMD3100 administration prevented the activation of ERK in the spinal cord. The mechanical hypersensitivity induced in na?¨ve rats by i.t. CXCL12 was alleviated by pretreatment with the MEK inhibitor PD98059. Collectively, our results revealed that TNF-a might mediate the upregulation of CXCL12 in the DRG and spinal cord following SNI, and that CXCL12/CXCR4 signaling via ERK activation contributes to the development and maintenance of neuropathic pain. | Liying Bai Xinru Wang Zhisong Li Cunlong Kong Yonghui Zhao Jun-Liang Qian Quancheng Kan Wei Zhang Ji-Tian Xu | 2016 | Neuroscience Bulletin2016，32，1： | 20 |
| 2 | Day-ahead Optimization Schedule for Gas-electric Integrated Energy System Based on Second-order Cone Programming显示文摘This paper proposes an optimal day-ahead opti-mization schedule for gas-electric integrated energy system(IES)considering the bi-directional energy flow.The hourly topology of electric power system(EPS),natural gas system(NGS),energy hubs(EH)integrated power to gas(P2G)unit,are modeled to minimize the day-ahead operation cost of IES.Then,a second-order cone programming(SOCP)method is utilized to solve the optimization problem,which is actually a mixed integer nonconvex and nonlinear programming issue.Besides,cutting planes are added to ensure the exactness of the global optimal solution.Finally,simulation results demonstrate that the proposed optimization schedule can provide a safe,effective and economical day-ahead scheduling scheme for gas-electric IES. | Yonghui Sun Bowen Zhang Leijiao Ge Denis Sidorov Jianxi Wang Zhou Xu | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 14 |
| 3 | Mass elevation effect and its forcing on timberline altitude显示文摘集体举起效果的概念(massenerhebungseffect, MEE ) 被 A 介绍。de Quervain 大约 100 年以前排队为象树那样的温度相关的参数说明观察趋势并且比在他们的外部边缘上在中央阿尔卑斯山脉发生在更高的举起的 snowline。它广泛地也在世界的另外的区域被观察了,但是没有重要,更不用说量,关于这现象的研究。特别,它完全通常在开发树带界线举起的恰当的模型被忽视了,与仅仅看作影响因素的经度或纬度。这篇论文试着确定到树带界线的 MEE 的贡献举起。认为更多广泛陆地团并且特别越高在陆地质量的内部的山底,越 greater 集体举起效果,这篇论文作为 MEE 的大小拿山底举起(MBE ) 。我们收集树带界线举起的 157 个数据点,并且把他们的纬度,经度和 MBE 用作独立变量在东南的欧亚的大陆为树带界线举起造一个多重线性回归方程。结果生产到树带界线高度活动范围 25.11% , 29.43% ,和 45.46% 的纬度,经度和 MBE 的贡献分别地。北纬度的诺思 | HAN Fang YAO Yonghui DAI Shibao WANG Chun SUN Ranhao XU Juan ZHANG Baiping | 2012 | Journal of Geographical Sciences2012，22，4： | 12 |
| 4 | Study on variational aerosol fields over Beijing and its adjoining areas derived from Terra-MODIS and ground sunphotometer observation显示文摘This paper presents a comprehensive observa-tion technique on derived aerosols data from mobile sun-photometer graph and Terra-Moderate Resolution Imaging Spectroradiometer (MODIS) observation. Research results suggest that after being treated by the variational technique with respect to sunphotometer observations, the Terra- MODIS remote sensing aerosol data are remarkably im-proved, thus for the first time revealing features of the influ-ence of aerosols and pollution emissions of Beijing and its adjoining areas (Hebei, Shandong, etc. provinces). The re-gional impact features of aerosols are related with the pe-ripheral U-shape topography of Beijing. Analyses with Hy-brid Single Particle Lagrangian Integrated Trajectory model (HYSPLIT-4) and meteorological data in the case studied confirm the pollutants diffusion process along the trajectory from the sources in the south-west region, and the regional aerosol impact features. | XU Xiangde ZHOU Xiuji WENG Yonghui TIAN Guoliang LIU Yujie YAN Peng DING Guoan ZHANG Yuxiang MAO Jietai QIU Hong | 2003 | Chinese Science Bulletin2003，48，18： | 7 |
| 5 | Analysis of factors affecting the prognosis of transcatheter arterial chemoembolization for hepatitis B-related hepatocellular carcinoma显示文摘Objectives:The purpose of this study was to investigate the prognostic factors for transcatheter arterial chemoembolization(TACE)for hepatitis B-related hepatocellular carcinoma(HCC).Materials and methods:The variables that may affect overall survival(OS),such as age,gender,AFP,Child Pugh classification,body mass index,HBV-DNA,Hbe Ag,tumor number,tumor diameter,BCLC stage,embolization method,ablation therapy,and targeted therapy,were analyzed by single factor and many factor COX regression.In addition,predictive factors of OS were stratified and a Kaplan-Meier survival curve was drawn.Results:Among the 136 patients,the median follow-up time was 14.5 months(range:2–72 months).HCC patients with the tumor diameter<3 cm had the highest survival rate,followed by patients with a tumor diameter of 3–5 cm;the survival rate of patients with the tumor diameter(greater than 5 cm)was the lowest.Among the BCLC stages,stage A patients had the highest survival rate,followed by stage B and stage C patients,which had the lowest survival rate.The survival rate of Child Pugh grade A patients was higher than those with Child Pugh grade B.Compared with patients who did not undergo ablation treatment,the survival rate of patients with combined ablation treatment was relatively high.The survival rate of patients receiving drug-eluting beads transarterial chemoembolization(DEB-TACE)treatment was higher than those receiving conventional transarterial chemoembolization(c TACE)treatment.Additionally,repeated TACE treatment improved the OS rate of patients.These six factors were related to patient prognosis and the differences were statistically significant(P<0.05).Conclusions:Tumor diameter,BCLC stage,TACE repetition,and TACE combined with ablation were independent prognostic factors of OS. | Jiangping Cun Yonghui Xu Weidong Li Xingxiang Zhao | 2021 | Journal of Interventional Medicine2021，4，2： | 7 |
| 6 | Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica显示文摘In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanli (ST36) and Yanglingquan (GB34). In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold (paw withdrawal latency) was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanli and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus. | Qiuling Xu Tao Liu Shuping Chen Yonghui Gao Junying Wang Lina Qiao Junling Liu | 2013 | Neural Regeneration Research2013，8，3： | 6 |
| 7 | Biological applications of copper-containing materials显示文摘Copper is an indispensable trace metal element in the human body,which is mainly absorbed in the stomach and small intestine and excreted into the bile.Copper is an important component and catalytic agent of many enzymes and proteins in the body,so it can influence human health through multiple mechanisms.Based on the biological functions and benefits of copper,an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials,which exhibit unique properties in protecting the cardiovascular system,promoting bone fracture healing,and exerting antibacterial effects.Copper can also be used in promoting incisional wounds healing,killing cancer cells,Positron Emission Tomography(PET)imaging,radioimmunological tracing and radiotherapy of cancer.In the present review,the biological functions of copper in the human body are presented,along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials.Furthermore,this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications. | Peng Wang Yonghui Yuan Ke Xu Hongshan Zhong Yinghui Yang Shiyu Jin Ke Yang Xun Qi | 2021 | Bioactive Materials2021，6，4： | 5 |
| 8 | In Situ Investigation of Dynamic Silver Crystallization Driven by Chemical Reaction and Diffusion显示文摘Rational synthesis of materials is a long-term challenging issue due to the poor understanding on the formation mechanism of material structure and the limited capability in controlling nanoscale crystallization.The emergent in situ electron microscope provides an insight to this issue.By employing an in situ scanning electron microscope,silver crystallization is investigated in real time,in which a reversible crystallization is observed.To disclose this reversible crystallization,the radicals generated by the irradiation of electron beam are calculated.It is found that the concentrations of radicals are spatiotemporally variable in the liquid cell due to the diffusion and reaction of radicals.The fluctuation of the reductive hydrated electrons and the oxidative hydroxyl radicals in the cell leads to the alternative dominance of the reduction and oxidation reactions.The reduction leads to the growth of silver crystals while the oxidation leads to their dissolution,which results in the reversible silver crystallization.A regulation of radical distribution by electron dose rates leads to the formation of diverse silver structures,confirming the dominant role of local chemical concentration in the structure evolution of materials. | Ting Liu Xiangyu Dou Yonghui Xu Yongjun Chen Yongsheng Han | 2020 | Research2020，，1： | 4 |
| 9 | Study on the fragmentation of granite due to the impact of single particle and double particles显示文摘Particle Impact Drilling(PID)is a novel method to improve the rate of penetration(ROP).In order to further improve the performance of PID,an investigation into the effect of single and double particles:(1)diameter;(2)initial velocity;(3)distance;and(4)angle of incidence was undertaken to investigate their effects on broken volume and penetration depth into hard brittle rock.For this purpose,the laboratory experiment of single particle impact rock was employed.Meanwhile,based on the LS-DYNA,a new finite element(FE)simulation of the PID,including single and double particles impact rock,has been presented.The 3-dimensional(3D),aix-symmetric,dynamicexplicit,Lagrangian model has been considered in this simulation.And the Elastic and Holmquist Johnson Cook(HJC)material behaviors have been used for particles and rocks,respectively.The FE simulation results of single particle impacting rock are good agreement with experimental data.Furthermore,in this article the optimal impact parameters,including diameter,initial velocity,distance and the angle of incidence,are obtained in PID. | Yuchun Kuang Wei Lin Xiaofeng Xu Yonghui Liu Kaisong Wu | 2016 | Petroleum2016，2，3： | 4 |
| 10 | Acute carbon monoxide poisoning in Shandong, China: an observational study显示文摘Background: Carbon monoxide (CO) poisoning remains a major cause of accidental injuries and multiple studies have indicated that CO is also associated with significantly severe or long-term toxicity to the central nervous system. Given that CO poisoning causes serious morbidity and mortality, a better understanding of epidemiological features and clinical characteristics of acute CO poisoning in China is crucial.Methods: We collected the clinical data of acute CO poisoning in patients between November 2019 and April 2020 across Shandong province, China and analyzed its characteristics focusing on the weekly amount and the severity of the confirmed cases.Results: A total number of 21,088 acute CO poisoning cases were diagnosed. The overall incidence of acute CO poisoning was approximately 0.021%. On severity rankings, 63% of confirmed cases (n=13,378) were mild, 27%(n=5635) were moderate, and 10% (n=2075) were severe. Interestingly, the coastal cities had more confirmed cases than the inland/suburban areas in Shandong. Meanwhile, the number of confirmed cases was negatively correlated with the local mean daily temperature (P=0.0167).Conclusions: Mild acute CO poisoning cases accounted for the majority of all confirmed cases during the winter of 2019. In Shandong province, which is located in east China, residents of the coastal cities are more susceptible to CO poisoning than residents of inland cities. | Lina Zhang Di Wu Mingyue Xu Yonghui Bian Youcun Wang Guangkai Gao Qing Sun | 2022 | Chinese Medical Journal2022，，13： | 4 |
| 11 | The cumulative analgesic effect of repeated electroacupuncture involves synaptic remodeling in the hippocampal CA3 region显示文摘In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-dependent protein kinase II expression and synaptic ultrastructure of neurons in the hippocampal CA3 region were examined. The thermal pain threshold (paw withdrawal latency) was increased significantly in both groups at 2 weeks after electroacupuncture intervention compared with 2 days of electroacupuncture. In ovariectomized rats with chronic constriction injury, the analgesic effect was significantly reduced. Electroacupuncture for 2 weeks significantly diminished the injury-induced increase in synaptic cleft width and thinning of the postsynaptic density, and it significantly suppressed the down-regulation of intracellular calcium/ calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. Repeated electroacupuncture intervention had a cumulative analgesic effect on injury-induced neuropathic pain reactions, and it led to synaptic remodeling of hippocampal neurons and upregulated calcium/calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. | Qiulinq Xu Tao Liu Shuping Chen Yonghui Gao Junying Wang Lina Qiao Junling Liu | 2012 | Neural Regeneration Research2012，7，18： | 3 |
| 12 | The implication of mass elevation effect of the Tibetan Plateau for altitudinal belts显示文摘加热效果(或集体举起效果, MEE ) 由于它的巨大的身体西藏的高原(TP ) 是强烈的。一些研究为亚洲气候在夏天和它的含意作为热来源在它的角色上被承担了,但是很少被了解了它为山的分发的 MEE 的含意高度的带(MAB ) 。用遵守并且遥远地察觉到数据的空气温度数据, MAB/treeline 数据,和翠菊 GDEM 数据,这份报纸总体上比较 MAB 和高山的 treelines 的高度 TP 和包围山脉 / 低地并且从 MEE 的观点解释差别。结果示威:1 ) 在一样,举起,空气温度和逐渐地种季节的长度从东方边增加到内部 TP,例如,在 4500 m (相应于 TP 的吝啬的高度) ,每月吝啬的温度是 3.58 敨映敬? | YAO Yonghui XU Mei ZHANG Baiping | 2015 | Journal of Geographical Sciences2015，25，12： | 3 |
| 13 | Phosphate recovery from anaerobic digester effluents using CaMg(OH)_4显示文摘Dolomite lime(DL)(CaMg(OH)_4) was used as an economical source of Mg^(2+)for the removal and recovery of phosphate from an anaerobic digester effluent of a municipal wastewater treatment plant(MWWTP) wastewater. Batch precipitation results determined that phosphate was effectively reduced from 87 to less than 4 mg-P/L when the effluent water was mixed with 0.3 g/L of DL. The competitive precipitation mechanisms of different solids in the treatment system consisting of Ca^(2+)–Mg^(2+)–NH_4^+–PO_4^(3-)CO_3^(2-)were determined by comparing model predictions with experimental results. Thermodynamic model calculations indicated that hydroxyapatite(Ca_(10)(PO_4)_6(OH)_2), Ca_4H(PO_4)_3?3H_2O, Ca_3(PO_4)_2(beta), and Ca_3(PO_4)_2(am2)were more stable than struvite(MgNH_4PO_3?6H_2O) and calcite(CaCO_3). However, X-ray diffraction(XRD) analysis determined the formation of struvite and calcite minerals in the treated effluent. Kinetic experimental results showed that most of the phosphate was removed from synthetic effluent containing NH_4^+within 2 hr, while only 20% of the PO_4^(3-)was removed in the absence of NH_4^+after 24 hr of treatment. The formation of struvite in the DL-treated effluent was due to the rapid precipitation rate of the mineral. The final pH of the DL-treated effluent significantly influenced the mass ratio of struvite to calcite in the precipitates. Because more calcite was formed when the p H increased from 8.4 to 9.6, a p H range of 8.0–8.5 should be used to produce solid with high PO_4^(3-)content. This study demonstrated that DL could be used for effective removal of phosphate from the effluent and that resultant precipitates contained high content of phosphate and ammonium. | Xueyu Liu Zhonghou Xu Jianfeng Peng Yonghui Song Xiaoguang Meng | 2016 | Journal of Environmental Sciences2016，28，6： | 3 |
| 14 | The progress on antifouling organic coating: From biocide to biomimetic surface显示文摘The advancement in material science and engineering technology has led to the development of antifouling(AF) coatings which are cheaper, durable, less toxic, and safe to the environment. The use of AF coatings containing tributyltin compounds was prohibited at the beginning of 2003, this necessitated the development of environmentally friendly coatings. The fouling release coating(FRC) lacks biocides and has low surface energy, low elastic modulus with smooth surface properties, hence a better release effect to fouling organisms. Several functional coatings have been recently developed based on fouling release(FR) technology to combat the effects of biofouling. Here, we provide a brief overview of innovative technologies and recent developments based on FRCs, including silicone, modified fluorinated polymer,cross-linked coatings, amphiphilic copolymer coating, hydrogel coatings, and biomimetic coatings. We also highlight the key issues and shortcomings of innovative technologies based on FRCs. This may give new insights into the future development of marine AF coatings. | Xu Han Jianhua Wu Xianhui Zhang Junyou Shi Jiaxin Wei Yang Yang Bo Wu Yonghui Feng | 2021 | Journal of Materials Science & Technology2021，，2： | 2 |
| 15 | In Vivo Study on Degradation Behavior and Histologic Response of Pure Magnesium in Muscles显示文摘When an orthopedics device is implanted into bone injury site, it will contact the soft tissue(skeletal muscle, fascia, ligament etc.) except for bone. Magnesium based biodegradable metals are becoming an important research object in orthopedics due to their bioactivity to promote bone healing. In this study,pure Mg rods with and without chemical conversion coating were implanted into the muscle tissue of rabbits. Implants and their surrounding tissues were taken out for weight loss measurement, crosssectional scanning electron microscopy observation, elemental distribution analysis and histological examination. The results showed that the chemical conversion coating would increase the in vivo corrosion resistance of pure Mg and decrease the accumulation of calcium(Ca) and phosphorus(P) elements around the implants. For the bare magnesium implant, both Ca and P contents in the surrounding tissues increased at the initial stage of implantation and then decreased at 12 weeks implantation, while for the magnesium with chemical conversion coating, Ca and P contents in the surrounding tissues decreased with the implantation time, but were not significant. The histological results demonstrated that there was no calcification in the muscle tissue with implantation of magnesium for up to 12 weeks. The chemical conversion coating not only increased the in vivo corrosion resistance of pure Mg, but also avoided the depositions of Ca and P in the surrounding tissues, meaning that pure magnesium should be biosafe when contacting with muscle tissues. | Shanshan Chen Lili Tan Bingchun Zhang Yonghui Xia Ke Xu Ke Yang | 2017 | Journal of Materials Science & Technology2017，33，5： | 2 |
| 16 | Real-time detection al- gorithm for small space targets based on max-median fil- ter显示文摘 | XU YONGHUI ZHANG JIHUI | 2014 | Journal of Information & Computational Science2014，11，4： | 1 |
| 17 | Meas- uring water storage fluctuations in Lake Dongting, China, by Topex/Poseidon satellite altimetry 显示文摘 | ZHANG Jiqun XU Kaiqin YANG Yonghui 2006 | 2006 | Environmental Mo- nitoring and Assessment2006，115，13： | 1 |
| 18 | Performance and stability of yield in response to plant density,year and location in maize hybrids of Northwest China显示文摘Identifying desirable genotypes with the best performance in diverse environments is a perpetual aim of plant breeding,and the interaction between genotype and environment(G×E)always plays a key role.This study was conducted to elucidate the genetic behaviour of different hybrid combinations at various densities in diverse environments.According to a line×tester design,32 hybrid combinations were obtained from 16 inbred individuals crossed with two testers and planted at three locations at three density levels(45,000,67,500 and 90,000 plants ha-1)during 2014-2017.Genotype(G),environment(E)and the interaction of genotype and environment(G×E)significantly affected grain yield at different densities.Increasing planting density enhanced grain yield and improved the efficiency of germplasm screening,where the effect of location on grain yield at different densities was larger than that of year and the GCA was larger than the SCA.Finally,four inbred lines(KB102,KB081,KA105,and KB106)with a high GCA,environmental adaptability,and several combinations using them as parents have been approved in ShannXi Province and National of China.In conclusion,the evaluation of combining ability at multiple densities and locations can effectively screen inbred lines and improve breeding efficiency. | Yuan Dong Zhiqian Feng Ting Li Ali Farhan Xiaokang Tian Yonghui Lao Yinxin Duan Leiyong Si Xinghua Zhang Jiquan Xue Shutu Xu | 2022 | Technology in Agronomy2022，2，1： | 1 |
| 19 | Tidal couplet formation and preservation,and criteria for discriminatingstorm-surge sedimentation on the tidal flats of central Jiangsu Province,China显示文摘 | Wang Jian Bai Chunguang Xu Yonghui | 2010 | Journal of Coastal Research2010，26，5： | 1 |
| 20 | Dispersion of carbon nanotubes by carbazole-tailed amphiphilic imidazolium ionic liquids in aqueous solutions显示文摘 | Bin Dong Yijin Su Yonghui Liu Jie Yuan Jingkun Xu Liqiang Zheng | 2011 | Journal of Colloid And Interface Science2011，，1： | 1 |
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