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| 1 | Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer显示文摘AIM:To evaluate the prognostic significance of the lymphocyte to monocyte ratio(LMR) in patients with unresectable metastatic colorectal cancer who received palliative chemotherapy.METHODS:A total of 104 patients with unresectable metastatic colorectal cancer who underwent palliative chemotherapy were enrolled. The LMR was calculated from blood samples by dividing the absolute lymphocyte count by the absolute monocyte count. Pretreatment LMR values were measured within one week before the initiation of chemotherapy,while posttreatment LMR values were measured eight weeks after the initiation of chemotherapy.RESULTS:The median pre-treatment LMR was 4.16(range:0.58-14.06). We set 3.38 as the cut-off level based on the receiver operating characteristic curve. Based on the cut-off level of 3.38,66 patients were classified into the high pre-treatment LMR group and 38 patients were classified into the low pretreatment LMR group. The low pre-treatment LMR group had a significantly worse overall survival rate(P = 0.0011). Moreover,patients who demonstrated low pre-treatment LMR and normalization after treatmentexhibited a better overall survival rate than the patients with low pre-treatment and post-treatment LMR values.CONCLUSION:The lymphocyte to monocyte ratio is a useful prognostic marker in patients with unresectable metastatic colorectal cancer who receive palliative chemotherapy. | Masatsune Shibutani Kiyoshi Maeda Hisashi Nagahara Hiroshi Ohtani Katsunobu Sakurai Sadaaki Yamazoe Kenjiro Kimura Takahiro Toyokawa Ryosuke Amano Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa | 2015 | World Journal of Gastroenterology2015，21，34： | 19 |
| 2 | 混合导电体型氧透膜材料的研究显示文摘研究了具有氧离子导电性和电子导电性的钴系钙钛矿型复合氧化物混合导电体材料中氧的选择性透过能力,考察了该体系中 A 位低价金属离子置换量、置换金属离子的种类及 B 位置换金属离子的种类对氧的透过率的影响.结果表明:改变钙钛矿型复合氧化物的组成,提高材料中氧空位浓度和氧离子导电率,有利于提高氧离子的扩散速度,即提高氧的透过率和降低氧透过的起始温度.将钙钛矿型复合氧化物混合导电体氧透膜与固体电解质氧透膜进行了比较,前者具有结构简单的优点,有希望成为一种新型高温氧分离膜介质材料. | 张华民 Yasutake Teraoka Noboru Yamazoe | 1993 | 无机材料学报1993，8，4： | 5 |
| 3 | Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma显示文摘AIM To elucidate the effect of expression of doublecortin and Ca M kinase-like-1(DCLK1) in patients with pancreatic ductal adenocarcinoma(PDAC). METHODS Tumor specimens were obtained from 136 patients with pancreatic cancer who had undergone resection without preoperative therapy between January 2000 and December 2013 at the Department of Surgical Oncology, Osaka City University. The resected specimens were analyzed for associations with clinicopathological data, including DCLK1 expression, epithelial mesenchymal transition(EMT) marker expression, and cancer stem cell(CSC) marker expression. Univariate and multivariate survival analyses were performed and we assessed the association between DCLK1 expression and clinicopathological factors, including the EMT marker and CSC marker.RESULTS In total, 48.5%(66/136) of the pancreatic cancer samples were positive for DCLK1. Patients with DCLK1-positive tumors had significantly shorter survival times than those with DCLK1-negative tumors(median, 18.7 mo vs 49.5 mo, respectively; P < 0.0001). Positive DCLK1 expression correlated with histological grade(P = 0.0290), preoperative CA19-9 level(P = 0.0060), epithelial cell adhesion molecule(Ep CAM) expression(P = 0.0235), and the triple-positive expression of CD44/CD24/Ep CAM(P = 0.0139). On univariate survival analysis, five factors were significantly associated with worse overall survival: histological grade of G2 to G4(P = 0.0091), high preoperative serum SPan-1 level(P = 0.0034), R1/2(P < 0.0001), positive expression of DCLK1(P < 0.0001) or CD44(P = 0.0245). On multivariate survival analysis, R1/2 [odds ratio(OR) = 2.019, 95% confidence interval(CI): 1.380-2.933; P = 0.0004] and positive DCLK1 expression(OR = 1.848, 95%CI: 1.2854-2.661; P = 0.0009) were independent prognostic factors. CONCLUSION DCLK1 expression was found to be an independent prognostic factor and it may play a crucial prognostic role by promoting acquisition of stemness. | Kohei Nishio Kenjiro Kimura Ryosuke Amano Bunzo Nakata Sadaaki Yamazoe Go Ohira Kotaro Miura Naoki Kametani Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa Masaichi Ohira | 2017 | World Journal of Gastroenterology2017，23，31： | 3 |
| 4 | Impact of laparoscopic liver resection for hepatocellular carcinoma with F4-liver cirrhosis显示文摘 | Akishige Kanazawa Tadashi Tsukamoto Sadatoshi Shimizu Shintaro Kodai Sadaaki Yamazoe Satoshi Yamamoto Shoji Kubo | 2013 | Surgical Endoscopy2013，，7： | 3 |
| 5 | Laparoscopic liver resection for treating recurrent hepatocellular carcinoma显示文摘 | Akishige Kanazawa Tadashi Tsukamoto Sadatoshi Shimizu Shintaro Kodai Satoshi Yamamoto Sadaaki Yamazoe Go Ohira Takayoshi Nakajima | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，5： | 3 |
| 6 | Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways显示文摘 | Matsuoka H Tsubaki M Yamazoe Y | 2009 | Exp Cell Res2009，315，12： | 1 |
| 7 | 显示文摘 | Teraoka Y Nobunaga T Yamazoe N | 1988 | Chemistry Letters1988，3，： | 1 |
| 8 | Study of WO3-based sensing materials for NH3 and NO detection显示文摘 | Wang X Miura N Yamazoe N | 2000 | Sensors and Actuators B: Chemical2000，66，13： | 1 |
| 9 | Construction of a CYP2El-template system for prediction of the metabolism on both site and preference order显示文摘 | Yamazoe Y Ito K Yoshinafi K | 2011 | Drug Metab Rev2011，43，： | 1 |
| 10 | Effect of additives on semiconductor gas sensors 显示文摘 | YAMAZOE N KUROKAWA Y SEIYAMA T | 1983 | Sens Actuators B1983，4，： | 1 |
| 11 | Oxide semiconduc- tor gas sensors 显示文摘 | Yamazoe Noboru Sakai Go Shimanoe Kengo | 2003 | Catalysis Survey Asia2003，，7： | 1 |
| 12 | Toward innovations of gas sensor teehnology显示文摘 | YAMAZOE N | 2005 | Sensors and Actuators B2005，108，： | 1 |
| 13 | Development of SnO2- based ethanol gas sensor显示文摘 | Mackawa T Tamaki J Yamazoe N | 1992 | Sensors and Actuators1992，9，： | 1 |
| 14 | Oxidation catalysis of perovskites-relationships to bulk structure and composition显示文摘 | Yamazoe N Teraoka Y | 1990 | Catalysis Today1990，8，2： | 1 |
| 15 | Initial MRI fmdings of nontraumatic osteonecrosis of the femoral head in renal allograft recipients 显示文摘 | Kubo T Yamazoe S Sugano N | 1997 | Magn Reson Imaging1997，9，： | 1 |
| 16 | Effects of B site partial substitutions of perovskite-type La0.6Sr0.4CoO3 on oxygen desorption显示文摘 | H. -M. Zhang N. Yamazoe Y. Teraoka | 1989 | Journal of Materials Science Letters1989，，9： | 1 |
| 17 | Toward innovations of gas sensor technology显示文摘 | Noboru Yamazoe | 2005 | Sensors and Actuators B2005，108，： | 1 |
| 18 | Sensots and Actuators B显示文摘 | Xu Chaonan Tamaki Jun Mirura Nofio Yamazoe Noboru | 1991 | 3:147 -1551991，3，： | 1 |
| 19 | Abundance,diversity,and dynamics of viruses on microorganisms in activated sludge processes显示文摘 | Otawa K Lee S H Yamazoe A | 2007 | Microbial Ecology2007，53，1： | 1 |
| 20 | Inhibition Selectivity of Grapefruit Juice Components on Human Cytochromes P450显示文摘 | Wichittra Tassaneeyakul Lian-Qing Guo Katsuyuki Fukuda Tomihisa Ohta Yasushi Yamazoe | 2000 | Archives of Biochemistry and Biophysics2000，，2： | 1 |
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