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| 1 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 2 | Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration显示文摘 | Hu Wang Hongna Zuo Jin Liu Fei Wen Yawei Gao Xudong Zhu Bo Liu Feng Xiao Wengong Wang Gang Huang Bin Shen Zhenyu JU | 2018 | Cell Research2018，28，10： | 16 |
| 3 | Overexpression of miR-30a in lung adenocarcinoma A549 cell line inhibits migration and invasion via targeting EYA2显示文摘MicroRNAs (miRNAs ) 是与癌症的致病有关的小非编码的 RNA 并且仔细的一个班。增加的证据显示 miR-30a 在癌症的发展期间起一个深刻作用。然而,在 non-small-cell 肺癌症(NSCLC ) 的 miR-30a 的功能仍然是模糊的。这里,我们发现 miR-30a 被 qRT-PCR 从 14 个病人在肺腺癌 A549 房间并且在织物样品减少,并且也发现在 A549 房间的 miR-30a 的 overexpression 由愈合创伤的试金禁止了移植和侵略然而并非房间增长和房间周期前进, matrigel 侵略试金,基于山的房间增长试金,和流动 基于cytometry 的房间周期分析分别地。我们进一步在肺腺癌房间行探索了 miR-30a-mediated 基因规定的潜在的机制。EYA2 是 miR-30a 的一个预言的目标,并且 EYA2 表示被 miR-30a 在乳癌房间禁止,这被发现了。我们证明 EYA2 是由在 A549 房间使用双酶的记者试金的 miR-30a 的一个直接目标并且证明 EYA2 蛋白质层次相反地在 A549 和 BEAS-2B 房间与 miR-30a 表示被相关。另外,我们也与表示向量和 miR-30a 模仿的 EYA2 由 cotransfection 在 A549 房间证实了 EYA2 overexpression 的营救效果。一起拿,我们的结果证明在肺腺癌 A549 房间的 miR-30a 的 overexpression 能禁止房间移植和侵略,它部分被归因于 EYA2 的减少表示。我们的调查结果建议 miR-30a 以后可以为肺腺癌的治疗被用作一个新潜在的目标。 | Yuncang Yuan Shangyong Zheng Qian Li Xudong Xiang Tangxin Gao Pengzhan Ran Lijuan Sun Qionglin Huang Fei Xie Jing Du Chunjie Xiao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 12 |
| 4 | A study on the Dushiling tungsten-copper deposit in the Miao'ershan-Yuechengling area, Northern Guangxi, China:Implications for variations in the mineralization of multi-aged composite granite plutons显示文摘The polymetallic Dushiling W-Cu deposit is a large, altered, skarn-type deposit, located in the northeastern part of the Miao'ershan-Yuechengling pluton, China. Two types of granite have been identified in the deposit: a medium-grained porphyritic biotite granite, and a medium- to fine-grained biotite granite. Both are spatially and temporally related to ore bodies, suggesting they may be the source of mineralization in the deposit. A medium- to fine-grained porphyritic biotite granite is exposed at the surface in the region of mineralization. U-Pb dating of zircons yielded magmatic ages of 423 Ma for the medium-grained porphyritic biotite granite and 421 Ma for the medium- to fine-grained porphyritic biotite granite, while a younger age(217 Ma) obtained for surface samples indicates later diagenesis. Thus, magmatism occurred during the Caledonian and Indosinian, respectively. The petrological and geochemical characteristics of the two Caledonian granites show that both are calc-alkaline and peraluminous.They are moderately enriched in Cs, Rb, U, and REE, and strongly depleted in Sr,Ba,P,and Ti; they show similar REE behavior,including negative Eu anomalies. These geochemical similarities suggest that the two granites were derived from the same source,although they were emplaced during different stages of the evolution of the magma. Furthermore, the granites are associated with mineralization, suggesting they were the source of mineralization in the Dushiling W-Cu deposit. Sm-Nd ages of scheelite from the Dushiling W-Cu deposit indicate that metallogenesis occurred at 417±35 Ma, while the two types of titanite, intergrown with scheelite, yield U-Pb ages of 423–425 Ma(in altered granite sample) and 218 Ma(in skarn sample). These ages place the main mineralization event in the late Caledonian, and later magmatic-hydrothermal activity occurred in the Indosinian. The ages obtained for the Dushiling W-Cu deposit in the western Nanling Range, northern Yuechengling, together with the occurrence and ages of the Niutangjie W deposit in southern Yuechengling, provide insight into the process of ore concentration during the Caledonian and Indosinian. | CHEN WenDi ZHANG WenLan WANG RuCheng CHU ZhuYin XIAO Rong ZHANG Di CHE XuDong | 2016 | Science China Earth Sciences2016，59，11： | 10 |
| 5 | The Influence of Extractable Organic Matter on Pore Development in the Late Triassic Chang 7 Lacustrine Shales, Yanchang Formation, Ordos Basin, China显示文摘To investigate the influence of extractable organic matter(EOM) on pore evolution of lacustrine shales, Soxhlet extraction, using dichloromethane, was performed on a series of Chang 7 shale samples(Ordos Basin, China) with vitrinite reflectance of 0.64% to 1.34%. Low-pressure gas adsorption experiments were conducted on the samples before and after extraction. The pore structure parameters were calculated from the gas adsorption data. The results show complex changes to the pore volumes and surface areas after extraction. The pore development of both the initial and extracted samples is strongly controlled by total organic carbon(TOC) content. Micropores developed mainly in organic matter(OM), while mesopores and macropores predominantly developed in fractions other than OM. The influence of EOM on micropores is stronger than on mesopores and macropores. Organic solvents with a higher boiling point should be used to explore the effect of EOM on pore structure in the future. | HAN Hui LIU Pengwei DING Zhengang SHI Pitong JIA Jianchao ZHANG Wei LIU Yan CHEN Shijia LU Jungang Chen Kang PENG Xudong WANG Zhiyong XIAO Shuqi GAO Yuans | 2018 | Acta Geologica Sinica(English Edition)2018，92，4： | 8 |
| 6 | Efficient and stable tin-based perovskite solar cells by introducing π-conjugated Lewis base显示文摘Tin-based perovskite solar cells(TPSCs)as the most promising candidate for lead-free PSCs have incurred extensive researches all over the world.However,the crystallization process of tin-based perovskite is too fast during the solution-deposited process,resulting in abundant pinholes and poor homogeneity that cause serious charge recombination in perovskite layer.Here,we employed theπ-conjugated Lewis base molecules with high electron density to systematically control the crystallization rate of FASnI3 perovskite by forming stable intermediate phase with the Sn-I frameworks,leading to a compact and uniform perovskite film with large increase in the carrier lifetime.Meanwhile,the introduction of theπ-conjugated systems also retards the permeation of moisture into perovskite crystal,which significantly suppresses the film degradation in air.These benefits contributed to a stabilizing power conversion efficiency(PCE)of 10.1%for the TPSCs and maintained over 90%of its initial PCE after 1000-h light soaking in air.Also,a steady-state efficiency of 9.2%was certified at the accredited test center. | Tianhao Wu Xiao Liu Xin He Yanbo Wang Xiangyue Meng Takeshi Noda Xudong Yang Liyuan Han | 2020 | Science China Chemistry2020，63，1： | 6 |
| 7 | Shaped charge penetration into high-and ultrahigh-strength Steel-Fiber reactive powder concrete targets显示文摘Experiments on shaped charge penetration into high and ultrahigh strength steel-fiber reactive powder concrete(RPC) targets were performed in this paper.Results show that the variation of penetration depth and crater diameter with concrete strength is different from that of shaped charge penetration into normal strength concrete(NSC).The crater diameter of RPC is smaller than that of NSC penetrated by the shaped charge.The jet particles are strongly disturbed and hardly reach the crater bottom because they pass through the narrow channel formed by jet penetration into the RPC.The effects of radial drift velocity and gap effects of jet particles for a shaped charge penetration into RFC target are discussed.Moreover,a theoretical model is presented to describe the penetration of shaped charge into RPC target.As the concrete strength increases,the penetration resistance increases and the entrance crater diameter decreases.Given the drift velocity and narrow crater channel,the low-velocity jet particles can hardly reach the crater bottom to increase the penetration depth.Moreover,the narrow channel has a stronger interference to the jet particles with increasing concrete strength;hence,the gap effects must be considered.The drift velocity and gap effects,which are the same as penetration resistance,also have significant effects during the process of shaped charge penetration into ultrahigh-strength concrete,The crater profiles are calculated through a theoretical model,and the results are in good agreement with the experiments. | Qiang-qiang Xiao Zheng-xiang Huang Xudong Zu Xin Jia Qi-feng Zhu Wei Cai | 2020 | Defence Technology(防务技术)2020，16，1： | 5 |
| 8 | Effects of nicotinamide and riboflavin on the biodesulfurization activity of dibenzothiophene by Rhodococcus erythropolis USTB-03显示文摘Rhodococcus erythropolis USTB-03 经由 DBT 作为一个结束产品在被变换成 2-hydroxybiphenyl (2HBP ) 的一条硫特定的小径是为 dibenzothiophene (DBT ) 的 biodesulfurization 的有希望的菌株。硫上的菸碱和核黄素的效果由 R.erythropolis USTB-03 的 DBT biodesulfurization 的特定的活动(SA ) 被调查。菸碱和核黄素被发现提高 SA 的表示,它以前没被报导。当 R.erythropolis USTB-03 在包含 10.0 mmol 的菸碱或 50.0 亩摩尔的核黄素的媒介上是成年的时, SA 从 68.0 左右被提起到超过 130 mmol 2HBP/(kg 干燥 cells-h ) 。当 R.erythropolis USTB-03 面对 5.0 mmol 的两菸碱和 25.0 umol 的核黄素是成年的时, SA 进一步被增加到 159.0 mmol 2HBP/(kg 干燥 cells-h ) 。这被建议黄素的减少的形式的生物合成单音的核苷酸(FMNH2 ) ,为 biodesulfurization 酶 Dsz C 和 A 的活动的必要辅酶,可能被菸碱和核黄素提高,它为 R.erythropolis USTB-03 的增加的 SA 负责。 | YAN Hai SUN Xudong XU Qianqian MA Zhao XIAO Chengbin Ning Jun | 2008 | Journal of Environmental Sciences2008，20，5： | 4 |
| 9 | Microstructure and Mechanical Properties of Galvanized Steel/AA6061 Joints by Laser Fusion Brazing Welding显示文摘Laser fusion brazing welding was proposed.Galvanized steel/AA6061 lapped joint was obtained by laser fusion brazing welding technique using the laser-induced aluminium molten pool spreading and wetting the solid steel surface.Wide joint interface was formed using the rectangular laser beam coupled with the synchronous powder feeding.The result showed that the tiny structure with the composition of a-Al and Al–Si eutectic was formed in the weld close to the Al side.And close to the steel side,a layer of compact Fe–Al–Si intermetallics,including the Al-rich FeAl3,Fe2Al5 phases and Al–Fe–Si s1 phase,was generated with the thickness of about 10–20 lm.Transverse tensile shows the brittlefractured characteristic along to the seam/steel interface with the maximum yield strength of 152.5 MPa due to the existence of hardening phases s1 and Al–Fe intermetallics. | Junxia L Wuxiong Yang Shikai Wu Xudong Zhao Rongshi Xiao | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，4： | 3 |
| 10 | The experimental rules of mica as a reference sample of AFM/FFM measurement显示文摘For the friction measurements with AFM/FFM, usually the relative values of friction signal can be obtained. In order to compare the micro-tribological properties of different samples, mica is often used as an reference sample for friction measurement. However, due to the friction force of new cleaved mica surface is unstable, it is urged to systematically investigate the tribological properties of mica to design the experimental rules of the reference sample mica for friction measurements. Experimental results show that the friction of mica varies with the cleaving time, humidity and surface state of tip. The friction measured with different tips on mica varies in the range of ±15%. For a new tip, the friction increases with the tip’s wear and then becomes stable. For new cleaved mica, the friction increases within thefirst two hours and then keeps unchanged. The friction of mica also decreases with the relative humidity because of its hydrophilicity. | QIAN Linmao LUO Jianbin WEN Shiwu XIAO Xudong | 2001 | Chinese Science Bulletin2001，46，4： | 3 |
| 11 | Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals显示文摘ASXL1 变化经常在 hematological 肿瘤被发现,并且 Asxl1 的损失在老鼠支持 myeloid 转变。这里我们在 vivo 在在 Histone H2A (H2AK119ub1 ) 上的 mono-ubiquitylated 离氨酸 119 的 deubiquitylation 为 ASXL1-BAP1 建筑群支持一个角色的现在的数据。Polycomb 组蛋白质在正常开发期间控制 INK4B-ARF-INK4A 地点的表达式,部分地通过催化 H2AK119 的 mono-ubiquitylation。自从地点的激活, INK4B-ARF-INK4A 玩一设有自动保险装置机制免于 tumorigenesis,我们调查了 ASXL1 依赖的 H2A deubiquitylation 是否在它的激活起一个作用。有趣地,我们发现 ASXL1 明确地为 p15 响应 oncogenic 发信号和外来的 anti-proliferative 的 INK4B 发信号。因为我们发现 ASXL1 和 BAP1 两个都在 INK4B 地点被充实,我们的结果建议 INK4B 地点的激活要求 H2AK119ub1 的 ASXL1/BAP1-mediated deubiquitylation。一致地,我们 ASXL1 变化与被联系的结果表演降低 p15 INK4B 和在主要骨头髓房间的造血的祖先的一个 proliferative 优点,和在多重房间线的 ASXL1 的那弄空导致抵抗到生长禁止的信号。一起拿,这研究连接 INK4B 表示的调停 ASXL1 的 H2A deubiquitylation 和 transcriptional 激活到它的肿瘤 suppressor 函数。 | Xudong Wu Ida Holst Bekker-Jensen Jesper Christensen Kasper Dindler Rasmussen Simone Sidoli Yan Qi Yu Kong Xi Wang Yajuan Cui Zhijian Xiao Guogang Xu Kristine Williams Juri Rappsilber Casper Kaae Sonderby Ole Winther Ole N Jensens Kristian Helin | 2015 | Cell Research2015，25，11： | 3 |
| 12 | Antithymocyte globulin/antilymphocyte globulin plus kidney-nourishing Chinese Medicinal:effect on severe aplastic anemia显示文摘OBJECTIVE:To explore the effect of antithymocyte globulin(ATG)/antilymphocyte globulin(ALG) plus kidney-nourishing Chinese medicinal(KNCM) on severe aplastic anemia(SAA).METHODS:Twenty-five subjects of severe aplastic anemia were treated with ATG/ALD plus KNCM between 1992 and 2009,and the clinical data before and after treatment were collected and analyzed.RESULTS:Of the 25 patients,9 were nearly cured,6 were improved,5 were in remission,and 5 failed.The overall effective rate was 80.0%.The 3-year,5-year,10-year,15-year survival rate were respectively 98.6%,97.3%,97.3%,67.5%,and median survival time was 180 months.Compared to the conditions before administering the medication of ATG/ALG plus KNCM,after 2 weeks,reticulocyte was first improved(P=0.001);one month later,followed by palette(P=0.037);two months later,by neutrophil cell in peripheral blood(P=0.001);three months later,then by the hemoglobin(P=0.012).By conducting 1-year follow-up,1 case of complication-paroxysmal nocturnal hemoglobinuria(PNH) was identified and the patient still alive today.CONCLUSION:ATG/ALG plus KNCM had better effect on SAA and could improve patients' survival rate. | Xudong Tang Feng Liu Liu Li Chi Liu Shanshan Zhang Haiyan Xiao Chunmei Zheng Shu Xu Rou Ma | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 3 |
| 13 | Privacy-Preserving Collaborative Filtering Based on Time-Drifting Characteristic显示文摘Recommendation has become increasingly important because of the information overload. Collaborative filtering(CF) technique, as the most popular recommendation method, utilizes the historical preferences of users to predict their future interests on other items.However, CF technique requires collecting users' rating information, which may lead to the disclosure of privacy. We propose a new randomized perturbation approach Time-drifting privacy-preserving collaborative filtering(TPPCF) to well balance privacy of users and accuracy of recommendation. Since users' recent ratings can better represent their interests and preferences, we incorporate a varying weight into the approach. Specifically, we assign higher weights to more recent ratings both when computing user similarity and perturbing users' ratings. To further improve the efficiency, we cluster the users into several groups to reduce computation cost. We demonstrate the effectiveness and efficiency of our method through experiments on Movie Lens dataset, which shows TPPCF can achieve higher privacy while generating more accurate recommendation. | ZHAO Feng XIONG Yan LIANG Xiao GONG Xudong LU Qiwei | 2016 | Chinese Journal of Electronics2016，25，1： | 2 |
| 14 | Graphene-loaded metal wire grating for deep and broadband THz modulation in total internal reflection geometry显示文摘We employed a metallic wire grating loaded with graphene and operating in total internal reflection (TIR) geometry to realize deep and broadband THz modulation. The non-resonant field enhancement effect of the evanescent wave in TIR geometry and in the subwavelength wire grating was combined to demonstrate a ~77% modulation depth (MD) in the frequency range of 0.2–1.4 THz. This MD, achieved electrically with a SiO_2∕Si gated graphene device, was 4.5 times higher than that of the device without a metal grating in transmission geometry. By optimizing the parameters of the metallic wire grating, the required sheet conductivity of graphene for deep modulation was lowered to 0.87 mS. This work has potential applications in THz communication and real-time THz imaging. | YIWEN SUN RICCARDO DEGLJINNOCENTI DAVID A.RITCHIE HARVEY E.BEERE LONG XIAO MICHAEL RUGGIERO J.AXEL ZEITLER RAYKO I.STANTCHEV DANNI CHEN ZHENGCHUN PENG EMMA MACPHERSON XUDONG LIU | 2018 | Photonics Research2018，6，12： | 2 |
| 15 | Cross-Lingual Non-Ferrous Metals Related News Recognition Method Based on CNN with A Limited Bi-Lingual Dictionary显示文摘To acquire non-ferrous metals related news from different countries’internet,we proposed a cross-lingual non-ferrous metals related news recognition method based on CNN with a limited bilingual dictionary.Firstly,considering the lack of related language resources of non-ferrous metals,we use a limited bilingual dictionary and CCA to learn cross-lingual word vector and to represent news in different languages uniformly.Then,to improve the effect of recognition,we use a variant of the CNN to learn recognition features and construct the recognition model.The experimental results show that our proposed method acquires better results. | Xudong Hong Xiao Zheng Jinyuan Xia Linna Wei | 2019 | Computers, Materials & Continua2019，，2： | 2 |
| 16 | Paleogene geological framework and tectonic evolution of the central anticlinal zone in Lufeng 13 sag,Pearl River Mouth Basin显示文摘The Paleogene geological framework and evolution process in the central anticline zone in the Lufeng 13 sag in Pearl River Mouth Basin is well analyzed through seismic data and drilling data,and control of tectonic evolution on hydrocarbon accumulation is also discussed.The results show that the central anticline zone in the Lufeng 13 sag develops the upper deformation layer and lower deformation layer.The“arched graben system”is developed in the upper deformation layer,and the magmatic diapir structure and flowing deformation of plastic strata is developed in the lower deformation layer.The evolution process of the central anticline zone can be divided into four stages,i.e.fault block uplifting stage,prototype stage,strengthening stage and finalization stage.The geological framework and tectonic evolution of the central anticline zone control Paleogene hydrocarbon accumulation.The Paleogene twolayer geological framework is favorable for development of structural traps and composite traps;the paleostructure highs are the direction of hydrocarbon migration,and the gravitational gliding faults are the main carrier bed for vertical hydrocarbon migration;the tectonic uplift is a key factor for reservoir diagenesis improvement and preservation of primary pores,and also controls distribution of high-quality reservoirs. | Xudong Wang Xiangtao Zhang Heming Lin Xiaoming Que Yong He Liankai Jia Zhangbo Xiao Min Li | 2019 | Petroleum Research2019，4，3： | 2 |
| 17 | The scaling of human mobility by taxis is exponential显示文摘 | Liang Xiao Zheng Xudong Lv Weifeng | 2011 | Physical A:Statis- tical Mechanics and Its Applications2011，391，5： | 1 |
| 18 | Temperature measurements in steady two-dimensional partially premixed flames using laser interferometric holography 显示文摘 | Xiao Xudong Chol Chun W Purl Ishwar K | 2000 | Combustion and Flame2000，120，： | 1 |
| 19 | Inflow boundary conditions for hybrid large eddy/Reynolds averaged Navier-Slokes simulations显示文摘 | Xiao Xudong Edwards J R | 2003 | AIAA Journal2003，41，8： | 1 |
| 20 | Linking microbial carbon pump capacity and efficacy to soil organic carbon storage and stability under heavy metal pollution显示文摘Heavy metal pollution can lead to a great loss of soil organic carbon(SOC).However,the microbial mechanisms that link heavy metal pollution to SOC remain poorly understood.Here,we investigated five apple-orchard soils at different distances from a Pb-Zn smelter.After assessing the heavy metal pollution level based on Grade Ⅱ of the national soil environmental quality standard(China),we found SOC stocks and microbial carbon pump(MCP)capacity(i.e.,microbial residue carbon)under medium and heavy pollution levels were significantly lower than those under safe,cordon and light pollution levels.The structural equation model showed causality in the SOC variations linked to pollution level through MCP capacity,which could contribute 77.8% of the variance in SOC storage.This verified MCP capacity can serve as a key parameter for evaluation of SOC storage under heavy metal pollution.Soil MCP efficacy,i.e.,the proportion of microbial residue carbon to SOC,also decreased under medium and heavy pollution.This suggested that,with a heavier pollution level,there was a higher rate of reduction of microbial residue carbon in soil than the rate of reduction of SOC.As MCP efficacy can be a useful assessment of SOC stability,the significantly positive relationship between MCP efficacy and clay content in correlation analysis implied that lower MCP efficacy was correlated with SOC stability under the heavier pollution level.Our study provides valuable insights to identify the mechanisms of microbially mediated C transformation processes that are influenced by heavy metal pollution in agroecosystems. | Xiao Liu Xia Xu Tian Ma Shiwei Zhou Xiaoli Bi Hongbo He Xudong Zhang Weihuan Li | 2023 | Soil Ecology Letters2023，5，2： | 1 |
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