|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Beclin 1-Vps34 complex architecture: Understanding the nuts and bolts of therapeutic targets显示文摘Autophagy 是由毁坏并且再循环细胞内部的内容帮助细胞的动态平衡的维护的一条重要 lysosomal 降级小径。autophagy 的 Dysregulation 被连接到越来越多的人的疾病。Beclin 1-Vps34 蛋白质蛋白质相互作用网络为 autophagy 规定是批评的并且对细胞的正直因此必要。特别地经由 Beclin 1-Vps34 建筑群的行动的调整, autophagy 的操作被认为一条有希望的线路与 autophagy 相关的疾病作斗争。这里,我们在核心部件和 Beclin 1-Vps34 建筑群的结构的建筑学上总结最近的调查结果,并且怎么这些调查结果提供珍贵卓见进位于这些建筑群并且为设计治疗学的策略的多重函数下面的分子的机制。 | Deanna H. Morris Calvin K. Yip Yi Shi Brian T. Chait Qing Jun Wang | 2015 | Frontiers in Biology2015，10，5： | 17 |
| 2 | Traumatic Brain Injury in the Elderly: Is it as Bad as we Think?显示文摘 | Calvin Mak Stephen Wong George Wong Stephanie Ng Kevin Wang Ping Lam Wai Poon | 2012 | Current Translational Geriatrics and Gerontology Reports2012，，3： | 1 |
| 3 | CD4(+)CD25(+) treg induction by an HSP60-derived peptide SJMHE1 from schistosoma japonicum is TLR2 dependent显示文摘Chronic schistosome infection results in the suppression of host immune responses, allowing long-term schistosome survival and restricting pathology.Current theories suggest that Treg play an important role in this regulation.However, the mechanism of Treg induction during schistosome infection is still unknown.The aim of this study was to determine the mechanism behind the induction of CD4(+)CD25(+) T cells by Schistosoma japonicum HSP60(SjHSP60)-derived peptide SJMHE1 as well as to elucidate the cellular and molecular basis for the induction of CD4(+)CD25(+) T cells during S.japonicum infection.Mice immunized with SJMHE1 or spleen and LN cells from naive mice pretreated.with SJMHE1 in vitro all displayed an increase in CD4(+)CD25(+) T-cell populations.Release of IL-10 and TGF-beta by SJMHE1 stimulation may contribute to suppression.Adoptively transferred SJMHE1induced CD4(+)CD25(+) T cells inhibited delayed-type hypersensitivity in BALB / c mice.Additionally, SJMHE1-treated APC were tolerogenic and induced CD4(+) cells to differentiate into suppressive CD4(+)CD25(+) Treg.Furthermore, our data support a role for TLR2 in SJMHE1-mediated CD4(+)CD25(+) Treg induction.These findings provide the basis for a more complete understanding of the S.japonicum-host interactions that contribute to host homeostatic mechanisms, preventing an excessive immune response. | Wang, Xuefeng Zhou, Sha Chi, Ying Wen, Xiaoyun Hoellwarth, Jason He, Lei Liu, Feng Wu, Calvin Dhesi, Shawn Zhao, Jiaqing Hu, Wei Su, Chuan | 2010 | 南京医科大学学报(自然科学版)2010，30，1： | 1 |
| 4 | Mechanisms for Progenitor Cell-Mediated Repair for Ischemic Heart Injury显示文摘 | Shengwen Calvin Li Julyana Acevedo Lang Wang Hong Jiang Jane Luo Richard G. Pestell William G. Loudon Anthony C. Chang | 2012 | Current Stem Cell ResearchandTherapy2012，，1： | 1 |
| 5 | Stem cell engineering for treatment of heart diseases: Potentials and challenges显示文摘 | Shengwen Calvin Li Lang Wang Hong Jiang Julyana Acevedo Anthony Christopher Chang William Gunter Loudon | 2008 | Cell Biology International2008，，3： | 1 |
| 6 | FuGENE HD transfection re- agent: Choice of a transfectian reagent with minimal off-target effect as analyzed by microarray transcriptional profiling 显示文摘 | Calvin S Wang J Emch J | 2006 | Biochemica2006，，4： | 1 |
| 7 | Stem cell engineering for treatment of heart diseases: Potentials and challenges显示文摘 | Shengwen Calvin Li Lang Wang Hong Jiang Julyana Acevedo Anthony Christopher Chang William Gunter Loudon | 2008 | Cell Biology International2008，，3： | 1 |
| 8 | FuGENE HD transfection reagent: choice of a transfection reagent with minimal off target effect as analyzed by microarray transcriptional profiling显示文摘 | Calvin S Wang J Emch J | 2006 | Gene Expression2006，4，： | 1 |
| 9 | Long Term Changes in Visual Acuity in an Older Population over a 15-Year Period: The Blue Mountains Eye Study显示文摘 | Thomas Hong Paul Mitchell Elena Rochtchina Calvin Fong Ee-Munn Chia Jie Jin Wang | 2013 | Ophthalmology2013，，： | 1 |
| 10 | Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients显示文摘 | Jinxin Zheng Zheng Zeng Duyi Zhang Yanyan Yu Fang Wang Calvin Q. Pan | 2012 | Liver Int2012，，10： | 1 |
| 11 | Calcium and Phosphorus Determinations in the Blood Plasma in Rickets and Tetany 显示文摘 | Hess J H Calvin J K Wang Chi Che Felcher A | 1923 | American Journal of Diseases of Children1923，26，3： | 1 |
| 12 | Connecting supplier and DoD blockchains for transparent part tracking显示文摘Blockchains have been around for more than ten years,and since 2015,a plethora of systems have been launched to target more flexible use cases.More recently,several enterprise blockchain systems,such as Consensys Quorum and Hyperledger Fabric,have been launched to make blockchain simpler to apply in complex organizational configurations.In this paper,we identify a specific Department of Defense use case,extrapolate requirements,and perform a thorough assessment of the different layers of the blockchain stack to identify the existing state of the art and undertake a gap analysis of the technology for this context.We describe a platform that meets many of these challenges and show how we architected,designed,and implemented a solution for this use case for deployment at NAVAIR.This solution connects transactions from two separate blockchain systems,Consensys Quorum and Hyperledger Fabric,by using a graph-based approach that preserves privacy while enabling full transparency across the military and supplier networks. | Francis Asuncion Adam Brinckman Dwayne Cole Jeffrey Curtis Matt Davis Timothy Dunlevy Calvin Farmer Andrew Harrison Daniel P.Johnson Joshua Joyce Chris Klubertanz Jonathan Lane John Martin Jarek Nabrzyski Joel Neidig Deysi Olivares Gregory Robinson Gabriel Rodriguez Chris Root Karen Rowand Al Salour Jeff Score David Scott Ian Taylor Chandler Thompson Huy Truong Xiqun Wang Dale Warren | 2021 | Blockchain(Research and Applications)2021，2，3： | 1 |
| 13 | 巴黎时装周:讲述中国设计师的故事显示文摘3月10日,巴黎2021秋冬时装周正式落下帷幕。受疫情影响,本季巴黎时装周仍旧以线上发布的形式进行呈现。根据官方日程表,有包括品牌UMA WANG、DAWEk MASHAMA以及CALVIN LUO等在内的7家中国设计师品牌参与本季巴黎女装周。其中MAISON MAI、CALVIN LUO将以静态展的形式呈现,另外5家以时装秀的形式呈现。 | 张倩倩 UMA WANG(图) DAWEI(图) MASHAMA(图) CALVIN LUO(图) | 2021 | 艺术与设计2021，，4： | 0 |
| 14 | Genome-wide methylation profiling reveals differentially methylated genes in blood DNA of small-cell lung cancer patients显示文摘Dear Editor,Small-cell lung cancer(SCLC),one of the most-deadly malignant tumors,accounts for∼15%of all lung cancers.1,2 Although highly responsive to the standard chemoradiotherapy,the recurrence rate of SCLC is nearly unity,with median survival time ranging from 2–6 months.Almost all SCLC patients are inoperable,leading to the difficulty in obtaining adequate biopsy tissue for research.3 Consequently,there is an urgent need to find noninvasive biomarkers to predict the risk and provide early diagnosis of SCLC.We aimed to identify potential epigenomic markers for SCLC development in blood DNA and reveal differentially methylated genes through a multi-omics approach,from genome-wide DNA methylation profiling,followed by pathway enrichment analyses and target gene validation utilizing Gene Expression Omnibus(GEO)and Oncomine microarray databases,to TCGA PanCancer cohorts.It is known that virtually all patients with SCLC are victims of tobacco smoking,4 but it is unknown whether stopping smoking before SCLC diagnosis would influence the epigenetic biomarkers under investigation.We here report a study that identified aberrantly methylated genes between current and former smokers among SCLC patients,revealing a set of candidate biomarkers in peripheral blood DNA for better stratifying patients with high risk. | Yanqi He Calvin Wei Zhifu Sun Julie M.Cunningham Liang Wang Zong Wei Ping Yang | 2022 | Precision Clinical Medicine2022，5，3： | 0 |
| 15 | Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing显示文摘Cellular senescence is a stress-induced,stable cell cycle arrest phenotype which generates a pro-inflammatory microenvironment,leading to chronic inflammation and age-associated diseases.Determining the fundamental molecular pathways driving senescence instead of apoptosis could enable the identification of senolytic agents to restore tissue homeostasis.Here,we identify thrombomodulin(THBD)signaling as a key molecular determinant of the senescent cell fate.Although normally restricted to endothelial cells,THBD is rapidly upregulated and maintained throughout all phases of the senescence program in aged mammalian tissues and in senescent cell models.Mechanistically,THBD activates a proteolytic feed-forward signaling pathway by stabilizing a multi-protein complex in early endosomes,thus forming a molecular basis for the irreversibility of the senescence program and ensuring senescent cell viability.Therapeutically,THBD signaling depletion or inhibition using vorapaxar,an FDA-approved drug,effectively ablates senescent cells and restores tissue homeostasis in liver fibrosis models.Collectively,these results uncover proteolytic THBD signaling as a conserved pro-survival pathway essential for senescent cell viability,thus providing a pharmacologically exploitable senolytic target for senescence-associated diseases. | Christopher C.Pan Raquel Maeso-Díaz Tylor R.Lewis Kun Xiang Lianmei Tan Yaosi Liang Liuyang Wang Fengrui Yang Tao Yin Calvin Wang Kuo Du De Huang Seh Hoon Oh Ergang Wang Bryan Jian Wei Lim Mengyang Chong Peter B.Alexander Xuebiao Yao Vadim Y.Arshavsky Qi-Jing Li Anna Mae Diehl Xiao-Fan Wang | 2023 | Cell Research2023，33，7： | 0 |
| 16 | Stereoselective construction of skipped polyol enabled by oxonia-Cope rearrangement and iodolactonization: enantioselective synthesis of (+)-yashabushitriol显示文摘Skipped polyol is a common motif in numerous biologically significant polyketides and has been the focus of the development of novel synthetic methods and strategies. In this work, we devised a highly diastereoselective approach to access skipped triol(anti,syn-isomer) from a chiral α-allenic alcohol which was derived from kinetic resolution in our previous studies. An iodolactonization and subsequent radical deiodonation efficiently introduced the hydroxyl group at C3 in a highly diastereoselective manner and exemplified in enantioselective total synthesis of (+)-yashabushitriol. | Guoli He Yan Wang Calvine Lai Wenhua Li Ran Hong | 2016 | Science China Chemistry2016，59，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员