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| 1 | Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogenactivated protein kinase in mouse lung显示文摘 | Xin-qi PENG Mahendra DAMARLA Jarrett SKIRBALL Stephanie NONAS Xiao-ying WANG Eugenia J HAN Emile J HASAN Xuan CAO Adel BOUEIZ Rachel DAMICO Rubin M TUDER Alfred M SClUTO Dana R ANDERSON Joe GNGARCIA David A KASS Paul M HASSOUN Jun-tian ZHANG | 2010 | Acta Pharmacologica Sinica2010，31，2： | 6 |
| 2 | Central role of myeloid MCPIP1 in protecting against LPSinduced inflammation and lung injury显示文摘Although systemic inflammatory responses attributable to infection may lead to significant lung injury,the precise molecular mechanisms leading to lung damage are poorly understood and therapeutic options remain limited.Here,we show that myeloid monocyte chemotactic protein-inducible protein 1(MCPIP1)plays a central role in protecting against LPS-induced inflammation and lung injury.Myeloid-specific MCPIP1 knockout mice developed spontaneous inflammatory syndromes,but at a late age compared to global MCPIP1 knockout mice.Moreover,mice with a myeloid-specific deletion of MCPIP1 were extremely sensitive to LPS-induced lung injury due to overproduction of proinflammatory cytokines and chemokines.We identified C/EBPβand C/EBPδ,two critical transcriptional factors that drive cytokine production and lung injury,as targets of MCPIP1 RNase.LPS administration caused MCPIP1 protein degradation in the lungs.Pharmacological inhibition of MALT1,a paracaspase that cleaves MCPIP1,by MI-2 selectively increased the MCPIP1 protein levels in macrophages and in the lungs.Meanwhile,administration of MI-2 protected mice from LPS-induced inflammation,lung injury and death.Collectively,these results indicate that myeloid MCPIP1 is central in controlling LPS-induced inflammation and lung injury.Pharmacological inhibition of MALT1 protease activity may be a good strategy to treat inflammatory diseases by enhancing MCPIP1 expression in myeloid cells. | Yong Li Xuan Huang Shengping Huang Hui He Tianhua Lei Fatma Saaoud Xiao-Qiang Yu Ari Melnick Anil Kumar Christopher J Papasian Daping Fan Mingui Fu | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 2 |
| 3 | Magnetic resonance image analysis by information theoretic criteria and stochastic site models显示文摘 | WANG Y ADALI T XUAN J | 2001 | IEEE Trans Inf Technol Biomed2001，5，2： | 1 |
| 4 | New Phenolic Constituents from the Stems of Spatholobus suberectus显示文摘 | Zhang S W Xuan L J | 2006 | Helvetica Chimica Acta2006，89，： | 1 |
| 5 | Seven new sesquiterpene gly- cosides from the root bark of Dictamnus dasycarpus 显示文摘 | Chang J Xuan L J Xu Y M | 2001 | J Nat Prod2001，64，7： | 1 |
| 6 | Integrative network analysis to identify aberrant pathway networks in ovarian cancer显示文摘 | Chen L Xuan J Gu J | 2012 | Pac Symp Bioeomput2012，，： | 1 |
| 7 | Exploring spatiotemporal patterns of phosphorus concentrations in a coastal bay with MODIS images and machine learning models显示文摘 | Chang N B Xuan Z M Yang Y J | 2013 | Remote Sensing of Environment2013，134，： | 1 |
| 8 | Interracial electron transfor and bioelectrocatalysis of carbonized plant material as effective anode of microbial fuel cell 显示文摘 | Karthikeyan R Wang B Xuan J | 2015 | Electrochimica Acta2015，157，： | 1 |
| 9 | Existence and convergence of solutions for the generalized BBM-Burgers equations with dissipative term 显示文摘 | Zhao H J Xuan B J | 1997 | Nonlinear Anal1997，28，11： | 1 |
| 10 | Characterization of sources and emission rates of mineral dust in Northern China显示文摘 | Xuan J Sokolik I N | 2002 | Atmospheric Environment2002，36，： | 1 |
| 11 | Distortionless data hiding based on integer wavelet transform 显示文摘 | Xuan G R Zhu J Chen J | 2002 | IEE Electronics Letters2002，38，25： | 1 |
| 12 | A posteriori output bound for partial differential equations based on elemental error bound computing显示文摘 | Xuan Z C Lee K H Peraire J | 2003 | Lecture Notes in Computer Science2003，2667，： | 1 |
| 13 | Quantitative char- acterization of creep constraint induced by crack depths in compact tension specimens显示文摘 | SUN P J WANG G Z XUAN F Z etal | 2011 | Engineering Fracture Mechan- ics2011，78，： | 1 |
| 14 | Mixture optimization of cement treated demolition waste with recycled masonry and concrete显示文摘 | Xuan D X Houben L J M Molenaar A A A | 2012 | Materials and structures2012，45，12： | 1 |
| 15 | Distortionless data hiding based on integer wavelet transform显示文摘 | Xuan G R Zhu J Chen J D | 2002 | IEE Electronics Letters2002，38，25： | 1 |
| 16 | Laboratory Assessment of Emission Reduction Strategies for the Agricultural Fumigants 1,3-Dichloropropene and Chl0ropicrin显示文摘 | ASHWORTH D J ERNST F F XUAN Ri-cheng | 2009 | Environ Sci Technol2009，43，13： | 1 |
| 17 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 18 | Acquirer-target social ties and merger outcomes显示文摘 | ISHII J XUAN Y | 2014 | Journal of Financial Economics2014，112，3： | 1 |
| 19 | Factors affecting ion-ic liquids based removal of an ionic dyes from water显示文摘 | PEI Y C WANG J J XUAN XP | 2007 | En-viron Sci Technol2007，41，14： | 1 |
| 20 | Distortionless data hiding based on integer wavelet transform 显示文摘 | Xuan G Zhu J Chen J | 2002 | IEE Electronics Letters2002，38，25： | 1 |
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