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| 1 | Mathematic principles of interrupted-sampling repeater jamming (ISRJ)显示文摘Coherent jamming is one of the important trends in modern radar electronic war- fare. High-speed sampling of wideband radio frequency (RF) signals and high iso- lation of two receive-transmit antennas are key technologies for the realization of coherent jamming. However, these technologies present significant challenges to engineering application. In this paper, a novel repeater jamming based on inter- rupted sampling technique is presented. For a jammer with a receive-transmit time-sharing antenna, a radar signal is sampled with a low rate by the jammer. Then, a train of false targets will be achieved after the jamming signal feed the matched filter of a pulse compression radar. For the case of the linear frequency modulated (LFM) pulse compression radars, mathematic principles of the interrupted-sam- pling repeater jamming is developed, and then the efficiency of the jamming is de- scribed and stated as expressions of key parameters which are also beneficial to the jamming design for other coherent radars. | WANG XueSong LIU JianCheng ZHANG WenMing FU QiXiang LIU Zhong XIE XiaoXia | 2007 | Science in China(Series F)2007，50，1： | 53 |
| 2 | Diagenetic fluids evolution and genetic mechanism of tight sandstone gas reservoirs in Upper Triassic Xujiahe Formation in Sichuan Basin, China显示文摘The reservoirs of the Upper Triassic Xujiahe Formation in Sichuan Basin have the characteristics of low compositional maturity, low contents of cements and medium textural maturity. The general physical properties of the reservoirs are poor, with low porosity and low permeability, and there are only a few reservoirs with medium porosity and low permeability in local areas. Based on the diagenetic mineral association, a diagenetic sequence of cements is established: early calcites (or micrite siderites) →first quartz overgrowth→chlorite coatings→dissolution of feldspars and debris→chlorite linings→ second quartz overgrowth (quartz widen or filled in remain intergranular pores and solution pores)→dissolution→third quartz overgrowth (quartz filled in intergranular and intragranular solution pores)→intergrowth (ferro) calcites→dolomites→ferro (calcites) dolomites→later dissolution→veins of quartz and calcites formation. Mechanical compaction is the main factor in making the reservoirs tight in the basin, followed by the second and third quartz overgrowth. In a long-term closed system, only feld-spars and some lithic fragments are dissolved by diagenetic fluids, while intergranular cements such as quartz and calcit are not dissolved and thus have little influence on the porosity of the Xujiahe Formation. This is the third factor that may have kept the sandstones of Xujiahe Formation tight finally. The hydrocarbon was extensively generated from organic materials after the second quartz overgrowth, and selectively entered favorable reservoirs to form tight sandstone gas reservoirs. | ZHU RuKai ZOU CaiNeng ZHANG Nai WANG XueSong CHENG Rong LIU LiuHong ZHOU ChuanMin SONG LiHong | 2008 | Science China Earth Sciences2008，51，9： | 29 |
| 3 | A novel integrated step-feed biofilm process for the treatment of decentralized domestic wastewater in rural areas of China显示文摘For wastewater treatment in rural areas, a novel three-stage step-feed wastewater treatment system, combined with a drop-aeration biofilm process, was tested in the laboratory to investigate its performance in removing suspended solids (SS), chemical oxygen demand (COD), NH4+-N, total nitrogen (TN), and total phosphorus (TP). The removal rates of SS, COD and NH4+-N were 90%, 80%, and 90% in efluent concentrations less than 10 mg/L, 50 mg/L and 8 mg/L, respectively. The TP removal rate was less satisfactory. The C/N ratio in the raw wastewater was often less than 3.5, and the removal efficiency of TN was therefore limited. A carbon-release batch experiment was carried out to measure the feasibility of enhancing denitrification at low influent C/N ratios. The result showed that the C/N could be over 9.0 in the supernatant. Polymerase chain reaction denaturing gradient gel electrophoresis technology was used to reveal the changes in the bacterial community during different stages of the integrated step-feed biofilm process. The results showed that banding patterns and the distribution of dominant bands for the same experimental period in different aerobic zones were similar. Phylogenetic analysis indicated that lanes 10, 11 and 12, which presented three aerobic zones at the same operation period, had the closest phylogenetic relationship among the lanes. | Hanwen Liang, Min Gao, Junxin Liu, Yuansong Wei, Xuesong Guo Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. | 2010 | Journal of Environmental Sciences2010，22，3： | 28 |
| 4 | Micro-Doppler characteristics of sliding-type scattering center on rotationally symmetric target显示文摘The feature of micro-motion is one of the most effective features used for radar recognition in midcourse phase.At present,the study of feature extraction and recognition is usually based on the assumption that the micro-motion of the scattering center and warhead itself is the same,and the radar echo is sinusoid-FM signal.However,this assumption ignores the fact that the scattering center would slide on the warhead with the change of the aspect angle.In this paper,a complete micro-motion model is set for the scattering centers of different positions on the warhead,and the mathematical expression of the micro-Doppler of the sliding-type scattering center is obtained for the first time.The approximation of Taylor expansion under the background of missile confrontation is studied subsequently.The curve of this micro-Doppler is not the generally assumed sinusoid.Dynamic measurement of a precessional target in microwave anechoic chamber is done to vividly observe the sliding feature of the scattering center.The measurement results agree with the theoretic analysis in this paper.This research on micro-Doppler characteristics of sliding-type scattering center provides a more accurate model for the micro-motion simulation and feature extraction of precessional warheads. | MA Liang LIU Jin WANG Tao LI YongZhen WANG XueSong | 2011 | Science China(Information Sciences)2011，54，9： | 24 |
| 5 | Novel research on main-lobe jamming polarization suppression technology显示文摘A novel main-lobe blanketing interference suppression method which named as spatial virtual multiple channel concurrent polarization filter technology is proposed.It processes sample data using the slow varied polarization property of a scanning antenna.The orthogonal polarized signal and polarization states of the receiving signal can be obtained.The optimal polarization is then calculated for use in polarization filtering to achieve the objective of suppressing noise jamming.The effect of elevation measurement error on interference suppression performance is eliminated by concurrent processing.Theoretical and simulation results show that,this technology enabled self-polarization information processing for single polarized radar which improved its working performance. | DAI HuanYao WANG XueSong LIU Yong LI YongZhen XIAO ShunPing | 2012 | Science China(Information Sciences)2012，55，2： | 16 |
| 6 | Effect of barium sulfate modification on the SO2 tolerance of V2O5/TiO2 catalyst for NH3-SCR reaction显示文摘Sulfur poisoning of V_2O_5/BaSO_4–TiO_2(VBT),V_2O_5/WO_3–TiO_2(VWT) and V_2O_5/BaSO_4–WO_3–TiO_2(VBWT) catalysts was performed in wet air at 350℃ for 3 hr,and activities for the selective catalytic reduction of NO_x with NH_3 were evaluated for 200–500℃.The VBT catalyst showed higher NO_x conversions after sulfur poisoning than the other two catalysts.The introduction of barium sulfate contributed to strong acid sites for the as-received catalyst,and eliminated the redox cycle of active vanadium oxide to some extent,which resulted in a certain loss of activity.Readily decomposable sulfate species formed on VBT-S instead of inactive sulfates on VWT-S.These decomposable sulfates increased the number of strong acid sites significantly.Some sulfate species escaped during catalyst preparation and barium sulfate was reproduced during sulfur poisoning,which protects vanadia from sulfur oxide attachment to a great extent.Consequently,the VBT catalyst exhibited the best resistance to sulfur poisoning. | Tengfei Xu Xiaodong Wu Xuesong Liu Li Cao Qiwei Lin Duan Weng | 2017 | Journal of Environmental Sciences2017，29，7： | 14 |
| 7 | Decentralized wastewater treatment technologies and management in Chinese villages显示文摘在中国在农村区域对待污水的问题在最近的年里吸引了增加的注意。然而,仅仅,有的 6% 农村区域在 2010 底喷洒排水和废水处理系统。估计当前使用的技术是必要的以便在农村区域的污水处理能适当地被开发,到提供可靠、买得起的废水处理,在这些区域。我们评估了在各一直在操作至少一年了的 62 台设备上进行案例研究当前在农村区域使用的污水处理技术。我们的学习在 2009 和 2011 之间被执行,并且目的是在那经期期间估计状况并且估计在村庄里涉及分散的污水治疗的任何问题。我们发现那个分散的污水处理是村庄里的最流行的废水处理方法,并且最普通的主要处理技术在农村区域使用了,这是化粪池。我们的调查加亮需要为估计自河质量建立标准,包括目标污染物质的一个范围。我们的结果也证明自河应该被再使用在不同区域满足本地环境要求,特别在生态地敏感的区域。 | Xuesong GUO Zehang LIU Meixue CHEN Junxin LIU Min YANG | 2014 | Frontiers of Environmental Science & Engineering2014，8，6： | 13 |
| 8 | An innovative integrated system utilizing solar energy as power for the treatment of decentralized wastewater显示文摘This article reports an innovative integrated system utilizing solar energy as power for decentralized wastewater treatment, which consists of an oxidation ditch with double channels and a photovoltaic (PV) system without a storage battery. Because the system operates without a storage battery, which can reduce the cost of the PV system, the solar radiation intensity affects the amount of power output from the PV system. To ensure that the power output is sufficient in all different weather conditions, the solar radiation intensity of 78 W/m 2 with 95% confidence interval was defined as a threshold of power output for the PV system according to the monitoring results in this study, and a step power output mode was used to utilize the solar energy as well as possible. The oxidation ditch driven by the PV system without storage battery ran during the day and stopped at night. Therefore, anaerobic, anoxic and aerobic conditions could periodically appear in the oxidation ditch, which was favorable to nitrogen and phosphate removal from the wastewater. The experimental results showed that the system was efficient, achieving average removal efficiencies of 88% COD, 98% NH 4 + -N, 70% TN and 83% TP, under the loading rates of 140 mg COD/(g MLSS·day), 32 mg NH 4 + -N/(g MLSS·day), 44 mg TN/(g MLSS·day) and 5 mg TP/(g MLSS·day). | Changfu Han Junxin Liu Hanwen Liang Xuesong Guo Lin Li | 2013 | Journal of Environmental Sciences2013，25，2： | 12 |
| 9 | Efficient BoPDS Gene Editing in Cabbage by the CRISPR/Cas9 System显示文摘Genome editing offers great advantages in identifying gene function and generating agronomically important mutations in crops. Here,we report that the genome of cabbage(Brassica oleracea var. capitata), an important cruciferous vegetable, can also be precisely edited by a CRISPR/Cas9 system stacked with multiple single-guide RNA-expressing cassettes. When the phytoene desaturase Bo PDS gene was used as the target gene, an albino-phenotype transgenic shoot in T0 Basta-resistant lines was observed, and 37.5% of the transgenic cabbage shoots carried Bo PDS gene mutations as a result of nucleotide deletions at the expected position. Moreover, mutations were detected in sites with the same target sequence in gene Bol016089 which is paralogous to the Bo PDS gene. Our results show that the CRISPR/Cas9 system is a powerful tool for cabbage variety improvement by genome editing. | Cunfa Ma Mengci Liu Qinfei Li Jun Si Xuesong Ren Hongyuan Song | 2019 | Horticultural Plant Journal2019，5，4： | 12 |
| 10 | Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer显示文摘5-methylcytosine (5mC ) 和它的氧化形式 5-hydroxymethylcytosine (5hmC ) 被建议了涉及 tumorigenesis。因为印射方法的广泛地使用的 5mC 的读出,定序的重亚硫酸盐(BS-seq ) ,是 5mC 的和, 5hmC 层次, 5mC/5hmC 模式和这二修正的关系仍然保持糟糕理解。由介绍真实 5mC (BS-seq 由帮助 Tet 的 BS-seq 改正了, TAB-seq ) 并且 5hmC (TAB-seq ) 在单个核苷酸的分辨率同时铺平,我们这里证明与匹配的正常纸巾相比没有在肾肿瘤的 5mC 的全球损失。相反地, 5hmC 全球性被失去在几乎所有肾肿瘤纸巾。在肿瘤纸巾的 5hmC 水平是为肾癌症的一个独立预示的标记,与与更短的全面幸存联系的 5hmC 的底层。而且,我们证明 5hmC 的损失与匹配的正常纸巾相比在肿瘤被连接到 hypermethylation,特别地在基因身体区域。惊人地,基因身体 hypermethylation 显著地与肿瘤相关的基因的 silencing 被联系。IDH1 的 Downregulation 作为在肾癌症位于 5hmC 损失下面的机制被识别。恢复 5hmC 层次稀释了肿瘤房间的侵略能力并且在一个异种皮移植模型压制了肿瘤生长。一起,我们的结果证明 5hmC 的损失在由改变 DNA methylation 模式的肾癌症是一个预示的标记和一个 oncogenic 事件。 | Ke Chen Jing Zhang Zhongqiang Guo Qin Ma Zhengzheng Xu Yuanyuan Zhou Ziying Xu Zhongwu Li Xiongjun- Ye Xuesong Li Bifeng Yuan Yuwen Ke Chuan He Liqun Zhou Jiang Liu WeiminCi | 2016 | Cell Research2016，26，1： | 10 |
| 11 | Removal of airborne microorganisms emitted from a wastewater treatment oxidation ditch by adsorption on activated carbon显示文摘Bioaerosol emissions from wastewater and wastewater treatment processes are a significant subgroup of atmospheric aerosols. Most previous work has focused on the evaluation of their biological risks. In this study, however, the adsorption method was applied to reduce airborne microorganisms generated from a pilot scale wastewater treatment facility with oxidation ditch. Results showed adsorption on granule activated carbon (GAC) was an efficient method for the purification of airborne microorganisms. The GAC itself had a maximum adsorption capacity of 2217 CFU/g for airborne bacteria and 225 CFU/g for fungi with a flow rate of 1.50 m 3 /hr. Over 85% of airborne bacteria and fungi emitted from the oxidation ditch were adsorbed within 80 hr of continuous operation mode. Most of them had a particle size of 0.65-4.7 μm. Those airborne microorganisms with small particle size were apt to be adsorbed. The SEM/EDAX, BET and Boehm's titration methods were applied to analyse the physicochemical characteristics of the GAC. Relationships between GAC surface characteristics and its adsorption performance demonstrated that porous structure, large surface area, and hydrophobicity rendered GAC an effective absorber of airborne microorganisms. Two regenerate methods, ultraviolet irradiation and high pressure vapor, were compared for the regeneration of used activated carbon. High pressure vapor was an effective technique as it totally destroyed the microorganisms adhered to the activated carbon. Microscopic observation was also carried out to investigate original and used adsorbents. | Lin Li Min Gao Junxin Liu Xuesong Guo | 2011 | Journal of Environmental Sciences2011，23，5： | 10 |
| 12 | RAPID AND NONDESTRUCTIVE MEASUREMENT SYSTEM FOR WELDING RESDlUAL STRESS BY ULTRASONIC METHOD显示文摘Traditional methods of residual stress measurement are generally destructive or semi-destructive,as well as expensive,time-consuming and complex to implement.With the new development of welded structure,traditional methods can not satisfy the need of full life task management.So the acoustical theory is introduced,since the ultrasonic technique provides a useful nondestructive tool in the evaluation of stresses.In this study an ultrasonic stress measurement experimental installation is established,which consists of a special transducer,a signal emission unit and a signal recipient processing unit.Longitudinal critically refracted wave is selected as the measurement wave mode.The supporting software is programmed by Labview software.The longitudinal residual stress and transverse residual stress of twin wire welded plate are measured by this installment,in which the measuring process is real-time,quick and nondestructive.The experiment results indicate that the system can satisfy the need of life evaluation for welded structure. The system is light and portable. | LU Hao LIU Xuesong ZHU Zheng ZHANG Shiping FANG Hongyuan | 2008 | Chinese Journal of Mechanical Engineering2008，21，6： | 8 |
| 13 | Structures and catalytic performances of Me/SAPO-34(Me=Mn,Ni,Co)catalysts for low-tem perature SCR of NO_x by ammonia显示文摘Me/SAPO-34(Me=Mn,Ni,Co)series of catalysts were prepared by a wetness impregnation method and investigated for the selective catalytic reduction of nitrogen oxides with ammonia(NH 3-SCR).Among them,Mn/SAPO-34 catalyst was found as the most promising candidate based on its superior low-temperature activity.The catalysts were characterized by X-ray diffraction(XRD),transmission electron microscopy images(TEM),nuclear magnetic resonance(NMR),X-ray photoelectron spectroscopy(XPS),temperature programmed reduction and desorption(TPR and TPD),and diffuse reflectance infrared Fourier transformed spectroscopy(DRIFTS)of NH_(3)/NO_(x)adsorption.Mn/SAPO-34 is obviously different from Ni/SAPO-34 and Co/SAPO-34 in the active species state and distribution.Surface MnO_(x)species which play an essential role in NO oxidation and NO_(2)adsorption,act as better active sites than nickel and cobalt mostly in the form of the aluminates and silicates. | Xuesong Liu Zhiming Sui Hongfeng Chen Yong Chen Haigang Liu Peng Jiang Zhongyun Shen Wensheng Linghu Xiaodong Wu | 2021 | Journal of Environmental Sciences2021，33，6： | 8 |
| 14 | CRISPR/Cas9-mediated multiple gene editing in Brassica oleracea var.capitata using the endogenous tRNA-processing system显示文摘Cabbage(Brassica oleracea var.capitata)is a biennial plant with strong self-incompatibility and an obligate requirement for prolonged vernalization by exposure to low temperatures to induce flowering.These characteristics significantly increase the difficulty of exploiting novel germplasm induced by physical or chemical mutagens.In this study,we report a CRISPR/Cas9 gene-editing system based on endogenous tRNA processing to induce high efficiency and inheritable mutagenesis in cabbage.Using the phytoene desaturase gene BoPDS,the S-receptor kinase gene BoSRK,and the male-sterility-associated gene BoMS1 as the target genes,multisite and multiple gene mutations were achieved using a construct with tandemly arrayed tRNA-sgRNA architecture to express multiple sgRNAs.The BoSRK3 gene mutation suppressed self-incompatibility completely,converting the self-incompatible line into a self-compatible line.In addition,the BoMS1 gene mutation produced a completely male-sterile mutant,which was highly cross compatible with its nonmutant isoline at the flowering stage as a result of a simultaneous BoSRK3 gene mutation,enabling the economic propagation of the male-sterile line through bee-mediated cross-pollination.Interestingly,higher site mutation efficiency was detected when a guide sequence was inserted into a location in the tandemly arrayed tRNA-sgRNA architecture that was distal from the upstream Pol III promoter.In addition,mutation sites were also detected in the paralogous genes of the BoPDS and BoSRK genes that had fully consistent sequences or base mismatches but beyond the“seed”region in the spacer sequence compared with the target sgRNAs.Collectively,our results demonstrate that the CRISPR/Cas9 system,coupled with an endogenous tRNA-processing system,is an efficient tool to improve cabbage traits. | Cunfa Ma Chenzeng Zhu Min Zheng Mengci Liu Dejun Zhang Baoli Liu Qinfei Li Jun Si Xuesong Ren Hongyuan Song | 2019 | Horticulture Research2019，6，1： | 8 |
| 15 | Investigation on mechanism of phosphate removal on carbonized sludge adsorbent显示文摘For the removal of phosphate(PO_4^(3-)) from water, an adsorbent was prepared via carbonization of sewage sludge from a wastewater treatment plant: carbonized sludge adsorbent(CSA). The mechanism of phosphate removal was determined after studying the structure and chemical properties of the CSA and its influence on phosphate removal. The results demonstrate that phosphate adsorption by the CSA can be fitted with the pseudo second-order kinetics and Langmuir isotherm models, indicating that the adsorption is single molecular layer adsorption dominated by chemical reaction. The active sites binding phosphate on the surface are composed of mineral particles containing Si/Ca/Al/Fe. The mineral containing Ca, calcite, is the main factor responsible for phosphate removal. The phosphate removal mechanism is a complex process including crystallization via the interaction between Ca^(2+) and PO_4^(3-); formation of precipitates of Ca^(2+), Al^(3+), and PO_4^(3-); and adsorption of PO_4^(3-)on some recalcitrant oxides composed of Si/Al/Fe. | Lei Zhang Junxin Liu Xuesong Guo | 2018 | Journal of Environmental Sciences2018，30，2： | 7 |
| 16 | Evaluation of phosphorus removal from wastewater by soils in rural areas in China显示文摘Low-cost, easy-maintenance and high-efficiency decentralized wastewater treatment technologies are urgently needed in rural areas of China. Processes with high potential for phosphorus removal are of great interest. However, commonly used treatment methods often do not meet the strict criteria for removing phosphorus from rural wastewater. In order to search an economic and simple technology for phosphorus removal from the common bio-technologies efluent, seven soil types collected from different rural areas in China were investigated for their ability to remove phosphorus. X-ray diffraction (XRD) was used to analyse the mineral structure, and inductively coupled plasma optical emission spectrometer (ICP-OES) was used to analyse the geochemical composition of the soil samples. Three primary minerals-quartz, albite and montmorillonite-were clearly detected. The samples were divided into two soil types, acidic soils and alkaline soils, based on their pH values. The geochemical composition study indicated that a higher percentage of Ca and Mg occurred in alkaline soils (pH>8) than in acidic soils (pH<6.5). Adsorption isotherms from batch experiments fitted the Langmuir and Freundlich models well, the maximum P adsorption capacities ranged from 0.256 to 1.598 mg P/g, indicating a high phosphorus removal potential for all of these soils. The P fractions extracted revealed that the sum of NaOH-extracted inorganic P (NaOH-Pi) was the major P component in the acidic soils, and CaCO3-bound phosphorus (Ca-P) in the alkaline soils. Dynamic adsorption simulation showed that these soils have the ability to remove phosphorus from wastewater. | Hanwen Liang, Junxin Liu, Yuansong Wei, Xuesong GuoResearch Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China | 2010 | Journal of Environmental Sciences2010，22，1： | 7 |
| 17 | Design and demonstration of a 0.22 THz gyrotron oscillator显示文摘Gyrotrons are the most powerful terahertz sources and have potential applications in many areas. A terahertz gyrotron oscillator with a pulsed solenoid producing up to an 8 T magnetic field has been designed, constructed and tested. In a 7.96 T magnetic field, 3 kW output power radiations at 0.22 THz frequency have been generated. | YAN Yang LIU Sheng Gang LI XiaoYun FU WenJie YUAN XueSong | 2009 | Chinese Science Bulletin2009，54，9： | 7 |
| 18 | Suitability Evaluation of Rural Settlements Based on Accessibility of Production and Living: A Case Study of Tingzu Town in Hubei Prov- ince of China显示文摘Rural settlements are the main carriers of agriculture, rural areas and farmers; thus, optimizing the production and living space of rural settlements is highly significant to rural development. Taking the effective allocation of resources as the starting point, a suitability evaluation system of rural settlements, based on accessibility of production and living, was proposed in this study to provide scientific basis for the optimization of production and living space. The accessibility of production and living was measured by an improved two-step floating catchment area method, which considered proximity and availability based on the inclination of rural residents. The suitability evaluation system consisted of traditional suitability evaluation and newly proposed limiting factor identification based on the loss score proportion of suitability. Tingzu Town of Hubei Province, China, was chosen as the case study area. Based on the results of the suitability evaluation system, corresponding suggestions on rural land consolidation, industry division, as well as the layout of health care and education facilities were proposed to optimize the production and living space of rural settlements in Tingzu Town. It is found that the suitability evaluation based on accessibility of production and living is more scientific and accurate than the traditional ones which significantly overestimate production and living convenience. Moreover, the limiting factor identification can help us put forward suggestions according to local conditions and bring about the highly targeted optimization of production and living space of rural settlements. | LIU Yaolin YE Qingqing LI Jiwei KONG Xuesong JIAO Limin | 2016 | Chinese Geographical Science2016，26，4： | 7 |
| 19 | Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway显示文摘The stiffness of the extracellular matrix(ECM)plays an important role in regulating the cellular programming.However,the mechanical characteristics of ECM affecting cell differentiation are still under investigated.Herein,we aimed to study the effect of ECM substrate stiffness on macrophage polarization.We prepared polyacrylamide hydrogels with different substrate stiffness,respectively.After the hydrogels were confirmed to have a good biocompatibility,the bone marrow-derived macrophages(BMMs)from mice were incubated on the hydrogels.With simulated by the low substrate stiffness,BMMs displayed an enhanced expression of CD86 on the cell surface and production of reactive oxygen species(ROS)in cells,and secreted more IL-1βand TNF-αin the supernatant.On the contrary,stressed by the medium stiffness,BMMs expressed more CD206,produced less ROS,and secreted more IL-4 and TGF-β.In vivo study by delivered the hydrogels subcutaneously in mice,more CD68+CD86+cells around the hydrogels with the low substrate stiffness were observed while more CD68+CD206+cells near by the middle stiffness hydrogels.In addition,the expressions of NIK,phosphorylated p65(pi-p65)and phosphorylated IκB(pi-IκB)were significantly increased after stimulation with low stiffness in BMMs.Taken together,these findings demonstrated that substrate stiffness could affect macrophages polarization.Low substrate stiffness promoted BMMs to shift to classically activated macrophages(M1)and the middle one to alternatively activated macrophages(M2),through modulating ROS-initiated NF-κB pathway.Therefore,we anticipated ECM-based substrate stiffness with immune modulation would be under consideration in the clinical applications if necessary. | Mimi Chen Yu Zhang Pinghui Zhou Xingzhi Liu Huan Zhao Xichao Zhou Qiaoli Gu Bin Li Xuesong Zhu Qin Shi | 2020 | Bioactive Materials2020，5，4： | 7 |
| 20 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
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