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| 1 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 2 | Tonoplast calcium sensors CBL2 and CBL3 control plant growth and ion homeostasis through regulating V-ATPase activity in Arabidopsis显示文摘对发展、环境的暗示的植物回答被钙经常调停(被多样的钙传感器播送的 Ca 2+) 信号。calcineurin 象 B 一样(CBL ) 蛋白质家庭代表通过和一组交往 CBL 蛋白质 kinases 的特定的相互作用译码钙信号的钙传感器。我们报导 Arabidopsis CBL2 和 CBL3 的功能的分析,对通过 N 终端指向 tonoplast 的 vacuolar 膜局部性的二个密切相关的 CBL 成员定序。当 cbl2 或 cbl3 单身者异种没从野类型显示出任何 phenotypic 差别时, cbl2 cbl3 两倍异种与叶尖端坏死,不发达的根,更短的 siliques 和更少种子被阻碍。这些缺点在 vha-a2 vha-a3 使人想起那些在 vacuolar H +-ATPase (V-ATPase ) 缺乏的两倍异种。确实, V-ATPase 活动在 cbl2 cbl3 被减少两倍变异的、连接 tonoplast CBL 类型钙传感器到 V-ATPase 的规定。而且, cbl2 cbl3 两倍异种在离子的忍耐和微量元素累积被损害,与在被显示了在离子区分工作的 V-ATPase 活动的缺点一致。我们的结果建议钙传感器 CBL2 和 CBL3 用作在钙发信号和 V-ATPase 之间的分子的连接,细胞内部的离子动态平衡的一个中央管理者。 | Ren-Jie Tang Hua Liu Yang Yang Lei Yang Xiao-Shu Gao Veder J Garcia Sheng Luan Hong-Xia Zhang | 2012 | Cell Research2012，22，12： | 26 |
| 3 | Effects of rare earth elements on inclusions and impact toughness of high-carbon chromium bearing steel显示文摘High-carbon chromium bearing steels with different rare earth (RE) contents were prepared to investigate the effects of RE on inclusions and impact toughness by different techniques. The results showed that RE addition could modify irregular Al2O3 and MnS into regular RE inclusions. With the increase of RE content, the reaction sequence of RE and potential inclusion forming elements should be O, S, As, P and C successively. RE inclusions containing C might precipitate in molten steel and solid state, but the precipitation tem perature was significantly higher than that of carbides in high-carbon chromium bearing steel. For experim ental bearing steels, the volume fraction of inclusions increased steadily with the increase of RE content, but smaller and more dispersed inclusions could be obtained by 0.018% RE content compared with bearing steel without RE, whereas the continuous increase of RE content led to an increasing trend for inclusion size and a gradual deterioration for inclusion distribution. RE addition could improve the transverse impact toughness and isotropy of bearing steel, and for modified highcarbon chrom ium bearing steel by RE alloying, the increase of RE content continuously increased both transverse and longitudinal im pact toughness until excessive RE addition. | Chaoyun Yang Yikun Luan Dianzhong Li Yiyi Li | 2019 | Journal of Materials Science & Technology2019，35，7： | 22 |
| 4 | A preliminary investigation on the occurrence and distribution of antibiotic resistance genes in the Beijiang River, South China显示文摘The occurrence of antibiotic resistance genes (ARGs) was investigated and quantified in 20 water samples collected in the Beijiang River, South China. Sulfonamide- and tetracycline-resistant bacteria were present in 17 and 14 of the collected 20 samples. For sulfonamide ARGs, sulI and sulII were frequently observed in the Beijiang River. The levels of sulI were higher than sulII (p < 0.05), with the mean values of (1.41 ± 1.12) × 10-2 and (1.58 ± 1.71) × 10-3 copies/16S rDNA, respectively. For tetracycline ARGs, tetG had the highest frequency, 100%, followed by tetA (85%), tetO (85%), tetC (70%), tetX (60%), tetM (40%) and tetQ (20%), while tetE and tetS were not detected in all the samples from the Beijiang River. On the other hand, tetC had the highest concentration, ranging from 8.30 × 10-2 to 13.20 copies/16S rDNA. The poor correlation between ARGs and antibiotic concentrations revealed that the self-amplification and persistence of ARGs were the reasons that made ARGs exist in the water environment even though the antibiotic selecting pressure was absent. Because so few field measurements have been conducted for investigating the levels of ARGs in rivers in South China, this study provides an important insight on better understanding the occurrence and spread of ARGs in such an ecosystem. | Zhenhao Ling Ying Yang Yuanli Huang Shichun Zou Tiangang Luan | 2013 | Journal of Environmental Sciences2013，25，8： | 20 |
| 5 | Breaches of the Baige Barrier Lake: Emergency response and dam breach flood显示文摘This paper documents the emergency response to the breaches of the Baige Barrier Lake. The lake was successively formed by landslides that occurred on October 10 and November 3, 2018 at the provincial border between Sichuan and Tibet in China. The barrier lake created by the '10.10' landslide breached on October 12 and triggered a flood with a peak discharge around 10000 m^3/s. The residual landslide barrier was enhanced by a second landslide on November 3, resulting in a higher barrier with larger flood potential. An overflow channel was excavated in the crest of the barrier to prompt the breach to be triggered at a lower water level. The second breach happened on November 12 with a measured peak discharge of 31000 m^3/s. Nearly 75000 people were evacuated before the two breaches. In order to prevent the downstream dams from possible over-topping, nearly 3.27×10~8 m^3 of the stored volume was released from the Liyuan reservoir 688 km downstream of Baige Barrier Lake. This paper presents the measured hydrographs and the back-analysis results for the '11.03' barrier lake. It is shown that the modern models of dam breach hydraulics can reasonably reproduce the barrier breach hydrographs;however, further studies are needed to define the key parameters which highly influence the calculated results. Knowledge acquired during the emergency response to the case can be shared with experts working on breaches of embankment dams and can be referenced to promote both the theory study and the engineering practice to mitigate the potential risks caused by this type of catastrophic events. | CAI YaoJun CHENG HaiYun WU ShuaiFeng YANG QiGui WANG Lin LUAN YueSheng CHEN ZuYu | 2020 | Science China(Technological Sciences)2020，63，7： | 19 |
| 6 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 7 | Casual sex and concurrent sexual partnerships among young people from an Yi community with a high prevalence of HIV in China显示文摘在四川省的 Liangshan 府,中国,有 HIV 感染的高流行,它在从注射药使用(IDU ) 的传播的模式的一个变化是反射的到异性爱的交际。然而,很少研究在多数 Yi 人口之中集中于 HIV 相关的异性爱的风险行为。这研究的目的是探索一个利已的性网络的特征并且估计随便性行为的流行。Yi 村民(n=108 ) 15-35 年,报导了的人,在上一年以内性交至于他们的性行为和网络被会见。深入的会见和焦点组讨论在性标准上提供了增补信息。逻辑回归分析被用来计算 unadjusted 机会比率(ORs ) 和 95 %信心间隔(CI ) 。大多数回答者报导了在他们的生活,和 66.7 % 在一些时间有随便性别;报导多重性合伙。仅仅 21.3 %曾经报导了使用了避孕套。在学习年期间, 137 个搭挡的一个总数涉及 153 性合伙。在报导性合伙之中, 67.3 %从一种随便性关系发源。为在尺寸 ≥ 的部件的网络成员; 3, 56.9 %涉及并发的性合伙。从来没结婚了过(或:2.11;95 %CI:1.03-4.33 ) 并且更年轻的年龄(或:0.89;95 %CI:0.83-0.95 ) 两个都与在尺寸 ≥ 的一个部件被联系; 3。尺寸(或:2.99;95 %CI:1.17-7.66 ) ,对(或:0.54;95 %CI:0.39-0.74 ) ,利已的性网络的弱部件的数字(或:30.04;95 %CI:6.47-139.46 ) 并且性(或:0.19;95 %CI:0.06-0.67 ) 都与在并发的性合伙被联系。为在四川省的 Yi 种族少数的 HIV 相关的干预必须因此探讨并发的性合伙并且支持避孕套使用。 | Yi Yang Rong-Sheng Luan Peng Liu Chun-Lin Wu Ying Zhou Wen Chen | 2012 | Asian Journal of Andrology2012，14，5： | 15 |
| 8 | A Mitochondrial Magnesium Transporter Functions in Arabidopsis Pollen Development显示文摘镁是在植物房间的一个丰富的二价的阳离子并且在许多生理的过程起一个关键作用。我们以前描述了编码通常认为的镁运输(MGT ) 的一个 10 成员 Arabidopsis 基因家庭的鉴定蛋白质。这里,我们报导那 MGT 家庭,的一个成员 AtMGT5,作为以一种集中依赖者方式操作的双功能的 Mg 搬运工作,也就是,它在 micromolar 层次用作一个 Mg 进口商并且在 millimolar 范围便于流出。AtMGT5 蛋白质在线粒体是局部性的,建议 AtMGT5 调停在 cytosol 和线粒体之间的 Mg-trafficking。AtMGT5 基因只在花开发的早阶段在花药被表示。AtMGT5 基因的二独立 T-DNA insertional 异种的检查证明 AtMGT5 为花粉开发和男富饶起了一个必要作用。这研究在植物在男 gametogenesis 为在 cytosol 和线粒体之间的 Mg2+ 运输建议一个关键角色。 | Le-Gong Li Lubomir N. Sokolov Yong-Hua Yang Dong-Ping Li Julie Ting Girdhar K. Pandy Sheng Luan | 2008 | Molecular Plant2008，1，4： | 14 |
| 9 | Pifithrin-α reduces cerebral vasospasm by attenuating apoptosis of endothelial cells in a subarachnoid haemorrhage model of rat显示文摘背景:服的血管痉挛追随者潜水艇 arachnoid 出血(SAH ) 的机制没被理解。这里,我们假设了 p53 导致的 endothelial 的那 apoptosis,它在 apoptosis (美洲狮) 的调整调节的人上面的目标基因他们破折号 p53 在服的血管痉挛的开发起了一个重要作用。我们也观察了一个 p53 禁止者的效果, pifithrin-alpha (PFT-alpha ) 在减少 p53 和美洲狮的表示以后,因而减少 endothelial 的 apoptosis 和减轻的服的血管痉挛。方法:称 300-350 g 的男 Sprague-Dawley 老鼠随机被划分成五个组:一个控制组(假冒的外科) ,一个 SAH 组,一个 SAH+dimethyl 硫氢化物(DMSO ) 组, SAH + PFT-alpha (0.2 mg/kg ) 组织, SAH + PFT-alpha (2.0 mg/kg ) 组织。PFT-alpha 在 SAH 以后立即 intraperitoneally 被注射。老鼠被牺牲在 SAH 以后的 24 个小时。西方的污点和免疫组织化学的染色被用来检测 p53,美洲狮和 caspase-3 蛋白质的层次。另外,死亡和神经病学的分数为每个组被估计。统计意义被 ANOVA 由 Tukey 测试跟随了的以一个方法执行的变化的分析保证。神经病学并且死亡分数被 Dunn 的方法和菲希尔分析准确测试分别地。结果:在 SAH ,西方的污点和免疫以后,组织化学的染色在 endothelial 和积极 endothelial 都是的标记的调停的 dUTP 刻痕结束( TUNEL )显著地在基部的动脉( P<0.05 )增加了的 TdT 的数字显示出 p53 ,美洲狮和 caspase-3 的层次,但是显著地由 PFT-alpha ( P<0.05 )减少了。这些变化被增加直径和基部的动脉(P<0.05 ) 的衰退的墙厚度伴随,以及减少了死亡和老鼠(P<0.05 ) 的神经病学的赤字。结论:PFT-alpha 能保护服的容器免受血管痉挛的开发的伤害并且改进神经病学的结果以及经由压制 p53 在服的容器的 endothelial 导致的 apoptosis 减少死亡。 | YAN Jun-hao YANG Xiao-mei CHEN Chun-hua HU Qin ZHAO Jing SHI Xian-zhong LUAN Li-ju YANG Lei QIN Li-hua ZHOU Chang-man | 2008 | Chinese Medical Journal2008，，5： | 13 |
| 10 | Additive manufacturing of high-strength CrMnFeCoNi high-entropy alloys-based composites with WC addition显示文摘Laser melting deposition with WC addition has been developed to fabricate high-strength CrMnFeCoNibased high-entropy alloys-based composites.By this technique,a microstructure of compact refined equiaxed grains can be achieved,and the tensile strength can be remarkably improved.The sample with 5 wt%WC addition shows a promising mechanical performance with a tensile strength of 800 MPa and an elongation of 37%.The improvement in mechanical property may be attributed to the formation of Cr(23)C6 reinforcement precipitates,which could promote the heterogeneous nucleation of grains and hinder the propagation of slip bands. | Jinfeng Li Shuo Xiang Hengwei Luan Abdukadir Amar Xue Liu Siyuan Lu Yangyang Zeng Guomin Le Xiaoying Wang Fengsheng Qu Chunli Jiang Guannan Yang | 2019 | Journal of Materials Science & Technology2019，35，11： | 13 |
| 11 | Tomato lncRNA23468 functions as a competing endogenous RNA to modulate NBS-LRR genes by decoying miR482b in the tomato-Phytophthora infestans interaction显示文摘Our previous studies indicated that tomato miR482b could negatively regulate the resistance of tomato to Phytophthora infestans and the expression of miR482b was decreased after inoculation with P.infestans.However,the mechanism by which the accumulation of miR482b is suppressed remains unclear.In this study,we wrote a program to identify 89 long noncoding RNA(lncRNA)-originated endogenous target mimics(eTMs)for 46 miRNAs from our RNA-Seq data.Three tomato lncRNAs,lncRNA23468,lncRNA01308 and lncRNA13262,contained conserved eTM sites for miR482b.When lncRNA23468 was overexpressed in tomato,miR482b expression was significantly decreased,and the expression of the target genes,NBS-LRRs,was significantly increased,resulting in enhanced resistance to P.infestans.Silencing lncRNA23468 in tomato led to the increased accumulation of miR482b and decreased accumulation of NBS-LRRs,as well as reduced resistance to P.infestans.In addition,the accumulation of both miR482b and NBS-LRRs was not significantly changed in tomato plants that overexpressed lncRNA23468 with a mutated eTM site.Based on the VIGS system,a target gene of miR482b,Solyc02g036270.2,was silenced.The disease symptoms of the VIGS-Solyc02g036270.2 tomato plants were in accordance with those of tomato plants in which lncRNA23468 was silenced after inoculation with P.infestans.More severe disease symptoms were found in the modified plants than in the control plants.Our results demonstrate that lncRNAs functioning as eTMs may modulate the effects of miRNAs in tomato and provide insight into how the lncRNA23468-miR482b-NBS-LRR module regulates tomato resistance to P.infestans. | Ning Jiang Jun Cui Yunsheng Shi Guanglei Yang Xiaoxu Zhou Xinxin Hou Jun Meng Yushi Luan | 2019 | Horticulture Research2019，6，1： | 12 |
| 12 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 13 | Experimental study of rotor blades vibration and noise in multistage high pressure compressor and their relevance显示文摘Rotor blades fault of aeroengine compressor is mostly caused by mechanical and aerodynamic excitation.And the excitation factor of high intensity sound wave to rotor blades should not be ignored.Experimental researches are conducted on a multistage high pressure compressor.When high level vibration occurs on the first stage of rotor blades, the noise spectrum presents typical characteristic for discrete multi-tone in the compressor.The amplitude of blade vibration displacement and the sound pressure level of characteristic frequency noise increases and decreases simultaneously and reaches the maximum value at the same time.This frequency merely occur on a certain speed range and is locked in a specific range which presents no variation with the rotating speed.When high level vibration occurs on the first stage of rotor blades, the noise spectrum presents a sharp peak and the propagation state of the characteristic frequency is a helix structure in the compressor.It can be confirmed that acoustic resonance occurs in the multistage compressor.The acoustic resonance frequency and its side band frequencies are generated by modulation of a rotating noise source at the rotor speed which is the excitation source of the rotor blades vibration. | Fengtong ZHAO Xiaodong JING Mingsui YANG Deyou WANG Yundong SHA Xiaochi LUAN | 2020 | Chinese Journal of Aeronautics2020，33，3： | 11 |
| 14 | Heavy Oil and Oil Sands:Global Distribution and Resource Assessment显示文摘Global recoverable resources of heavy oil and oil sands have been assessed by CNPC using a geology-based assessment method combined with the traditional volumetric method, spatial interpolation method, parametric-probability method etc. The most favourable areas for exploration have been selected in accordance with a comprehensive scoring system. The results show:(1) For geological resources, CNPC estimate 991.18 billion tonnes of heavy oil and 501.26 billion tonnes of oil sands globally, of which technically recoverable resources of heavy oil and oil sands comprise 126.74 billion tonnes and 64.13 billion tonnes respectively. More than 80% of the resources occur within Tertiary and Cretaceous reservoirs distributed across 69 heavy oil basins and 32 oil sands basins. 99% of recoverable resources of heavy oil and oil sands occur within foreland basins, passive continental-margin basins and cratonic basins.(2) Since residual hydrocarbon resources remain following large-scale hydrocarbon migration and destruction, heavy oil and oil sands are characterized most commonly by late hydrocarbon accumulation, the same basin types and source-reservoir conditions as for conventional hydrocarbon resources, shallow burial depth and stratabound reservoirs.(3) Three accumulation models are recognised, depending on basin type: degradation along slope; destruction by uplift; and migration along faults.(4) In addition to mature exploration regions such as Canada and Venezuela, the Volga-Ural Basin and the Pre-Caspian Basin are less well-explored and have good potential for oil-sand discoveries, and it is predicted that the Middle East will be an important region for heavy oil development. | LIU Zuodong WANG Hongjun Graham BLACKBOURN MA Feng HE Zhengjun WEN Zhixing WANG Zhaoming YANG Zi LUAN Tiansi WU Zhenzhen | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 9 |
| 15 | Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes显示文摘 | Yang, JA Luan, XF Gui, HY Yan, P Yang, DF Song, XL Liu, W Hu, G Yah, BF | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 8 |
| 16 | ZrC-ZrB_2-SiC ceramic nanocomposites derived from a novel single-source precursor with high ceramic yield显示文摘For the first time, ZrC-ZrB_2-SiC ceramic nanocomposites were successfully prepared by a single-source-precursor route, with allylhydridopolycarbosilane(AHPCS),triethylamine borane(TEAB),and bis(cyclopentadienyl) zirconium dichloride(Cp_2 ZrCl_2) as starting materials. The polymer-to-ceramic transformation and thermal behavior of obtained single-source precursor were characterized by means of Fourier transform infrared spectroscopy(FT-IR) and thermal gravimetric analysis(TGA). The results show that the precursor possesses a high ceramic yield about 85% at 1000 ℃.The phase composition and microstructure of formed ZrC-ZrB_2-SiC ceramics were investigated by means of X-ray diffraction(XRD) and high resolution transmission electron microscopy(HRTEM).Meanwhile, the weight loss and chemical composition of the resultant ZrC-ZrB_2-SiC nanocomposites were investigated after annealing at high temperature up to 1800 ℃. High temperature behavior with respect to decomposition as well as crystallization shows a promising high temperature stability of the formed ZrC-ZrB_2-SiC nanocomposites. | Zhaoju YU Xuan LV Shuyi LAI Le YANG Wenjing LEI Xingang LUAN Ralf RIEDEL | 2019 | Journal of Advanced Ceramics2019，8，1： | 8 |
| 17 | Effects of ion concentration and natural organic matter on arsenic(V) removal by nanofiltration under different transmembrane pressures显示文摘The removal of As(V) from synthetic water was studied using four different nanofiltration (NF) membranes (ESNA-1-K1, NF270, ESNA-1-LF, and HODRA-CORE). The influences of ion concentration, transmembrane pressure (TMP), and the presence of natural organic matter (humic acid, HA) on the arsenic removal efficiency and permeate flux were investigated. The arsenic rejection of ESNA- 1-LF was higher than those of the other membranes in all experiments (> 94%), and the HODRA-CORE membrane gave the lowest removal of arsenic (< 47%). An increase in the ion concentration in the feed solution and addition of HA decreased the arsenic rejection of the HODRA-CORE membrane. However, both increasing of the ion concentration and addition of HA made the rejection increased for the other membranes (ESNA-1-K1, NF270, and ESNA-1-LF). With increasing TMP, for all four NF membranes, increases in both arsenic rejection and permeate flux were observed. The permeate fluxes of the four NF membranes decreased to some extent after addition of HA to the solutions for operating time of 6 hr. | Yang Yu Changwei Zhao Yangui Wang Weihong Fan Zhaokun Luan | 2013 | Journal of Environmental Sciences2013，25，2： | 7 |
| 18 | PDK1 plays a critical role in regulating cardiac function in mice and human显示文摘背景 PDK1 是在哺乳动物的开发起一个关键作用的必要蛋白质 kinase。老鼠缺乏 PDK1 在 E9.5 导致多重畸形和胚胎的致命性。阐明在心的 PDK1 的角色,我们调查了在不同生长时期和在我们采用了的人的失败的 heart.Methods 发信号的 PDK1 的改变在心缺乏 PDK1 的鼠标的心脏的显型产生 PDK1flox/flox 的 Cre/loxP 系统:-MHC-Cre 老鼠,明确地在出生在心肌删除了 PDK1,和 tamoxifen 可诱导的心特定的 PDK1 猛烈老鼠(PDK1flox/flox : MerCreMer 老鼠) ,在哪个 PDK1 与 tamoxifen 响应处理在心肌层被删除。从人的失败的心和正常的心的 Transmural 心肌的纸巾从左室的顶被取样分析由西方的 blotting.Results PDK1flox/flox 表明小径的 PDK1/Akt 的活动:-MHC-Cre 老鼠在 5 和 10 个星期死于心失败旧。PDK1flox/flox-MerCreMer 老鼠在 8 个星期在 tamoxifen 处理的开始以后从 5 ~ 21 个星期死于心失败旧。我们在人的失败的心纸巾发现那个表达式 PDK1 的层次显著地与我们的结果建议的控制 hearts.Conclusion 相比被减少发信号的那 PDK1 网络参加在鼠标调整心脏的生存能力和功能,并且可以也涉及人的心失败疾病。 | DI Ruo-min FENG Qiu-ting CHANG Zai LUAN Qing ZHANG Yang-yang HUANG Jun LI Xin-li YANG Zhong-zhou | 2010 | Chinese Medical Journal2010，，17： | 7 |
| 19 | Inner Envelope CHLOROPLAST MANGANESE TRANSPORTER 1 Supports Manganese Homeostasis and Phototrophic Growth in Arabidopsis显示文摘 | Bin Zhang Chi Zhang Congge Liu Yanping Jing Yuan Wang Ling Jin Lei Yang Aigen Fu Jisen Shi Fugeng Zhao Wenzhi Lan Sheng Luan | 2018 | Molecular Plant2018，11，7： | 6 |
| 20 | Biofilm-inspired adhesive and antibacterial hydrogel with tough tissue integration performance for sealing hemostasis and wound healing显示文摘Uncontrolled bleeding and infection can cause significant increases in mortalities.Hydrogel sealants have attracted extensive attention for their ability to control bleeding.However,because interfacial water is a formidable barrier to strong surface bonding,a challenge remains in finding a product that offers robust tissue adhesion combined with anti-infection properties.Inspired by the strong adhesive mechanism of biofilm and mussels,we report a novel dual bionic adhesive hydrogel(DBAH)based on chitosan grafted with methacrylate(CS-MA),dopamine(DA),and N-hydroxymethyl acrylamide(NMA)via a facile radical polymerization process.CS-MA and DA were simultaneously included in the adhesive polymer for imitating the two key adhesive components:polysaccharide intercellular adhesin(PIA)of staphylococci biofilm and 3,4-dihydroxy-L-phenylalanine(Dopa)of mussel foot protein,respectively.DBAH presented strong adhesion at 34 kPa even upon three cycles of full immersion in water and was able to withstand up to 168 mm Hg blood pressure,which is significantly higher than the 60–160 mm Hg measured in most clinical settings.Most importantly,these hydrogels presented outstanding hemostatic capability under wet and dynamic in vivo movements while displaying excellent antibacterial properties and biocompatibility.Therefore,DBAH represents a promising class of biomaterials for high-efficiency hemostasis and wound healing. | Wei Han Bo Zhou Kai Yang Xin Xiong Shifang Luan Yu Wang Zheng Xu Peng Lei Zhengshan Luo Jian Gao Yijing Zhan Guopu Chen Lei Liang Rui Wang Sha Li Hong Xu | 2020 | Bioactive Materials2020，5，4： | 6 |
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