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| 1 | Trabecular-like Ti-6Al-4V scaffolds for orthopedic: fabrication by selective laser melting and in vitro biocompatibility显示文摘Porous metal scaffolds play an important role in the orthopedic field, due to their wide applications in prostheses implantation. Some previous studies showed that the scaffolds with trabecular bone structure reconstructed via computed tomography had satisfactory biocompatibility. However, the reverse modeling scaffolds were inflexible for customized design. Therefore, a top-down designing biomimetic bone scaffold with favorable mechanical performances and cytocompatibility is urgently demanded for orthopedic implants. An emerging additive manufacturing technique, selective laser melting, was employed to fabricate the trabecular-like porous Ti-6Al-4 V scaffolds with varying irregularities(0.05-0.5) and porosities(48.83%–74.28%) designed through a novel Voronoi-Tessellation based method. Micro-computed tomography and scanning electron microscopy were used to characterize the scaffolds’ morphology.Quasi-static compression tests were performed to evaluate the scaffolds’ mechanical properties. The MG63 cells culture in vitro experiments, including adhesion, proliferation, and differentiation, were conducted to study the cytocompatibility of scaffolds. Compressive tests of scaffolds revealed an apparent elastic modulus range of 1.93–5.24 GPa and an ultimate strength ranging within 44.9–237.5 MPa, which were influenced by irregularity and porosity, and improved by heat treatment. Furthermore, the in vitro assay suggested that the original surface of the SLM-fabricated scaffolds was favorable for osteoblasts adhesion and migration because of micro scale pores and ravines. The trabecular-like porous scaffolds with full irregularity and higher porosity exhibited enhanced cells proliferation and osteoblast differentiation at earlier time, due to their preferable combination of small and large pores with various shapes. This study suggested that selective laser melting-derived Ti-6Al-4 V scaffold with the trabecular-like porous structure designed through Voronoi-Tessellation method, favorable mechanical performance, and good cytocompatibility was a potential biomaterial for orthopedic implants. | Huixin Liang Youwen Yang Deqiao Xie Lan Li Ning Mao Changjiang Wang Zongjun Tian Qing jiang Lida Shen | 2019 | Journal of Materials Science & Technology2019，35，7： | 12 |
| 2 | Microstructure, biodegradation, antibacterial and mechanical properties of ZK60-Cu alloys prepared by selective laser melting technique显示文摘Magnesium(Mg) alloys are receiving increasing attention for body implants owing to their good biocompatibility and biodegradability. However, they often suffer from bacterial infections on account of their insufficient antibacterial ability. In this study, ZK60-x Cu(x = 0, 0.2, 0.4, 0.6 and 0.8 wt%) alloys were prepared by selective laser melting(SLM) with alloying copper(Cu) to enhance their antibacterial ability.Results showed that ZK60-Cu alloys exhibited strong antibacterial ability due to combination of release of Cu ions and alkaline environment which could kill bacteria by destroying cellular membrane structure,denaturing enzymes and inhibiting deoxyribonucleic acid(DNA) replication. In addition, their compressive strength increased due to grain refinement and uniformly dispersing of short-bar shaped MgZnCu phases. Moreover, ZK60-Cu alloys also exhibited good cytocompatibility. In summary, ZK60-Cu alloys with antibacterial ability may be promising implants for biomedical applications. | Cijun Shuai Long Liu Mingchun Zhao Pei Feng Youwen Yang Wang Guo Chengde Gao Fulai Yuan | 2018 | Journal of Materials Science & Technology2018，34，10： | 12 |
| 3 | Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold显示文摘Zinc(Zn)possesses desirable degradability and favorable biocompatibility,thus being recognized as a promising bone implant material.Nevertheless,the insufficient mechanical performance limits its further clinical application.In this study,reduced graphene oxide(RGO)was used as reinforcement in Zn scaffold fabricated via laser additive manufacturing.Results showed that the homogeneously dispersed RGO simultaneously enhanced the strength and ductility of Zn scaffold.On one hand,the enhanced strength was ascribed to(i)the grain refinement caused by the pinning effect of RGO,(ii)the efficient load shift due to the huge specific surface area of RGO and the favorable interface bonding between RGO and Zn matrix,and(iii)the Orowan strengthening by the homogeneously distributed RGO.On the other hand,the improved ductility was owing to the RGO-induced random orientation of grain with texture index reducing from 20.5 to 7.3,which activated more slip systems and provided more space to accommodate dislocation.Furthermore,the cell test confirmed that RGO promoted cell growth and differentiation.This study demonstrated the great potential of RGO in tailoring the mechanical performance and cell behavior of Zn scaffold for bone repair. | Youwen Yang Yun Cheng Shuping Peng Liang Xu Chongxian He Fangwei Qi Mingchun Zhao Cijun Shuai | 2021 | Bioactive Materials2021，6，5： | 4 |
| 4 | Single MoTe_(2) sheet electrocatalytic microdevice for in situ revealing the activated basal plane sites by vacancies engineering显示文摘Activating basal plane inert sites will endow MoTe_(2) with prominent hydrogen evolution reaction(HER)catalytic capability and arouse a new family of HER catalysts.Herein,we fabricated single MoTe_(2) sheet electrocatalytic microdevice for in situ revealing the activated basal plane sites by vacancies introducing.Through the extraction of electrical parameters of single MoTe_(2) sheet,the in-plane and interlayer conductivities were optimized effectively by Te vacancies due to the defect levels.More deeply,Te vacancies can induce the delocalization of electrons around Mo atoms and shift the d-band center,as a consequence,facilitate the adsorption of H from the catalyst surface for HER catalysis.Benefiting by the coordinated regulation of band structure and local charge density,the overpotential at−10 mA·cm^(−2)was reduced to 0.32 V after Te vacancies compared to 0.41 V for the basal plane sites of same MoTe_(2) nanosheet.Meanwhile,the insights gained from single nanosheet electrocatalytic microdevice can be applied to the improved HER of the commercial MoTe_(2) power.That the in situ testing of the atomic structure-electrical behavior-electrochemical properties of a single nanosheet before/after vacancies introducing provides reliable insight to structure-activity relationships. | Huan Yang Yinghe Zhao Qunlei Wen Yan Mi Youwen Liu Huiqiao Li Tianyou Zhai | 2021 | Nano Research2021，14，12： | 3 |
| 5 | Dual alloying improves the corrosion resistance of biodegradable Mg alloys prepared by selective laser melting显示文摘Mg alloys have been regarded as revolutionary metallic biomaterials for biodegradable bone implants,but their applications are mainly blocked by the too rapid degradation in physiological environment.This study explores the dual alloying effects of Mn and/or Sn on the performance of Mg alloys prepared by selective laser melting.The observed microstructure indicated remarkable refinement of both the grains and intermetallic phases in the Mn-and/or Sn-containing alloys during the rapid solidification process.Moreover,approximately a half decrease in corrosion rate was observed for AZ61-0.4Mn-0.8Sn alloy with respect to AZ61 alloy.The improved corrosion behavior was primarily due to the enhanced protective effects of surface layers,in which Mn-and/or Sn-rich phases acted as a helpful barrier against medium penetration and thereby alleviated the current exchange with the matrix.In addition,the solute Mn and/or Sn positively shifted the corrosion potential,which also brought about a better corrosion resistance.Furthermore,the strength and hardness of the alloys were also effectively improved and comparable to those of cortical bone.This could be ascribed to the dissolved Mn and/or Sn atoms and the finely dispersed intermetallic phases,which might cause lattice distortion and precipitation hardening.Besides,the Mn-and/or Sn-containing alloys showed good cytocompatibility as indicated by the normal morphology and increased viability of MG-63 cells.These findings suggest that the developed AZ61-Mn-Sn alloy is a promising candidate for biodegradable bone implants. | Chengde Gao Sheng Li Long Liu Shizhen Bin Youwen Yang Shuping Peng Cijun Shuai | 2021 | Journal of Magnesium and Alloys2021，9，1： | 3 |
| 6 | Impact of pathological response after preoperative transcatheter arterial chemoembolization(TACE)on incidences of microvascular invasion and early tumor recurrence in hepatocellular carcinoma:a multicenter propensity score matching analysis显示文摘Background:To study the influence of pathological responses(PR)after transcatheter arterial chemoembolization(TACE)on incidences of microvascular invasion(MVI)and early recurrence in hepatocellular carcinoma(HCC)patients.Methods:Between 2013 to 2015,consecutive HCC patients who underwent liver resection with“curative”intent at three hospitals were enrolled in this study.Patients with different areas of PR after preoperative TACE were compared with those without preoperative TACE on the incidences of MVI,early recurrence rates and patterns of recurrence before and after propensity score matching(PSM).Results:Of 1,970 patients,737 patients who received preoperative TACE were divided into three groups according to the areas of PR:≥90%(n=226),60-90%(n=447),and<60%(n=64).PR≥90%was an independent protective factor of incidences of MVI[odds ratio(OR),0.144;95%confidence interval(CI),0.082-0.245,P<0.001)and early recurrence(HR,0.742;95%CI,0.561-0.963,P=0.032);while PR<60%was an independent risk factor of incidences of MVI(OR,6.076;95%CI,3.004-11.728,P<0.001)and early recurrence(HR,1.428;95%CI,1.095-1.929;P=0.009).Furthermore,patients with PR<60%were significantly more likely to develop multiple intrahepatic recurrences involving multiple hepatic segments when compared with patients without preoperative TACE.Conclusions:This study indicated the area of PR after TACE was closely associated with the incidences of MVI and early tumor recurrence.Patients with PR<60%were at significantly higher risks of having more MVI,early and multiple tumor recurrences. | Yun Yang Zheng Dang Peng Lu Youwen Qian Kongying Lin Zeya Pan Wan Yee Lau Weiping Zhou | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 2 |
| 7 | Mechanism for corrosion protection of β-TCP reinforced ZK60 via laser rapid solidification显示文摘It remains the primary issue to enhance the corrosion resistance of Mg alloys for their clinical applications.In this study,β-tricalcium phosphate(β-TCP)was composited with Mg-6Zn-1Zr(ZK60)using laser rapid solidification to improve the degradation behavior.Results revealed rapid solidification effectively restrained the aggregation ofβ-TCP,which thus homogenously distributed along grain boundaries ofα-Mg.Significantly,the uniformly distributedβ-TCP in the matrix promoted the formation of apatite layer on the surface,which contributed to the formation of a compact corrosion product layer,hence retarding the further degradation.Furthermore,ZK60/8β-TCP(wt.%)composite showed improved mechanical strength,as well as improved cytocompatibility.It was suggested that laser rapidly solidified ZK60/8β-TCP composite might be a potential materials for tissue engineering. | Youwen Deng Youwen Yang Chengde Gao Pei Feng Wang Guo Chongxian He Jian Chen Cijun Shuai | 2018 | International Journal of Bioprinting2018，4，1： | 2 |
| 8 | A bifunctional bone scaffold combines osteogenesis and antibacterial activity via in situ grown hydroxyapatite and silver nanoparticles显示文摘Hydroxyapatite(HA)nanoparticles and silver(Ag)nanoparticles are expected to enable desirable bioactivity and antibac-terial properties on biopolymer scaffolds.Nevertheless,interfacial adhesion between HA/Ag and the biopolymer is poor due to the large physicochemical differences between these components.In this study,poly L-lactic acid(PLLA)powder was first surface-modified with bioactive polydopamine(PDA)in an alkaline environment.Next,HA and Ag nanoparticles were grown in situ on the PDA-coated PLLA powder,which was then adhered to the porous bone scaffold using a selective laser-sintering process.Results showed that HA and Ag nanoparticles were homogenously distributed in the matrix,with enhanced mechanical properties.Simulated body fluid bioactivity tests showed that the in situ grown HA-endowed scaffold shows excellent bioactivity.In vitro tests confirmed that the scaffold exhibits favorable biocompatibility with human umbilical cord mesenchymal stem cells,as well as strong antibacterial activity against Gram-negative Escherichia coli.Furthermore,in vivo assays indicated that the scaffold promoted bone generation,with a new bone area fraction of 71.8%after 8 weeks’implantation,without inflammation. | Youwen Yang Yun Cheng Fang Deng Lida Shen Zhenyu Zhao Shuping Peng Cijun Shuai | 2021 | Bio-Design and Manufacturing2021，4，3： | 2 |
| 9 | Polymyxin resistance caused by large-scale genomic inversion due to IS26 intramolecular translocation in Klebsiella pneumoniae显示文摘Polymyxin B and polymyxin E(colistin)are presently considered the last line of defense against human infections caused by multidrug-resistant Gram-negative organisms such as carbapenemase-producer Enterobacterales,Acinetobacter baumannii,and Klebsiella pneumoniae.Yet resistance to this last-line drugs is a major public health threat and is rapidly increasing.Polymyxin S2(S2)is a polymyxin B analogue previously synthesized in our institute with obviously high antibacterial activity and lower toxicity than polymyxin B and colistin.To predict the possible resistant mechanism of S2for wide clinical application,we experimentally induced bacterial resistant mutants and studied the preliminary resistance mechanisms.Mut-S,a resistant mutant of K.pneumoniae ATCC BAA-2146(Kpn2146)induced by S2,was analyzed by whole genome sequencing,transcriptomics,mass spectrometry and complementation experiment.Surprisingly,large-scale genomic inversion(LSGI)of approximately 1.1 Mbp in the chromosome caused by IS26mediated intramolecular transposition was found in Mut-S,which led to mgrB truncation,lipid A modification and hence S2resistance.The resistance can be complemented by plasmid carrying intact mgrB.The same mechanism was also found in polymyxin B and colistin induced drug-resistant mutants of Kpn2146(Mut-B and Mut-E,respectively).This is the first report of polymyxin resistance caused by IS26 intramolecular transposition mediated mgrB truncation in chromosome in K.pneumoniae.The findings broaden our scope of knowledge for polymyxin resistance and enriched our understanding of how bacteria can manage to survive in the presence of antibiotics. | Haibin Li Lang Sun Han Qiao Zongti Sun Penghe Wang Chunyang Xie Xinxin Hu Tongying Nie Xinyi Yang Guoqing Li Youwen Zhang Xiukun Wang Zhuorong Li Jiandong Jiang Congran Li Xuefu You | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 1 |
| 10 | A Review on Distortion and Residual Stress in Additive Manufacturing显示文摘Additive manufacturing(AM)has gained extensive attention and tremendous research due to its advantages of fabricating complex-shaped parts without the need of casting mold.However,distortion is a known issue for many AM technologies,which decreases the precision of as-built parts.Like fusion welding,the local high-energy input generates residual stresses,which can adversely affect the fatigue performance of AM parts.To the best of the authors’knowledge,a comprehensive review does not exist regarding the distortion and residual stresses dedicated for AM,despite some work has explored the interrelationship between the two.The present review is aimed to fill in the identified knowledge gap,by first describing the evolution of distortion and residual stresses for a range of AM processes,and second assessing their influencing factors.This allows us to elucidate their formation mechanisms from both the micro-and macro-scales.Moreover,approaches which have been successfully adopted to mitigate both the distortion and residual stresses are reviewed.It is anticipated that this review paper opens many opportunities to increase the success rate of AM parts by improving the dimension precision and fatigue life. | Deqiao Xie Fei Lv Youwen Yang Lida Shen Zongjun Tian Cijun Shuai Bo Chen Jianfeng Zhao | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，3： | 1 |
| 11 | 显示文摘 | Yang Youwen Li Liang Huang Xiaohu | 2006 | Materials Letters2006，60，4： | 1 |
| 12 | Laser additive manufacturing of zinc:formation quality,texture,and cell behavior显示文摘Laser powder bed fusion(LPBF)makes it possible for biodegradable zinc(Zn)to be used to produce customized orthopedic implants.In this research,we investigate the impact of laser power and scanning speed on the development of surface quality,relative densification,and texture during LPBF of Zn implants.Increasing laser power was able to decrease melt viscosity and surface tension,which improved the metallurgical bonding between adjacent tracks.Uneven and twisted tracks also became continuous and straight.Scanning speed could controlmolten-pool temperature to restrain grain natural orientation,achieving various crystal orientations and a weakened texture.Importantly,it further avoided the thermal expansion and contraction caused by excessive energy storage and accumulation in the matrix,thus reducing the generation of high-dislocation density.As a result,by selecting a reasonable laser power and scanning speed,the LPBF parts exhibited a flat surface morphology and a high density over 99.5%.Their average hardness,mechanical strength,and elongation reached 50.2 HV,127.8 MPa,and 7.6%,respectively.Additionally,the parts displayed a moderate degradation rate and excellent osteogenic properties.All these results provide a basis for selecting process parameters to optimize the comprehensive properties of LPBF-processed Zn parts for biodegradable applications. | Mingli Yang Liuyimei Yang Shuping Peng Fang Deng Yageng Li Youwen Yang Cijun Shuai | 2023 | Bio-Design and Manufacturing2023，6，2： | 1 |
| 13 | An nMgO containing scaffold:Antibacterial activity,degradation properties and cell responses显示文摘Bone repair failure caused by implant-related infections is a common and troublesome problem.In this study,an antibacterial scaffold was developed via selective laser sintering with incorporating nano magnesium oxide(nMgO)to poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV).The results indicated the scaffold exerted high antibacterial activity.The antibacterial mechanism was that nMgO could cause oxidative damage and mechanical damage to bacteria through the production of reactive oxygen species(ROS)and direct contact action,respectively,which resulted in the damage of their structures and functions.Besides,nMgO significantly increased the compressive properties of the scaffold including strength and modulus,due to its excellent mechanical properties and uniform dispersion in the PHBV matrix.Moreover,the degradation tests indicated nMgO neutralized the acid degradation products of PHBV and benefited the degradation of the scaffold.The cell culture demonstrated that nMgO promoted the cellular adhesion and proliferation,as well as osteogenic differentiation.The present work may open the door to exploring nMgO as a promising antibacterial material for tissue engineering. | Cijun Shuai Wang Guo Chengde Gao Youwen Yang Ping Wu Pei Feng | 2018 | International Journal of Bioprinting2018，4，1： | 1 |
| 14 | Additive manufacturing of bone scaffolds显示文摘Additive manufacturing(AM)can obtain not only customized external shape but also porous internal structure for scaffolds,both of which are of great importance for repairing large segmental bone defects.The scaffold fabrication process generally involves scaffold design,AM,and post-treatments.Thus,this article firstly reviews the state-of-the-art of scaffold design,including computer-aided design,reverse modeling,topology optimization,and mathematical modeling.In addition,the current characteristics of several typical AM techniques,including selective laser sintering,fused deposition modeling(FDM),and electron beam melting(EBM),especially their advantages and limitations are presented.In particular,selective laser sintering is able to obtain scaffolds with nanoscale grains,due to its high heating rate and a short holding time.However,this character usually results in insufficient densification.FDM can fabricate scaffolds with a relative high accuracy of pore structure but with a relative low mechanical strength.EBM with a high beam-material coupling efficiency can process high melting point metals,but it exhibits a low-resolution and poor surface quality.Furthermore,the common post-treatments,with main focus on heat and surface treatments,which are applied to improve the comprehensive performance are also discussed.Finally,this review also discusses the future directions for AM scaffolds for bone tissue engineering. | Youwen Yang Guoyong Wang Huixin Liang Chengde Gao Shuping Peng Lida Shen Cijun Shuai | 2019 | International Journal of Bioprinting2019，5，1： | 1 |
| 15 | A Fe-promoted Ni–P amorphous alloy catalyst (Ni–Fe–P) for liquid phase hydrogenation of m - and p -chloronitrobenzene显示文摘 | Xinhuan Yan Junqing Sun Youwen Wang Jianfeng Yang | 2006 | Journal of Molecular Catalysis A Chemical2006，，1： | 1 |
| 16 | Fabrication of InSb- core/alumina- sheath nanocables显示文摘 | Youwen Yang Liang Li Xiaohu Huang | 2006 | Materials Letters2006，60，： | 1 |
| 17 | In-situ deposition of apatite layer to protect Mg-based composite fabricated via laser additive manufacturing显示文摘Biodegradable magnesium(Mg) and its alloy show huge potential as temporary bone substitute due to the favorable biocompatibility and mechanical compatibility. However, one issue deserves attention is the too fast degradation. In this work, mesoporous bioglass(MBG)with high pore volume(0.59 cc/g) and huge specific surface area(110.78 m^(2)/g) was synthesized using improved sol-gel method, and introduced into Mg-based composite via laser additive manufacturing. Immersion tests showed that the incorporated MBG served as powerful adsorption sites, which promoted the in-situ deposition of apatite by successively adsorbing Ca2+and HPO42-. Such dense apatite film acted as an efficient protection layer and enhanced the corrosion resistance of Mg matrix, which was proved by the electrochemical impedance spectroscopy measurements. Thereby, Mg based composite showed a significantly decreased degradation rate of 0.31 mm/year. Furthermore,MBG also improved the mechanical properties as well as cell behavior. This work highlighted the advantages of MBG in the fabrication of Mg-based implant with enhanced overall performance for orthopedic application. | Youwen Yang Changfu Lu Lida Shen Zhenyu Zhao Shuping Peng Cijun Shuai | 2023 | Journal of Magnesium and Alloys2023，11，2： | 1 |
| 18 | A multi-scale porous scaffold fabricated by a combined additive manufacturing and chemical etching process for bone tissue engineering显示文摘It is critical to develop a fabrication technology for precisely controlling an interconnected porous structure of scaffolds to mimic the native bone microenvironment.In this work,a novel combined process of additive manufacturing(AM)and chemical etching was developed to fabricate graphene oxide/poly(L-lactic acid)(GO/PLLA)scaffolds with multiscale porous structure.Specially,AM was used to fabricate an interconnected porous network with pore sizes of hundreds of microns.And the chemical etching in sodium hydroxide solution constructed pores with several microns or even smaller on scaffolds surface.The degradation period of the scaffolds was adjustable via controlling the size and quantity of pores.Moreover,the scaffolds exhibited surprising bioactivity after chemical etching,which was ascribed to the formed polar groups on scaffolds surfaces.Furthermore,GO improved the mechanical strength of the scaffolds. | Cijun Shuai Youwen Yang Pei Feng Shuping Peng Wang Guo Anjie Min Chengde Gao | 2018 | International Journal of Bioprinting2018，4，2： | 1 |
| 19 | Implantation induced defects and electrical properties of Sb-implanted ZnO显示文摘Defects in Sb implanted Zn O single crystals have been studied by using photoluminescence(PL) spectroscopy,X-ray diffraction(XRD) and Raman scattering.Electrical properties of the samples were analyzed by Hall effect measurement.The results indicate that the annealed Sb-implanted sample is n-type with a free electron concentration of the same amplitude as the calculated implantation concentration.The well-known oxygen vacancy related deep level green PL band is suppressed in the as-implanted sample and recovers to the level close to the as-grown Zn O single crystal after annealing.These phenomena suggest that a large portion of as-implanted Sb atoms occupy oxygen lattice site in an unstable state and move to the interstitial site,forming the complex donor defect upon high temperature annealing,resulting in n-type conduction even if the implantation dose is quite high. | XIE Hui LIU Tong LIU JingMing CAO Ke Wei DONG ZhiYuan YANG Jun ZHAO YouWen | 2015 | Science China(Technological Sciences)2015，58，8： | 1 |
| 20 | Conversion of a B Nanowire Array to an Array of Bi-Bi2O3 Core-Shel Nanowires and Bi2O3 Nanotubes显示文摘 | Li Liang Yang Youwen Li Guanghai | 2006 | Small2006，2，4： | 1 |
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