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| 1 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 2 | A Strategy for Merging Objective Estimates of Global Daily Precipitation from Gauge Observations, Satellite Estimates, and Numerical Predictions显示文摘This paper describes a strategy for merging daily precipitation information from gauge observations, satellite estimates(SEs), and numerical predictions at the global scale. The strategy is designed to remove systemic bias and random error from each individual daily precipitation source to produce a better gridded global daily precipitation product through three steps.First, a cumulative distribution function matching procedure is performed to remove systemic bias over gauge-located land areas. Then, the overall biases in SEs and model predictions(MPs) over ocean areas are corrected using a rescaled strategy based on monthly precipitation. Third, an optimal interpolation(OI)–based merging scheme(referred as the HL-OI scheme)is used to combine unbiased gauge observations, SEs, and MPs to reduce random error from each source and to produce a gauge—satellite–model merged daily precipitation analysis, called BMEP-d(Beijing Climate Center Merged Estimation of Precipitation with daily resolution), with complete global coverage. The BMEP-d data from a four-year period(2011–14) demonstrate the ability of the merging strategy to provide global daily precipitation of substantially improved quality.Benefiting from the advantages of the HL-OI scheme for quantitative error estimates, the better source data can obtain more weights during the merging processes. The BMEP-d data exhibit higher consistency with satellite and gauge source data at middle and low latitudes, and with model source data at high latitudes. Overall, independent validations against GPCP-1DD(GPCP one-degree daily) show that the consistencies between BMEP-d and GPCP-1DD are higher than those of each source dataset in terms of spatial pattern, temporal variability, probability distribution, and statistical precipitation events. | Suping NIE Tongwen WU Yong LUO Xueliang DENG Xueli SHI Zaizhi WANG Xiangwen LIU Jianbin HUANG | 2016 | Advances in Atmospheric Sciences2016，33，7： | 3 |
| 3 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 4 | The Mycobacterium bovis BCG prime-Rv0577 DNA boost vaccination induces a durable Thl immune response in mice显示文摘肺结核遗体一个主要全球健康问题和有效疫苗着急地被需要。在这研究,我们使用了联合了 immunodominant 抗原 Rv0577 的基于 DNA 、基于蛋白质的疫苗增加 BCG 并且在 BALB/c 老鼠评估了他们的 immunogenicity。我们的数据建议增强软件疫苗可以实质地提高 BCG 的 immunogenicity 并且加强两 CD4+ T 调停房间的 Th1 和 CD8+ T 调停房间的 cytolytic 回答。与基于蛋白质的疫苗相比,基于 DNA 的疫苗能导致更持久的 Th1 有免疫力的反应,在刺激抗原的 splenocyte 文化由抗体反应,增长反应, CD4+/CD8+ 的百分比和 cytokine 分泌物的高水平描绘了。在结论,我们第一次,开发了蛋白质 -- 并且 plasmid 基于 DNA 的增强软件疫苗基于 Rv0577。我们的调查结果建议那抗原基于 Rv0577 的 DNA 疫苗是产生免疫性的并且能高效地增加 BCG,它能在对 TB 的有效种痘策略的设计是有用的。 | Dongqing Gu Wei Chen Youjun Mi Xueli Gong Tao Luo Lang Bao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 2 |
| 5 | A compressed sensing-based iterative algorithm for CT reconstruction and its possible application to phase contrast imaging显示文摘 | Li Xueli Luo Shuqian | 2011 | BioMedical Engineering Online2011，10，： | 1 |
| 6 | Isolation and Identification of Root Rot Fungus of Astragalus membranaceus显示文摘The perennial root of Astragalus membranaceus is used as a medicine,while root rot is a main factor causing reduction of quality and commodity value of A. membranaceus. The screening and research of the pathogenic species and their characteristics could provide theoretical and practical basis for the control of this disease. A pathogenic strain was isolated and purified from the root part of four-year-old A. membranaceus,and identified by morphological and molecular biological methods as Fusarium oxysporum. This study will provide a theoretical basis for the research of the biological characteristics and control of F. oxysporum. | Yipeng WANG Jiaqi LUO Shiyao SHAN Jishan JIANG Xueli QUAN Songquan WU Shichen HUANG | 2018 | Agricultural Biotechnology2018，7，4： | 1 |
| 7 | Immune‑Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults显示文摘Ageing is often accompanied with a decline in immune system function,resulting in immune ageing.Numerous studies have focussed on the changes in different lymphocyte subsets in diseases and immunosenescence.The change in immune phenotype is a key indication of the diseased or healthy status.However,the changes in lymphocyte number and phenotype brought about by ageing have not been comprehensively analysed.Here,we analysed T and natural killer(NK)cell subsets,the phenotype and cell differentiation states in 43,096 healthy individuals,aged 20–88 years,without known diseases.Thirty-six immune parameters were analysed and the reference ranges of these subsets were established in different age groups divided into 5-year intervals.The data were subjected to random forest machine learning for immune-ageing modelling and confirmed using the neural network analysis.Our initial analysis and machine modelling prediction showed that na.ve T cells decreased with ageing,whereas central memory T cells(Tcm)and effector memory T cells(Tem)increased cluster of differentiation(CD)28-associated T cells.This is the largest study to investigate the correlation between age and immune cell function in a Chinese population,and provides insightful differences,suggesting that healthy adults might be considerably influenced by age and sex.The age of a person's immune system might be different from their chronological age.Our immune-ageing modelling study is one of the largest studies to provide insights into‘immune-age’rather than‘biological-age’.Through machine learning,we identified immune factors influencing the most through ageing and built a model for immune-ageing prediction.Our research not only reveals the impact of age on immune parameter differences within the Chinese population,but also provides new insights for monitoring and preventing some diseases in clinical practice. | Zhenghu Jia Zhiyao Ren Dongmei Ye Jiawei Li Yan Xu Hui Liu Ziyu Meng Chengmao Yang Xiaqi Chen Xinru Mao Xueli Luo Zhe Yang Lina Ma Anyi Deng Yafang Li Bingyu Han Junping Wei Chongcheng Huang Zheng Xiang Guobing Chen Peiling Li Juan Ouyang Peisong Chen Oscar Junhong Luo Yifang Gao Zhinan Yin | 2023 | Phenomics2023，3，4： | 1 |
| 8 | Monte Carlo calculation of the thermal radiation heat toad of the ITER pre - production cryopump 显示文摘 | Luo Xueli Volker Hauer Christian Day | 2012 | Fusion Engineering and Design2012，87，： | 1 |
| 9 | Advanced Process and Electron Device Technology显示文摘This article reviews advanced process and electron device technology of integrated circuits,including recent featuring progress and potential solutions for future development.In 5 years,for pushing the performance of fin field-effect transistors(FinFET)to its limitations,several processes and device boosters are provided.Then,the three-dimensional(3 D)integration schemes with alternative materials and device architectures will pave paths for future technology evolution.Finally,it could be concluded that Moore’s law will undoubtedly continue in the next 15 years. | Dan Zhang Xiaojing Su Hao Chang Hao Xu Xiaolei Wang Xiaobin He Junjie Li Fei Zhao Qide Yao Yanna Luo Xueli Ma Hong Yang Yongliang Li Zhenhua Wu Yajuan Su Tao Yang Yayi Wei Anyan Du Huilong Zhu Junfeng Li Huaxiang Yin Jun Luo Tianchun Ye Wenwu Wang | 2022 | Tsinghua Science and Technology2022，27，3： | 1 |
| 10 | Intra-Organizational Social Media and Employee Idea Generation:Analysis based on the Spanning-Relevance Framework显示文摘Intra-organizational social media platforms are expected to help build a flexible corporate stage that facilitates employees'communication and leverages creative idea generation.However,whether and how these systems can expedite the creativity of employees remains unclear.This paper attempts to address the impacts of employees'social relationships on intra-organizational social media on their idea generation quantity and quality.Drawn upon the extant literature in the fields of information systems and organizational behavior,a theoretical model is postulated on the basis of analyzing the attributes of social ties and exchanged information content in light of a two-dimensional framework that juxtaposes boundary spanning and work relevance.The model is empirically tested using data obtained from two internal application systems of a large telecommunications company.Test results validate that employees'online social relationships with different attributes are discriminably associated with their group identification and proactive creativity.Meanwhile,proactive creativity and group identification both show the positive impacts on idea generation quantity,whereas only proactive creativity has a significant positive impact on idea generation quality.These findings contribute to the literature on intra-organizational social media and employee idea generation,by uncovering the links among employees'online social relationships,mental processes,and idea generation. | Benjiang Lu Xunhua Gu Nianlong Luo Xueli Wang Guoqing Chen | 2022 | Journal of Systems Science and Systems Engineering2022，31，6： | 0 |
| 11 | Microstructure and Mechanical Properties of Graphene Reinforced K418 Superalloy by Selective Laser Melting显示文摘In order to obtain the superalloy with excellent properties, graphene reinforced K418 nickel base superalloy(GNPs/K418 composite) was prepared by selective laser melting technique in this study. Through systematically comparing and analyzing the microstructure and mechanical property of K418 superalloy and GNPs/K418 composite, it is found that the percentage of small-diameter grain(≤ 15 μm) increased from 84% to 90%, and the max strength of grain orientation(<001>) reduce from 5.76 to 4.17 due to the addition of GNPs. And GNPs can also improve the height and the full width at the half peak of the strong diffraction peak of GNPs/K418 composite. Besides, GNPs/K418 composite is a kind of sandwiched structure, which is consist of GNPs, carbides, and K418 matrix. Therefore, the hardness of the GNPs/K418 composite is 4.1% and 6.9% higher than that of the K418 matrix in the transverse and vertical direction, respectively. The room temperature tensile strength of the GNPs/K418 composite is 9% higher than that of the K418 matrix. And the 600℃ and 900℃ tensile strengths of the GNPs/K418 composite are 7.6% and 10.4% higher than that of the K418 matrix, respectively. It is inferred that the effect of graphene on K418 matrix strengthening is mainly fine grain strengthening and Orowan strengthening. However, the elongation rate of the composite material is reduced, which is attributed to crack sprouting at the interface between the matrix and GNPs under high stress. | Yongxin Lu Fan Luo Zhen Chen Jian Cao Kai Song Lei Zhao Xueli Xu Hongduo Wang Wenya Li | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，9： | 0 |
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