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| 1 | Cancer statistics in China and United States,2022:profiles,trends,and determinants显示文摘Background:The cancer burden in the United States of America(USA)has decreased gradually.However,China is experiencing a transition in its cancer profiles,with greater incidence of cancers that were previously more common in the USA.This study compared the latest cancer profiles,trends,and determinants between China and USA.Methods:This was a comparative study using open-source data.Cancer cases and deaths in 2022 were calculated using cancer estimates from GLOBOCAN 2020 and population estimates from the United Nations.Trends in cancer incidence and mortality rates in the USA used data from the Surveillance,Epidemiology,and End Results program and National Center for Health Statistics.Chinese data were obtained from cancer registry reports.Data from the Global Burden of Disease 2019 and a decomposition method were used to express cancer deaths as the product of four determinant factors.Results:In 2022,there will be approximately 4,820,000 and 2,370,000 new cancer cases,and 3,210,000 and 640,000 cancer deaths in China and the USA,respectively.The most common cancers are lung cancer in China and breast cancer in the USA,and lung cancer is the leading cause of cancer death in both.Age-standardized incidence and mortality rates for lung cancer and colorectal cancer in the USA have decreased significantly recently,but rates of liver cancer have increased slightly.Rates of stomach,liver,and esophageal cancer decreased gradually in China,but rates have increased for colorectal cancer in the whole population,prostate cancer in men,and other seven cancer types in women.Increases in adult population size and population aging were major determinants for incremental cancer deaths,and case-fatality rates contributed to reduced cancer deaths in both countries.Conclusions:The decreasing cancer burden in liver,stomach,and esophagus,and increasing burden in lung,colorectum,breast,and prostate,mean that cancer profiles in China and the USA are converging.Population aging is a growing determinant of incremental cancer burden.Progress in cancer prevention and care in the USA,and measures to actively respond to population aging,may help China to reduce the cancer burden. | Changfa Xia Xuesi Dong He Li Maomao Cao Dianqin Sun Siyi He Fan Yang Xinxin Yan Shaoli Zhang Ni Li Wanqing Chen | 2022 | Chinese Medical Journal2022，，5： | 827 |
| 2 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 3 | Synergistically Enhanced Mucoadhesive and Penetrable Polypeptide Nanogel for Efficient Drug Delivery to Orthotopic Bladder Cancer显示文摘Intravesical chemotherapy has been recommended after the gold standard of transurethral resection of the bladder tumor to prevent bladder cancer(BC)from local recurrence in the clinic.However,due to rapid urine excretion and barrier protection of the bladder wall,the clinical performances of chemotherapeutic drugs are severely compromised.In the present work,a smart positively charged disulfide-crosslinked nanogel of oligoarginine-poly(ethylene glycol)-poly(L-phenylalanine-co-L-cystine)(R_(9)-PEG-P(LP-co-LC))was prepared to prolong the retention period and enhance the penetration capability of chemotherapeutic agent toward the bladder wall.PEG significantly improved the aqueous dispersibility of the 10-hydroxycamptothecin(HCPT)-loaded R_(9)-PEG-P(LP-co-LC)(i.e.,R_(9)NG/HCPT)and enhanced the mucoadhesive capability by the nonspecific interaction between PEG chain and the bladder mucosa accompanied with the electrostatic interaction between the cationic R_(9)and negatively charged bladder mucosa.Besides,R_(9),as a cell-penetrating peptide,efficiently penetrated through the cell membrane and delivered carried cargo.The disulfide bond endowed the selective release behavior of HCPT triggered by the intracellular reductive microenvironment.As an advanced chemotherapeutic nanoformulation,the smart R_(9)NG/HCPT demonstrated superior cytotoxicity against human BC 5637 cells in vitro and remarkably enhanced tumor suppression activity toward orthotopic BC models of mouse and rat in vivo,indicating its great potential in the clinical intravesical BC chemotherapy. | Hui Guo Faping Li Heping Qiu Weiguo Xu Pengqiang Li Yuchuan Hou Jianxun Ding Xuesi Chen | 2020 | Research2020，，1： | 7 |
| 4 | Biomimetic biphasic scaffolds for osteochondral defect repair 5th China-Europe Symposium on Biomaterials in Regenerative Medicine(CESB 2015)Hangzhou,China April 7–10,2015显示文摘The osteochondral defects caused by vigorous trauma or physical disease are difficult to be managed.Tissue engineering provides a possible option to regenerate the damaged osteochondral tissues.For osteochondral reconstruction,one intact scaffold should be considered to support the regeneration of both cartilage and subchondral bone.Therefore,the biphasic scaffolds with the mimic structures of osteochondral tissues have been developed to close this chasm.A variety of biomimetic bilayer scaffolds fabricated from natural or synthetic polymers,or the ones loading with growth factors,cells,or both of them make great progresses in osteochondral defect repair.In this review,the preparation and in vitro and/or in vivo verification of bioinspired biphasic scaffolds are summarized and discussed,as well as the prospect is predicted. | Xuezhou Li Jianxun Ding Jincheng Wang Xiuli Zhuang Xuesi Chen | 2015 | Regenerative Biomaterials2015，2，3： | 7 |
| 5 | Recent developments in intelligent biomedical polymers显示文摘Intelligent polymers or stimuli-responsive polymers may exhibit distinct transitions in physical-chemical properties, including conformation, polarity, phase structure and chemical composition in response to changes in environmental stimuli. Due to their unique 'intelligent' characteristics, stimuli-sensitive polymers have found a wide variety of applications in biomedical and nanotechnological fields. This review focuses on the recent developments in biomedical application of intelligent polymer systems, such as intelligent hydrogel systems, intelligent drug delivery systems and intelligent molecular recognition systems. Also, the possible future directions for the application of these intelligent polymer systems in the biomedical field are presented. | XIAO ChunSheng TIAN HuaYu ZHUANG XiuLi CHEN XueSi JING XiaBin | 2009 | Science China Chemistry2009，52，2： | 6 |
| 6 | Cytotoxicity of liver targeted drug-loaded alginate nanoparticles显示文摘In this study, novel liver targeted doxorubicin (DOX) loaded alginate (ALG) nanoparticles were prepared by CaCl2 crosslinking method. Glycyrrhetinic acid (GA, a liver targeted molecule) modified alginate (GA-ALG) was synthesized in a heterogeneous system, and the structure of GA-ALG and the substitu-tion degree of GA were analyzed by 1H NMR, FT-IR and elemental analysis. The drug release profile under the simulated physiological condition and cytotoxicity experiments of drug-loaded GA-ALG nanoparticles were carried out in vitro. Transmission electron micrographs (TEM) and dynamic light scattering (DLS) analysis showed that drug-loaded GA-ALG nanoparticles have spherical shape structure with the mean hydrodynamic diameter around 214 ± 11 nm. The drug release was shown to last 20 days, and the MTT assay suggested that drug-loaded GA-ALG nanoparticles had a distinct kill-ing effect on 7703 hepatocellular carcinoma cells. | ZHANG ChuangNian WANG Wei WANG ChunHong TIAN Qin HUANG Wei YUAN Zhi CHEN XueSi | 2009 | Science China Chemistry2009，52，9： | 6 |
| 7 | Preparation of Mesoporous Nano-Hydroxyapatite Using a Surfactant Template Method for Protein Delivery显示文摘 | Xiaodong Wu Xiaofeng Song Dongsong Li Jianguo Liu Peibiao Zhang Xuesi Chen | 2012 | Journal of Bionic Engineering2012，9，2： | 6 |
| 8 | A fast and versatile cross-linking strategy via o-phthalaldehyde condensation for mechanically strengthened and functional hydrogels显示文摘Fast and catalyst-free cross-linking strategy is of great significance for construction of covalently cross-linked hydrogels.Here,we report the condensation reaction between o-phthalaldehyde(OPA)and N-nucleophiles(primary amine,hydrazide and aminooxy)for hydrogel formation for the first time.When four-arm poly(ethylene glycol)(4 a PEG)capped with OPA was mixed with various N-nucleophile-terminated 4 aPEG as building blocks,hydrogels were formed with superfast gelation rate,higher mechanical strength and markedly lower critical gelation concentrations,compared to benzaldehyde-based counterparts.Small molecule model reactions indicate the key to these cross-links is the fast formation of heterocycle phthalimidine product or isoindole(bis)hemiaminal intermediates,depending on the N-nucleophiles.The second-order rate constant for the formation of phthalimidine linkage(4.3 M-1s-1)is over 3000 times and 200 times higher than those for acylhydrazone and oxime formation from benzaldehyde,respectively,and comparable to many cycloaddition click reactions.Based on the versatile OPA chemistry,various hydrogels can be readily prepared from naturally derived polysaccharides,proteins or synthetic polymers without complicated chemical modification.Moreover,biofunctionality is facilely imparted to the hydrogels by introducing amine-bearing peptides via the reaction between OPA and amino group. | Zhen Zhang Chaoliang He Yan Rong Hui Ren Tianran Wang Zheng Zou Xuesi Chen | 2021 | National Science Review2021，8，4： | 4 |
| 9 | Co-delivery of doxorubicin and paclitaxel with linear-dendritic block copolymer for enhanced anti-cancer efficacy显示文摘A series of well-defined amphiphilic linear-dendritic block copolymers(telodendrimers, MPEG-b-PAMAM-cholesterol) with 1,2,4 or 8 cholesteryl groups(named as P1, P2, P4, P8, respectively) were synthesized. Their chemical structures were characterized with 1H NMR and mass spectrum(MALDI-TOF MS). The telodendrimers could self-assemble into micelles in aqueous solution, and encapsulate chemotherapeutic drug doxorubicin(DOX) and paclitaxel(PTX) for combination therapy. All the telodendrimers could encapsulate DOX with similar capability. However, their drug-loading capability of PTX is increased with the increasing number of cholesteryl groups. P8 exhibited much higher PTX loading efficiency than its counterparts. Thus, P8 was selected for further application of drug delivery in the paper. The drug-loading micellar nanoparticles(NPs) of P8 were spherical in shape and their diameters were less than 150 nm which were determined by dynamic light scattering measurements(DLS) and transmission electron microscope(TEM). In vitro drug release experiment demonstrated that P8 exhibited a controlled release manner for both DOX and PTX, and the two drugs were released simultaneously. In vitro cytotoxicity experiment further demonstrated that the co-delivery of DOX and PTX in P8 exhibited better anti-cancer efficiency than the delivery systems encapsulated with single drug(DOX or PTX). This indicates a synergistic effect. The co-delivery system showed potential in future anti-cancer treatment. | ZHANG Yu XIAO ChunSheng LI MingQiang DING JianXun YANG ChenGuang ZHUANG XiuLi CHEN XueSi | 2014 | Science China Chemistry2014，57，4： | 4 |
| 10 | Tumor microenvironment-responsive hyaluronate-calcium carbonate hybrid nanoparticle enables effective chemo-therapy for primary and advanced osteosarcomas显示文摘Osteosarcoma 是在骨头的最普通的恶意。当前的化疗提议与重要副作用限制了功效,为特别先进并且 relapsed osteosarcomas。提出 Nanoparticle 的化学疗法的药可以被用来解决这些问题,但是这些明确的表达的几个方面仍然保持不能令人满意例如怎么在血液改进他们的稳定性,阻止不受欢迎的药漏,并且在肿瘤提高指向的药累积。在这研究,一个肿瘤微型环境应答的钙碳酸盐(CaCO 3)-crosslinked hyaluronate (哈) nanoparticle 经由一个绿过程被准备有效地为 osteosarcoma 的各种各样的阶段的处理交付 doxorubicin (纪录影片) 。装载纪录影片的 hyaluronate 钙碳酸盐混血儿 nanoparticle (HA-DOX/CaCO 3) 在 vitro 并且在 vivo 表明了优异稳定性,并且当由酸的肿瘤微型环境被触发时,很快在肿瘤地点释放了纪录影片。与免费纪录影片和交叉连接得非的 nanoparticle (哈纪录影片) 相比, HA-DOX/CaCO 3 向鼠科的 osteosarcoma 的主要、先进的模型展出了大多数有势力抑制功效,导致有效肿瘤抑制,改进了幸存时间,并且减少了不利效果。在先进 osteosarcoma 模型,最重要地, HA-DOX/CaCO 3 potently 压制了为特别地的在 84.6% 的生长,为 osteosarcoma 处理显示这个平台的潜力,推进了的肿瘤和 relapsed 盒子。建议多糖 nanoparticle 将是一个有希望的药交货平台预付 osteosarcoma nanomedicine。 | Yi Zhang Lulu Cai Di Li Yeh-Hsing Lao Dingzhuo Liu Mingqiang Li Jianxun Ding Xuesi Chen | 2018 | Nano Research2018，11，9： | 4 |
| 11 | Bioactive polypeptide hydrogels modified with RGD and N-cadherin mimetic peptide promote chondrogenic differentiation of bone marrow mesenchymal stem cells显示文摘Cell-material and cell-cell interactions represent two crucial aspects of the regulation of cell behavior.In the present study,poly(L-glutamic acid)(PLG)hydrogels were prepared by catalyst-free click crosslinking via a strain-promoted azide-alkyne cycloaddition(SPAAC)reaction between azido-grafted PLG(PLG-N3)and azadibenzocyclooctyne-grafted PLG(PLG-ADIBO).The bioactive peptides c(RGDfK)and N-cadherin mimetic peptide(N-Cad)were both conjugated to the PLG hydrogel(denoted PLG+RGD/N-Cad)in order to regulate cell-material and cell-cell interactions.Gelation time and storage modulus of the hydrogels were tunable through variations in the concentration of polypeptide precursors.The hydrogels degraded gradually in the presence of proteinases.The viability of bone marrow mesenchymal stem cells(BMSCs)was maintained when cultured with extracts of the hydrogels or encapsulated within the hydrogels.Degradation was observed within 10 weeks following the subcutaneous injection of hydrogel solution in rats,displaying excellent histocompatibility in vivo.The introduction of RGD into the PLG hydrogel promoted the adhesion of BMSCs onto the hydrogels.Moreover,when encapsulated within the PLG+RGD/NCad hydrogel,BMSCs secreted cartilage-specific matrix,in addition to chondrogenic gene and protein expression being significantly enhanced in comparison with BMSCs encapsulated in hydrogels without N-Cad modification.These findings suggest that these biodegradable,bioactive polypeptide hydrogels have great potential for use in 3D cell culture and in cartilage tissue engineering. | Yan Rong Zhen Zhang Chaoliang He Xuesi Chen | 2020 | Science China Chemistry2020，63，8： | 4 |
| 12 | Glycyrrhetinic acid-modified nanoparticles for drug delivery: Preparation and characterization显示文摘In this work, glycyrrhetinic acid-modified chitosan (mGA-suc-CTS) used as liver targeted carrier for drug delivery, was prepared via hemisuccinate as a bridged group. The structure of the product was confirmed by IR and NMR methods and the degree of substitution (DS) of glycyrrhetinic acid groups was estimated via elemental analysis. Nanoparticles were formed by ionic gelation methold. The drug-loading and release behavior of the nanoparticles were investigated using BSA as the model drug. The results indicated that the carrier with a highest DS of 5.19% could be got and the DS was controlled by changing reaction temperature or feed ratio. BSA could be entrapped into the nanoparticles with the drug-loading ratio of 26.3% and the encapsulation efficiency of 81.5%. A sustained release over an 11-day period was observed in pH 7.4 in vitro. | TIAN Qin WANG Wei HE XiaoTing ZHU XiaoCui HUANG Wei ZHANG ChuangNian YUAN Zhi CHEN XueSi | 2009 | Chinese Science Bulletin2009，54，18： | 4 |
| 13 | DOX/IL-2/IFN-g co-loaded thermo-sensitive polypeptide hydrogel for efficient melanoma treatment显示文摘Melanoma has been a serious threat to the human health;however,effective therapeutic methods of this cancer are still limited.Combined local therapy is a crucial approach for achieving a superior anti-tumor efficacy.In this paper,a chemo-immunotherapy system of DOX,IL-2 and IFN-g based on poly(g-ethyl-Lglutamate)-poly(ethylene glycol)-poly(g-ethyl-L-glutamate)(PELG-PEG-PELG)hydrogel was developed for local treatment of melanoma xenograft.The drug release process of this system exhibited a short term of burst release(the first 3 days),followed by a long-term sustained release(the following 26 days).The hydrogel degraded completely within 3 weeks without obvious inflammatory responses in the subcutaneous layer of rats,showing a good biodegradability and biocompatibility.The DOX/IL-2/IFN-g co-loaded hydrogel also showed enhanced anti-tumor effect against B16F10 cells in vitro,through increasing the ratio of cell apoptosis and G2/S phage cycle arrest.Moreover,the combined strategy presented improved therapy efficacy against B16F10 melanoma xenograft without obvious systemic side effects in a nude mice model,which was likely related to both the enhanced tumor cell apoptosis and the increased proliferation of the CD3t/CD4t T-lymphocytes and CD3t/CD8t T-lymphocytes.Overall,the strategy of localized co-delivery of DOX/IL-2/IFN-g using the polypeptide hydrogel provided a promising approach for efficient melanoma therapy. | Qiang Lv Chaoliang He Fenli Quan Shuangjiang Yu Xuesi Chen | 2018 | Bioactive Materials2018，3，1： | 4 |
| 14 | Controlled synthesis of polypeptides显示文摘Polypeptides are one kind of promising biodegradable and biocompatible biomedical polymers with the structural units of various a-amino acids.Polypeptides were first polymerized by the ring-opening polymerization(ROP)of α-amino acid N-carboxyanhydrides(NCAs)by Leuchs and Hermann in 1906.In the past decades,several effective strategies,including the selection of initiators,the adjustment of reaction conditions,and the introduction of catalysts,have been reported to improve the controllability of the ROP of various a-amino acid NCAs to synthesize different polypeptides with precise chemical structures and low polydispersity indexes.In this Review,the strategies,mechanisms,challenges,and opportunities for controlled synthesis of polypeptides by the ROP of differentα-amino acid NCAs have been declared. | Yang Liu Di Li Jianxun Ding Xuesi Chen | 2020 | Chinese Chemical Letters2020，31，12： | 3 |
| 15 | A Novel Nano/Micro-Fibrous Scaffold by Melt-Spinning Method for Bone Tissue Engineering显示文摘 | Liguo Cui Ning Zhang Weiwei Cui Peibiao Zhang Xuesi Chen | 2015 | Journal of Bionic Engineering2015，12，1： | 3 |
| 16 | Mechanical and thermal properties of polypeptide modified hydroxyapatite/poly(L-lactide) nanocomposites显示文摘A new type of polypeptide(poly(-benzyl-L-glutamate)(PBLG))modified hydroxyapatite(HA)/poly(L-lactide)(PLLA)nanocomposites(PBLG-g-HA/PLLA)were prepared by the solvent-mixing method,and their mechanical and thermal properties were investigated.The tensile test showed that the mechanical properties of PBLG-g-HA/PLLA nanocomposites were better than that of PLLA,even a 0.3 wt%content of PBLG-g-HA in the nanocomposites could make the tensile strength 12%higher than that of the neat PLLA sample,and the tensile modulus was about 17%higher than that of the PLLA sample.The thermal gravimetric analysis(TGA)showed that the PBLG-g-HA/PLLA composites have better thermal stability than the PLLA sample.The differential scanning calorimetry(DSC)was used to characterize the effect of PBLG-g-HA on the crystallization of PLLA.The isothermal crystallization behavior showed that the half crystallization time(t1/2)of PBLG-g-HA/PLLA was much shorter than that of the PLLA sample.When the PBLG-g-HA content was 10%,t1/2 was only 18.7 min,while t1/2 of the PLLA sample was 61.4 min.The results showed that the PBLG-g-HA worked as a nucleating agent and enhanced the crystallization speed of PLLA. | WEI JunChao DAI YanFeng CHEN YiWang CHEN XueSi | 2011 | Science China Chemistry2011，54，3： | 3 |
| 17 | PLLA-PCys co-electrospun fibers for capture and elution of glutathione S-transferase显示文摘The copolymer poly(L-lactic acid)-b-poly(L-cysteine) (PLA-b-PCys) was co-electrospun with PLGA into ultrafine fibers. The reduced glutathione (GSH) was conjugated to the fiber surfaces via disulfide bonds. The glutathione S-transferase (GST) was captured onto the GSH fibers via specific substrate-enzyme interaction between the bound GSH and GST. The captured GST was eluted with free GSH aqueous solution and lyophilized to get pure GST powders. The results show that the GSH moieties on the fiber surface retain the bioactivity of the free GSH and thus they can bind specifically with GST and the GST in solution is captured onto the fiber surface. In addition, the bound GSH is not as active as free GSH so that the captured GST can be eluted off from the fiber by free GSH aqueous solution. Based on this principle, GST itself or its fused proteins can be separated and purified very easily. The preliminary purification efficiency is 6.5 mg·(gPCys)-1. Further improvements are undertaken. | LU TianCheng SUN Jing DONG XiaoQing CHEN XueSi WANG Yu JING XiaBin | 2009 | Science China Chemistry2009，52，12： | 3 |
| 18 | Polymer nanoparticles as adjuvants in cancer immunotherapy显示文摘Immunotherapy is a promising strategy to inhibit cancer progression viaactivation of the immune system. In immunotherapy, adjuvants as immunologicstimulants or delivery systems play a critical role in inducing the antitumorimmune response and decreasing the side effects of immune stimulants. Polymernanoparticles have attracted increasing attention as an indispensable componentof immunotherapy, owing to their favorable properties, such as excellentbiocompatibility and biodegradability, flexible size, high activity as immunestimulants, large surface area for binding multivalent immune ligands, and highloading capacity for immune-related components. In cancer immunotherap^polymer nanoparticles can protect cargo from the surrounding milieu, deliverthe antigens and immunostimulatory molecules to antigen-presenting cells,or stimulate robust T cell response. This review summarizes the currentadvancements in polymer nanopartide adjuvants for cancer immunotherapyand predicts their prospects in fundamental and clinical studies. | Shengxian Li Xiangru Feng Jixue Wang Liang He Chunxi Wang Jianxun Ding Xuesi Chen | 2018 | Nano Research2018，11，11： | 3 |
| 19 | Gold Nanoparticles for Cancer Theranostics显示文摘金 nanoparticles 在生物医学的场地里看见了崭新的开发,特别地为癌症治疗。因为他们的容易的准备, functionalization, biocompatibility, non-cytotoxicity,和 detectability,他们收到了广泛的注意。Functionalized 金 nanoparticles 能在药和基因的地里被使用交货, photothermal 治疗,和 bioimaging。这评论为准备金 nanoparticles 的各种各样的形状介绍方法并且在癌症治疗的场地里描述他们的当前的应用。而且,评论在临床的 theranostics 介绍发展线路和金 nanoparticles 的当前的问题。 | Hong Liang Huayu Tian Mingxiao Deng Xuesi Chen | 2015 | Chinese Journal of Chemistry2015，33，9： | 3 |
| 20 | Biocompatible in situ-forming glycopolypeptide hydrogels显示文摘A lack of biological activity hinders the application of synthetic hydrogels in tissue engineering and regenerative medicine.However,the use of glycopolypeptides in hydrogel synthesis may provide the materials with the desired biological activities.Herein,we prepared three in situ-forming hydrogels from various phenol-functionalized glycopolypeptides.The gelation time,mechanical properties,degradation properties,and biocompatibility of the hydrogels were assessed.Gelation time ranged from 11 to 380s,depending on the concentration of horseradish peroxidase.The galactose-modified polypeptide hydrogel showed the highest storage modulus with an obvious stress relaxation phenomenon.The prepared hydrogels exhibited good degradation properties and compatibility to cells and tissues.Furthermore,the rate of immune cell accumulation around the mannosemodified polypeptide hydrogel was the fastest among the hydrogels. | SHI Shun YU ShuangJiang LI Gao HE ChaoLiang CHEN XueSi | 2020 | Science China(Technological Sciences)2020，63，6： | 3 |
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