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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 3 | Room-temperature NH_3 sensors with high sensitivity and short response/recovery times显示文摘Micro-sensors are fabricated by co-electrospinning In2O3and SnO2nanofibers on the substrates of SiO2/Si with interdigitated Pt signal electrodes.The total sensor area is 1.36 mm 9 0.55 mm and the active area is only0.63 mm 9 0.55 mm.Excellent NH3sensing properties are obtained based on the sensors at room temperature.The sensitivity is at most 28 when the sensors are exposed to NH3of 10 ppm.The response time is 8 s or so and the recovery time is nearly 2 s.Not only fine selectivity,but also longtime stability is obtained.The results not only demonstrate the obtained micro-sensors are very promising devices for NH3detection,but also show a possible route for large-scale NH3sensor fabrication at the industrial level. | Qingcheng Liang Di Li Shang Gao Dayong Jiang Jianxun Zhao Jieming Qin Jianhua Hou | 2014 | Chinese Science Bulletin2014，59，4： | 2 |
| 4 | Glucosamine-carrying temperature and pH-sensitive microgels:preparation,characterization,and in vitro drug release studies显示文摘 | Teng Dayong Hou Jingli Zhang Xinge | | 0，，： | 1 |
| 5 | Seasonal Distribution of Observed Colored Dissolved Organic Matter(CDOM)in the Eastern Indian Ocean显示文摘Colored dissolved organic matter(CDOM)is a crucial constituent that affects the optical absorption properties of seawater.Owing to the relatively limited measured data on the spatial distribution characteristics of CDOM in the tropical eastern Indian Ocean,this study analyzes the optical absorption characteristics of CDOM in the southeast Indian Ocean using the data collected during four seasons from 2013 to 2017.This work also systematically describes the seasonal horizontal and vertical distribution characteristics of CDOM in this area and conducts a preliminary analysis of the relevant factors affecting CDOM absorption characteristics in this region.Results indicate that the CDOM ag(440)during summer was remarkably lower than that in the coastal waters of Europe and coastal waters of China but slightly higher than that in the western and southeast Pacific.The spatial distribution of surface CDOM shows remarkable seasonal differences,and the spatial distribution characteristics of CDOM in the 5°S,92°E region differ between spring/summer and autumn/winter.The values of ag(400)and ag(440)are weak/strong at a surface/subsurface level of 100 m,with differences found between summer and winter.The correlation of CDOM with temperature,salinity,and chlorophyll-a concentration is relatively low,indicating that CDOM is an independent driving mechanism influenced by phytoplankton degradation,photobleaching,and water mixing. | CAI Xiaoqing MENG Jie YUAN Chao LIU Rongjie HOU Erhu BI Dayong LI Yaoru QIAN Chengcheng ZHONG Shan | 2023 | Journal of Ocean University of China2023，22，4： | 0 |
| 6 | Finite volume method-based numerical simulation method for hydraulic fracture initiation in rock around a perforation显示文摘1 Introduction Hydraulic fracturing is a technique for increasing permeability in oil and gas resource development,grouting reinforcement in mine management,and geostress measurement.For the purpose of enhancing hydraulic fracturing in horizontal wells,oriented perforating methods have been developed(Kurdi,2018;Michael and Gupta,2020a;Yan et al.,2020).Fluid is injected into the rock through perforations,which increases fluid pressure within rock and decreases rock temperature.Then,the rock around the perforation is fractured.Therefore,fracture initiation pressure is intimately connected to the reservoir’s physical and mechanical properties,geo-stress,and temperature(Morgan and Aral,2015). | Yu ZHANG Shaohao HOU Songhua MEI Yanan ZHAO Dayong LI | 2023 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2023，24，1： | 0 |
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