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| 1 | Astragalus saponin attenuates the expression of fibrosis-related molecules in irradiated cardiac fibroblasts显示文摘导致放射的心疾病的主要病理学的变化是纤维变性。新兴的证据显示了那 Astragalusmembranaceus 和它的提炼之物,距骨 saponin (著名计算机生产厂商) ,被用于治疗纤维变性疾病。在现在的学习,照耀导致的纤维变性损坏上的著名计算机生产厂商的效果是坚定的。在与 1 被照耀或 2-Gy X 光以后, endoplasmic 蜂窝胃形态学的明显的变化在心脏的成纤维细胞(CF ) 被观察,建议它的 proteinprocessing 功能是 imbalanced,它间接地显示那纤维变性损坏被照耀引起 CF。TGF-1 和骨胶原的 expressionlevels (Col-1 ) 我在 48-h 被增加照耀以后。20 g/ml 著名计算机生产厂商的管理减少了反应的氧 speciesin 的生产照耀的 CF 并且减少 Col-1, TGF-1,和 p-Smad2/3 的表示。聚合酶链反应(PCR ) 数组分析证明有 30 基因,主要被分类进 extracellularmatrix,改变酶,煽动性的 cytokines/chemokines,和 TGF- 总科,在有 1-Gy X 光检查的处理以后是起来调整的,而大多数这些基因是下面调整的什么时候 pretreatedwith 著名计算机生产厂商的 20 g/ml。另外,在有 1-Gy X 光检查的处理以后是下面调整的 TIMP1 和 Smad7 基因是起来调整的什么时候有著名计算机生产厂商的 20 g/ml 的 pretreated。Inconclusion,导致放射的纤维变性损坏在细胞的水平被观察。著名计算机生产厂商稀释了照耀的 CF 和这反纤维变性效果可以是的这纤维变性损坏 effectin 仔细与它的抗氧化剂行动有关。在照耀的 CF 的 fibrosis-relatedmolecules 的参与被一个 PCR 数组系统地第一次表明。著名计算机生产厂商颠倒了基因的多数由照耀改变了的 expressionof,它进一步证实了它的反纤维变性效果。 | Jing Gu Kai Liu Hailong Li Xiaogang Wang Kehu Yang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 11 |
| 2 | Effect of Aidi injection plus chemotherapy on gastric carcinoma:a Meta-analysis of randomized controlled trials显示文摘OBJECTIVE: To conduct a Meta-analysis of studies on the effect of Aidi injectioncombined with chemotherapy versus chemotherapy alone in the treatment of gastric cancer(GC).METHODS: Nine electronic databases and six gray literature databases were comprehensively searcheduntil April 20,2013. Two reviewers independently selected and assessed included trialsaccording to the inclusion and exclusion criteria. The risk of bias tool from the Cochrane Handbook version 5.1.0was used to assess trial quality. All calculations were performed using Review Manager 5.0.RESULTS: Thirty-two studies including 1927 participants met the inclusion criteria,most of which were low quality. Compared with chemotherapy alone,Aidi injection plusthe same chemotherapy significantly improved the effective rate [OR = 1.52,95% CI(1.24,1.86),P < 0.0001],clinical beneficial rate [OR = 1.77,95% CI(1.33,2.36),P < 0.0001],and quality of life [OR = 3.02,95% CI(2.39,3.82),P <0.000 01]. There was a significant improvement in nausea and vomiting incidence [OR = 0.34,95%CI(0.24,0.47),P < 0.000 01],diarrhea [OR = 0.47,95%CI(0.33,0.69),P < 0.000 01],leukopenia( 3,0.51),P = 0.05],hemⅢ-ogⅣ)[OR = 0.34,95%CI(0.2lobin decrease(thromⅢ-boⅣ) [OR = 0.42,95%CI(0.18-1.00),P = 0.05],cytopenia(4],and Ⅲ-damⅣ) [OR = 0.46,95%CI(0.22,0.96),P = 0.0age to liver function [OR = 0.36,95%CI(0.24,0.54),P < 0.000 01].CONCLUSION: Aidi injection combined with chemotherapy significantly improved the clinical effect of chemotherapy,reducing the incidence of adverse events. Use of the CONSORT statement for randomized controlled trials is recommended for stricter reporting. | Wang Jiancheng Ge Long Zhao Ye Li Jinlong Zhang Pan Mao Lei Yang Kehu | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 9 |
| 3 | Clinicopathological and prognostic role of MMP-9 in esophageal squamous cell carcinoma: a meta-analysis显示文摘Objective:Many studies reported that matrix metalloproteinase-9(MMP-9)participated in the development of esophageal squamous cell carcinoma(ESCC)and resulted in poor prognosis,however,they all included few patients and had inconsistent results.So we conducted a meta-analysis to explore the correlation between overexpression of MMP-9 and the clinicopathological characteristics and overall survival(OS)of ESCC.Methods:PubMed,EMBASE,Web of Science,Chinese Biomedical Literature Database,Google Scholar and other databases were searched for relevant studies.The Newcastle-Ottawa quality assessment scale was used to assess the methodological quality of included study and RevMan 5.2 software was used to conduct meta-analysis.Results:A total of 35 studies were included,and the results of meta-analysis showed that overexpression of MMP-9 was associated with grade of differentiation[well/moderate vs.poor:odds ratio(OR):0.39,95%confidence interval(CI):0.29-0.52;P<0.00001],lymph node metastasis(negative vs.positive:OR:0.24,95%CI:0.16-0.34;P<0.00001),TNM stage(T1/T2 vs.T3/T4:OR:0.28,95%CI:0.14-0.54;P=0.0002),the depth of invasion(T1/T2 vs.T3/T4:OR:0.29,95%CI:0.17-0.49;P<0.00001),and vascular invasion of ESCC(negative vs.positive:OR:0.35,95%CI:0.21-0.58;P<0.0001),and also associated with poor overall survival of ESCC(HR:2.17,95%CI:1.32-3.57;P=0.002).Subgroup analysis showed that more than 10%of carcinoma cell staining was associated with significant increase of mortality risk(HR:2.44,95%CI:1.16-5.15;P=0.02),and sensitive analysis suggested that MMP-9 was an independent prognostic factor in ESCC(HR:1.49,95%CI:1.16-1.91;P=0.002).Conclusions:On the basis of limited evidence,overexpression of MMP-9 may be a potential independent prognosis factor of ESCC patients in Asia,and high-quality studies assessing the prognostic significance of MMP-9 for ESCC patients are still needed. | Rong Zeng Lei Duan Yuke Kong Yaojun Liang Xiaolu Wu Xuequan Wei Kehu Yang | 2013 | Chinese Journal of Cancer Research2013，25，6： | 5 |
| 4 | 调强适形放疗在乳腺癌保乳术后应用的系统评价(英文)显示文摘Objective:The aim of this study was to assess the long-term effect of breast conservation with breast intensitymodulated radiotherapy (IMRT) for early-stage breast cancers.Methods:Pub Med,EMBASE,Cochrane Library,Chinese Biomedical Literature Database were searched to identify relevant original published trails,and the references of eligible studies were manually screened.Randomized controlled trails reported in any language,comparing breast IMRT with conventional radiotherapy (RT) in patients with early-stage breast cancer were eligible for inclusion.Two investigators independently assessed the quality of included trials and extracted data.The RevMan 5.0 software was used for statistical analysis.Results:Four trials involving 1440 patients were included.The results showed that in the IMRT group,the occurrence of acute moist dermatitis,the edema of the mammary gland and the occurrence of hyperpigmentation were lower than those of RT group,the pooled risk ratio value and 95% confidence interval were 0.28 (0.17-0.48),0.03 (0.00-0.21) and 0.06 (0.02-0.15) respectively.The use of IMRT did not correlate with pain and quality of life,but the presence of moist desquamation did significantly correlate with pain and reduced quality of life.Conclusion:The currently available evidence showed that IMRT significantly reduces the occurrence of moist acute dermatitis anywhere in the breast and alleviates the suffering of patients and improves the quality of life of patients.Future large-scale,high-quality,double-blind trials are needed. | Xiupeng Ye Ling Su Xiaohu Wang Kehu Yang inhui Tian Qiuning Zhang Qiang Wang Xiaojun Li Yuqing Kang Liyun Guo Ruifeng Liu Shifang Feng | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，12： | 2 |
| 5 | Preoperative carbohydrate loading for elective surgery: a systematic review and meta-analysis显示文摘 | Lun Li Zehao Wang Xiangji Ying Jinhui Tian Tiantian Sun Kang Yi Peng Zhang Zhang Jing Kehu Yang | 2012 | Surgery Today2012，，7： | 1 |
| 6 | A New Approach to Sensor Node LocalizationUsing RSS Measurements in Wireless Sensor Networks 显示文摘 | Wang Gang Yang Kehu | 2011 | IEEETransactions on Wireless Communications2011，10，5： | 1 |
| 7 | Lichtenstein?s Operation, Mesh Plug, or Prolene Hernia System Repair for Groin Hernia: Which is Better?显示文摘 | Kehu Yang Bin Ma Gang Zhao | 2010 | Annals of Surgery2010，，1： | 1 |
| 8 | A New Approach to Sensor Node Localization Using RSS Measurements in Wireless Sensor Networks 显示文摘 | Wang Gang Yang Kehu | 2011 | IEEE Transactions on Wireless Communieations2011，10，5： | 1 |
| 9 | Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers显示文摘 | Jian Shu Chen Wu Yetao Wu Zhiyuan Li Sida Shao Wenhui Zhao Xing Tang Huan Yang Lijun Shen Xiaohan Zuo Weifeng Yang Yan Shi Xiaochun Chi Hongquan Zhang Ge Gao Youmin Shu Kehu Yuan Weiwu He Chao Tang Yang Zhao Hongkui Deng | 2013 | Cell2013，，5： | 1 |
| 10 | Iron deficiency anemia in Helicobacter pylori infection: meta-analysis of randomized controlled trials显示文摘 | Yuan Wenzhen Li Yumin Yang Kehu Ma Bin Guan Quanlin Wang Donghai Yang Lijuan | 2010 | Scandinavian Journal of Gastroenterology2010，，6： | 1 |
| 11 | Probiotics in pa- tients with severe acute panereatitis: A meta- analysis显示文摘 | Shaoliang Sun Kehu Yang Xiaodong He | 2009 | Lange- nbecks Arch Surg2009，394，1： | 1 |
| 12 | Iron deficiency anemiain Helicobacter pylori infection: meta - analysis of randomizedcontrolled trials 显示文摘 | Yuan W Li Yumin Yang Kehu | 2010 | Scand J Gastroenterol2010，45，： | 1 |
| 13 | A New Approach to Sensor Node Localization Using RSS Measurements in Wireless Sensor Networks 显示文摘 | Wang Gang Yang Kehu | 2011 | IEEE Transactions on Wireless Communication2011，10，5： | 1 |
| 14 | Garlic in Clinical Practice: An Evidence-Based Overview显示文摘 | Lun Li Tiantian Sun Jinhui Tian Kehu Yang Kang Yi Peng Zhang | 2013 | Critical Reviews in Food Science and Nutrition2013，，7： | 1 |
| 15 | A New Approach to Sensor Node Local- ization Using RSS Measurements in Wireless Sensor Networks显示文摘 | Wang Gang Yang Kehu | 2011 | IEEE Transactions on Wireless Communications2011，10，5： | 1 |
| 16 | Network meta-analyses could be improved by searching more sources and by involving a librarian显示文摘 | Lun Li Jinhui Tian Hongliang Tian David Moher Fuxiang Liang Tongxiao Jiang Liang Yao Kehu Yang | 2014 | Journal of Clinical Epidemiology2014，，： | 1 |
| 17 | A new approach to sensor node Localization using RSS measurements in wireless sensor networks显示文摘 | Guang Wang Kehu Yang | 2011 | IEEE Transactions On Wireless Communications2011，10，5： | 1 |
| 18 | Iron deficiency anemia in Helicobacter pylori infection: meta-analysis of randomized con- trolled trials显示文摘 | Yuan W Li Yumin Yang Kehu | 2010 | Seand J Gastroenterol2010，45，6： | 1 |
| 19 | 'Efficient convex re- laxation methods for robust target localization by a sensor networks using time difference of arrivals显示文摘 | Yang Kehu Wang Gang Luo Zhi-Quan | 2009 | IEEE Trans on Signal processing2009，57，7： | 1 |
| 20 | 放疗联合手术治疗胃癌的Meta-分析(英文)显示文摘Objective:We carried out a meta-analysis to assess the effectiveness and safety of radiotherapy combined with surgery for gastric cancer.Methods:Randomized Clinical Trials (RCTs) in which radiotherapy (preoperative,intraoperative and postoperative),was compared with surgery alone in resectable gastric cancer were identified by searching Cochrane Library (Issue 2,2009),PubMed (Jan 1966-Jun 2009),EMBASE (Jan 1974-Jun 2009),Chinese Biomedical Literature Database (Jan 1978-Jun 2009),Chinese Science and Technology Periodicals Database (Jan 1989-Jun 2009),China National Knowledge Infrastructure (Jan 1994-Jun 2009) and Wanfang database (Jan 1997-Jun 2009) in English and Chinese languang.Two researchers assessed the quality of included randomized controlled trials (RCT) extracted data independently.The RevMan 5.0 software was used for meta-analysis.Our researchers assessed the quality of included randomized controlled trials (RCT) extracted data independently.The RevMan 5.0 software was used for meta-analysis.Results:Nine randomized controlled trials of 1 548 patients were selected for meta-analysis.Five randomized controlled trials were related with comparison of preoperative radiotherapy plus surgery with single surgery.Two randomized controlled trials were the comparative studies between surgery plus postoperative and single surgery.The meta-analysis results showed that:(1) compared with surgery alone,preoperative radiotherapy combined with surgery can increase 3 years (OR=1.78;95% CI 1.14-2.78,P=0.01),5 years (OR=1.67;95% CI 1.22-2.29,P=0.001),10 years (OR=1.64;95% CI 1.03-2.60,P=0.04) survival rate and resection rate (OR=2.15;95% CI 1.31-3.54,P=0.003);reduce the of tumor recurrence rate (OR=0.59;95% CI 0.37-0.92,P=0.02) and metastasis rate (OR=0.44;95% CI 0.27-0.73,P=0.001);(2) The tumor recurrent rates (OR=0.19,95% CI 0.03-1.14,P=0.07) and tumor metastasis rate (OR=0.09;95% CI 0.00-1.77,P=0.11) had no difference between single surgery group and peri-operative radiotherapy plus surgery group;(3) Postoperative radiotherapy compared with surgery alone had no significant effects on 1 year (OR=0.83;95% CI 0.60-1.15,P=0.26) and 3 years (OR=0.75;95% CI 0.51-1.11,P=0.15) survival rate compared with single surgery,but the 5-year survival rates (OR=0.57;95% CI 0.34-0.95,P=0.03) of the patients who received surgery alone was higher than those who received combined therapy.No difference of the tumor recurrence rate (OR=0.59;95% CI 0.33-1.05,P=0.07),tumor metestasis rate (OR=0.90;95% CI 0.51-1.59,P=0.71) and anastomotic leak (OR=0.98;95% CI 0.25-3.65,P=0.98) were observed between the two groups.Conclusion:Preoperative radiotherapy combined surgery is more rational and effective than surgery alone of gastric cancer.However,in terms of the clinical effects of perioperarive or postoperative radoiotherapy combined with surgery,much multicenter,largescale,high-quality,double-blind and rigorously designed studies would be needed than currently available in the future. | Liyun Guo Xiaohu Wang Bin Ma Kehu Yang Qjuning Zhang Xiupeng Ye Hongtao Luo Ruifeng Liu | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，8： | 1 |
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