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| 1 | Preoperative diagnosis of malignant pulmonary nodules in lung cancer screening with a radiomics nomogram显示文摘Background:Lung cancer is the most commonly diagnosed cancer worldwide.Its survival rate can be significantly improved by early screening.Biomarkers based on radiomics features have been found to provide important physiological information on tumors and considered as having the potential to be used in the early screening of lung cancer.In this study,we aim to establish a radiomics model and develop a tool to improve the discrimination between benign and malignant pulmonary nodules.Methods:A retrospective study was conducted on 875 patients with benign or malignant pulmonary nodules who underwent computed tomography(CT)examinations between June 2013 and June 2018.We assigned 612 patients to a training cohort and 263 patients to a validation cohort.Radiomics features were extracted from the CT images of each patient.Least absolute shrinkage and selection operator(LASSO)was used for radiomics feature selection and radiomics score calculation.Multivariate logistic regression analysis was used to develop a classification model and radiomics nomogram.Radiomics score and clinical variables were used to distinguish benign and malignant pulmonary nodules in logistic model.The performance of the radiomics nomogram was evaluated by the area under the curve(AUC),calibration curve and Hosmer-Lemeshow test in both the training and validation cohorts.Results:A radiomics score was built and consisted of 20 features selected by LASSO from 1288 radiomics features in the training cohort.The multivariate logistic model and radiomics nomogram were constructed using the radiomics score and patients’age.Good discrimination of benign and malignant pulmonary nodules was obtained from the training cohort(AUC,0.836;95%confidence interval[CI]:0.793-0.879)and validation cohort(AUC,0.809;95%CI:0.745-0.872).The Hosmer-Lemeshow test also showed good performance for the logistic regression model in the training cohort(P=0.765)and validation cohort(P=0.064).Good alignment with the calibration curve indicated the good performance of the nomogram.Conclusions:The established radiomics nomogram is a noninvasive preoperative prediction tool for malignant pulmonary nodule diagnosis.Validation revealed that this nomogram exhibited excellent discrimination and calibration capacities,suggesting its clinical utility in the early screening of lung cancer. | Ailing Liu Zhiheng Wang Yachao Yang Jingtao Wang Xiaoyu Dai Lijie Wang Yuan Lu Fuzhong Xue | 2020 | Cancer Communications2020，40，1： | 22 |
| 2 | Generation of arbitrary vector vortex beams on hybrid-order Poincaré sphere显示文摘We propose theoretically and verify experimentally a method of combining a q-plate and a spiral phase plate to generate arbitrary vector vortex beams on a hybrid-order Poincaré sphere. We demonstrate that a vector vortex beam can be decomposed into a vector beam and a vortex, whereby the generation can be realized by sequentially using a q-plate and a spiral phase plate. The generated vector beam, vortex, and vector vortex beam are verified and show good agreement with the prediction. Another advantage that should be pointed out is that the spiral phase plate and q-plate are both fabricated on silica substrates, suggesting the potential possibility to integrate the two structures on a single plate. Based on a compact method of transmissive-type transformation, our scheme may have potential applications in future integrated optical devices. | Zhenxing Liu Yuanyuan Liu Yougang Ke Yachao Liu Weixing Shu Hailu Luo Shuangchun Wen | 2017 | Photonics Research2017，5，1： | 18 |
| 3 | Giant photonic spin Hall effect in momentum space in a structured metamaterial with spatially varying birefringence显示文摘The photonic spin Hall effect(SHE)in the reflection and refraction at an interface is very weak because of the weak spin-orbit interaction.Here,we report the observation of a giant photonic SHE in a dielectric-based metamaterial.The metamaterial is structured to create a coordinate-dependent,geometric Pancharatnam–Berry phase that results in an SHE with a spin-dependent splitting in momentum space.It is unlike the SHE that occurs in real space in the reflection and refraction at an interface,which results from the momentum-dependent gradient of the geometric Rytov–Vladimirskii–Berry phase.We theorize a unified description of the photonic SHE based on the two types of geometric phase gradient,and we experimentally measure the giant spin-dependent shift of the beam centroid produced by the metamaterial at a visible wavelength.Our results suggest that the structured metamaterial offers a potential method of manipulating spin-polarized photons and the orbital angular momentum of light and thus enables applications in spin-controlled nanophotonics. | Xiaohui Ling Xinxing Zhou Xunong Yi Weixing Shu Yachao Liu Shizhen Chen Hailu Luo Shuangchun Wen Dianyuan Fan | 2015 | Light(Science & Applications)2015，4，1： | 15 |
| 4 | Time-frequency characteristics based motion estimation and imaging for high speed spinning targets via narrowband waveforms显示文摘This paper focuses on the motion parameters estimation and inversed synthetic aperture radar (ISAR) imaging for the high-speed spinning targets via the time-frequency characteristics. Assuming that the translational motion is compensated with the available motion compensation techniques, then the residual part of translational motion and the spinning motion are estimated with high precision based on the timefrequency characteristics. Combining with the procedure of the motion estimation, a novel coherent timefrequency spectrum intensity redistribution method, coherent single range Doppler interferometry (CSRDI), is proposed, which provides higher resolution and sustain lower signal to noise rate (SNR) than the current approach. Numerical simulation confirms the validity and high precision of the proposed approaches. | ZHANG Lei , LI YaChao, LIU Yan, XING MengDao & BAO Zheng National Lab for Radar Signal Processing, Xidian University, Xi’an 710071, China | 2010 | Science China(Information Sciences)2010，53，8： | 9 |
| 5 | 热处理对SLM成形的Inconel 718合金组织的影响显示文摘研究了固溶+双级时效处理对激光选区熔化(SLM)工艺制备的Inconel 718高温合金微观组织形态和析出相的影响。结果表明,SLM沉积态合金为椭圆状晶组织,其由细小柱状晶组成。沉积态合金经固溶处理后转变成等轴细晶组织,且随固溶温度升高,晶粒尺寸增大。经固溶+双级时效处理后,合金会在晶界和晶内析出多种析出相,在940~1 020℃固溶过程中晶界析出短棒状δ相(Ni3Nb),在620~720℃时效过程中晶内析出针状δ、圆盘状γ″(Ni3Nb)和黑点状γ′相(Ni3Al,Ti)。 | 邓晓阳 鲁世强 Wang Yachao Shi Jing 欧阳德来 | 2017 | 特种铸造及有色合金2017，37，8： | 9 |
| 6 | Preparation of ternary Cr_2 O_3-SiC-TiO_2 composites for the photocatalytic production of hydrogen显示文摘Novel ternary Cr 2 O 3 -SiC-TiO 2 composites were synthesized by implanting Cr 3+ into SiC-TiO 2 via sol-gel and impregnation approaches. The results from X-ray diffraction, scanning electron microscopy and trans- mission electron microscopy show that the Cr 3+ species were doped onto the surface of the SiC-TiO 2 carrier. The diffuse reflectance ultraviolet-visible absorption spectra revealed that the absorption edges of the ternary Cr 2 O 3 -SiC-TiO 2 composites were gradually shifted red with increasing chromium content. The luminescence intensities of the composites decreased with increasing doped Cr 3+ content due to the reduction in the number of recombination sites of electron-hole pairs. The ternary Cr 2 O 3 -SiC-TiO 2 com- posites showed high hydrogen-producing activities, which probably results from the formation of donor levels of the Cr 3+ species in the forbidden band of the SiC semiconductor. | Yaojun Zhang Yong Xu Tuo Li Yachao Wang | 2012 | Particuology2012，10，1： | 8 |
| 7 | Functional analysis of alternative splicing of the FLOWERING LOCUS T orthologous gene in Chrysanthemum morifolium显示文摘As the junction of floral development pathways,the FLOWERING LOCUS T(FT)protein called‘florigen’plays an important role in the process of plant flowering through signal integration.We isolated four transcripts encoding different isoforms of a FT orthologous gene CmFTL1,from Chrysanthemum morifolium cultivar‘Jimba’.Sequence alignments suggested that the four transcripts are related to the intron 1.Expression analysis showed that four alternative splicing(AS)forms of CmFTL1 varied depending on the developmental stage of the flower.The functional complement experiment using an Arabidopsis mutant ft-10 revealed that the archetypal and AS forms of CmFTL1 had the function of complementing late flower phenotype in different levels.In addition,transgenic confirmation at transcript level showed CmFTL1 and CmFTL1ast coexist in the same tissue type at the same developmental stage,indicating a post-transcriptional modification of CmFTL1 in Arabidopsis.Moreover,ectopic expression of different AS forms in chrysanthemum resulted in the development of multiple altered phenotypes,varying degrees of early flowering.We found that an alternative splicing form(CmFTL1-astE134)without the exon 2 lacked the ability causing the earlier flower phenotype.The evidence in this study indicates that complex alternative processing of CmFTL1 transcripts in C.morifolium may be associated with flowering regulation and hold some potential for biotechnical engineering to create early-flowering phenotypes in ornamental cultivars. | Yachao Mao Jing Sun Peipei Cao Rong Zhang Qike Fu Sumei Chen Fadi Chen Jiafu Jiang | 2016 | Horticulture Research2016，3，1： | 7 |
| 8 | Five-wavelength optical-resolution photoacoustic microscopy of blood and lymphatic vessels显示文摘Optical-resolution photoacoustic microscopy(OR-PAM)has been developed for anatomical,functional,and molecular imaging but usually requires multiple scanning for different contrasts.We present five-wavelength OR-PAM for simultaneous imaging of hemoglobin concentration,oxygen saturation,blood flow speed,and lymphatic vessels in single raster scanning.We develop a five-wavelength pulsed laser via stimulated Raman scattering.The five pulsed wavelengths,i.e.,532,545,558,570,and 620∕640 nm,are temporally separated by several hundreds of nanoseconds via different optical delays in fiber.Five photoacoustic images at these wavelengths are simultaneously acquired in a single scanning.The 532-and 620∕640-nm wavelengths are used to image the blood vessels and dye-labeled lymphatic vessels.The blood flow speed is measured by a dual-pulse method.The oxygen saturation is calculated and compensated for by the Grüneisen-relaxation effect.In vivo imaging of hemoglobin concentration,oxygen saturation,blood flow speed,and lymphatic vessels is demonstrated in preclinical applications of cancer detection,lymphatic clearance monitoring,and functional brain imaging. | Chao Liu Jiangbo Chen Yachao Zhang Jingyi Zhu Lidai Wang | 2021 | Advanced Photonics2021，3，1： | 7 |
| 9 | Polarization evolution of vector beams generated by q-plates显示文摘The polarization evolution of vector beams(VBs) generated by q-plates is investigated theoretically and experimentally.An analytical model is developed for the VB created by a general quarter-wave q-plate based on vector diffraction theory.It is found that the polarization distribution of VBs varies with position and the value q.In particular,for the incidence of circular polarization,the exit vector vortex beam has polarization states that cover the whole surface of the Poincarésphere,thereby constituting a full Poincarébeam.For the incidence of linear polarization,the VB is not cylindrical but specularly symmetric,and exhibits an azimuthal spin splitting.These results are in sharp contrast with those derived by the commonly used model,i.e.,regarding the incident light as a plane wave.By implementing q-plates with dielectric metasurfaces,further experiments validate the theoretical results. | WEIXING SHU XIAOHUI LING XIQUAN FU YACHAO LIU YOUGANG KE HAILU LUO | 2017 | Photonics Research2017，5，2： | 7 |
| 10 | Detection, parameter estimation and imaging of maneuvering target in wide-band signal显示文摘The signal-to-noise ratio may be increased by the cross-range coherence integration so as to detect the moving target in low signal-to-noise ratio (SNR) condition. But, the radial velocity, acceleration and the change of acceleration due to the maneuvering motion of target may induce serious range migration and cross-range high-order phase terms leading to the unfocused cross-range image, the reduction of signal-noise ratio and the invalidation of target detection. Therefore, in order to solve these problems, this paper proposes a new method based on the adjacent correlation and scale transform methods for detection, parameters estimation and imaging of maneuvering targets in wide-band signal. This method can align the range and remove the cross-range high-order phase terms induced by the radial motion of target, enabling us to detect the target and estimate its moving parameters better. Finally, the simulated target is used to confirm that the method proposed by this paper can perfectly detect the maneuvering target in low signal-to-noise ratio condition, estimate its motion parameters and obtain an ISAR image of target. | LI YaChao XlNG MengDao ZHANG Long BAO Zheng | 2009 | Science in China(Series F)2009，52，6： | 4 |
| 11 | Ex situ and in situ AFM investigations on the growth of the (100) face of KDP with different pH values显示文摘Through investigations on the growth of the (100) face of potassium dihydrogen phosphate (KDP) crystal by ex situ atomic force microscopy (AFM) with different pH values at different supersaturations at 40°C,it was found that the growth of crystal was controlled by step flow at lower supersaturations,and the morphologies of steps were different under different growth conditions.In addition,at the higher supersaturations,2D nucleation mechanism controlled the growth.When the supersaturations were lower,the dislocation mechanism controlled the growth of crystal,and when σ≥0.05,2D nucleation mechanism played a dominant role in the growth of the (100) face for pH=4.2 and pH=2.5.However,for pH=5.0,the dislocation mechanism also dominated the growth of crystal when the supersaturations were lower,but when σ≥0.03,the crystal growth was controlled by 2D nucleation mechanism.Through investigations on the step flow of the (100) face of KDP crystal by in situ AFM with different pH values at lower supersaturations at 25°C,the velocities of normal growth of the (100) face were estimated at different growth conditions by in situ AFM.It was found that when the pH value was 5.0,the normal growth rate was the fastest at the same supersaturation compared to the other pH values and screw dislocation mechanism controlled the crystal growth.In addition,we found that with the reduction of the supersaturation of the solution,the density of steps also decreased,the width of steps became larger.Finally,a phenomenon which was the obvious anisotropic growth of steps in the step flow was observed by in situ AFM at σ=0.025 at pH=5.0. | CHENG Min,LI MingWei,GUO JinLi & CAO YaChao College of Power Engineering,Chongqing University,Chongqing 400030,China | 2010 | Science China(Technological Sciences)2010，53，6： | 4 |
| 12 | Potential effect of sedimentary iron-phosphorus accumulation on frequent algal bloom in the Pearl River Estuary显示文摘Based on laboratory culture of harmful alga on iron and phosphorus uptake, and the study of accu-mulation of iron-phosphorus in cores and release of iron and phosphorus from surficial sediments collected in the Pearl River Estuary, the reasons of the high frequency of phytoplankton bloom therein are discussed. The results show that Fe starvation can make algal growth rate slow down and the peak of cell number decrease. Fe and P contents in algal cell bear a significant correlation and the molar ratio of P:Fe is ~356:1, suggesting that algal uptake of Fe and P is synergistic. Total Fe and total P in sediments are positively correlated and Fe-P is the main species of inorganic sedimentary P. Through continuous leaching with agitation, 34.26%―80.21% of exchangeable P and 4.04%―22.52% of ex-changeable Fe are released from surficial sediments, implying that the accumulation of Fe-P in sedi-ments is available for providing nutrients (P and essential Fe) for the demand of phytoplankton bloom. These factors might be responsible for a higher frequency of red tides than other marine regions. | WENG HuanXin SUN XiangWei CHEN JingFeng CHEN JianFang CHEN LiHong CHEN XiangHua QIN YaChao | 2007 | Science China Earth Sciences2007，50，3： | 3 |
| 13 | Chemical constituents and ACE inhibitory activity of desert plant Suaeda physophora Pall.显示文摘Suaeda physophora Pall.is a kind of desert plant mostly growing in saline habitats in Xinjiang Uygur Autonomous Region.In order to have a better utilization of halophytes,a screening for ACE inhibitors from halophytes growing in Xinjiang was carried out.The result showed that the 70%EtOH extract and n-BuOH extract of S.physophora Pall.possessed significant ACE inhibitory activities.So we focused on its biochemical constituents firstly.One new quinazoline alkaloid,namely Suaedine(1),along with six known compounds(2–7)was isolated from the aerial parts of S.physophora Pall.The structure of the new quinazoline alkaloid was established by one-and two-dimensional nuclear magnetic resonance,optical rotation and mass spectrometry analysis.The flavonoid compounds(2–4)and phenolic compound(5)exhibited significant ACE activities.It was the first time to focus on the chemical constituents and bioactivities of this plant. | Ruizhi Men Ning Li Yachao Xing Yingzhan Tang Chengyu Tan Fantong Meng Juan Zhang Hui Ni Xiaoguang Jia | 2013 | Acta Pharmaceutica Sinica B2013，3，5： | 3 |
| 14 | Confocal visible/NIR photoacoustic microscopy of tumors with structural, functional, and nanoprobe contrasts显示文摘Distinguishing early-stage tumors from normal tissues is of great importance in cancer diagnosis.We report fiberbased confocal visible/near-infrared(NIR)optical-resolution photoacoustic microscopy that can image tumor microvasculature,oxygen saturation,and nanoprobes in a single scanning.We develop a cost-efficient single laser source that provides 532,558,and 1064 nm pulsed light with sub-microseconds wavelength switching time.Via dual-fiber illumination,we can focus the three beams to the same point.The optical and acoustic foci are confocally aligned to optimize the sensitivity.The visible and NIR wavelengths enable simultaneous tumor imaging with three different contrast modes.Results show obvious angiogenesis,significantly elevated oxygen saturation,and accumulated nanoparticles in the tumor regions,which offer comprehensive information to detect the tumor.This approach also allows us to identify feeding and draining vessels of the tumor and thus to determine local oxygen extraction fraction.In the tumor region,the oxygen extraction fraction significantly decreases along with tumor growth,which can also assist in tumor detection and staging.Fiber-based confocal visible/NIR photoacoustic microscopy offers a new tool for early detection of cancer. | JIANGBO CHEN YACHAO ZHANG XIAOZHEN LI JINGYI ZHU DENGFENG LI SHENGLIANG LI CHUN-SING LEE LIDAI WANG | 2020 | Photonics Research2020，8，12： | 2 |
| 15 | Investigation of β-Ga2O3 films and β-Ga2O3/GaN heterostructures grown by metal organic chemical vapor deposition显示文摘In this work,(-201)β-Ga2O3 films are grown on GaN substrate by metal organic chemical vapor deposition(MOCVD).It is revealed that theβ-Ga2O3 film grown on GaN possesses superior crystal quality,material homogeneity and surface morphology than the results of common heteroepitaxialβ-Ga2O3 film based on sapphire substrate.Further,the relevance between the crystal quality of epitaxialβ-Ga2O3 film and theβ-Ga2O3/GaN interface behavior is investigated.Transmission electron microscopy result indicates that the interface atom refactoring phenomenon is beneficial to relieve the mismatch strain and improve the crystal quality of subsequentβ-Ga2O3 film.Moreover,the energy band structure ofβ-Ga2O3/GaN heterostructure grown by MOCVD is investigated by X-ray photoelectron spectroscopy and a large conduction band offset of 0.89 eV is obtained.The results in this work not only convincingly demonstrate the advantages ofβ-Ga2O3 films grown on GaN substrate,but also show the great application potential of MOCVDβ-Ga2O3/GaN heterostructures in microelectronic applications. | YaChao Zhang YiFan Li ZhiZhe Wang Rui Guo ShengRui Xu ChuanYang Liu ShengLei Zhao JinCheng Zhang Yue Hao | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，11： | 2 |
| 16 | Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis显示文摘To study the dynamic behavior of a process,time-resolved data are collected at different time instants during each of a series of experiments,which are usually designed with the design of experiments or the design of dynamic experiments methodologies.For utilizing such time-resolved data to model the dynamic behavior,dynamic response surface methodology(DRSM),a datadriven modeling method,has been proposed.Two approaches can be adopted in the estimation of the model parameters:stepwise regression,used in several of previous publications,and Lasso regression,which is newly incorporated in this paper for the estimation of DRSM models.Here,we show that both approaches yield similarly accurate models,while the computational time of Lasso is on average two magnitude smaller.Two case studies are performed to show the advantages of the proposed method.In the first case study,where the concentrations of different species are modeled directly,DRSM method provides more accurate models compared to the models in the literature.The second case study,where the reaction extents are modeled instead of the species concentrations,illustrates the versatility of the DRSM methodology.Therefore,DRSM with Lasso regression can provide faster and more accurate datadriven models for a variety of organic synthesis datasets. | Yachao Dong Christos Georgakis Jacob Santos-Marques Jian Du | 2022 | Frontiers of Chemical Science and Engineering2022，16，2： | 2 |
| 17 | Property analysis of bistatic forward-looking SAR with arbitrary geometry显示文摘Bistatic forward-looking synthetic aperture radar(SAR) has many advantages and applications owing to its twodimensional imaging capability.There could be various imaging configurations because of the geometric flexibility of bistatic platforms,resulting in kinds of models built independently among which there could be some similar even the same motion features.Comprehensive research on such systems in a more comprehensive and general point of view is required to address their difference and consistency.Property analysis of bistatic forwardlooking SAR with arbitrary geometry is achieved including stripmap and spotlight modes on airborne platform,missile-borne platform,and hybrid platform of both.Emphasis is placed on azimuth space variance of some key parameters significantly affecting the subsequent imaging processing,based on which the frequency spectra are further described and compared considering respective features of different platforms for frequency imaging algorithm developing.Simulation results confirm the effectiveness and correctness of our analysis. | Ziqiang Meng Yachao Li Mengdao Xing Zheng Bao | 2016 | Journal of Systems Engineering and Electronics2016，27，1： | 2 |
| 18 | Survey of mycotic mastitis in dairy cows from Heilong, jiang Province, China 显示文摘 | Yulong Zhou Yachao Ren Chunling Fan | 2013 | Trop Anim Health Prod2013，45，8： | 1 |
| 19 | Efficacy of Xylooligosaccharides and Probiotics Additive to the Diets of Sows and/or Piglets on Performance,Milk Composition and Appearance of Diarrhea in Sows and Their Offspring显示文摘The present study investigated the effects of dietary supplementation of xylooligosaccharides( XOS) and probiotics( PR) on performance,milk composition and diarrhea incidence of sows or their offspring.From day 90 of gestation until weaning,a total of 60 multiparous sows were randomly assigned to three groups and given three different diets that included either the control diet( s CON,n = 20),the control diet containing 175 mg/kg XOS( s XOS,n = 20) or175 mg/kg XOS and 300 mg/kg probiotics( s XOS + PR,n = 20).On day 21 of age,offspring were assigned within sow treatments to the piglet basal diet( p CON)or the piglet basal diet supplemented with 175 mg/kg XOS( p XOS) for 28 d.Sow feed intake was recorded daily.Body weight and feed consumption of the pigs in each replicate were determined biweekly( on day 0,14 and 28) to calculate the average daily gain( ADG) of body weight,average daily feed intake( ADFI)and the gain-to-feed ratio( G∶ F).The colostrum and milk samples were obtained on day 0 and 14 of lactation,respectively.Sow XOS or XOS + PR dietary had no effect on the number of total piglets born and born alive and the piglet weight at birth.Milk composition in sow colostrum and milk were not affected by sow diet XOS or( XOS + PR) supplementation( P > 0.05).No maternal dietary effect was observed on the weaning weight and pre-weaning weight gains of piglets.However,there were interaction effects between sow and piglet dietary treatments on diarrhea rate and diarrhea index during day 35-49( P = 0.03) and day 21-49( P =0.02).Although sow diet XOS and( XOS + PR) supplementation did not influence growth performance of weanling piglets,such as ADG and ADFI( P >0.05),piglets XOS supplementation significantly decreased ADFI during the whole experiment period and increased G∶ F during day 35-49 and day 21-49( P <0.05).These results might suggest that combination of XOS and PR in sow diets had negative impact on the diarrhea incidence of offspring.XOS supplementation in weaned piglet diets decreased ADFI and feed conversion efficiency of weaning piglets. | Li Yuanfeng Xiao Xia He Jian Wang Yachao Ao Xiang Gou Qingbi He Zongze | 2017 | Animal Husbandry and Feed Science2017，9，6： | 1 |
| 20 | Chirp Scaling Algorithm for GEO SAR Based on Fourth-order Range Equation显示文摘 | Bao Min Xing Mengdao Li Yachao | 2012 | Electronics Letters2012，48，1： | 1 |
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