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| 1 | Small molecule ROR'/t an- tagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms显示文摘 | Sheng X Yosef N Yang JF et aZ | 2014 | Immunity2014，40，： | 1 |
| 2 | Blocking effect of tricyclopinate on nicotinic receptors in cultured sympathetic neurons显示文摘 | ZhengJQ He XP Yang AZ | 2000 | Acta Pharmacol Sin2000，21，11： | 1 |
| 3 | An appropriate time-window for measuring soil CO2 efflux: a case study on a Black soil in north-east China 显示文摘 | Shi XH Zhang XP Yang XM Mclaughlin NB Liang AZ Fan RQ | 2012 | Acta Agric Scand B-S P2012，62，5： | 1 |
| 4 | Hepatitis B virus genotypeassociated variability in antiviral response to adefovir dipivoxil therapy in Chinese Han population显示文摘 | Zeng AZ Deng H Yang C | 2008 | Tohoku J Exp Med2008，216，3： | 1 |
| 5 | Simultaneous quantification of four indole alkaloids in Catharanthus roseus cell line C20hi by UPLC-MS 显示文摘 | He LH Yang L Xiong AZ | 2011 | Anal Sci2011，27，4： | 1 |
| 6 | Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells显示文摘 | Deborah AZ Marty FB Yang Gong | 2001 | Cacer Res2001，61，13： | 1 |
| 7 | Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus 显示文摘 | Liao HX Lynch R Zhou T Gao F Alam SM Boyd SD Fire AZ Roskin KM Schramm CA Zhang Z ZhuJ Sha- piro L NISC Comparative Sequencing Program Mullikin JC Gnanakaran S Hraber P Wiehe K Kelsoe G Yang G Xia SM Montefiori DC Parks R Lloyd KE Scearce RM Soderberg KA Cohen M Kamanga G Louder MK Tran LM Chen Y Cai F Chen S Moquin S Du X Joyce MG Srivatsan S Zhang B Zheng A Shaw GM Hahn BH Kepler TB Korber BT Kwong PD Mascola JR Haynes BF | 2013 | Nature2013，496，7446： | 1 |
| 8 | Constant elasticity of variance model for proportional reinsurance and investment strategies显示文摘 | Gu M Yang Y Li S et aZ | 2010 | Insurance: Mathematics and Economics2010，46，3： | 1 |
| 9 | Antimicrobial resistance of Listeria monocytogenes and Listeria innocua from meat products and meat-processing environment显示文摘 | Diego Gómez Ester Azón Noelia Marco Juan J. Carrami?ana Carmina Rota Agustín Ari?o Javier Yangüela | 2014 | Food Microbiology2014，，： | 1 |
| 10 | Application of anaerobic ammonium-oxidizing consortium to achieve completely autotrophic ammonium and sulfate removal 显示文摘 | Liu S Yang F Gong Z et aZ | 2008 | Bioresource Technology2008，99，15： | 1 |
| 11 | Encapsulating drug in biodegradable ultrafine fibers through coaxial electrospinning 显示文摘 | Huang ZM He CL Yang AZ | 2006 | Journal of Biomedical Materials Research2006，77，1： | 1 |
| 12 | Blocking effect of tricyclopinate on nicotinic receptors in cultured sympathetic neurons显示文摘 | Zheng JQ He XP Yang AZ Liu CG | 2000 | Acta Pharmacol Sin2000，21，11： | 1 |
| 13 | Hepatitis B virus genotype-associated variability in antiviral response to adefovir dipivoxil therapy in Chinese Han population 显示文摘 | Zeng AZ Deng H Yang C | 2008 | Tohoku J Exp Med2008，216，3： | 1 |
| 14 | Bile acids metabonomic study on the CC14 - and r- naphthylisothiocyanate- induced animal models: quanti- tative analysis of 22 bile acids by ultraperformanee liquid chromatography - mass spectrometry 显示文摘 | Yang L Xiong AZ He YQ | 2008 | Chem Res Toxicol2008，21，： | 1 |
| 15 | Epidemiological-Serosurvey of Hepatitis B in China - Declining HBV prevalence- Due to Hepatitis B vaccination 显示文摘 | Xiaoteng Liang Shengli Bi Weizhong Yang et aZ | 2009 | Vaccine2009，27，47： | 1 |
| 16 | Celastrol, a triterpene ex tracted from the Chinese 'Thunder of God Vine, ' is a potent proteasome inhibitor and suppresses human prostate cancergrowth in nude mice显示文摘 | Yang H Chen D Cui QC et aZ | 2006 | Cancer Res2006，66，9： | 1 |
| 17 | Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing显示文摘Cellular senescence is a stress-induced,stable cell cycle arrest phenotype which generates a pro-inflammatory microenvironment,leading to chronic inflammation and age-associated diseases.Determining the fundamental molecular pathways driving senescence instead of apoptosis could enable the identification of senolytic agents to restore tissue homeostasis.Here,we identify thrombomodulin(THBD)signaling as a key molecular determinant of the senescent cell fate.Although normally restricted to endothelial cells,THBD is rapidly upregulated and maintained throughout all phases of the senescence program in aged mammalian tissues and in senescent cell models.Mechanistically,THBD activates a proteolytic feed-forward signaling pathway by stabilizing a multi-protein complex in early endosomes,thus forming a molecular basis for the irreversibility of the senescence program and ensuring senescent cell viability.Therapeutically,THBD signaling depletion or inhibition using vorapaxar,an FDA-approved drug,effectively ablates senescent cells and restores tissue homeostasis in liver fibrosis models.Collectively,these results uncover proteolytic THBD signaling as a conserved pro-survival pathway essential for senescent cell viability,thus providing a pharmacologically exploitable senolytic target for senescence-associated diseases. | Christopher C.Pan Raquel Maeso-Díaz Tylor R.Lewis Kun Xiang Lianmei Tan Yaosi Liang Liuyang Wang Fengrui Yang Tao Yin Calvin Wang Kuo Du De Huang Seh Hoon Oh Ergang Wang Bryan Jian Wei Lim Mengyang Chong Peter B.Alexander Xuebiao Yao Vadim Y.Arshavsky Qi-Jing Li Anna Mae Diehl Xiao-Fan Wang | 2023 | Cell Research2023，33，7： | 0 |
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