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| 1 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 2 | Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans——Qingdao City,Shandong Province,China,September 2020显示文摘Summary What is already known about this topic?Though coronavirus disease 2019(COVID-19)has largely been controlled in China,several outbreaks of COVID-19 have occurred from importation of cases or of suspected virus-contaminated products.Though several outbreaks have been traced to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)isolated on the outer packaging of cold chain products,live virus has not been obtained. | Huilai Ma Zhaoguo Wang Xiang Zhao Jun Han Yong Zhang Hong Wang Cao Chen Ji Wang Fachun Jiang Jie Lei Jingdong Song Shaofeng Jiang Shuangli Zhu Huihui Liu Dongyan Wang Yao Meng Naiying Mao Yanhai Wang Zhen Zhu Zhixiao Chen Bingling Wang Qinqin Song Haijun Du Qun Yuan Dong Xia Zhiqiang Xia Peipei Liu Yuchao Wu Zijian Feng Ruqin Gao George F.Gao Wenbo Xu | 2021 | China CDC weekly2021，3，30： | 13 |
| 3 | Severe burn injury alters intestinal microbiota composition and impairs intestinal barrier in mice显示文摘Background:The intestinal barrier integrity is crucial for maintaining intestinal homeostasis,and the mechanisms of intestinal barrier disruption induced by burn injury remain obscure.This study was aimed to investigate the changes of intestinal microbiota and barrier function in burned mice to further comprehend the mechanisms of burn-induced intestinal barrier dysfunction.Methods:Samples were from mice inflicted with 30%total body surface area(TBSA)full-thickness burns.The intestinal permeability,tight junction proteins expressions,zonula occludens-1(ZO-1)localization,inflammatory cytokines expressions,and short-chain fatty acids(SCFAs)contents were determined.The microbial community was assessed via 16S rDNA Illumina sequencing.Results:The intestinal permeability was increased after severe burn injury,peaking at 6 h post-burn,with approximately 20-folds of the control(p<0.001).The expression of tight junction proteins(ZO-1,occludin,claudin-1,and claudin-2)was significantly altered(p<0.05).The ZO-1 morphology was dramatically changed following burn injury.The fecal SCFAs’contents(acetate,propionate,butyrate,isobutyrate,and isovalerate)were noticeably declined after burn injury(p<0.05).The expressions of pro-inflammatory cytokines(interleukin(IL)-1βand IL-6)in ileal mucosa were increased,whereas the expressions of anti-inflammatory cytokines(IL-4 and IL-13)were decreased following burn injury(p<0.05).In addition,burned mice showed an alteration of intestinal microbial community,such as decreased diversity,reduced Bacteroidetes abundance,and increased Firmicutes abundance.Conclusions:The severe burn-induced intestinal barrier dysfunction is along with the alterations of microbial community. | Yanhai Feng Yalan Huang Yu Wang Pei Wang Fengjun Wang | 2019 | Burns & Trauma2019，7，1： | 11 |
| 4 | Reemergent Cases of COVID-19—Xinfadi Wholesales Market,Beijing Municipality,China,June 11,2020显示文摘No new local coronavirus disease 2019(COVID-19)cases were reported in Beijing for over 56 days before the reemergent COVID-19 cases that were reported on June 11,2020,and more than 200 confirmed cases have been reported as of June 20 in Beijing.All confirmed COVID-19 cases were associated with Xinfadi Wholesale Market.Here,we reported the phylogenetic characteristics of the COVID-19 viruses(also known as severe acute respiratory syndrome coronavirus 2,SARS-CoV-2,and human coronavirus 2019,HCoV-19)sequenced from the clinical specimens of 2 human cases and 1 environmental sample. | Wenjie Tan Peihua Niu Xiang Zhao Yang Pan Yong Zhang Lijuan Chen Li Zhao Yanhai Wang Dayan Wang Jun Han George FGao Chun Huang Wenbo Xu Guizhen Wu | 2020 | China CDC weekly2020，2，27： | 6 |
| 5 | Description of the First Strain of 2019-nCoV,C-Tan-nCoV Wuhan Strain-National Pathogen Resource Center,China,2020显示文摘The recent outbreak of novel coronavirus-infected pneumonia(NCIP)in China(1)has attracted much attention domestically and internationally.As the outbreak occurred,China carried out emergency responses quickly,notified the World Health Organization(WHO)in a timely manner,and shared the viral gene sequence with international communities immediately after pathogenic identification. | Qiang Wei Yanhai Wang Juncai Ma Jun Han Mengnan Jiang Li Zhao Fei Ye Jingdong Song Bo Liu Linhuan Wu Wenjie Tan Guizhen Wu George FGao Jianjun Liu | 2020 | China CDC weekly2020，2，6： | 5 |
| 6 | Inactivation of TFEB and NF-kB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion显示文摘It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M(Mar-M, a naturally occurring bisbibenzyl) suppressed proinflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated the pro-tumorigenic effects of SASP and enhanced survival in drug-resistant mouse models.No toxicity was detected on normal fibroblast cells or in animals following this treatment. Inactivation of transcription factor EB(TFEB) and nuclear factor-k B(NF-k B) by Mar-M significantly accounted for its suppression on the components of SASP. Furthermore, inhibition of SASP by Mar-M contributed to a synergistic effect during co-treatment with doxorubicin to lower toxicity and enhance antitumor efficacy. Thus, chemotherapy-driven pro-inflammatory activity, seen to contribute to drug-resistance, is an important target for Mar-M. By decreasing SASP, Mar-M may be a potential approach to overcome tumor malignancy. | Huanmin Niu Lilin Qian Bin Sun Wenjian Liu Fang Wang Qian Wang Xiaotian Ji Yanhai Luo Effat Un Nesa Hongxiang Lou Huiqing Yuan | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 4 |
| 7 | Let-7b-5p regulates proliferation and apoptosis in multiple myeloma by targeting IGF1R显示文摘多重骨髓瘤(公里) 全球是从 hematological 恶意的死亡的最普通的原因,并且最近的研究表明了 let-7b-5p 能在 tumorigenesis 起一个禁止的作用。然而,在公里的 let-7b-5p 的角色仍然保持不清楚。这研究的目的是阐明 let-7b-5p 在公里由充当肿瘤 suppressor 的分子的机制。这里,量的即时聚合酶链反应结果证明 let-7b-5p 的表示显著地在公里纸巾和公里房间线(RPMI-8226 和 U266 房间) 被减少。而且, let-7b-5p 的在表示上显著地压制了 RPMI-8226 房间增长并且导致了 S/G2 房间周期拘捕和 apoptosis。酶记者试金结果证明(IGF1R ) 像胰岛素的生长因素受体 1 被 let-7b-5p 否定地在 post-transcriptional 水平调整。在 RPMI-8226 房间的 IGF1R 的 mRNA 和蛋白质层次由 let-7b-5p 是下面调整的。而且, let-7b-5p 禁止者改变的房间显型能被 IGF1R silencing (si-IGF1R ) 救。一起拿,我们的结果证明 let-7b-5p 在公里作为肿瘤 suppressor 工作,建议那 let-7b-5p 可以是为公里的一个潜在的治疗学的目标。 | Honghai Xu Cong Liu Yuelin Zhang Xiong Guo Zongzhi Liu Zhenqun Luo Yanhai Chang Shizhang Liu Zhengming Sun Xiaoqing Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 4 |
| 8 | Histone Lysine Methyltransferase SDG8 Is Involved in Brassinosteroid-Regulated Gene Expression in Arabidopsis thaliana显示文摘植物类固醇荷尔蒙, brassinosteroids (BR ) ,在植物生长,开发,和对 environmentalstresses 的回答起重要作用。BR 通过对血浆膜和另外的发信号的部件局部性的受体发信号调整抄写因素的 BES1/BZR1family,它调制几千基因的表示。BES1/BZR1 和他们的 interactingproteins 怎么工作调整基因的大数字,完全没被理解。这里,我们报导那 histone lysinemethyltransferase SDG8,在 histone 含有 3 离氨酸 36 di- 和 trimethylation (H3K36me2 和 me3 ) ,涉及 BR-regulatedgene 表示。BES1 与 SDG8 交往,直接或间接地通过 IWS1,抄写延伸因素 involvedin 调整 BR 的基因表示。猛烈变异的 sdg8 与损害 BR 回答显示减少的生长显型。全球基因表示研究表明了那, whileBR 在野类型的植物调整大约 5000 基因,荷尔蒙在 sdg8 比 700 基因调整少数变异。另外,多于调整 BR 的基因的一半,差别在 sdg8 异种被影响。一个染色质 Immunoprecipitation (薄片) 实验证明 H3K36me3 在 sdg8 异种在调整 BR 的基因被减少。把结果基于这些,我们建议 SDG8 在调停起一个必要作用调整 BR 的基因表示。Ourresults 因此揭示 histone 修正由支配基因 expression.Key 词的神经质的规定的主要机制: | Xiaolei Wang Jiani Chen Zhouli Xie Sanzhen Liu Trevor Nolan Huaxun Ye Mingcai Zhang Hongqing Guo Patrick S. Schnable Zhaohu Li Yanhai Yin | 2014 | Molecular Plant2014，7，8： | 3 |
| 9 | Instability characteristics of the cracked roof rock beam under shallow mining conditions显示文摘To establish the movement relationship for the roof breaking under shallow mining conditions, the mechanical model of the roof rock beam was built, then the structure instability process of the roof rock beam was analyzed. The changing criterion of the vertical displacement was established and the relationship between the deflection and the rotary motion of roof block was determined. Regarding a mining face in Shangwan Mine, the responsing laws of the deflection and horizontal thrust of the roof rock beam were obtained through FLAC3D numerical analysis. The results show that the structure instability of the cracked roof rock beam depends on the interaction between the vertical load and the horizontal thrust.For the roof rock beam, when the vertical load keeps constant, the horizontal thrust fluctuating rises with increasing deflection. The horizontal thrust increases constantly with the deeper buried depth and the smaller span. | Zhao Yanhai Wang Shuren Zou Zhengsheng Ge Linlin Cui Fang | 2018 | International Journal of Mining Science and Technology2018，28，3： | 2 |
| 10 | A regu- larization for the projection twin support vector machine显示文摘 | SHAO Yanhai WANG Zhen CHEN Weijie | 2013 | Knowledge-based systems2013，37，： | 1 |
| 11 | Im- provements on twin support vector machines显示文摘 | SHAO Yanhai ZHANG Chunhua WANG Xiaobo | 2011 | IEEE trans- actions on neural networks2011，2，6： | 1 |
| 12 | The first strain of monkeypox isolated in the Chinese Mainland and preserved at the National Pathogen Resource Center of China显示文摘On September 16,2022,the first imported monkeypox case was reported in the Chinese Mainland.Laboratory tests including nucleic acid detection were carried out in Chongqing Nan’an Centre for Disease Control and Prevention and Chongqing Center for Disease Control and Prevention.After that,monkeypox virus was isolated by the Institute for Viral Disease Control and Prevention and preserved at the National Pathogen Resource Center on September 18,2022.The National Pathogen Resource Center shared the basic information of monkeypox virus strain,samples,biosafety,strain imaging,RT-PCR primers,and probes sequence timely to support the prevention and control of monkeypox epidemic and facilitate the scientific research on vaccine development,drug screening and evaluation of monkeypox virus in the future. | Qiang Wei Baoying Huang Wei Huang Jingdong Song Li Mei Li Zhao Jing Yin Juan Zhang Wenling Wang Fei Ye Caiyun Li Liling Bai Yanhai Wang Yao Deng Bo Liu Mengnan Jiang Guizhen Wu Jun Han Hua Zhao Hua Ling Wenjie Tan Jianjun Liu | 2022 | Infectious Medicine2022，1，4： | 1 |
| 13 | Synthesis of polyaniline nanofibers with high electrical conductivity from CTAB-SDBS mixed surfactants显示文摘 | Zhou Donghua Li Yanhai Wang Jingyu | | 0，，23： | 1 |
| 14 | BES1 Accumulates in the Nucleus in Response to Brassinosteroids to Regulate Gene Expression and Promote Stem Elongation显示文摘 | Yanhai Yin Zhi-Yong Wang Santiago Mora-Garcia Jianming Li Shigeo Yoshida Tadao Asami Joanne Chory | 2002 | Cell2002，，2： | 1 |
| 15 | A numerical investigation of hydraulic fracturing on coal seam permeability based on PFC‑COMSOL coupling method显示文摘Hydraulic fracturing and permeability enhancement are effective methods to improve low-permeability coal seams.However,few studies focused on methods to increase permeability,and there are no suitable prediction methods for engineering applications.In this work,PFC2D software was used to simulate coal seam hydraulic fracturing.The results were used in a coupled mathematical model of the interaction between coal seam deformation and gas flow.The results show that the displacement and velocity of particles increase in the direction of minimum principal stress,and the cracks propagate in the direction of maximum principal stress.The gas pressure drop rate and permeability increase rate of the fracture model are higher than that of the non-fracture model.Both parameters decrease rapidly with an increase in the drainage time and approach 0.The longer the hydraulic fracturing time,the more complex the fracture network is,and the faster the gas pressure drops.However,the impact of fracturing on the gas drainage effect declines over time.As the fracturing time increases,the difference between the horizontal and vertical permeability increases.However,this difference decreases as the gas drainage time increases.The higher the initial void pressure,the faster the gas pressure drops,and the greater the permeability increase is.However,the influence of the initial void pressure on the permeability declines over time.The research results provide guidance for predicting the anti-reflection effect of hydraulic fracturing in underground coal mines. | Kai Wang Guodong Zhang Yanhai Wang Xiang Zhang Kangnan Li Wei Guo Feng Du | 2022 | International Journal of Coal Science & Technology2022，9，1： | 1 |
| 16 | Antibody Response to COVID-19 Virus--Heilongjiang Province and Gansu Province,China,2020显示文摘What is already known about this topic?Coronavirus disease 2019(COVID-19)has become a global pandemic,while the profile of antibody response against the COVID-19 virus has not been well clarified.What is added by this report?In this study,210 serum samples from 160 confirmed COVID-19 cases with different disease severities were recruited.The IgM,IgA,IgG,and neutralizing antibodies(NAb)against COVID-19 virus were determined.Our findings indicated that four antibodies could be detectable at low levels within 2 weeks of disease onset,then rapidly increasing and peaking from the 3^(rd) to 5^(th) Weeks.NAb decreased between 5^(th) and 9^(th) Weeks,and a higher IgM/IgA level was observed in the groups with mild/moderate severity within 2 weeks(p<0.05),while all 4 types of antibodies were higher in the group with severe/critical severity after 4 weeks(p<0.05).What are the implications for public health practice?Our study on the dynamics of serological antibody responses against COVID-19 virus among COVID-19 patients complements the recognition regarding the humoral immune response to COVID-19 virus infection.The findings will help in the interpretation of antibody detection results for COVID-19 patients and be beneficial for the evaluation of vaccination effects. | Naiying Mao Zhen Zhu Shuangli Zhu Deshan Yu Jun Xu Aili Cui Lei Cao Jinyuan Guo Huiling Wang Dongyan Wang Dongmei Yan Yang Song Qian Yang Zhongyi Jiang Hui Zhang Chang Shu Ming Yang Yanhai Wang Jinbo Xiao Zhenzhi Han Yong Zhang Yan Zhang Wenbo Xu | 2020 | China CDC weekly2020，2，34： | 1 |
| 17 | AMPD3 is involved in anthrax LeTx-induced macrophage cell death显示文摘The responses of macrophages to Bacillus anthracis infection are important for the survival of the host,since macrophages are required for the germination of B.anthracis spores in lymph nodes,and macrophage death exacerbates anthrax lethal toxin(LeTx)-induced organ collapse.To elucidate the mechanism of macrophage cell death induced by LeTx,we performed a genetic screen to search for genes associated with LeTx-induced macrophage cell death.RAW264.7 cells,a macrophage-like cell line sensitive to LeTx-induced death,were randomly mutated and LeTx-resistant mutant clones were selected.AMP deaminase 3(AMPD3),an enzyme that converts AMP to IMP,was identified to be mutated in one of the resistant clones.The requirement of AMPD3 in LeTxinduced cell death of RAW 264.7 cells was confirmed by the restoration of LeTx sensitivity with ectopic reconstitution of AMPD3 expression.AMPD3 deficiency does not affect LeTx entering cells and the cleavage of mitogen-activated protein kinase kinase(MKK)by lethal factor inside cells,but does impair an unknown downstream event that is linked to cell death.Our data provides new information regarding LeTx-induced macrophage death and suggests that there is a key regulatory site downstream of or parallel to MKK cleavage that controls the cell death in LeTx-treated macrophages. | Sangun Lee Yanhai Wang Sung Ouk Kim Jiahuai Han | 2011 | Protein & Cell2011，2，7： | 0 |
| 18 | Simulation of directional propagation of hydraulic fractures induced by slotting based on discrete element method显示文摘Hydraulic fracturing(HF)technology can safely and efficiently increase the permeability of coal seam,which is conducive to CBM exploration and prevent coal and gas outburst.However,conventional HF fractures tend to expand in the direction of maximum principal stress,which may be inconsistent with the direction of fracturing required by the project.Therefore,the increased direction of coal seam permeability is different from that expected.To solve these problems,PFC2D software simulation is used to study directional hydraulic fracturing(DHF),that is the combination of slotting and hydraulic fracturing.The effects of different slotting angles(θ),different horizontal stress difference coefficients(K)and different injection pressures on DHF fracture propagation are analyzed.The results show that the DHF method can overcome the dominant effect of initial in-situ stress on the propagation direction of hydraulic fractures and control the propagation of fractures along and perpendicular to the slotting direction when θ,K and liquid injection pressure are small.When the DHF fracture is connected with manual slotting,the pressure will shake violently,and the fracturing curve presents a multi-peak type.The increase and decrease of particle pressure around the fracturing hole reflect the process of pressure accumulation and fracture propagation at the fracture tip respectively.Compared with conventional HF,DHF can not only shorten the fracturing time but also make the fracture network more complex,which is more conducive to gas flow.Under the action of in-situ stress,the stress between slots will increase to exceed the maximum horizontal principal stress.Moreover,with the change in fracturing time,the local stress of the model will also change.Hydraulic fractures are always expanding to the area with large local stress.The research results could provide certain help for DHF theoretical research and engineering application. | Kai Wang Guodong Zhang Feng Du Yanhai Wang Liangping Yi Jianquan Zhang | 2023 | Petroleum2023，9，4： | 0 |
| 19 | Radiotherapy for Lowly Malignant Cranial Inflammatory Myofibroblastic Tumor Accompanied with Intracranial Invasion:Case Report and Literature Review显示文摘Inflammatory myofibroblastic tumor(IMT) is rare in clinical practice.As its treatment mainly involves surgery,radiotherapy alone is seldom reported in literature.Here we report a case of lowly malignant cranial IMT with intracranial invasion in a female patient. As surgery was not suitable,intensity modulated radiation therapy(IMRT) was administered.After radiotherapy,the cranial lesions tended to show efficacy. | 马俊刚 Xueqin Yang Ge Wang Xian Yu Nan Hu Yanhai Liu Zhenzhou Yang | 2012 | 肿瘤预防与治疗2012，25，2： | 0 |
| 20 | HRV16 Infection Induces Changes in the Expression of Multiple piRNAs显示文摘Human rhinovirus(HRV)is one of the most important cold-causing pathogens in humans.Piwi-interacting RNAs(piRNAs)are a recently discovered class of small non-coding RNAs whose best-understood function is to repress mobile element(ME)activity in animal germline.However,the profile of human/host piRNA during HRV infection is largely unknown.Here we performed high-throughput sequencing of piRNAs from H1-HeLa cells infected with HRV16 at 12 h,24 h,and 36 h.The results showed that 22,151,664,24,362,486 and 22,726,546 piRNAs displayed differential expression after HRV16 infection for three time points.A significant differential expression of 21 piRNAs was found in all time points and further verified by RT-qPCR,including 7 known piRNAs and 14 newly found piRNAs.In addition,piRNA prediction was performed on Piano using the SVM algorithm and transposon information.It found that novel_pir78110,novel_pir78107,novel_pir78097,novel_pir78094 and novel_pir76584 are associated with the DNA/hobo of Drosophila,Ac of maize and Tam3 of snapdragon(hAT)-Charlie transposon.The novel_pir97924,novel_pir105705 and novel_pir105700 recognize long interspersed nuclear elements 1(LINE-1).The novel_pir33182 and novel_pir46604 are related to the long terminal repeat(LTR)/(Endogenous Retrovirus1)ERV1 repetitive element.The novel_pir73855 is related to the LTR/ERVK repetitive element.Both novel_pir70108 and novel_pir70106 are associated with the LTR/ERVL-MaLR repetitive element.The novel_pir15900 is associated with the DNA/hAT-Tip100 repetitive element.Overall,our results indicated that rhinovirus infection could reduce the expression of some piRNAs to facilitate upregulation of LINE-1 transcription or retrotransposons'expression,which is helpful to further explore the mechanism of rhinovirus infection. | Jie Li Xinling Wang Yanhai Wang Juan Song Qinqin Song Yanbin Wang Jun Han | 2021 | Virologica Sinica2021，36，4： | 0 |
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