|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know显示文摘Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 是一个重要造血的生长因素和有免疫力的调节的人。GM-CSF 也在各种各样的传播白血球的功能的活动有深刻效果。它被许多房间类型在收到有免疫力的刺激之上包括 T 房间,巨噬细胞, endothelial 房间和成纤维细胞生产。尽管 GM-CSF 局部地被生产,它能以一种 paracrine 方式行动到在主人防卫提高他们的功能的成员传播 neutrophils,单核白血球和淋巴细胞。最近的集中的调查为它增加树枝状的房间(DC ) 成熟和功能以及巨噬细胞活动的能力作为一个有免疫力的助手在 GM-CSF 的应用程序上被集中。在经历化疗的癌症病人对待嗜中性白血球减少症临床上被使用,在在治疗期间的爱滋病病人,并且在在骨髓移植以后的病人。有趣地, GM-CSF-deficient 老鼠的造血的系统看起来正常;最重要的变化在一些特定的 T 房间回答。尽管 GM-CSF 的分子的克隆用 T 房间的 cDNA 图书馆被执行, T 房间在激活以后生产 GM-CSF,是众所周知的,在 T 房间功能上有在由 T 房间和它的效果的生产的这 cytokine 的系统的调查的缺乏。在这篇文章,我们将在 T 房间主要集中于 GM-CSF 的免疫生物学。 | Yufang Shi Catherine H Liu Arthur I Roberts Jyoti Das Guangwu Xu Guangwen Ren Yingyu Zhang Liying Zhang Zeng Rong Yuan Hung Sheng William Tan Gobardhan Das Satish Devadas | 2006 | Cell Research2006，16，2： | 22 |
| 2 | Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes显示文摘Being infected by SARS-CoV-2 may cause damage to multiple organs in patients, such as the lung, liver and heart. Angiotensin-converting enzyme 2(ACE2), reported as a SARS-CoV-2 receptor, is also expressed in human male testes. This suggests a potential risk in human male reproductive system. However, the characteristics of ACE2-positive cells and the expression of other SARS-CoV-2 process-related genes are still worthy of further investigation. Here, we performed singlecell RNA seq(scRNA-seq) analysis on 853 male embryo primordial germ cells(PGCs) and 2,854 normal testis cells to assess the effects of the SARS-CoV-2 virus on the male reproductive system from embryonic stage to adulthood. We also collected and constructed the scRNA-seq library on 228 Sertoli cells from three non-obstructive azoospermia(NOA) patients to assess the effects at disease state. We found that ACE2 expressing cells existed in almost all testis cell types and Sertoli cells had highest expression level and positive cells ratio. Moreover, ACE2 was also expressed in human male PGCs. In adulthood, the level of ACE2 expression decreased with the increase of age. We also found that ACE2 positive cells had high expressions of stress response and immune activation-related genes. Interestingly, some potential SARS-CoV-2 process-related genes such as TMPRSS2, BSG, CTSL and CTSB had different expression patterns in the same cell type. Furthermore, ACE2 expression level in NOA donors’ Sertoli cells was significantly decreased. Our work would help to assess the risk of SARS-CoV-2 infection in the male reproductive system. | Xixi Liu Yidong Chen Wenhao Tang Li Zhang Wei Chen Zhiqiang Yan Peng Yuan Ming Yang Siming Kong Liying Yan Jie Qiao | 2020 | Science China(Life Sciences)2020，63，7： | 14 |
| 3 | Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis显示文摘人的大脑开发的细胞的复杂性强烈地被调查了,尽管全部人的服的外皮的地区性的描述没基于单个房间的 transcriptome 分析被报导。这里,我们从人的中间怀孕期的胚胎的 22 个大脑区域在超过 4,000 个单个房间上执行了 RNA-seq。我们识别了 29 房间亚簇,它证明在每个区域和脑桥的不同比例显示出星形细胞的特别高的百分比。胚胎的神经原不象成年神经原一样多样,尽管他们在成年人拥有了他们的命运的重要特征。神经原开发是在服的外皮的 unsynchronized,当背面的区域看起来比在这个阶段的腹的区域更成熟。区域特定的基因包括地在每 neuronal 亚簇被识别,并且这些基因的一个大比例是联系的神经疾病。我们的结果介绍区域化的基因表示的一处系统的风景和人的服的外皮的神经原成熟。 | Xiaoying Fan Ji Dong Suijuan Zhong Yuan Wei Qian Wu Liying Yan Jun Yong Le Sun Xiaoye Wang Yangyu Zhao Wei Wang Jie Yan Xiaoqun Wang Jie Qiao Fuchou Tang | 2018 | Cell Research2018，28，7： | 11 |
| 4 | Biodegradation of geosmin in drinking water by novel bacteria isolated from biologically active carbon显示文摘Three strains of Gram-negative bacteria capable of removing geosmin from drinking water were isolated from biologically active carbon and identified to be Chryseobacterium sp., Sinorhizobium sp. and Stenotrophomonas sp. based on physio-biochemistry analysis and 16S rRNA gene sequence analysis. Removal efficiencies of 2 mg/L geosmin in mineral salts medium were 84.0%, 80.2% and 74.4% for Chryseobacterium sp., Sinorhizobium sp. and Stenotrophomonas sp., respectively, while removal efficiencies of 560 ng/L geosmin in filter influent were 84.8%, 82.3% and 82.5%, respectively. The biodegradation of geosmin was determined to be a pseudo first-order reaction, with rate constants at 2 mg/L and 560 ng/L being 0.097 and 0.086 day 1 , 0.089 and 0.084 day 1 , 0.074 and 0.098 day 1 for the above mentioned degraders, respectively. The biomass of culture in the presence of geosmin was much higher than that in the absence of geosmin. | Beihai Zhou Rongfang Yuan Chunhong Shi Liying Yu Junnong Gu Chunlei Zhang | 2011 | Journal of Environmental Sciences2011，23，5： | 9 |
| 5 | DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells显示文摘染色质改变为人的初发的细菌房间的 epigenetic reprogramming 是重要的。然而,全面染色质状态还没为人的胎儿的细菌房间(FGC ) 被分析了。这里,我们使用 nucleosome 占有和 methylation 定序方法在人和老鼠在胎儿的细菌房间开发期间在一系列关键时间点分析染色体宽的染色质可接近性和 DNA methylome。我们在人和老鼠 FGC 发现 116 887 和 137 557 个弄空 nucleosome 的区域(NDR ) ,盖住 germline 特定、高度有活力的规章的 genomic 元素的一个大集合,例如 enhancers。而且,我们发现远侧的 NDR 在人的 FGC 为象 NANOG , SOX17 , AP2 和 OCT4 那样的 pluripotency 和细菌房间主人管理者的有约束力的主题明确地被充实,显示在pluripotency相关的基因和细菌之间的精细的规章的平衡的存在在人的 FGC 的房间特定的基因,并且为在 vivo 的细菌房间开发的这些基因的功能的意义。我们的工作为把提供一张全面、高分辨率的路线图染色质状态转变动力学在人和老鼠 FGC 的 epigenomic reprogramming 期间。 | Hongshan Guo Boqiang Hu Liying Yan Jun Yong Yan Wu Yun Gao Fan Guo Yu Hou Xiaoying Fan Ji Dong Xiaoye Wang Xiaohui Zhu Jie Yan Yuan Wei Hongyan Jin Wenxin Zhang Lu Wen FuchouTang Jie Qiao | 2017 | Cell Research2017，27，2： | 9 |
| 6 | Clinical applications of MARSALA for preimplantation genetic diagnosis of spinal muscular atrophy显示文摘Conventional PCR methods combined with linkage analysis based on short tandem repeats(STRs) or Karyomapping with single nucleotide polymorphism(SNP) arrays, have been applied to preimplantation genetic diagnosis(PGD) for spinal muscular atrophy(SMA), an autosome recessive disorder. However, it has limitations in SMA diagnosis by Karyomapping, and these methods are unable to distinguish wildtype embryos with carriers effectively. Mutated allele revealed by sequencing with aneuploidy and linkage analyses(MARSALA) is a new method allowing embryo selection by a one-step next-generation sequencing(NGS) procedure, which has been applied in PGD for both autosome dominant and X-linked diseases in our group previously. In this study, we carried out PGD based on MARSALA for two carrier families with SMA affected children. As a result, one of the couples has given birth to a healthy baby free of mutations in SMA-causing gene. It is the first time that MARSALA was applied to PGD for SMA, and we can distinguish the embryos with heterozygous deletion(carriers) from the wild-type(normal) ones accurately through this NGS-based method. In addition, direct mutation detection allows us to identify the affected embryos(homozygous deletion), which can be regarded as probands for linkage analysis, in case that the affected family member is absent. In the future, the NGS-based MARSALA method is expected to be used in PGD for all monogenetic disorders with known pathogenic gene mutation. | Yixin Ren Xu Zhi Xiaohui Zhu Jin Huang Ying Lian Rong Li Hongyan Jin Yan Zhang Wenxin Zhang Yanli Nie Yuan Wei Zhaohui Liu Donghong Song Ping Liu Jie Qiao Liying Yan | 2016 | Journal of Genetics and Genomics2016，43，9： | 9 |
| 7 | Three‑Dimensional Ordered Mesoporous Carbon Spheres Modified with Ultrafine Zinc Oxide Nanoparticles for Enhanced Microwave Absorption Properties显示文摘Currently,electromagnetic radiation and interference have a significant effect on the operation of electronic devices and human health systems.Thus,developing excellent microwave absorbers have a huge significance in the material research field.Herein,a kind of ultrafine zinc oxide(ZnO)nanoparticles(NPs)supported on three-dimensional(3D)ordered mesoporous carbon spheres(ZnO/OMCS)is prepared from silica inverse opal by using phenolic resol precursor as carbon source.The prepared lightweight ZnO/OMCS nanocomposites exhibit 3D ordered carbon sphere array and highly dispersed ultrafine ZnO NPs on the mesoporous cell walls of carbon spheres.ZnO/OMCS-30 shows microwave absorbing ability with a strong absorption(−39.3 dB at 10.4 GHz with a small thickness of 2 mm)and a broad effective absorption bandwidth(9.1 GHz).The outstanding microwave absorbing ability benefits to the well-dispersed ultrafine ZnO NPs and the 3D ordered mesoporous carbon spheres structure.This work opened up a unique way for developing lightweight and high-efficient carbon-based microwave absorbing materials. | Yan Song Fuxing Yin Chengwei Zhang Weibing Guo Liying Han Ye Yuan | 2021 | Nano-Micro Letters2021，13，5： | 6 |
| 8 | Effects of vitrification and cryostorage duration on single-cell RNA-Seq profiling of vitrified-thawed human metaphase Ⅱ oocytes显示文摘Oocyte cryopreservation is widely used for clinical and social reasons.Previous studies have demonstrated that conventional slow-freezing cryopreservation procedures,but not storage time,can alter the gene expression profiles of frozen oocytes.Whether vitrification procedures and the related frozen storage durations have any effects on the transcriptomes of human metaphase Ⅱ oocytes remain unknown.Four women(30–32 years old)who had undergone IVF treatment were recruited for this study.RNA-Seq profiles of 3 fresh oocytes and 13 surviving vitrified-thawed oocytes(3,3,4,and 3 oocytes were cryostored for 1,2,3,and 12 months)were analyzed at a single-cell resolution.A total of 1987 genes were differentially expressed in the 13 vitrifiedthawed oocytes.However,no differentially expressed genes were found between any two groups among the 1-,2-,3-,and 12-month storage groups.Further analysis revealed that the aberrant genes in the vitrified oocytes were closely related to oogenesis and development.Our findings indicated that the effects of vitrification on the transcriptomes of mature human oocytes are induced by the procedure itself,suggesting that long-term cryostorage of human oocytes is safe. | Ying Huo Peng Yuan Qingyuan Qin Zhiqiang Yan Liying Yan Ping Liu Rong Li Jie Yan Jie Qiao | 2021 | Frontiers of Medicine2021，15，1： | 6 |
| 9 | Biodegradation of 2-methylisoborneol by bacteria enriched from biological activated carbon显示文摘在喝水的最普通的味道和气味混合物(TOC ) 之一是不能被常规水处理乐意地移开的 2-methylisoborneol (2-MIB ) 。为降级的 2-MIB 的四细菌的紧张从一个生物的激活的碳过滤器的表面被孤立,并且作为小球菌 spp 被描绘,黄质菌属 spp, Brevibacterium spp。并且 Pseudomonas spp。基于 16S rRNA 分析。有 515 ng 的起始的集中的 2-MIB 的移动效率 ??? ????????????????????????????????? 漠 ? 桴 ? 瑳敲杮桴 ? | Rongfang YUAN Beihai ZHOU Chunhong SHI Liying YU Chunlei ZHANG Junnong GU | 2012 | Frontiers of Environmental Science & Engineering2012，6，5： | 6 |
| 10 | Boosted electromagnetic wave absorption performance from synergistic induced polarization of SiC_(NWs)@MnO_(2)@PPy heterostructures显示文摘In the last decade,electromagnetic pollution has caused people’s considerable attention.Developing absorbing material with low cost,lightweight,simple preparation,and high electromagnetic attenuation efficiency has become a feasible means to deal with this problem.In this work,core–shell SiC_(NWs)@MnO_(2)@PPy(NWs:nanowires,PPy:polypyrrole)heterostructures composed of SiC nanowires core,MnO_(2)nanosheets inter-layer,and PPy coating were successfully prepared through chemical vapor deposition and two-step electrodeposition process.Taking advantage of the interfacial polarization and dipole polarization,the obtained product displays excellent electromagnetic wave absorption performances with the minimum reflection loss(RLmin)of−50.59 dB when the matching thickness is 2.41 mm,and the optimal effective absorption bandwidth(EAB)value reaches to 6.64 GHz at a matching thickness of 2.46 mm,revealing that the SiC_(NWs)@MnO_(2)@PPy nanocomposite could be served as a promising electromagnetic wave absorbing material.On the basis of systematic analysis concerning the electromagnetic parameters,the dissipation process of the incident electromagnetic wave was demonstrated reasonably,which may provide a referable preparation strategy for novel heterostructures,especially nonmagnetic lightweight absorbing material. | Meng Zhang Laibin Zhao Wenxin Zhao Ting Wang Liying Yuan Yuying Guo Yuxin Xie Tingting Cheng Alan Meng Zhenjiang Li | 2023 | Nano Research2023，16，2： | 4 |
| 11 | Genetic testing and PGD for unexplained recurrent fetal malformations with MAGEL2 gene mutation显示文摘Birth defects are caused by multiple factors,such as chromosome abnormality,environmental factors,and maternal factors.In this study,we focused on exploring the genetic causes of a non-consanguineous couple who suffered from four times of unsuccessful pregnancy due to unexplained recurrent fetal malformations with similar symptoms and normal chromosome copy number variations.Using trio-whole exome sequencing(trio-WES) for this couple and one of the affected fetuses,we found a mutation,c.1996 delC on the maternal imprinted gene MAGEL2 that was carried by the affected fetus and husband,leading to Schaaf-Yang syndrome.To screen this mutation,we further performed preimplantation genetic diagnosis(PGD) strategy followed by a gene pedigree validation and pathogenicity analysis.After the transfer of a PGD-screened embryo,a normal newborn without previous abnormal symptoms was born(February 15,2019).We present the first data that identified a pathogenic gene(MAGEL2 c.1996 delC) in a fetus with Schaaf-Yang syndrome in the EAS(East Asian) database and overcame this genetic defect by using processed PGD for this couple based on the WES results. | Wei Guo Yanli Nie Zhiqiang Yan Xiaohui Zhu Yuqian Wang Shuo Guan Ying Kuo Wenxin Zhang Xu Zhi Yuan Wei Liying Yan Jie Qiao | 2019 | Science China(Life Sciences)2019，62，7： | 4 |
| 12 | Identifying normal embryos from reciprocal translocation carriers by whole chromosome haplotyping显示文摘Reciprocal translocation is a chromosomal structural abnormality that arises when two non-homologous chromosomes rearrange and attach with each other, an incidence that occurs in about 1/500to 1/625 newborns (Mackie and Scriven, 2002). This event typically does not lead to any significant loss of genetic material, thus reciprocal translocation carriers do not exhibit any severe | Zhiqiang Yan Yuqian Wang Yanli Nie Xu Zhi Xiaohui Zhu Meng Qin Shuo Guan Yixin Ren Ying Kuo Di Chang Wei Chen Peng Yuan Liying Yan Jie Qiao | 2018 | Journal of Genetics and Genomics2018，45，9： | 4 |
| 13 | Effect of ultrasonic vibration on finished quality in ultrasonic vibration assisted micromilling of Inconel718显示文摘Inconel718 was machined with the traditional micromilling(TMM)and ultrasonic vibration assisted micromilling(UVAMM)with the different technology parameters,whose surface quality and burrs formation were studied.The results show that TMM often forms pits,bumps and gullies in the size effect range.UVAMM effectively improves the surface quality compared with TMM.The surface defects are significantly reduced with the increase of feed per tooth(fz).When fz exceeds 4 lm,the effect of ultrasonic vibration on the surface quality is no longer obvious.The minimum burr size on the down milling side and the up milling side are 50.23 lm and 36.57 lm,respectively.The feasibility of vibration cutting in improving surface quality and suppressing burr size was verified.UVAMM effectively suppresses the formation of built-up edge,which can significantly improve the micromilling process.The cutting force is obtained through simulation and experiment.They are agreement in the change trend.The finite element simulation can be used to predict the cutting force.Compared with TMM,feeding force(Fx),radial force(Fy)and axial force(Fz)of UVAMM decrease by 7.6%,11.5%and 1.3%,respectively. | Bin FANG Zhonghang YUAN Depeng LI Liying GAO | 2021 | Chinese Journal of Aeronautics2021，34，6： | 3 |
| 14 | An Equivalent Substitute Strategy for Constructing 3D Ordered Porous Carbon Foams and Their Electromagnetic Attenuation Mechanism显示文摘Three-dimensional(3D)ordered porous carbon is generally believed to be a promising electromagnetic wave(EMW)absorbing material.However,most research works targeted performance improvement of 3D ordered porous carbon,and the specific attenuation mechanism is still ambiguous.Therefore,in this work,a novel ultra-light egg-derived porous carbon foam(EDCF)structure has been successfully constructed by a simple carbonization combined with the silica microsphere template-etching process.Based on an equivalent substitute strategy,the influence of pore volume and specific surface area on the electromagnetic parameters and EMW absorption properties of the EDCF products was confirmed respectively by adjusting the addition content and diameter of silica microspheres.As a primary attenuation mode,the dielectric loss originates from the comprehensive effect of conduction loss and polarization loss in S-band and C band,and the value is dominated by polarization loss in X band and Ku band,which is obviously greater than that of conduction loss.Furthermore,in all samples,the largest effective absorption bandwidth of EDCF-3 is 7.12 GHz under the thickness of 2.13 mm with the filling content of approximately 5 wt%,covering the whole Ku band.Meanwhile,the EDCF-7 sample with optimized pore volume and specific surface area achieves minimum reflection loss(RL_(min))of−58.08 dB at 16.86 GHz while the thickness is 1.27 mm.The outstanding research results not only provide a novel insight into enhancement of EMW absorption properties but also clarify the dominant dissipation mechanism for the porous carbon-based absorber from the perspective of objective experiments. | Meng Zhang Hailong Ling Ting Wang Yingjing Jiang Guanying Song Wen Zhao Laibin Zhao Tingting Cheng Yuxin Xie Yuying Guo Wenxin Zhao Liying Yuan Alan Meng Zhenjiang Li | 2022 | Nano-Micro Letters2022，14，10： | 3 |
| 15 | Advances in preimplantation genetic diagnosis/screening显示文摘Preimplantation genetic diagnosis(PGD)gives couples who have a high risk of transmitting genetic disorders to their baby the chance to have a healthy offspring through embryo genetic analysis and selection.Preimplantation genetic screening(PGS)is an effective method to select euploid embryos that may prevent repeated implantation failure or miscarriage.However,how and to whom PGS should be provided is a controversial topic.The first successful case of PGD of a human being was reported in 1990,and there have been tremendous improvements in this technology since then.Both embryo biopsy and genetic technologies have been improved dramatically,which increase the accuracy and expand the indications of PGD/PGS. | YAN LiYing WEI Yuan HUANG Jin ZHU XiaoHui SHI XiaoDan XIA Xi YAN Jie LU CuiLing LIAN Ying LI Rong LIU Ping QIAO Jie | 2014 | Science China(Life Sciences)2014，57，7： | 3 |
| 16 | Efficient 16 Boolean logic and arithmetic based on bipolar oxide memristors显示文摘The physically separated memory and logic units in traditional von Neumann computers place essential limits on the performance and cause increased energy consumption,and hence in-memory computing is required to overcome this bottleneck.Here,a new bipolar memristor based in-memory logic approach is proposed,which is capable of achieving all 16 possible Boolean logic functions in a single device in less than3 steps.This approach does not require initialization and can facilitate logic cascading,and the calculation taking place in-situ is showcased by 1-bit full adder and 2-bit multiplier with improved efficiency,thus showing a great prospect in future in-memory computing architecture. | Rui YUAN Mingyuan MA Liying XU Zhenhua ZHU Qingxi DUAN Teng ZHANG Yu ZHU Yu WANG Ru HUANG Yuchao YANG | 2020 | Science China(Information Sciences)2020，63，10： | 3 |
| 17 | Fundamentals and applications of enzyme powered micro/nano-motors显示文摘Micro/nanomotors(MNMs)are miniaturized machines that can convert many kinds of energy into mechanical motion.Over the past decades,a variety of driving mechanisms have been developed,which have greatly extended the application scenarios of MNMs.Enzymes exist in natural organisms which can convert chemical energy into mechanical force.It is an innovative attempt to utilize enzymes as biocatalyst providing driving force for MNMs.The fuels for enzymatic reactions are biofriendly as compared to traditional counterparts,which makes enzyme-powered micro/nanomotors(EMNMs)of great value in biomedical field for their nature of biocompatibility.Until now,EMNMs with various shapes can be propelled by catalase,urease and many others.Also,they can be endowed with multiple functionalities to accomplish on-demand tasks.Herein,combined with the development process of EMNMs,we are committed to present a comprehensive understanding of EMNMs,including their types,propelling principles,and potential applications.In this review,we will introduce single enzyme that can be used as motor,enzyme powered molecule motors and other micro/nano-architectures.The fundamental mechanism of energy conversion process of EMNMs and crucial factors that affect their movement behavior will be discussed.The current progress of proof-of-concept applications of EMNMs will also be elaborated in detail.At last,we will summarize and prospect the opportunities and challenges that EMNMs will face in their future development. | Hao Yuan Xiaoxia Liu Liying Wang Xing Ma | 2021 | Bioactive Materials2021，6，6： | 3 |
| 18 | Surface composites fabricated by vacuum infiltration casting technique显示文摘Alumina (Al2O3) particles reinforced copper matrix surface composites were fabricated on the bronze substrate using the vacuum infiltration casting technique. Three cases were obtained in the vacuum infiltration casting technique: no infiltration, partial infiltration and full infiltration (the thickness of preforms do not exceed 3.5 mm). The reason of no infiltration is that the vacuum degree is not enough so that the force acting on the liquid metal is lower than the resistance due to the surface tension. Partial infil- tration is because of somewhat lower vacuum degree and pouring temperature. Full desired infiltration is on account of suitable in- filtration casting conditions, such as vacuum degree, pouring temperature, grain size and preheating temperature of the preform. The most important factor of affecting formation of surface composites is the vacuum degree, then pouring temperature and particle size. The infiltration mechanism was discussed on the bases of different processing conditions. The surface composite up to 3.5 mm in thickness with uniformly distributed Al2O3 particles could be fabricated via the vacuum infiltration casting technique. | Guirong Yang Yuan Hao Wenming Song Jinjun Lii Ying Ma | 2005 | Journal of University of Science and Technology Beijing2005，12，5： | 3 |
| 19 | Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells显示文摘Although cholecystokinin octapeptide-8 is important for neurological function, its neuroprotective properties remain unclear. We speculated that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against oxidative injury. In this study, retinal pigment epithelial cells were treated with peroxynitrite to induce oxidative stress. Peroxynitrite triggered apoptosis in these cells, and increased the expression of Fas-associated death domain, Bax, caspase-8 and Bcl-2. These changes were suppressed by treatment with cholecystokinin octapeptide-8. These results suggest that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against apoptosis induced by peroxynitrite. | Yuan Liu Yueling Zhang Zhaohui Gu Lina Hao Juan Du Qian Yang Suping Li Liying Wang Shilei Gong | 2014 | Neural Regeneration Research2014，9，14： | 2 |
| 20 | A novel pathogenic mutation in FBN2 associated with congenital contractural arachnodactyly for preimplantation genetic diagnosis显示文摘Congenital contractural arachnodactyly(CCA,OMIM:121050),also known as Beals syndrome,belongs to a group of rare autosomal dominant(AD)diseases of connective tissue(Maslen et al.,1997).People with CCA share many distinguishing features,such as arachnodactyly,camp tod actyly,multiple joint contractures(especially finger,elbow,and knee joints),crumpled ears,scoliosis,pectus deformities,and muscular hypoplasia(Jurko et al.,2013).It exhibits no specific geographic or ethnic predilection(Frederic et al.,2009). | Jiaxin Li Yuqian Wang Xiaohui Zhu Yanli Nie Ying Kuo Shuo Guan Jin Huang Ying Lian Yangyu Zhao Rong Li Yuan Wei Jie Qiao Liying Yan | 2020 | Journal of Genetics and Genomics2020，47，5： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员