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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 3 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 4 | Genome-Wide Association Studies of Image Traits Reveal Genetic Architecture of Drought Resistance in Rice显示文摘理解植物怎么对干旱作出回应能有益于繁殖的干旱抵抗(医生) 。用一台非破坏性的 phenotyping 设备,为 507 米饭就职的 51 个基于图象的特点(i 特点) 被提取。这些 i 特点能被用来监视干旱回答 ? 并且高评估医生可遗传性和这些特点的大变化在自然人口在干旱应力下面被观察。染色体宽的协会研究(GWAS )?i 特点和传统的医生特点识别了 470 协会 loci,某包含知道医生相关的基因。这 470 loci, 443 loci (94%) 用 i 特点被识别, 437 loci (93%) 与以前报导的医生相关的量的特点 loci,和 313 loci (66.6%)co 局部性被 GWAS reproducibly 在不同的年里识别。协会网络,基于 GWAS 建立了结果,揭示中心 i 特点和中心 loci。这表明把的可行性和必要性复杂医生特点进可继承、简单的 i 特点。作为原则的证明,我们说明了这条综合途径的力量以前识别 unreported 医生相关的基因。OsPP15 与中心 i 特点被联系,并且它在医生的角色被基因转变实验证实。而且, i 特点能被用于医生连接分析,并且 69 个 i 特点地点协会被 recombinant 的 GWAS 和连接分析识别生来的线人口。最后,我们证实了 i 特点的关联在这个领域里搀。我们的学习为医生为原因的基因的基因解剖和发现提供一条有希望的新奇途径。 | Zilong Guo Wanneng Yang Yu Chang Xiaosong Ma Haifu Tu Fang Xiong Ni Jiang Hui Feng Chenglong Huang Peng Yang Hu Zhao Guoxing Chen Hongyan Liu Lijun Luo Honghong Hu Qian Liu Lizhong Xiong | 2018 | Molecular Plant2018，11，6： | 21 |
| 5 | Prognostic analysis of patients with gastrointestinal stromal tumors: a single unit experience with surgical treatment of primary disease显示文摘背景胃肠的 stromal 肿瘤(大意) ,胃肠的道的间充质的肿瘤的最普通的类型,是一个最近公认的肿瘤。大意的生物行为是高度可变的。外科的切除术为大意仍然是主要治疗。在这研究,我们回顾地与 181 个大意病人一起分析了我们的外科的经验决定治疗和病理学的特征和这些大意 patients.Methods 的预后因素的效果在 Ren 收到了在1999年1月和2007年12月之间的外科的切除术的有大意的 181 个病人的 clinicopathological 特征和后续数据 Ji 医院回顾地被考察。包括 CD117 (工具包) 的 Immunohistochemical 污点, CD34,和另外的标记被使用。肿瘤尺寸,有丝分裂的索引和另外的病理学的参数被记录。根据 NIH 风险组层化系统的一致基于最大的肿瘤尺寸和有丝分裂的索引(每 50 高力量地),肿瘤被分类进 very-low-risk 组( 15 个肿瘤,8.3%),低风险的组( 48 ,26.5%),中间风险的组( 52 ,28.7%)并且高风险的组( 66 ,36.5%)。预示的因素被考克斯分析包括年龄,性别,肿瘤尺寸,肿瘤地点,有丝分裂的索引, NIH 范畴和外科的过程分析。结果(59.1%) 107 181 个肿瘤位于胃, 51 (28.2%) 在小肠, 9 (5.0%) 在冒号和直肠,并且 14 (7.7%) 在另外的地点包括网膜和肠系膜。病人的中部的年龄是 58 (范围, 24-84 ) 年,和 102 个病人(56.4%) 是男性的。肿瘤尺寸从 0.5 ~ 30 厘米,当吝啬的尺寸是 7.02 厘米时。转移在 7 个病人被发现。(97.2%) 176 181 个病人经历了激进的切除术,并且在他们之中, 26 个病人与邻近的机关支持者一起收到了广泛的切除术到肿瘤。为在 immunostaining 的 KIT 蛋白质(CD117 ) 的积极的率是 94.5%(171/181 ) ,当那为 CD34 是 86.2% 时(156/181 ) 。1- , 3- ,和 181 个病人的 5 年的幸存率被估计分别地是 95.2% , 87.9% 和 78.5% 。在 multivisceral 切除术的年龄,肿瘤尺寸,肿瘤地点,有丝分裂的索引, NIH 范畴,和存在或缺席有重要差别(P < 0.05 ) 。但是在在这些组之间的性别没有重要差别。比例的模型揭示了的考克斯危险那个先进临床的阶段和大肿瘤尺寸贡献了更坏的预后。因为复发和转移或高复发风险,与 imatinib 被对待的病人显示出外科的切除术是的稳定的 disease.Conclusions 为主要大意的治疗的标准答案。NIH 分类简单、有效评估大意行为和预后。指向的治疗象 imatinib 那样,一个工具包酷氨酸 kinase 禁止者,可以在大意的治疗起一个重要作用。 | CAO Hui ZHANG Yun WANG Ming SHEN Dan-ping SHENG Zhi-yong NI Xing-zhi WU Zhi-yong LIU Qiang SHEN Yan-ying SONG Yan-yan | 2010 | Chinese Medical Journal2010，，2： | 20 |
| 6 | Optimization of acidic extraction of astaxanthin from Phaffia rhodozyma显示文摘Optimization of a process for extracting astaxanthin from Phaffia rhodozyma by acidic method was investigated,regarding several extraction factors such as acids,organic solvents,temperature and time. Fractional factorial design,central composite design and response surface methodology were used to derive a statistically optimal model,which corresponded to the following optimal condition: concentration of lactic acid at 5.55 mol/L,ratio of ethanol to yeast dry weight at 20.25 ml/g,tem-perature for cell-disruption at 30 °C,and extraction time for 3 min. Under this condition,astaxanthin and the total carotenoids could be extracted in amounts of 1294.7 μg/g and 1516.0 μg/g,respectively. This acidic method has advantages such as high extraction efficiency,low chemical toxicity and no special requirement of instruments. Therefore,it might be a more feasible and practical method for industrial practice. | Hui NI Qi-he CHEN Guo-qing HE Guang-bin WU Yuan-fan YANG | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，1： | 11 |
| 7 | LORELEI-LIKE GPI-ANCHORED PROTEINS 2/3 Regulate Pollen Tube Growth as Chaperones and Coreceptors for ANXUR/BUPS Receptor Kinases in Arabidopsis显示文摘Pollen tube growth is crucial for successful fertilization.In Arabidopsis thaliana,the ANXUR(ANX)/BUPS receptor kinase complex controls and maintains pollen tube growth in response to autocrine rapid alkalin-ization factor 4/19(RALF4/19)signaling;however,the molecular and cellular mechanisms underlying the ANX/BUPS-mediated regulation of pollen tube growth remain unclear.In this study,we found that pollen-specific LORELEI-like GPI-anchored proteins 2 and 3(LLG2/3)promote pollen tube growth in vitro and in vivo.LLG2/3 interacte with ANX/BUPS in a RALF4-concentration-dependent manner,suggesting that ANX/BUPS and LLG2/3 might form a receptor-coreceptor complex for perceiving RALF peptide signals.Disruption of the ANX/BUPS-LLG2/3 interaction led to the cytoplasmic retention of ANX1/2,in either llg2/3 knockdown mutants or in anx1/2 mutants lacking the J region,which mediates the ANX/BUPS-LLG2/3 interaction.Moreover,we found that RALF4 induced the production of reactive oxygen species(ROS),which stimulate pollen tube growth and reduce pollen burst rate.ROS levels are reduced in the pollen tubes of LLG2/3 RNAi lines,and application of exogenous H2O2 could partially rescue the defective pollen tube growth of LLG2/3 RNAi lines.Taken together,our study identifies LLG2/3 as novel regulatory components of pollen tube growth,and shows that they chaperone ANX/BUPS for secretion to the apical plasma membrane of pollen tube and act as coreceptors of ANX/BUPS in the acti-vation of ROS production for promoting pollen tube growth. | Hanqian Feng Chen Liu Rong Fu Minmin Zhang Hui Li Lianping Shen Qiqi Wei Xiang Sun Lin Xu Bin Ni Chao Li | 2019 | Molecular Plant2019，12，12： | 10 |
| 8 | High-performance silicon−graphene hybrid plasmonic waveguide photodetectors beyond 1.55μm显示文摘Graphene has attracted much attention for the realization of high-speed photodetection for silicon photonics over a wide wavelength range.However,the reported fast graphene photodetectors mainly operate in the 1.55μm wavelength band.In this work,we propose and realize high-performance waveguide photodetectors based on bolometric/photoconductive effects by introducing an ultrathin wide silicon−graphene hybrid plasmonic waveguide,which enables efficient light absorption in graphene at 1.55μm and beyond.When operating at 2μm,the present photodetector has a responsivity of ~70 mA/W and a setup-limited 3 dB bandwidth of >20 GHz.When operating at 1.55μm,the present photodetector also works very well with a broad 3 dB bandwidth of >40 GHz(setup-limited)and a high responsivity of ~0.4 A/W even with a low bias voltage of−0.3 V.This work paves the way for achieving highresponsivity and high-speed silicon-graphene waveguide photodetection in the near/mid-infrared ranges,which has applications in optical communications,nonlinear photonics,and on-chip sensing. | Jingshu Guo Jiang Li Chaoyue Liu Yanlong Yin Wenhui Wang Zhenhua Ni Zhilei Fu Hui Yu Yang Xu Yaocheng Shi Yungui Ma Shiming Gao Limin Tong Daoxin Dai | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 9 | NEAT1/miR-140-3p/MAPK1 mediates the viability and survival of coronary endothelial cells and affects coronary atherosclerotic heart disease显示文摘Studies have shown that long non-coding RNAs(lncRNA)play critical roles in coronary atherosclerotic heart disease(CAD).However,the function of lncRNA nuclear enriched abundant transcript 1(NEAT1)in CAD is unclear.In this study,we aimed to investigate the functions of lncRNA NEAT1 in CAD.RTPCR and western blot analysis were carried out to examine the expressions of related RNAs.Colony formation assay,cell proliferation assay,apoptosis assay,and dual-luc讦erase reporter assay were con ducted to investigate the abilities of colony migration,cell proliferatio n,apoptosis,and targeting.The results showed that NEAT1 was up-regulated in CAD blood samples and in human coronary endothelial cells(HCAECs).Transfection of pcNEATI sign讦icantly inhibited the survival rate of HCAECs and induced apoptosis of HCAECs.MiR-140-3p was down-regulated in HCAECs.NEAT1 directly targeted miR-140-3p,and the expression of miR-140-3p was inversely correlated with the expression of NEAT1 in CAD patients.In addition,co-transfection of NEAT1 with miR-140-3p mimic reversed the effect of pcNEATI on cell viability and apoptosis,mitogenactivated protein kinase 1(MAPK1)was proved to be a target gene of miR-140-3p,and the miR-140-3p mimic was shown to reduce the expression of MAPK1 in HCAECs.pcNEATI sigrdficantly increased the expression level of MAPK1,while shNEATI significantly reduced the expression level of MAPK1.Our results revealed that lncRNA NEAT1 increased cell viability and inhibited CAD cell apoptosis possibly by activating the miR-140-3p/MAPK1 pathway,and lncRNA NEAT1 might serve as a potential therapeutic target for CAD. | Hui Zhang Ningning Ji Xinyan Gong Shimao Ni Yu Wang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，9： | 9 |
| 10 | Effects of meteorological elements on admission rates of cerebral infarction patients with hypertensive nephropathy from nine hospitals in Changchun city, Jilin Province显示文摘 | YANG Bo-yu ZHANG Yue XU Chang-yan JIA Bo-ting WANG Chun-jie JIA Zhan-jun NI Hui WANG De-hui ZHANG Zhe ZHAO Gang YANG-Li-ming | 2013 | Chinese Medical Journal2013，，10： | 9 |
| 11 | TDOA Localization Algorithm with Compensation of Clock Offset for Wireless Sensor Networks显示文摘This paper presents a source localization algorithm based on the source signal's time-difference-of-arrival(TDOA) for asynchronous wireless sensor network.To obtain synchronization among anchors,all anchors broadcast signals periodically,the clock offsets and skews of anchor pairs can be estimated using broadcasting signal's time-of-arrivals(TOA) at anchors.A kalman filter is adopted to improve the accuracy of clock offsets and track the clock drifts due to random fluctuations.Once the source transmits signal,the TOAs at anchors are stamped respectively and source's TDOA error due to clock offset and skew of anchor pair can be mitigated by a compensation operation.Based on a Gaussian noise model,maximum likelihood estimation(MLE) for the source position is obtained.Performance issues are addressed by evaluating the Cramer-Rao lower bound and the selection of broadcasting period.The proposed algorithm is simple and effective,which has close performance with synchronous TDOA algorithm. | XIONG Hui CHEN Zhiyuan YANG Beiya NI Rongpei | 2015 | China Communications2015，12，10： | 8 |
| 12 | Genome analysis and signature discovery for diving and sensory properties of the endangered Chinese alligator显示文摘Crocodilians 正在潜水能为时间的长时期在水下面屏息并且是有优秀感觉能力的黄昏的动物的爬行动物。他们包括鸟的一个姐妹系并且没有性染色体。这里,我们报导危及的中国短吻鳄(短吻鳄 sinensis ) 的染色体顺序并且描述它的唯一的特征。下一代的定序产生了未加工的顺序的 314 Gb,产出 2.3 Gb 的一种染色体尺寸。22 200 基因的一个总数用 de novo 在短吻鳄 sinensis 被预言,基于相同、基于 RNA 的联合模型。长潜水的行为的基因基础包括酸式碳酸盐绑定血红素基因,磷酸盐绑定和特殊酸式碳酸盐绑定氧搬运的常规的 co-functioning,和断然选择的精力的复制新陈代谢,铵酸式碳酸盐排泄和心肌收缩。进一步,我们阐明了柔韧的短吻鳄 sinensis 感觉系统包括一个显著地扩展的嗅觉的受体全部剧目,很快演变神经相关的细胞的部件和视觉感觉,和夜里的积极选择视觉相关的视蛋白和健全联系察觉的 otopetrin。我们也为抗菌剂肽的天生的免疫和表示为分成三部分的包含主题的 C 类型 lectin 和 butyrophilin 基因的适应免疫以及扩大与系特定的抗原演讲基因的一个可观的数字发现了一个开发得好的免疫系统。在 situ 杂交的 Multifluorescence 显示出那个短吻鳄染色体 3,它编码 DMRT1,与鸡染色体 Z 一起展出重要 synteny。最后,人口历史分析百万年以前显示了人口混合 0.60-1.05,当 Qinghai 西藏的高原被高举时。 | Qiu-Hong Wan Sheng-Kai Pan Li Hu Ying Zhu Peng-Wei Xu Jin-Quan Xia Hui Chen Gen-Yun He Jing He Xiao-Wei Ni Hao-Long Hou Sheng-Guang Liao Hai-Qiong Yang Ying Chen Shu-Kun Gao Yun-Fa Ge Chang-Chang Cao Peng-Fei Li Li-Ming Fang Li Liao Shu Zhang Meng-Zhen Wang Wei Dong Sheng-Guo Fang | 2013 | Cell Research2013，23，9： | 8 |
| 13 | Upconversion nano-photosensitizer targeting into mitochondria for cancer apoptosis induction and cyt c fluorescence monitoring显示文摘反应的氧种类(mitoROS ) 玩的 mitochondrial 的混乱在癌症房间 apoptosis 的一个主要角色。这里,我们设计了 core/shell-structured 有由 photosensitizer (PS ) 涂的核心合并了的做 lanthanide 的 upconversion nanoparticle (UCNP ) 的指向线粒体的基于 upconversion 的使 nano 具有感光性(TPP-UC (PS )) 稠密的硅石壳。有外部在红外线附近的激光(NIR ) 的后面的照耀,在引起为激活的基于 upconversion 的光力学的治疗(UC 太平洋夏季时间) 胀大的严肃的 mitochondrial 矩阵的线粒体的 TPP-UC (PS ) ,和细胞色素 c (cyt c ) 的动员响应增加的 mitoROS 被放大。明确地,这包含 heme cyt c 能被改变 TPP-UC (PS ) s upconversion 光信号(UCL ) 监视,它可以便于在里面为 apoptosis 研究的 cyt c 的 situ 察觉。作为概念的一个证明,我们的设计 TPP-UC (PS ) 可以为在 NIR 刺激下面控制癌症房间 apoptosis 并且为用动态 UCL 学习 apoptosis 提供重要机会,它被本地 cyt c 影响。 | Yanyan Liu Jiawen Zhang Changjing Zuo Zhen Zhang Dalong Ni Chen Zhang Jing Wang Hui Zhang Zhenwei Yao Wenbo Bu | 2016 | Nano Research2016，9，11： | 8 |
| 14 | No expenditure difference among patients with liver cancer at stageⅠ-ⅣV:Findings from a multicenter cross-sectional study in China显示文摘Objective:The number of liver cancer patients in China accounts for more than half of the world.However,China currently lacks national,multicenter economic burden data,and meanwhile,measuring the differences among different subgroups will be informative to formulate corresponding policies in liver cancer control.Thus,the aim of the study was to measure the economic burden of liver cancer by various subgroups.Methods:A hospital-based,multicenter and cross-sectional survey was conducted during 2012・2014,covering 39 hospitals and 21 project sites in 13 provinces across China.The questionnaire covers clinical information,sociology,expenditure,and related variables.All expenditure data were reported in Chinese Yuan(CNY)using 2014 values.Results:A total of 2,223 liver cancer patients were enrolled,of whom 59.61%were late-stage cases(III-IV),and 53.8%were hepatocellular carcinoma.The average total expenditure per liver cancer patient was estimated as 53,220 CNY,including 48,612 CNY of medical expenditures(91.3%)and 4,608 CNY of non-medical expenditures(8.7%).The average total expenditures in stage I,H,m and stage IV were 52,817 CNY,50,877 CNY,50,678 CNY and 54,089 CNY(P>0.05),respectively.Non-medical expenditures including additional meals,additional nutrition care,transportation,accommodation and hired informal nursing were 1,453 CNY,839 CNY,946 CNY,679 CNY and 200 CNY,respectively.The one-year out-of-pocket expenditure of a newly diagnosed patient was 24,953 CNY,and 77.2%of the patients suffered an unmanageable financial burden.Multivariate analysis showed that overall expenditure differed in almost all subgroups(P<0.05),except for sex,clinical stage,and pathologic type.Conclusions:There was no difference in treatment expenditure for liver cancer patients at different clinical stages,which suggests that maintaining efforts on treatment efficacy improvement is important but not enough.To fiirtherly reduce the overall economic burden from liver cancer,more effort should be given to primary and secondary prevention strategies. | Haike Lei Lin Lei Jufang Shi Yongzhong Wu Ling Liang Huiyao Huang Mei He Fangzhou Bai Maomao Cao Hui Qiu Yuting Wang Chengcheng Liu Jia Du Hong Wang Yan Zhang Mengdi Cao Ji Peng Ni Li Chunfeng Qu Min Dai Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 7 |
| 15 | Optimization of slightly acidic electrolyzed water spray for airborne culturable bacteria reduction in animal housing显示文摘Slightly acidic electrolyzed water(SAEW)spray has been considered as a novel approach for airborne bacteria reduction in animal housing.This study aimed to optimize the operating parameters of SAEW spray based on the size distribution of sprayed aerosols,the available chlorine travelling loss in sprayed aerosols,and the reduction efficiency of airborne culturable bacteria(CB).The optimized operating parameters were the nozzle orifice diameter and the spray pressure.The size distribution characteristics of sprayed SAEW aerosols under different operating parameters were quantified.The pH and available chlorine concentrations of the original SAEW solution and the SAEW aerosols collected at 0 m,0.25 m,0.50 m,0.75 m,and 1.00 m from the spray nozzle head were analyzed.A bioaerosol nebulizing generator was used to simulate animal housing environment in an environmentally-controlled chamber.Six SAEW spray trials under different operating parameters were conducted at a spray dosage of 80 mL/m2 in the chamber.Airborne CB concentrations before and after spray were measured to investigate the reduction efficiency of airborne CB.Dv(50),the volume-based diameter below which 50%of the particle being present,increased with the nozzle orifice diameter and decreased with the spray pressure.The travelling loss of available chlorine in the sprayed SAEW aerosols was greatly dependent on Dv(50).SAEW spray with medium size sprayed aerosols(Dv(50)=86.62μm,67.94μm,and 54.53μm)showed significantly higher airborne CB reduction efficiencies than large(Dv(50)=121.80μm and 96.00μm)or small size aerosols(Dv(50)=42.57μm).The spray operating parameters that provide medium size sprayed aerosols(Dv(50)~60-90μm)are recommended for SAEW spray in animal housing. | Zheng Weichao Ni Li Hui Xue Li Baoming Zhang Jiafa | 2016 | International Journal of Agricultural and Biological Engineering2016，9，4： | 7 |
| 16 | Correlation between muscular strength and basal nuclei ischemic/hemorrhagic stroke-induced corticospinal tract injury,as detected by diffusion tensor imaging and tractography显示文摘BACKGROUND:Conventional neuroimaging diagnosis does not assist with the monitoring or evaluation of basal nuclei ischemic and hemorrhagic stroke,or motor functional recovery.Magnetic resonance,diffusion tensor imaging,and diffusion tensor tractography have all been used to observe features of cerebral white matter fibrous structures.In addition,diffusion tensor tractography is the only non-invasive imaging method to display the corticospinal tract in vivo.OBJECTIVE:To evaluate the impairment degree of corticospinal tract induced by basal nuclei ischemic and hemorrhagic stroke through the use of magnetic resonance,diffusion tensor imaging,and diffusion tensor tractography,and to analyze the correlation to muscular strength.DESIGN,TIME AND SETTING:A retrospective case analysis was performed at the Department of Medical Imaging,Neurology and Neurosurgery,Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA between November 2002 and June 2008.PARTICIPANTS:A total of 15 patients with acute or subacute cerebral ischemic stroke and nine with hemorrhagic stroke in the basal nuclei were selected.METHODS:Magnetic resonance,diffusion tensor imaging,and diffusion tensor tractography results and data were analyzed.Fractional anisotropy and directionally encoded color maps were obtained.Three-dimensional tractography of bilateral corticospinal tract was created,and corticospinal tract integrity was graded.Fractional anisotropy of infarct region and corresponding contralateral normal regions were measured,and hematoma volume in hemorrhagic stroke patients was determined.Hand motor function ability was evaluated using Brunstorm criteria.MAIN OUTCOME MEASURES:Fractional anisotropy of infarct region and corresponding contralateral normal regions;hematoma volume in hemorrhagic stroke patients;correlation between muscular strength and corticospinal tract impairment degree in ischemic stroke and hemorrhagic stroke patients before and after treatment.RESULTS:In ischemic stroke patients,the fractional anisotropy value was significantly lower in the infarct area of white matter than in the normal hemisphere(P < 0.01).The impairment degree of corticospinal tract negatively correlated with muscular strength of the corresponding hand(r =-0.97 P < 0.01).The hematoma volume of hemorrhagic stroke patients significantly negatively correlated with Spearman test results for muscular strength of the corresponding hand(r =-0.88,P < 0.01).CONCLUSION:Corticospinal tract impairment severity negatively correlated with muscular strength and motor functional recovery,which suggested that diffusion tensor imaging and diffusion tensor tractography could be used to evaluate corticospinal tract motor function. | Shangwen Xu Ziqian Chen Jinhua Chen Youqiang Ye Yuning Lin Ping Ni Hui Xiao Gennian Qian | 2010 | Neural Regeneration Research2010，5，13： | 7 |
| 17 | Anti-inflammatory and Anti-oxidant Effects of Licorice Flavonoids on Ulcerative Colitis in Mouse Model显示文摘Licorice(Glycyrrhizae Radix or Liquiritiae Radix) is traditionally used to treat various diseases including inflammation and gastric ulcers. Licorice is rich in flavonoid compounds and possesses anti-inflammatory activities. To investigate the protective effects of licorice flavonoids(LFs) in both acetic acid-induced and dextran sulphate sodium(DSS)-induced ulcerative colitis(UC) mouse model and its underlying mechanism. Acute UC was induced by intra-rectal acetic acid(4% v/v) after pretreatment with LFs(100, 200, and 400 mg/kg, p.o.), 0.9% saline(20 mL/kg, p.o.) or Sulfasalazine(SASP)(600 mg/kg, p.o.) for 10 d. Quantitative analysis of chemical components of LFs was also conducted by HPLC. Our results showed that pre-treatment with LFs significantly reduced the wet weight/length ratio of colon, percentage of affected area, macroscopic and histological damage scores in acid-induced UC mice. LFs also significantly decreased the oxidative stress and pro-inflammatory cytokines, upregulated nuclear factor erythroid 2-related factor 2(Nrf2) pathway and downregulated nuclear transcription factor kappa B(NF-κB) pathway. At last, LFs also showed obvious antiulcer effect on the DSS-induced UC model. The major components of LFs were licochalcone A, glabrone, licoflavone, and licoflavone B. This study demonstrates that the protective effect of LFs may at least in part be due to its anti-oxidant activity through Nrf2 pathway and anti-inflammatory activity through NF-κB pathway. | Dong-yu Liu Li Gao Juan Zhang Xiao-wei Huo Hui Ni Li Cao | 2017 | Chinese Herbal Medicines2017，9，4： | 6 |
| 18 | A brief introduction to the FUTang Updating medical REcords(FUTURE)database显示文摘Introduction Futang Research Center of Pediatric Development(FRCPD),the first nonprofit social service organization engaging in pediatric research in China,was founded in May 2013.Until August 2021,FRCPD has 40 tertiary children’s hospitals,accounting for about 65.6%of all national public children’s hospitals,which was reported to be 61 in China Health Statistical Yearbook(2020).The hospitals are distributed in 30 provinces,autonomous regions,and municipalities(except for Tibet autonomous region),and most of them are in the capital of the province,forming a broad frontline representing the best quality of health care for the diagnosis and treatment of children’s disease in China.Based on the idea of sharing,FRCPD realized the exchange of experts,medical resources,research findings,educational events,preventive strategies,and management experiences among members.In the long run,FRCPD aims to continuously promote the quality of healthcare and medical service capability for children in China. | Xinyu Wang Yueping Zeng Jian Tian Hui Xu Fei Song Yongli Guo Xin Xu Guoshuang Feng Xin Ni | 2021 | Pediatric Investigation2021，5，3： | 6 |
| 19 | Studies on optimization of nitrogen sources for astaxanthin production by Phaffia rhodozyma显示文摘Fermentation of Phaffia rhodozyma is a major method for producing astaxanthin, an important pigment with industrial and pharmaceutical application. To improve astaxanthin productivity, single factor and mixture design experiments were used to investigate the effects of nitrogen source on Phaffia rhodozyma cultivation and astaxanthin production. Results of single factor experiments showed nitrogen source could significantly affect P. rhodozyma cultivation with respect to carbon source utilization, yeast growth and astaxanthin accumulation. Further studies of mixture design experiments using (NH4)2SO4, KNO3 and beef extract as nitrogen sources indicated that the proportion of three nitrogen sources was very important to astaxanthin production. Validation experiments showed that the optimal nitrogen source was composed of 0.28 g/L (NH4)2SO4, 0.49 g/L KNO3 and 1.19 g/L beef extract. The kinetic characteristics of batch cultivation were investigated in a 5-L pH-stat fermentor. The maximum amount of biomass and highest astaxanthin yield in terms of volume and in terms of biomass were 7.71 mg/L and 1.00 mg/g, respectively. | NI Hui CHEN Qi-he RUAN Hui YANG Yuan-fan LI Li-jun WU Guang-bin Hid Yang HE Guo-qing | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，5： | 6 |
| 20 | Effect of high magnetic field on the crystallization of Nd_2Fe_(14)B/α-Fe nanocomposite magnets显示文摘Nd8.1Dy0.9Fe76.95Co8.55B5.5 nanocomposite magnets annealed with and without a 10 T magnetic field were inves-tigated in this article. The ribbons with coexisting amorphous and crystalline phases were selected to do this study. The re-sults of M?ssbauer spectroscopy revealed that the content of α-Fe increased when annealed in high strength magnetic field. The size of the grains also increased considerably after the application of magnetic annealing. All these led to the decrease of the magnetic properties, especially the coercivity of the ribbons. | WANG Zhanyong XU Hui NI Jiansen LI Qiang ZHOU Bangxin | 2006 | Rare Metals2006，25，4： | 6 |
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