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| 1 | Effect of Xiaoaiping injection on advanced hepatocellular carcinoma in patients显示文摘OBJECTIVE: To investigate the effect of Xiaoaiping Injection (XAP) on advanced hepatocellular carcinoma (HCC) in patients. METHODS: Sixty-eight patients with advanced HCC were assigned to a control group of 36 and a treatment group of 32.The control group was treated with best supportive treatment (BST) and the treatment group was given XAP plus BST. XAP was administered daily by iv and the treatment course was lasted for 30 days for both groups.The immediate therapeutic efficacy, Karnofsky performance status (KPS) scores, and the changes in immunity indicators (CD3+, CD4+ and CD8+ T cells) were measured and compared before and after treatment. The progression-free survival (PFS) rate and overall survival (OS) rate in the 2 groups were analyzed. RESULTS: The immediate therapeutic efficacy and KPS of the treatment group were better than those in the control group (P<0.05). Patients in the treat-ment group had higher percentages of CD3 and CD4 T-lymphocytes in peripheral blood than those in the control group (P<0.05). The median survival time was 27.0 weeks in the treatment group and 24.5 weeks in the control group. The 6-months cumulative survival rates in the treatment and control groups were 33.3% and 25.0% , respectively, with no significant difference (P>0.05). The PFS was 18 weeks in the treatment group and 15 weeks in control group (P<0.05). CONCLUSION: XAP enhances the quality of life (QOL) of patients with advanced HCC, improves their immunity and extends their PFS. | Zhengrong Huang Yong Wang Jiajun Chen Rongping Wang Qiang Chen | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 22 |
| 2 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 3 | Analysis of the global T_m–T_s correlation and establishment of the latitude-related linear model显示文摘In this study,the correlation between Tm,a key variable in GNSS water vapor inversion,and surface temperature(Ts)was calculated on a global scale based on the global geodetic observing system(GGOS)atmosphere Tmdata and European centre for medium-range weather forecasts(ECMWF)surface temperature data.The results show that their correlation is mainly affected by latitudes,and the correlation is stronger at high latitudes and weaker at low latitudes.Although the correlation is relatively weak in the tropic areas,the temperature changes so little in a year in these areas that we can still achieve good Tmresults by linear regression model.Based on these facts,‘‘GGOS atmosphere’’Tmdata and ECMWF Tsdata from 2005 to2011 were used to establish the global latitude-related linear regression model.The new model has root mean square error(RMSE)of 3.2,3.3,and 4.4 K,respectively,compared with respect to the‘‘GGOS atmosphere’’data,COSMIC data,and radiosonde data and is more accurate than the Bevis Tm–Tsrelationship. | Yibin Yao Bao Zhang Chaoqian Xu Jiajun Chen | 2014 | Chinese Science Bulletin2014，59，19： | 14 |
| 4 | Enhanced flushing of polychlorinated biphenyls contaminated sands using surfactant foam: Effect of partition coefficient and sweep efficiency显示文摘Foam flushing is an in situ soil remediation technology based on the traditional surfactant flushing method. The contribution of mobility control to contaminant removal by foam is helpful for improving this technology. Foam flushing of polychlorinated biphenyl (PCB)- contaminated unconsolidated media was performed to evaluate the effect of the partition coefficient (PC) and sweep efficiency (SE) on PCB removal. Column flushing with surfactant solution and foam with different types and concentrations of surfactant was carried out for PCB removal. Two types of quartz sand were investigated to evaluate the Jamin effect on the SE value of the washing agent. The results demonstrate that a small PC value and large SE value are necessary to achieve high PCB removal for foam flushing. Compared with solution flushing, the introduction of foam can effectively control the mobility of the washing agent. Similar to solution flushing, solubilization is a key factor which dominates the removal of PCBs in foam flushing. In addition, the SE value and PCB removal by foam flushing is less affected by particle size. Therefore, foam flushing was proved to be more effective in porous media with low hydraulic conductivity and high porosity. An integrated flushing with water, surfactant solution and foam was performed and the results prove that this technology successfully combines the advantages of solution solubilization and mobility control by foam, and thus further increases the remediation efficiency of PCBs to 94.7% for coarse sand. | Hao Wang Jiajun Chen | 2012 | Journal of Environmental Sciences2012，24，7： | 13 |
| 5 | The mechanism of astragaloside Ⅳ promoting sciatic nerve regeneration显示文摘3-O-beta-D-xylopyranosyl-6-O-beta-D-glucopyranosyl-cycloastragenol (astragaloside Ⅳ), the main active component of the traditional Chinese medicine astragalus membranaceus, has been shown to be neuroprotective. This study investigated whether astragaloside Ⅳ could promote the repair of injured sciatic nerve. Denervated sciatic nerve of mice was subjected to anastomosis. The mice were intraperitoneally injected with 10, 5, 2.5 mg/kg astragaloside Ⅳ per day for 8 consecutive days. Western blot assay and real-time PCR results demonstrated that growth-associated protein-43 expression was upregulated in mouse spinal cord segments L4-6 after intervention with 10, 5, 2.5 mg/kg astragaloside Ⅳ per day in a dose-dependent manner. Luxol fast blue staining and electrophysiological detection suggested that astragaloside Ⅳ elevated the number and diameter of myelinated nerve fibers, and simultaneously increased motor nerve conduction velocity and action potential amplitude in the sciatic nerve of mice. These results indicated that astragaloside Ⅳ contributed to sciatic nerve regeneration and functional recovery in mice. The mechanism underlying this effect may be associated with the upregulation of growth-associated protein-43 expression. | Xiaohong Zhang Jiajun Chen | 2013 | Neural Regeneration Research2013，8，24： | 13 |
| 6 | S and Pb Isotopic Constraints on the Relationship between the Linong Granodiorite and the Yangla Copper Deposit,Yunnan,China显示文摘The Yangla copper deposit, located in western Yunnan Province, China, is a typical giant, newly started mining copper deposit with an estimated Cu reserves of about 1,200,000 tons. The deposit is spatially and temporally associated with the Linong granodiorite, which is rich in SiO2 (SiO2=58.25 wt%-69.84 wt%) and alkalis (Na2O+K2O=5.98 wt%-8.34 wt%), indicating an association with shoshonitic series to high-K calc-alkaline series granites, and shows low contents of TiO2 (0.35 wt%-0.48 wt%), MgO (1.51 wt%-1.72 wt%), and Al2O3 (13.38 wt%-19.75 wt%). The δ34S values of sulfides of the main ore stage from copper ores vary range from ?4.2‰ to ?0.9‰, indicating a much greater contribution from the mantle to the ore-forming fluids. The δ34S values of the late ore stage is 9.8‰, indicating enrichment of biogenic sulfur which may derive from the crustal hydrothermal fluid. The 208Pb/204Pb, 207Pb/204Pb and 206Pb/204Pb of sulfides of the main ore stage from copper ores range within 38.66-38.73, 15.71-15.74 and 18.35-19.04, respectively, implying that the Pb was derived from the mantle, with the crustal component, probably representing mixtures of mantle lead and crustal lead. Sulfide of the late ore stage in their Pb isotopic composition, 208Pb/204Pb= 38.69, 207Pb/204Pb=15.70, 206Pb/204Pb=18.35, implying that the Pb was derived from the crust. The Linong granodiorite is syn-collisional, produced by partial melting of thickened lower crust, which was triggered by the westward subduction of the Jinshajiang Oceanic plate. During a transition in geodynamic setting from collision-related compression to extension, gently dipping ductile shear zones (related to subduction) were transformed to brittle shear zones, consisting of a series of thrust faults in the Jinshajiang tectonic belt. The tensional thrust faults would have been a favorable environment for ore-forming fluids. The ascending magma provided a channel for the ore-forming fluid from the mantle wedge. After the magma arrived at the base of the early-stage Linong granodiorite, the platy granodiorite at the base of the body would have shielded the late-stage magma from the fluid. The magma would have cooled slowly, and some of the ore-forming fluid in the magma would have entered the gently dipping thrust faults near the Linong granodiorite, resulting in mineralization. | YANG Xi'an LIU Jiajun HAN Siyu WANG Huan CHEN Siyao | 2012 | Acta Geologica Sinica(English Edition)2012，86，6： | 9 |
| 7 | Use of acupuncture to treat cerebral infarction in the last 10 years A Scopus-based literature analysis显示文摘OBJECTIVE: To identify global research trends in the use of acupuncture to treat cerebral infarction. DATA RETRIEVAL: We performed a bibliometric analysis of studies on the use of acupuncture to treat cerebral infarction published during 2002-2011, retrieved from Scopus, using the Key Words of acupuncture and cerebral infarction or ischemic stroke. SELECTION CRITERIA: Inclusion criteria: peer-reviewed articles on the use of acupuncture to treat cerebral infarction indexed in Scopus and published between 2002 and 2011; types of publications were original research articles, reviews, meeting abstracts, proceedings papers, book chapters, editorial material, and news items. Exclusion criteria: articles that required manual searching or telephone access; documents that were not published in the public domain; and corrected papers. MAIN OUTCOME MEASURES: (a) Annual publication output; (b) language of publication; (c) type of publication; (d) key words of publication; (e) publication by research field; (f) publication by journal; (g) publication by country and institution; (h) publication by author; (i) most-cited papers between 2002 and 2006; and (j) most-cited papers between 2007 and 2011. RESULTS: A total of 160 publications on the use of acupuncture to treat cerebral infarction from 2002-2011 were retrieved from Scopus. The number of publications increased gradually over the 10-year study period; most were written in Chinese or English. Articles and reviews constituted the major types. The most frequent key word used was acupuncture. The most prolific journals in this area were Zhongguo Zhen Jiu and the Chinese Journal of Clinical Rehabilitation. Of the 160 publications retrieved, half came from Chinese authors and institutions. Tianjin University of Traditional Chinese Medicine was the most prolific research institute. Two papers were cited 30 times; they were published in 2002 and 2009, respectively. CONCLUSION: In the field of neuroscience, there is little literature on acupuncture for cerebral infarction. The most-cited papers were cited 30 times in the past 3 years. We believe that, with advances in the study of mechanisms in neurobiology, research on acupuncture will also advance and will become the concern of more scholars. | Jiajun Chen Min Yao Yunhua Zhao Xiya Jin Yuanbing Li Lihong Huang | 2012 | Neural Regeneration Research2012，7，36： | 7 |
| 8 | Thermal Shock-Activated Spontaneous Growing of Nanosheets for Overall Water Splitting显示文摘Nanomaterials based on nickel foam(NF) have been widely applied in energy conversion and storage field.Traditional synthesis methods such as hydrothermal method which is dangerous and high cost limited the scalable developments.Herein,we report a fast,simple,and low-cost synthesis method of nanomaterials based on NF by Joule-heating and water soaking treatment.Thin carbon-coated CoS on NF(NF-C/CoS) was synthesized by Joule-heating for a few seconds with rapid cooling.And then,NF-C/CoS/NiOOH with core-shell heterostructure was fabricated by soaking treatment of NF-C/CoS in water on which NiOOH nanosheets grew spontaneously.The formation mechanism is proposed that the coordination complex precursor converts into C/CoS on NF driven by Joule-heating,and the nickel on the surface of NF is activated to form metastable nickel simultaneously.The metastable nickel reacting with water leads to the formation of NiOOH,and the induction of CoS makes NiOOH grow continuously.This synthesis technology provides a new route to manufacture NF-based nanostructures,and the as-fabricated NF-C/CoS/NiOOH exhibits great potential as electrocatalyst for oxygen evolution reaction and hydrogen evolution reaction. | Han Wu Qi Lu Jinfeng Zhang Jiajun Wang Xiaopeng Han Naiqin Zhao Wenbin Hu Jiajun Li Yanan Chen Yida Deng | 2020 | Nano-Micro Letters2020，12，11： | 6 |
| 9 | NSHV trajectory prediction algorithm based on aerodynamic acceleration EMD decomposition显示文摘Aiming at the problem of gliding near space hypersonic vehicle(NSHV)trajectory prediction,a trajectory prediction method based on aerodynamic acceleration empirical mode decomposition(EMD)is proposed.The method analyzes the motion characteristics of the skipping gliding NSHV and verifies that the aerodynamic acceleration of the target has a relatively stable rule.On this basis,EMD is used to extract the trend of aerodynamic acceleration into multiple sub-items,and aggregate sub-items with similar attributes.Then,a prior basis function is set according to the aerodynamic acceleration stability rule,and the aggregated data are fitted by the basis function to predict its future state.After that,the prediction data of the aerodynamic acceleration are used to drive the system to predict the target trajectory.Finally,experiments verify the effectiveness of the method.In addition,the distribution of prediction errors in space is discussed,and the reasons are analyzed. | LI Fan XIONG Jiajun LAN Xuhui BI Hongkui CHEN Xin | 2021 | Journal of Systems Engineering and Electronics2021，32，1： | 6 |
| 10 | Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrinα2β1显示文摘Exosomes play critical roles in regulating various physiological and pathological processes,including immune stimulation,immune suppression,cardiovascular diseases,and cancers.Recent studies show that exosomes that transport specific microRNAs(miRNAs)are involved in tumor development.However,the molecular mechanism by which tumor invasion and migration are regulated by exosomes from non-small cell lung cancer(NSCLC)is not well understood.Here,we show that exosomes shuttling low levels of miR-34c-3p are involved in NSCLC progression.Our results showed that exosomes derived from NSCLC cells carrying low levels of miR-34c-3p could be transported into the cytoplasm of NSCLC cells and accelerate NSCLC invasion and migration by upregulating integrinα2β1.A luciferase assay revealed that integrinα2β1 was the direct target of miR-34c-3p,and overexpression of integrinα2β1 could promote the invasion and migration of NSCLC cells.The analysis of exosomes derived from clinical serum samples indicated that the expression of miR-34c-3p was significantly downregulated in exosomes from NSCLC patients compared with that of normal controls.A549-derived exosomes promoted NSCLC cells lung metastases in vivo.Exosomes shuttling low levels of miR-34c-3p were associated with the progression of NSCLC in vitro and in vivo.Our data demonstrate that exosomes shuttling low levels of miR-34c-3p can accelerate the invasion and migration of NSCLC by upregulating integrinα2β1.MiR-34c-3p can be a diagnostic and prognostic marker for NSCLC.High expression of integrinα2β1 is positively related to the migration and metastasis of NSCLC cells. | Wenjing Huang Yanyan Yan Yun Liu Minting Lin Jinxiang Ma Wei Zhang Jianwei Dai Jiajun Li Qiaoru Guo Hubiao Chen Bolat Makabel Hong Liu Chaoyue Su Hong Bi Jianye Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 11 | Research progress on hydrothermal dissolution and hydrolysis of lignocellulose and lignocellulosic waste显示文摘 | Yan ZHAO Wenjing LU Jiajun CHEN Xiangfeng ZHANG Hongtao WANG | 2014 | Frontiers of Environmental Science & Engineering2014，8，2： | 5 |
| 12 | Namib desert beetle inspired special patterned fabric with programmable and gradient wettability for efficient fog harvesting显示文摘Efficient collection of water from fog provides a potential solution to solve the global freshwater shortage problem, particularly in the desert or arid regions. In this work, a flexible and highly efficient fog collector was prepared by mimicking the back exoskeleton structure of the Namib desert beetle. The improved fog collector was constructed by a superhydrophobic-superhydrophilic patterned fabric via a simple weaving method, followed by in-situ deposition of copper particles. Compared with the conventional fog collector with a plane structure, the fabric has shown a higher water-harvesting rate at 1432.7 mg/h/cm2,owing to the biomimetic three-dimensional structure, its enhanced condensation performance enabled by the copper coating and the rational distribution of wetting units. The device construction makes use of the widely available textile materials through mature manufacturing technology, which makes it highly suitable for large-scale industrial production. | Zhihua Yu Huimei Zhang Jianying Huang Shuhui Li Songnan Zhang Yan Cheng Jiajun Mao Xiuli Dong Shouwei Gao Shanchi Wang Zhong Chen Yaoxing Jiang Yuekun Lai | 2021 | Journal of Materials Science & Technology2021，，2： | 5 |
| 13 | Accelerating DNN-based 3D point cloud processing for mobile computing显示文摘3D point cloud data,which are produced by various 3D sensors such as LIDAR and stereo cameras,have been widely deployed by industry leaders such as Google,Uber,Tesla,and Mobileye,for mobile robotic applications such as autonomous driving and humanoid robots.Point cloud data,which are composed of reliable depth information,can provide accurate location and shape characteristics for scene understanding,such as object recognition and semantic segmentation.However,deep neural networks(DNNs),which directly consume point cloud data,are particularly computation-intensive because they have to not only perform multiplication-and-accumulation(MAC)operations but also search neighbors from the irregular 3D point cloud data.Such a task goes beyond the capabilities of general-purpose processors in realtime to figure out the solution as the scales of both point cloud data and DNNs increase from application to application.We present the first accelerator architecture that dynamically configures the hardware onthe-fly to match the computation of both neighbor point search and MAC computation for point-based DNNs.To facilitate the process of neighbor point search and reduce the computation costs,a grid-based algorithm is introduced to search neighbor points from a local region of grids.Evaluation results based on the scene recognition and segmentation tasks show that the proposed design harvests 16.4x higher performance and saves 99.95%of energy than an NVIDIA Tesla K40 GPU baseline in point cloud scene understanding applications. | Bosheng LIU Xiaoming CHEN Yinhe HAN Jiajun LI Haobo XU Xiaowei LI | 2019 | Science China(Information Sciences)2019，62，11： | 4 |
| 14 | An energy conduction model for cell image segmentation显示文摘Cell image segmentation is an essential step in cytopathological analysis.Although their execution speed is fast,the results of cell image segmentation by conventional pixel-based,edge-based and continuity-based methods are often coarse.Fine structures in a cell image can be obtained with a method that quickly adjusts the threshold levels.However,the processing time of such a method is usually long and the final results may be sensitive to intensity differences and other factors.In this article,a new energy model is proposed that synthesizes a differential equation from the conventional and level set methods,and utilizes the nonuniformity property of cell images (e.g.cytoplasms are more uneven than the background).The feasibility and robustness of the proposed model was demonstrated by processing relatively complicated background images of both simulated and real cell images. | MA JingFeng BU JiaJun HOU Kai BAO ShangLian CHEN Chun | 2011 | Chinese Science Bulletin2011，56，10： | 4 |
| 15 | Defect passivation of CsPbI2Br perovskites through Zn(Ⅱ) doping:toward efficient and stable solar cells显示文摘Defect passivation is an important strategy to achieve perovskite solar cells(PVSCs) with enhanced power conversion efficiencies(PCEs) and improved stability because the trap states induced by defects in the interfaces and grain boundaries of perovskites are harmful to both large open circuit voltage and high photocurrent of devices. Here, zinc cations(Zn^2+) were used as a dopant to passivate defects of the CsPbI2Br perovskite leading to Zn^2+-doped CsPbI2Br film with fewer trap states, improved charge transportation, and enhanced light-harvesting ability. Thus, the best-performance PVSC based on CsPbI2 Br with the optimal Zn^2+doping shows a higher PCE of 12.16% with a larger open-circuit voltage(VOC) of 1.236 V, an improved shortcircuit current(JSC) of 15.61 mA cm^-2 in comparison with the control device based on the pure CsPbI2Br which exhibits a PCE of 10.21% with a VOCof 1.123 V, a JSCof 13.27 mA cm^-2. Time-resolved photoluminescence results show that the Zn^2+doping leads to perovskite film with extended photoluminescence lifetime which means a longer diffusion length and subsequently enhanced photocurrent and open circuit voltage. This work provides a simple strategy to boost the performance of PVSCs through Zn^2+doping. | Jiajun Lu Shan-Ci Chen Qingdong Zheng | 2019 | Science China Chemistry2019，62，8： | 4 |
| 16 | Enabling Energy Efficiency in 5G Network显示文摘The mobile Internet and Internet of Things are considered the main driving forc⁃es of 5G,as they require an ultra-dense deployment of small base stations to meet the in⁃creasing traffic demands.5G new radio(NR)access is designed to enable denser network deployments,while leading to a significant concern about the network energy consump⁃tion.Energy consumption is a main part of network operational expense(OPEX),and base stations work as the main energy consumption equipment in the radio access network(RAN).In order to achieve RAN energy efficiency(EE),switching off cells is a strategy to reduce the energy consumption of networks during off-peak conditions.This paper intro⁃duces NR cell switching on/off schemes in 3GPP to achieve energy efficiency in 5G RAN,including intra-system energy saving(ES)scheme and inter-system ES scheme.Addition⁃ally,NR architectural features including central unit/distributed unit(CU/DU)split and dual connectivity(DC)are also considered in NR energy saving.How to apply artificial in⁃telligence(AI)into 5G networks is a new topic in 3GPP,and we also propose a machine learning(ML)based scheme to save energy by switching off the cell selected relying on the load prediction.According to the experiment results in the real wireless environment,the ML based ES scheme can reduce more power consumption than the conventional ES scheme without load prediction. | LIU Zhuang GAO Yin LI Dapeng CHEN Jiajun HAN Jiren | 2021 | ZTE Communications2021，19，1： | 4 |
| 17 | High-performance oxygen reduction and evolution carbon catalysis: From mechanistic studies to device integration显示文摘能容易集成于存在的高效、便宜的氧减小和进化催化剂的发展设备为利用 O 2-H2 O 化学,例如再生燃料房间和金属空气电池。此处,我们报导 NH 3-activated 做 N 的层次碳(NHC ) 催化剂经由一条可伸缩的线路综合了,并且表明它的设备集成。NHC 催化剂为氧减小反应(ORR ) 和氧进化反应(OER ) 展出了好性能,当综合时,借助于电气化学的研究和评估示威了进一个再生燃料房间的氧电极。为 ORR 和 OER 观察的活动比得上最先进的磅和红外催化剂在碱的环境完成的那些。我们进一步通过密度为电气化学的活动作为活跃地点识别了碳缺点的关键角色功能的理论计算和高分辨率的 TEM 可视化。这个工作加亮 NHC 的潜力在再生燃料房间并且可能代替商业宝贵金属为断断续续的可更新的精力的划算的存储的金属空气电池。 | John W. F. To Jia Wei Desmond Ng Samira Siahrostami Ai Leen Koh Yangjin Lee Zhihua Chen Kara D. Fong Shucheng Chen Jiajun He Won-Gyu Bae Jennifer Wilcox Hu Young Jeong Kwanpyo Kim Felix Studt Jens K. Nфrskov Thomas F. Jaramillo Zhenan Bao | 2017 | Nano Research2017，10，4： | 4 |
| 18 | Synergistic effects of immunoregulation and osteoinduction of ds-block elements on titanium surface显示文摘Ds-block elements have been gaining increasing attention in the field of biomaterials modification,owing to their excellent biological properties,such as antibiosis,osteogenesis,etc.However,their function mechanisms are not well understood and conflicting conclusions were drawn by previous studies on this issue,which are mainly resulted from the inconsistent experimental conditions.In this work,three most widely used ds-block elements,copper,zinc,and silver were introduced on titanium substrate by plasma immersion ion implantation method to investigate the rule of ds-block elements in the immune responses.Results showed that the implanted samples could decrease the inflammatory responses compared with Ti sample.The trend of anti-inflammatory effects of macrophages on samples was in correlation with cellular ROS levels,which was induced by the implanted biomaterials and positively correlated with the number of valence electrons of ds-block elements.The co-culture experiments of macrophages and bone marrow mesenchymal stem cells showed that these two kinds of cells could enhance the anti-inflammation and osteogenesis of samples by the paracrine manner of PGE2.In general,in their steady states on titanium substrate(Cu2+,Zn2+,Ag),the ds-block elements with more valence electrons exhibit better anti-inflammatory and osteogenic effects.Moreover,molecular biology experiments indicate that the PGE2-related signaling pathway may contribute to the desired immunoregulation and osteoinduction capability of ds-block elements.These findings suggest a correlation between the number of valence electrons of ds-block elements and the relevant biological responses,which provides new insight into the selection of implanted ions and surface design of biomaterials. | Lan Chen Donghui Wang Jiajun Qiu Xianming Zhang Xingdan Liu Yuqin Qiao Xuanyong Liu | 2021 | Bioactive Materials2021，6，1： | 3 |
| 19 | MoS_2 decorated lignin-derived hierarchical mesoporous carbon hybrid nanospheres with exceptional Li-ion battery cycle stability显示文摘Lignin is the most abundant and important macromolecule in organic matter and its yield is second only to cellulose. Lignin is abundant in source, low in price, and has a large number of active groups such as methoxy group and carboxyl group, so it has great utilization value. We used lignin as a carbon source to prepare porous carbon nanosphere(PCN) materials, and in-situ synthesized the MoS_ 2 on its surface. The high specific surface area(462.8 m^2/g), large pore volume and good electron conductivity of the porous carbon scaffold facilitated the reversible electro-chemical reaction of S towards metallic Li, and thus the nano-hybrid showed a high specific energy and excellent cycle stability which still remained 520m Ah/g after 50 cycles. | Feng Chen Long Wu Zeping Zhou Jiajun Ju Zhengping Zhao Mingqiang Zhong Tairong Kuang | 2019 | Chinese Chemical Letters2019，30，1： | 3 |
| 20 | Numerical modeling of radionuclide migration in porous media with nonequilibrium sorption显示文摘Numericalmodelingofradionuclidemigrationinporousmediawithnonequilibriumsorption￥ChenJiajun;DaiJie(DepartmentofEnvironmentalEn... | Chen Jiajun Dai Jie(Department of Environmental Engineering,Tsinghua University,Beijing 100084,China)(Tianjin Institute of Geological Investigation and Research,Tianjin 300191,China)Xu Zhaoyi Tian Kaiming(Changchun University of Earth Sciences,Changchun 1 | 1996 | Journal of Environmental Sciences1996，8，1： | 3 |
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