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| 1 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 2 | A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis显示文摘 | Yibin Deng Xiaoyang Ren Lin Yang Yahong Lin Xiangwei Wu | 2003 | Cell2003，，1： | 1 |
| 3 | TRAIL-induced apoptosis requires bax-dependent mitochondrial release of Smac/DIABLO显示文摘 | Yubin Deng Yahong Lin Xianwei WU | 2002 | Genes Dev2002，16，： | 1 |
| 4 | Synthesis and Spectroscopic Characterization of meso-Tetra( Schiff-base substitutedphenyl) porphyrins and Their Zinc Complexes显示文摘 | Wu Yahong Chen Lin Yu Jian | 2013 | Dyes Pigm2013，97，： | 1 |
| 5 | Key issues for implementation of Chinese open government information regulations 显示文摘 | Piotrowski S J Zhang Yahong Lin Weiwei | 2009 | Public Administration Re- view2009，69，1： | 1 |
| 6 | 8-Oxoguanine DNA glycosylase protects cells from senescence via the p53-p21 pathway显示文摘Cellular senescence is an important factor leading to pulmonary fibrosis.Deficiency of 8-oxoguanine DNA glyco-sylase(OGG1)in mice leads to alleviation of bleomycin(BLM)-induced mouse pulmonary fibrosis,and inhibition of the OGG1 enzyme reduces the epithelial mesenchymal transition(EMT)in lung cells.In the present study,we find decreased expression of OGG1 in aged mice and BLM-induced cell senescence.In addition,a decrease in OGG1 expression results in cell senescence,such as increases in the percentage of SA-β-gal-positive cells,and in the p21 and p-H2AX protein levels in response to BLM in lung cells.Furthermore,OGG1 promotes cell transformation in A549 cells in the presence of BLM.We also find that OGG1 siRNA impedes cell cycle progression and inhibits the levels of telomerase reverse transcriptase(TERT)and LaminB1 in BLM-treated lung cells.The increase in OGG1 expression results in the opposite phenomenon.The mRNA levels of senescence-associated secretory phenotype(SASP)components,including IL-1α,IL-1β,IL-6,IL-8,CXCL1/CXCL2,and MMP-3,in the absence of OGG1 are obviously increased in A549 cells treated with BLM.Interestingly,we demonstrate that OGG1 binds to p53 to inhibit the activation of p53 and that silencing of p53 reverses the inhibition of OGG1 on senescence in lung cells.Ad-ditionally,the augmented cell senescence is shown in vivo in OGG1-deficient mice.Overall,we provide direct evidence in vivo and in vitro that OGG1 plays an important role in protecting tissue cells against aging associated withthep53pathway. | Shenglan Gao Lujun Chen Ziying Lin Zhiliang Xu Yahong Wang Huayu Ling Zijun Wu Yu Yin Weimin Yao Keng Wu Gang Liu | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
| 7 | The ubiquitin ligase E6AP facilitates HDAC6-mediated deacetylation and degradation of tumor suppressors显示文摘Dear Editor,Protein acetylation status can regulate protein stability via the ubiquitin-proteasome pathway,which plays a critical role in the regulation of various cellular functions and becomes a target for cancer therapy.1,2 Histone deacetylase 6(HDAC6)belongs to the class II of the histone deacetylase/acuc/apha family and regulates cancer cell proliferation,invasion,and metastasis.3 Combination of HDAC6 inhibitors(HDAC6i)with proteasome inhibitors(PI)shows synergistic anticancer activity.4 Although many studies reveal how acetyltransferases/deacetylases regulate protein acetylation and subsequent protein ubiquitination and degradation,whether an E3 ubiquitin ligase regulates protein acetylation remains largely unknown.In addition,the mechanisms undelying synergistic anticancer activity of HDAC6i and PI remain poorly understood. | Yanan Zhang Zhida Chen Jing Lin Jie Liu Yahong Lin Huayue Li Yongyi Xi Bo Wei Lihua Ding Qinong Ye | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 8 | Fungi with potential probiotic properties isolated from Fuzhuan brick tea显示文摘Several of the fungal species associated with Fuzhuan brick tea(FBT)are considered as potential probiotics,but few studies have investigated the probiotic properties of these fungi.Here,we isolated 18 fungal strains from two types of FBT and identified these strains based on internal transcribed spacer(ITS)fragment sequence similarity to reference strains(sequence similarity>98%).Of the 18 strains,10 tolerated simulated human digestive conditions for sufficient periods in vitro:pH 2-3,0.3%-0.5%(m/V)bile salts,and artificial gastrointestinal juices.We then measured the antimicrobial activity of the remaining 10 strains against 5 enteropathogenic bacteria and tested the bacteriostatic effects of the thalli and fermentation broth extracts.Of the 6 strains with strong bacteriostatic effects,we eliminated Eurotium cristatum S-9 due to its low hydrophobicity of(26.12±0.35)%.Finally,2 exhibited good adhesion abilities to human cells(>100%).Notably,2 strains can survive in vivo,because they can be isolated from C57BL/6 mice feces.Thus,2 strains,Aspergillus cristatus H-1 and A.cristatus H-5,are herein identified as promising candidate probiotic strains.It may be put forward a novel research focus on evaluating potential probiotic fungi from FBT. | Xin Wang Yuanyuan Cui Chaowei Sang Bin Wang Yirong Yuan Lin Liu Yahong Yuan Tianli Yue | 2022 | Food Science and Human Wellness2022，11，3： | 0 |
| 9 | Black Box Modeling Method and Its Application in Refractories Techniques显示文摘Concept of black box, condition of modeling and control methods were introduced. Taking high purity silica brick as an example, the silica brick featured with high purity, low porosity, low true density and high strength was developed through problem analysis, test design, modeling and optimization. Using information technology to upgrade refractories industry was discussed. | WANG Jiezeng YUAN Lin YE Yahong LI Penghai WANG Juntao | 2012 | China's Refractories2012，21，4： | 0 |
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