|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinicopathological features and prognosis assessment of extranodal follicular dendritic cell sarcoma显示文摘AIM: To establish a model for prognosis assessment of extranodal follicular dendritic cell (FDC) sarcoma.METHODS: Nine lesions were examined by routine and molecular approaches.Clinicopathological factors from the new cases and 97 reported cases were analyzed for their prognostic values.RESULTS: The current lesions were found in f ive male and four female patients,located mainly in the head and neck area and averaging 7.2 cm in size.Six patients had recurrence or metastasis and three remained free of disease.The 106 patients (male/female ratio,1.1:1) were aged from 9 to 82 years (median,44 years).The tumor sizes ranged from 1.5 to 21 cm (mean,7.4 cm).Abdominal/pelvic region was affected most frequently (43%).Surgical resection was performed in 100 patients,followed by radiation and/or chemotherapy in 35 of them.Follow-up data were available in 91 cases,covering a period of 3-324 mo (mean,27 mo;median,19 mo).Of the informative cases,38 (42%) had recurrence or metastasis,and 12 (13%) died of the disease.These tumors were classif ied histologically into lowand high-grade lesions.A size ≥ 5 cm (P = 0.003),highgrade histology (P = 0.046) and a mitotic count ≥ 5/10 HPF (P = 0.013) were associated with tumor recurrence.The lesions were def ined as low-,intermediateand high-risk tumors,and their recurrence rates were 16%,46% and 73%,and their mortality rates 0%,4% and 45%,respectively.CONCLUSION: Extranodal FDC tumors behave like soft tissue sarcomas.Their clinical outcomes are variable and can be evaluated according to their sizes and grades. | Li, Lan Shi, Yong-Hong Guo, Zhi-Juan Qiu, Tian Guo, Lei Yang, Hong-Ying Zhang, Xun Zhao, Xin-Ming Su, Qin | 2010 | World Journal of Gastroenterology2010，16，20： | 18 |
| 2 | Compatibility of rubber stoppers for recombinant antitumor-antivirus protein injection by gas chromatography-mass spectrometry显示文摘A simple, rapid, and sensitive gas chromatography-mass spectrometry (GC-MS) method was developed and validated for the simultaneous determination of two fatty acids, methyl hexadecanoate (MH) and methyl stearate (MS), to allow the evaluation of packaging-drug compatibility. The two migrants were quantified in selective ion-monitoring (SIM) mode, with limits of detection (LOD) of 0.0030 μg/mL and 0.0121 μg/mL. Linear calibration curves for MH and MS were obtained in the concentration ranges of 0.1011–5.0570 μg/mL and 0.2015–10.0740 μg/mL, respectively. The developed method was successfully applied to estimate the safety of the injection of recombinant antitumor-antivirus protein (RAAP). The results showed that the possible maximum daily intake was 3.0 ng and 12.1 ng for MH and MS, respectively. As these values were both below the permitted daily exposure, the migrants can be considered as having low safety risk and do not affect the quality of the injection. | Zhaorui Meng Xun Gao Haifeng Yu Lan Zhang Xiangyong Yu Longshan Zhao | 2019 | Journal of Pharmaceutical Analysis2019，9，3： | 4 |
| 3 | Analysis of process parameters effects on friction stir welding of dissimilar aluminum alloy to advanced high strength steel显示文摘 | Xun Liu Shuhuai Lan Jun Ni | 2014 | Materials and Design2014，，： | 2 |
| 4 | Real-Time PCR Detection of Lactic Acid Bacteria in Cecal Contents of Eimeria tenella-lnfect- ed Broilers Fed Soybean Oligosacchafides and Soluble Soybean Polysaccharides显示文摘 | Lan Y Xun S Tamminga S | 2004 | Poultry Science2004，83，10： | 1 |
| 5 | Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo显示文摘Midline2 (MID2 ) 是连接到肿瘤前进和乳癌 1 的一个新奇交往搭挡的结合 ubiquitin E2 酶,早发作(BRCA1 ) 。然而,在乳癌的 MID2 的角色仍然保持未知。这研究在乳癌调查了 MID2 的表示,预示的价值,和角色。MID2 mRNA 和蛋白质的表示是显著地,在乳癌织物和确定的房间的 upregulated 在正常的胸与那相比排队上皮的房间和配对的邻近的非肿瘤织物(P < 0.001 ) 。Immunohistochemical 分析证明 MID2 是在 284 中的 272 个的 overexpressed (95.8%) paraffinembedded,转存的乳癌织物。而且,与先进临床的舞台增加的 MID2 表示(P < 0.001 ) 。高 MID2 表示显著地与先进临床的阶段和 T 被联系, N,和 M 阶段(所有 P < 0.05 ) 。Univariate 和 multivariate 分析显示那高 MID2 表情是为在全部队的差的全面幸存的一个独立预示的因素(93.73 对 172.1 个月;P < 0.001, logrank 测试) 并且在有阶段 Tis + 的亚群我 + II 和 III + IV。而且, 3-(4,5-dimethyl-2-thiazolyl )-2,5-diphenyl-2H-tetrazolium 溴化物殖民地形成,和抛锚无关的生长能力试金被进行。结果证明 MID2 表示的 siRNA silencing 显著地在 vitro 减少了 MCF-7 和 MDA-MB-231 细胞增长并且在 vivo 堵住了 MDA-MB-231 细胞异种皮移植肿瘤的生长(P < 0.05 ) 。这研究显示 MID2 可以在乳癌是一个新奇预示的标记和 interventional 目标。 | Lan Wang JuehengWu Jie Yuan Xun Zhu Hongmei Wu Mengfeng Li | 2016 | Frontiers of Medicine2016，10，1： | 1 |
| 6 | High glucose enhances hydrogen peroxide induced apoptosis in bovine aortic endothelial cells显示文摘 | Guo Xun Liu Wen Lan Chen Li wei | 2000 | Acta pharmacolsin2000，21，1： | 1 |
| 7 | Comparison of the clinical features and therapeutics of COVID-19 in cardio-cerebrovascular disease(CCVD)and non-CCVD patients显示文摘Cardio-cerebrovascular disease(CCVD)is a major comorbidity of coronavirus disease 2019(COVID-19).However,the clinical characteristics and outcomes remain unclear.In this study,102 cases of COVID-19 from January 22,2020 to March 26,2020 in Xixi Hospital of Hangzhou were included.Twenty cases had pre-existing CCVD.Results showed that compared with non-CCVD patients,those with CCVD are more likely to develop severe disease(15%versus 1%),and the proportion of pneumonia severity index grade IV was significantly higher(25%versus 3.6%).Computed tomography images demonstrated that the proportion of multiple lobe lesion involvement was significantly higher in the CCVD group than in the non-CCVD group(90%versus 63.4%).Compared with non-CCVD group,the levels of C-reactive protein,fibrinogen,D-dimer,and serum amyloid-A were higher,whereas the total protein and arterial partial Pa02 were lower in the CCVD group.Although no statistical difference was observed in the outcomes between groups,CCVD patients received more intensive comprehensive treatment to improve COVID-19 symptoms compared with non-CCVD patients.Integrated Chinese and Western medicine treatments have certain advantages in controlling the severe conversion rate and mortality of COVID-19.In addition,given that COVID-19 patients are usually related to coagulation disorders and thrombosis risk,the application of Chinese medicine in promoting blood circulation and removing stasis should be strengthened. | Yu Wang Lan Li Yuanjiang Pan Yu He Zuhua Chen Yunhao Xun Yuhan Xu Yilei Guo Jiehong Yang Jianchun Guo Haitong Wan | 2021 | Frontiers of Medicine2021，15，4： | 1 |
| 8 | Neurogenic responses to amyloid-beta plaques in the brain of Alzheimer's disease-like transgenic (pPDGF-APPSw,Ind) mice显示文摘 | Gan Li Qiao Shu-hong Lan Xun | 2008 | Neurobiol Dis2008，29，1： | 1 |
| 9 | Development of low-coherence high-power laser drivers for inertial confinement fusion显示文摘The use of low-coherence light is expected to be one of the effective ways to suppress or even eliminate the laser–plasma instabilities that arise in attempts to achieve inertial confinement fusion.In this paper,a review of low-coherence high-power laser drivers and related key techniques is first presented.Work at typical low-coherence laser facilities,including Gekko XII,PHEBUS,Pharos III,and Kanal-2 is described.The many key techniques that are used in the research and development of low-coherence laser drivers are described and analyzed,including low-coherence source generation,amplification,harmonic conversion,and beam smoothing of low-coherence light.Then,recent progress achieved by our group in research on a broadband low-coherence laser driver is presented.During the development of our low-coherence high-power laser facility,we have proposed and implemented many key techniques for working with low-coherence light,including source generation,efficient amplification and propagation,harmonic conversion,beam smoothing,and precise beam control.Based on a series of technological breakthroughs,a kilojoule low-coherence laser driver named Kunwu with a coherence time of only 300 fs has been built,and the first round of physical experiments has been completed.This high-power laser facility provides not only a demonstration and verification platform for key techniques and system integration of a low-coherence laser driver,but also a new type of experimental platform for research into,for example,high-energy-density physics and,in particular,laser–plasma interactions. | Yanqi Gao Yong Cui Lailin Ji Daxing Rao Xiaohui Zhao Fujian Li Dong Liu Wei Feng Lan Xia Jiani Liu Haitao Shi Pengyuan Du Jia Liu Xiaoli Li Tao Wang Tianxiong Zhang Chong Shan Yilin Hua Weixin Ma Xun Sun Xianfeng Chen Xiuguang Huang Jian Zhu Wenbing Pei Zhan Sui Sizu Fu | 2020 | Matter and Radiation at Extremes2020，5，6： | 1 |
| 10 | Synthesis,phase behaviors,and mechancial properties of biphenyl-type epoxy resins and composites显示文摘 | Shao Ping Ren Li Yah Liang Yan Xun Lan | 2007 | Journal of Applied Polymer Science2007，，106： | 1 |
| 11 | Analysis of process para-meters effects on friction stir welding of dissimilar alumi- num alloy to advanced high strength steel显示文摘 | Xun Liu Shuhuai Lan Jun Ni | 2014 | Materials and Design2014，28，3： | 1 |
| 12 | Application of artificial intelligence in clinical diagnosis and treatment:an overview of systematic reviews显示文摘Objective This study aimed to summarize the characteristics and methodological quality of systematic reviews on the application of artificial intelligence(AI)in clinical diagnosis and treatment.Methods We systematically searched seven English-and Chinese-language literature databases to identify sys-tematic reviews on the application of AI,deep learning,or machine learning in the diagnosis and treatment of any disease published in 2020.We evaluated the methodological quality of the included systematic reviews using“A Measurement tool for the assessment of multiple systematic reviews”(AMSTAR).We also conducted meta-analyses on the diagnostic accuracy of AI on selected disease categories with a large number of included studies and low clinical heterogeneity.Results A total of 40 systematic reviews reporting 1,083 original studies were included,covering 31 diseases from 11 groups of diseases.Eleven systematic reviews were related to neoplasms and nine were systematic reviews related to diseases of the digestive system.We selected digestive system diseases for the meta-analysis.The pooled sensitivities(with 95%confidence interval(CI))of AI to assist the diagnosis of helicobacter pylori,gastrointestinal ulcers,hemorrhage,esophageal tumors,gastric tumors,and intestinal tumors(with 95%CI)were 0.91(0.83-0.95),0.99(0.76-1.00),0.95(0.83-0.99),0.90(0.85-0.93),0.90(0.82-0.95),and 0.93(0.88-0.96),respectively,and the pooled specificities were 0.82(0.77-0.87),0.97(0.86-1.00),1.00(0.99-1.00),0.80(0.71-0.87),0.93(0.87-0.97),and 0.89(0.85-0.92),respectively.The AMSTAR items“the list of included studies”(n=39,97.5%)and“the characteristics of the included studies”(n=39,97.5%)had the highest compliance among the reviews;the compliance was relatively low to the items“the consideration of publication status”(n=1,2.5%),“the consideration of scientific quality”(n=19,47.5%),“data synthesis methods”(n=18,45.0%),and“the evaluation of publication bias”(n=13,32.5%).Conclusions The main subjects of systematic reviews on AI applications in clinical diagnosis and treatment pub-lished in 2020 were diseases of the digestive system and neoplasms.The methodological quality of the systematic reviews on AI needs to be improved,paying particular attention to publication bias and the rigorous evaluation of the quality of the included studies. | Shouyuan Wu Jianjian Wang Qiangqiang Guo Hui Lan Juanjuan Zhang Ling Wang Estill Janne Xufei Luo Qi Wang Yang Song Joseph LMathew Yangqin Xun Nan Yang Myeong Soo Lee Yaolong Chen | 2022 | Intelligent Medicine2022，2，2： | 1 |
| 13 | Delineating the rice crop activities in Northeast China through regional parametric synthesis using satellite remote sensing time-series data from 2000 to 2015显示文摘Accurate rice area extraction and yield simulations are important for understanding how national agricultural policies and environmental issues affect regional spatial changes in rice farming. In this study, an improved regional parametric syntheses approach, that is, the rice zoning adaptability criteria and dynamic harvest index(RZAC-DHI), was established, which can effectively simulate the rice cultivation area and yield at the municipal level. The RZAC was used to extract the rice area using Moderate Resolution Imaging Spectroradiometer time-series data and phenological information. The DHI was calculated independently, and then yield was obtained based on the DHI and net primary productivity(NPP). Based on the above results, we analyzed the spatial–temporal patterns of the rice cultivation area and yield in Northeast China(NEC) during 2000–2015. The results revealed that the methods established in this study can effectively support the yearly mapping of the rice area and yield in NEC, the average precisions of which exceed 90 and 80%, respectively. The rice planting areas are mainly located on the Sanjiang, Songnen and Liaohe plains, China, which are distributed along the Songhua and Liaohe rivers. The rice cultivation area and yield in this region increased significantly from 2000 to 2015, with increases of nearly 58 and 90%, respectively. The rice crop area and yield increased the fastest in Heilongjiang Province, China, whereas small changes occurred in Jilin and Liaoning provinces, China. Their gravity centers exhibited evident northward and eastward shifts, with offset distances of 107 and 358 km, respectively. Moreover, Heilongjiang Province has gradually become the new main rice production region. The methodologies used in this study provide a valuable reference for other related studies, and the spatial-temporal variation characteristics of the rice activities have raised new attention as to how these shifts affect national food security and resource allocation. | CAO Dan FENG Jian-zhong BAI Lin-yan XUN Lan JING Hai-tao SUN Jin-ke ZHANG Jia-hua | 2021 | Journal of Integrative Agriculture2021，20，2： | 1 |
| 14 | Transcriptional profile of shrimp white spot syndrome virus(WSSV)genes with DNA microarray显示文摘 | LAN Yong-shen XU Xun YANG Feng | 2006 | Arch Virol2006，151，9： | 1 |
| 15 | Identification and Characterisation of Phenolics in Polygonum capitatum by Ultrahigh‐Performance Liquid Chromatography with Photodiode Array Detection and Tandem Mass Spectrometry显示文摘 | Shang‐Gao Liao Li‐Juan Zhang Fa Sun Zhen Wang Xun He Ai‐Min Wang Yong‐Jun Li Yong Huang Yan‐Yu Lan Bo‐Li Zhang Yong‐Lin Wang | 2013 | Phytochem. Anal2013，，6： | 1 |
| 16 | Antibacterial and anti-inflammatory effects of extracts and fractions from Polygonum capitatum显示文摘 | Shang-Gao Liao Li-Juan Zhang Fa Sun Jin-Juan Zhang A-Ying Chen Yan-Yu Lan Yong-Jun Li Ai-Min Wang Xun He Ying Xiong Li Dong Xiao-Jun Chen Yue-Ting Li Li Zuo Yong-Lin Wang | 2011 | Journal of Ethnopharmacology2011，，3： | 1 |
| 17 | Genome-wide evolution analysis reveals low CpG contents of fast-evolving genes and identifies antiviral microRNAs显示文摘Noncoding RNAs(ncRNAs) play important roles in many biological processes and provide materials for evolutionary adaptations beyond protein-coding genes, such as in the arms race between the host and pathogen. However, currently, a comprehensive high-resolution analysis of primate genomes that includes the latest annotated ncRNAs is not available. Here, we developed a computational pipeline to estimate the selections that act on noncoding regions based on comparisons with a large number of reference sequences in introns adjacent to the interested regions. Our method yields result comparable with those of the established codon-based method and phyloP method for coding genes;thus, it provides a holistic framework for estimating the selection on the entire genome. We further showed that fastevolving protein-coding genes and their corresponding 50 UTRs have a significantly lower frequency of the CpG dinucleotides than those evolving at an average pace, and these fast-evolving genes are enriched in the process of immunity and host defense. We also identified fast-evolving miRNAs with antiviral functions in cells. Our results provide a resource for high-resolution evolution analysis of the primate genomes. | Wenhong Zu Hang Zhang Xun Lan Xu Tan | 2020 | Journal of Genetics and Genomics2020，47，1： | 1 |
| 18 | Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity显示文摘Recent clinical studies have shown that mutation of phosphatase and tensin homolog deleted on chromosome 10(PTEN)gene in cancer cells may be associated with immunosuppressive tumor microenvironment(TME)and poor response to immune checkpoint blockade(ICB)therapy.Therefore,efficiently restoring PTEN gene expression in cancer cells is critical to improving the responding rate to ICB therapy.Here,we screened an adeno-associated virus(AAV)capsid for efficient PTEN gene delivery into B16F10 tumor cells.We demonstrated that intratumorally injected AAV6-PTEN successfully restored the tumor cell PTEN gene expression and effectively inhibited tumor progression by inducing tumor cell immunogenic cell death(ICD)and increasing immune cell infiltration.Moreover,we developed an anti-PD-1 loaded phospholipid-based phase separation gel(PPSG),which formed an in situ depot and sustainably release anti-PD-1 drugs within 42 days in vivo.In order to effectively inhibit the recurrence of melanoma,we further applied a triple therapy based on AAV6-PTEN,PPSG^(@anti-PD-1)and CpG,and showed that this triple therapy strategy enhanced the synergistic antitumor immune effect and also induced robust immune memory,which completely rejected tumor recurrence.We anticipate that this triple therapy could be used as a new tumor combination therapy with stronger immune activation capacity and tumor inhibition efficacy. | Yongshun Zhang Lan Yang Yangsen Ou Rui Hu Guangsheng Du Shuang Luo Fuhua Wu Hairui Wang Zhiqiang Xie Yu Zhang Chunting He Cheng Ma Tao Gong Ling Zhang Zhirong Zhang Xun Sun | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 19 | Erratum to: Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo显示文摘The immunohistochemistry(IHC)staining of MID2 in“ANT”from Patient 2 and“T”from Patient 6 in original Fig.2C(Page 45)should be corrected.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. | Lan Wang Jueheng Wu Jie Yuan Xun Zhu Hongmei Wu Mengfeng Li | 2021 | Frontiers of Medicine2021，15，6： | 0 |
| 20 | Solvent-free Rapid Synthesis of Styryl Dyes with Benzimidazole Nucleus Using Microwave Irradiation显示文摘The reactions of 2-methylbenzimidazole or 2-methylbenzimidazolium iodide with aromatic aldehydes are accelerated under microwave irradiation by using Ac2O or piperidine as dehydrant or catalyst in the absence of any solvent. The approach provides an attractive and environmentally friendly pathway to several useful styryl dyes with benzimidazole nucleus. | Lan Ying WANG*, Xiao Gang ZHANG, Ying Qi JIA, Zu Xun ZHANG Department of Chemistry, Northwest University, Xian 710069 | 2003 | Chinese Chemical Letters2003，14，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员