| 1 | Facile fabrication of a biocompatible composite gel with sustained release of aspirin for bone regeneration显示文摘Hydrogels are extracellular-matrix-like biomimetic materials that have wide biomedical applications in tissue engineering and drug delivery.However,most hydrogels cannot simultaneously fulfill the mechanical and cell compatibility requirements.In the present study,we prepared a semi-interpenetrating network composite gel(CG)by incorporating short chain chitosan(CS)into a covalent tetra-armed poly(ethylene glycol)network.In addition to satisfying physicochemical,mechanics,biocompatibility,and cell affinity requirements,this CG easily encapsulated acetylsalicylic acid(ASA)via electrostatic interactions and chain entanglement,achieving sustained release for over 14 days and thus promoting periodontal ligament stem cell(PDLSC)proliferation and osteogenic differentiation.In vivo studies corroborated the capacity of PDLSCs and ASA-laden CG to enhance new bone regeneration in situ using a mouse calvarial bone defect model.This might be attributed to PDLSCs and host mesenchymal stem cells expressing monocyte chemoattractant protein-1,which upregulated M2 macrophage recruitment and polarization in situ,indicating its appealing potential in bone tissue engineering. | Yunfan Zhang Xueyu Dou Lingyun Zhang Hufei Wang Ting Zhang Rushui Bai Qiannan Sun Xing Wang Tingting Yu Decheng Wu Bing Han Xuliang Deng | 2022 | Bioactive Materials2022，7，5： | 2 |
| 2 | Synergistic control of dual cross-linking strategy toward tailor-made hydrogels显示文摘Simple, efficient and accurate controllable systems for materials are becoming more essential, in response to the explosively growing demands in the fields of chemistry and material science. Herein, tailored hydrogels are explored depending on synergistic regulation of p H-responsive chemical networks with an 'on/off' function and physical networks with dynamic selfoptimized arrangement. Thiol-disulfide exchange reaction endows hydrogels with controlled architectures while hydrogen bondstrengthened 2-ureido-4[1H]-pyrimidinone(UPy) moieties contributes a significant increase in mechanical strengths. The integration of that dual cross-linking(DC) network ensures the hydrogels with customized structure and enhanced mechanical property. Such controllably strategy is universally applicable and will open a new avenue to flexibly fabricate desired hybrid hydrogels with distinctive features and functions for their potential applications. | Xueyu Dou Qingchen Cao Feifei Sun Yaqiang Wang Hufei Wang Hong Shen Fei Yang Xing Wang Decheng Wu | 2020 | Science China Chemistry2020，63，12： | 0 |
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