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| 1 | Boron neutron capture therapy for malignant melanoma: first clinical case report in China显示文摘A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy(BNCT) was designed to evaluate whether the world's first in-hospital neutron irradiator(IHNI) was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography(PET/CT) scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals. | Zhong Yong Zewen Song Yongmao Zhou Tong Liu Zizhu Zhang Yanzhong Zhao Yang Chen Congjun Jin Xiang Chen Jianyun Lu Rui Han Pengzhou Li Xulong Sun Guohui Wang Guangqing Shi Shaihong Zhu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 13 |
| 2 | Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens,a natural waste recycler显示文摘The black soldier fly(BSF),Hermetia illucens(Diptera:Stratiomyidae),is renowned for its bioconversion of organic waste into a sustainable source of animal feed.We report a high-quality genome of 1.1 Gb and a consensus set of 16,770 gene models for this beneficial species.Compared to those of other dipteran species,the BSF genome has undergone a substantial expansion in functional modules related to septic adaptation,including immune system factors,olfactory receptors,and cytochrome P450s.We further profiled midgut transcriptomes and associated microbiomes of BSF larvae fed with representative types of organic waste.We find that the pathways related to digestive system and fighting infection are commonly enriched and that Firmicutes bacteria dominate the microbial community in BSF across all diets.To extend its potential practical applications,we further developed an efficient CRISPR/Cas9-based gene editing approach and implemented this to yield flightless and enhanced feeding capacity phenotypes,both of which could expand BSF production capabilities.Our study provides valuable genomic and technical resources for optimizing BSF lines for industrialization. | Shuai Zhan Gangqi Fang Minmin Cai Zongqing Kou Jun Xu Yanghui Cao Liang Bai Yixiang Zhang Yongmao Jiang Xingyu Luo Jian Xu Xia Xu Longyu Zheng Ziniu Yu Hong Yang Zhijian Zhang Sibao Wang Jeffery K.Tomberlin Jibin Zhang Yongping Huang | 2020 | Cell Research2020，30，1： | 9 |
| 3 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 4 | Neutron Capture Therapy (NCT) & In-Hospital Neutron Irradiator (IHNI)——a new technology on binary targeting radiation therapy of cancer显示文摘BNCT is finally becoming 'a new option against cancer'.The difficulties for its development progress of that firstly is to improve the performance of boron compounds,secondly,it is the requirements of quantification and accuracy upon radiation dosimetry evaluation in clinical trials.Furthermore,that is long anticipation on hospital base neutron sources.It includes dedicated new NCT reactor,accelerator based neutron sources,and isotope source facilities.In addition to reactors,so far,the technology of other types of sources for clinical trials is not yet completely proven.The In-Hospital Neutron Irradiator specially designed for NCT,based on the MNSR successfully developed by China,can be installed inside or near the hospital and operated directly by doctors.The Irradiator has two neutron beams for respective treatment of the shallow and deep tumors.It is expected to initiate operation in the end of this year.It would provide a safe,low cost,and effective treatment tool for the NCT routine application in near future. | Zhou Yongmao | 2009 | Engineering Sciences2009，7，4： | 6 |
| 5 | An isomorphism theorem for Teichmüller curves显示文摘It is proved that for any Fuchsian group Γ such that H/Γ is a hyperbolic Riemann surface, the Teichmüller curve V(Γ) has a unique complex manifold structure so that the natural projection of the Bers fiber space F(Γ) onto V(Γ) is holomorphic with local holomorphic sections.An isomorphism theorem for Teichmüller curves is deduced, which generalizes a classical result that the Teichmüller curve V(Γ) depends only on the type of Γ and not on the orders of the elliptic elements of Γ when H/Γ is a compact hyperbolic Riemann surface. | CAI Yongmao SHEN Yuliang | 2006 | Science China Mathematics2006，49，5： | 3 |
| 6 | Application of exosomes as liquid biopsy in clinical diagnosis显示文摘Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating tumor cells,extracellular vesicles,nucleic acids,and so forth.Exosomes are small extracellular vesicles with sizes between 30–150 nm.They are secreted by multivesicular bodies through exocytosis in live cells and can participate in intercellular communication due to their contents,including nucleic acids,proteins,and lipids.Herein,we investigate publication frequencies on exosomes over the past 10 years,and review recent clinical studies on liquid biopsy of exosomes in the fields of oncology,pregnancy disorders,cardiovascular diseases,and organ transplantation.We also describe the advantages of exosomes as an effective liquid biopsy tool and the progression of exosome extraction methods.Finally,we depict the commercial development of exosome research and discuss the future role of exosomes in liquid biopsy. | Biting Zhou Kailun Xu Xi Zheng Ting Chen Jian Wang Yongmao Song Yingkuan Shao Shu Zheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 7 | Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats显示文摘In this study, rat models of Parkinson's disease induced by substantia nigra injection of 6-hydroxy-dopamine were intragastrically administered Zhichan powder daily for 50 days. Reverse transcription PCR results showed that tyrosine hydroxylase mRNA expression in the rat substantia nigra was significantly increased, while monoamine oxidase B mRNA expression was significantly decreased in the Zhichan powder group, compared with the model group. In addition, the levels of striatal dopamine and homovanillic acid, the ratio of dopamine to homovanillic acid, and the activity of blood superoxide dismutase were all higher in the Zhichan powder group than in the model group, but the content of malondialdehyde in blood was lower. Our experimental findings indicate that Zhichan powder has an antioxidant effect, it can regulate the expression of monoamine oxidase B and tyrosine hydroxylase in the substantia nigra of Parkinson's disease rats, and it can facilitate the secretion of striatal dopamine and its metabolite homovanillic acid. | Qingwei Zhou Jiajun Chen Shihong Yi Yongwei Lou Weimin Tang Yongmao Liu Pengguo Zhang | 2012 | Neural Regeneration Research2012，7，27： | 2 |
| 8 | Advanced finite element analysis of a complex deep excavation case history in Shanghai显示文摘上海南方火车站的北方平方购物中心的构造是大规模建筑群自顶向下的深挖掘工程。挖掘邻近几根当前、最新计划的地铁线,并且由附近的交换车站挖掘影响。这挖掘的高度不规则的几何学极大地在 3D 增加复杂性有限元素建模。推进的数字建模在这描述了纸包括详细说明结构并且 geotechnical 行为。重要特征在分析被考虑,例如, 1 )土壤的小紧张的僵硬, 2 )在隔膜墙中的构造关节, 3 )收缩实际上地板平板和横梁, 4 )复杂构造序列,并且 5 )深挖掘的形状效果。数字结果与地数据,和某贵重物品同意结论被产生很好。 | Yuepcng DONG Harvey BURD Guy HOULSBY Yongmao HOU | 2014 | Frontiers of Structural and Civil Engineering2014，8，1： | 2 |
| 9 | A Method for OLED Test显示文摘Several important parameters of the OLED were analyzed in this paper, a testing method based on the CCD was propounded and how to improve the performance of this system were also disserted. | Yongmao Feng, Tiefu Ding Changchun Institute of Optics fine Mechanics and Physics, CAS, P. R. China, Tel: 86-431-4627053 | 2003 | 光学学报2003，23，S1： | 2 |
| 10 | Discrimination of brownheart of Korla pear using vibration frequency spectrum technique显示文摘The purpose of this work was to use a nondestructive method for detecting the brownheart of Korla pear to reduce the chance of infection among pears without brownheart.A mechanical impulse method based on vibration testing system was used to excite the fruits.The consistent acquisition signal indicated that the test is repeatable at the same positions of fruit equator(cheek).A remarkable frequency signal was excited at 9-12 N force by a rubber tipped hammer.The dominant frequency was identified at the maximum response magnitude to assess the internal defect,and the result was not influenced by the distances between the defect borders and the excitation points.The sharp increase of defect mass could significantly affect the dominant frequency.Relationship between the dominant response frequency(fd)and the defect mass percentage(ω)was characterized by an equation fd=410.649e-0.0833ω+261.947 with a good correlation coefficient(R2=0.925).A defect mass of 2.281%was determined as a discrimination threshold.Once the threshold exceeded 2.281%,the defective pear could be classified with a high accuracy rate of 96.7%.This finding would provide guidance for determining the optimal detecting time to the brownheart of Korla pears,according to the specific storage conditions when the vibration frequency spectrum method is deployed. | Xu Hubo Wu Jie Wang Zhaopeng Gao Yongmao Wang Zhipeng Zhao Zhengqiang | 2017 | International Journal of Agricultural and Biological Engineering2017，10，2： | 1 |
| 11 | Performance monitoring of processes with multiple operating modes through multiple PLS models显示文摘 | Zhao Shijian Zhang Jie Xu Yongmao | 2006 | Journal of Process Control2006，16，7： | 1 |
| 12 | Per formance Comparison of UDP based Protocols over Fast Long Distance Network显示文摘 | Ren Yongmao Tang Haina Li Jun | 2009 | Information Technology Journal2009，8，60： | 1 |
| 13 | Mechanism of Action of Camptothecin显示文摘 | LEROY F.LIU SHYAMAL D.DESAI TSAI‐KUNLI YONGMAO MEISUN SAI‐PENGSIM | 2006 | Annals of the New York Academy of Sciences2006，，1： | 1 |
| 14 | Comparison of Inhibitor MCI and NANO2 in Carbonation-lnduced Corrosion显示文摘 | Xu Yongmao She Hailong | 2004 | Material Performance2004，1，： | 1 |
| 15 | Stress-induced butterfly and square-like magnetostriction loops transition显示文摘The stress-induced magnetic domain switching in Fe Ga thin films is studied using phase-field method.In particular,the magnetic field is applied along the [110] direction and biaxial stresses are applied along[100] and [010].A compressive pre-stress corresponds to a smaller coercive magnetic field while a tensile pre-stress corresponded to a larger coercive field.At the same time,it is also found that the transition between butterfly and square-like magnetostriction loops occurs at the critical opposite biaxial stress state.The two different evolutions correspond to two different mechanisms:one is that the single domain swings across a fan area back and forth;the other is that the single domain turns a clockwise circle.The results can be explained by the stress tuned anisotropy energy well. | Zengyao Lv Honglong Zhang Chao Zhang Yongmao Pei | 2017 | Theoretical & Applied Mechanics Letters2017，7，2： | 1 |
| 16 | A Study on Nanoscale Infrared Absorbent Working in Waveband Range of 1300-400 cm^(-1)显示文摘Nanoscale powder of SiO_2/Al_2O_3/TiO_2 composite was prepared by sol-gel method.Microstructure and mor- phology of the obtained samples were characterized by infrared(IR),X-ray diffraction(XRD)analysis and transmission electron microscopy(TEM).It is proved that infrared absorbing peaks of the samples are in waveband range of 1300-400 cm^(-1),and the peak shape changes with their component.Mechanism of the in- frared peak's positions and shapes which changes with the size and morphology of the prepared nano-particles has been tentatively discussed. | Yongmao HU Jinzhong XIANG Xueqing ZHANG Ruheng LI Xinghui WU | 2008 | Journal of Materials Science & Technology2008，24，5： | 1 |
| 17 | Performance monitoring of processes with multiple operating modes through multiple PLS models显示文摘 | Zhao Shijian Zhang Jie Xu Yongmao | 2006 | Journal of Process Control2006，16，7： | 1 |
| 18 | Monitoring of processes with multiple operating modes through multiple principle component analysis models显示文摘 | ZHAO Shijian ZHANG Jie XU Yongmao | 2004 | Industrial & Engineering Chemistry Research2004，43，22： | 1 |
| 19 | Monitoring of processes with multiple operating modes through multiple principal component analysis models显示文摘 | ZHAO Shijian ZHANG Jie XU Yongmao | 2004 | Industrial and Engineering Chemistry Research2004，43，22： | 1 |
| 20 | Performance monitoring of processes with multiple operating modes through multiple PLS models 显示文摘 | ZHAO Shijian ZHANG Jie XU Yongmao | 2006 | Journal of Process Control2006，16，7： | 1 |
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