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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021,64,1: | 122 |
| 2 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014,24,4: | 18 |
| 3 | Image edge detection based on beamlet transform显示文摘Combining beamlet transform with steerable filters, a new edge detection method based on line gradient is proposed. Compared with operators based on point local properties, the edge-detection results with this method achieve higher SNR and position accuracy, and are quite helpful for image registration, object identification, etc. Some edgedetection experiments on optical and SAR images that demonstrate the significant improvement over classical edge operators are also presented. Moreover, the template matching result based on edge information of optical reference image and SAR image also proves the validity of this method. | Li Jing Huang Peikang Wang Xiaohu Pan Xudong | 2009 | Journal of Systems Engineering and Electronics2009,20,1: | 10 |
| 4 | Flow Control for a Two-Stage Proportional Valve with Hydraulic Position Feedback显示文摘The current research mainly focuses on the flow control for the two-stage proportional valve with hydraulic position feedback which is named as Valvistor valve.Essentially,the Valvistor valve is a proportional throttle valve and the flow fluctuates with the change of load pressure.The flow fluctuation severely restricts the application of the Valvistor valve.In this paper,a novel flow control method the Valvistor valve is provided to suppress the flow fluctuation and develop a high performance proportional flow valve.The mathematical model of this valve is established and linearized.Fuzzy proportional-integral-derivative(PID)controller is adopted in the closed-loop flow control system.The feedback is obtained by the flow inference with back-propagation neural network(BPNN)based on the spool displacement in the pilot stage and the pressure differential across the main orifice.The results show that inference with BPNN can obtain the flow data fast and accurately.With the flow control method,the flow can keep at the set point when the pressure differential across the main orifice changes.The flow control method is effective and the Valvistor valve changes from proportional throttle valve to proportional flow valve.For the developed proportional flow valve,the settling time of the flow is very short when the load pressure changes abruptly.The performances of hysteresis,linearity and bandwidth are in a high range.The linear mathematical model can be verified and the assumptions in the system modeling is reasonable. | He Wang Xiaohu Wang Jiahai Huang Long Quan | 2020 | Chinese Journal of Mechanical Engineering2020,33,6: | 6 |
| 5 | Void fraction measurement of bubble and slug flow in a small channel using the multivision technique显示文摘 | Huajun Li Xiaohu Zheng Haifeng Ji Zhiyao Huang Baoliang Wang Haiqing Li | 2017 | Particuology2017,15,4: | 5 |
| 6 | New discoveries from the classic Quaternary mammalian fossil area of Yanjinggou,Chongqing,and their chronological explanations显示文摘Yanjinggou in Wanzhou District of Chongqing is one of the earliest reported and most famous Quaternary mammalian fossil areas in China.The fauna from this area used to be taken as a benchmark for the biochronological comparison of Quaternary paleontology of South China,but the chronology of this fauna has many controversies for the lack of exact locational and stratigraphical records.The present article,on the basis of recent investigations and discoveries,discusses and explains the distribution and biochronology of the mammalian faunas in the Yanjinggou area.The newly discovered Dayakou fissure fauna,including Rhizomys troglodytes,Homotherium sp.,Panthera pardus,Stegodon orientalis,Dicerorhinus sumatrensis,Hesperotherium sinense,Sus sp.,Cervavitus fenqii,Cervus sp.and Muntiacus sp.,is correlated to the middle Early Pleistocene.The presence of Early Pleistocene mammalian fauna in the Yanjinggou area is therefore confirmed.The'Wanhsien fauna'or'Yenchingkou(=Yanjinggou)fauna'as a Mid-Late Pleistocene biostratigraphical datum should be abandoned.The Dayakou fauna and the Upper Cave fauna of Pingba,both in the Yanjinggou area,are correlated to the middle Early Pleistocene and the early Middle Pleistocene in age,respectively. | CHEN ShaoKun PANG LiBo HE CunDing WEI GuangBiao HUANG WanBo YUE ZongYing ZHANG XiaoHu ZHANG Hua QIN Li | 2013 | Chinese Science Bulletin2013,58,31: | 4 |
| 7 | Blockchain-enabled wireless communications:a new paradigm towards 6G显示文摘With the deployment of fifth-generation(5 G)wireless networks worldwide,research on sixth-generation(6 G)wireless communications has commenced.It is expected that 6 G networks can accommodate numerous heterogeneous devices and infrastructures with enhanced efficiency and security over diverse,e.g.spectrum,computing and storage,resources.However,this goal is impeded by a number of trust-related issues that are often neglected in network designs.Blockchain,as an innovative and revolutionary technology that has arisen in the recent decade,provides a promising solution.Building on its nature of decentralization,transparency,anonymity,immutability,traceability and resiliency,blockchain can establish cooperative trust among separate network entities and facilitate,e.g.efficient resource sharing,trusted data interaction,secure access control,privacy protection,and tracing,certification and supervision functionalities for wireless networks,thus presenting a new paradigm towards 6 G.This paper is dedicated to blockchain-enabled wireless communication technologies.We first provide a brief introduction to the fundamentals of blockchain,and then we conduct a comprehensive investigation of the most recent efforts in incorporating blockchain into wireless communications from several aspects.Importantly,we further propose a unified framework of the blockchain radio access network(B-RAN)as a trustworthy and secure paradigm for 6 G networking by utilizing blockchain technologies with enhanced efficiency and security.The critical elements of B-RAN,such as consensus mechanisms,smart contract,trustworthy access,mathematical modeling,cross-network sharing,data tracking and auditing and intelligent networking,are elaborated.We also provide the prototype design of B-RAN along with the latest experimental results. | Jiaheng Wang Xintong Ling Yuwei Le Yongming Huang Xiaohu You | 2021 | National Science Review2021,8,9: | 4 |
| 8 | The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy显示文摘Cytokines exert powerful immunomodulatory effects that are critical to physiology and pathology in humans.The application of natural cytokines in clinical studies has not been clearly established,and there are often problems associated with toxicity or lack of efficacy.The key reasons can be attributed to the pleiotropy of cytokine receptors and undesired activation of off-target cells.With a deeper understanding of the structural principles and functional signals of cytokine-receptor interactions,artificial modification of cytokine signaling through protein engineering and synthetic immunology has become an increasingly feasible and powerful approach.Engineered cytokines are designed to selectively target cells.Herein,the theoretical and experimental evidence of cytokine engineering is reviewed,and the“supercytokines”resulting from structural enhancement and the“immunocytokines”generated by antibody fusion are described.Finally,the“engager cytokines”formed by the crosslinking of cytokines and bispecific immune engagers and other synthetic cytokines formed by nonnatural analogs are also discussed. | Xiaohu Zheng Yaqi Wu Jiacheng Bi Yingying Huang Ying Cheng Yangyang Li Yuwei Wu Guoshuai Cao Zhigang Tian | 2022 | Cellular & Molecular Immunology2022,19,2: | 4 |
| 9 | Design and Implementation of a TDD-Based 128-Antenna Massive MIMO Prototype System显示文摘Owing to the dramatic mobile IP growth,the emerging Internet of Things,and cloud-based applications,wireless networking is witnessing a paradigm shift.By fully exploiting spatial degrees of freedom,massive multiple-input-multiple-output(MIMO) systems promise significant gains in data rates and link reliability.Although the research community has recognized the theoretical benefits of these systems,building the hardware of such complex systems is a challenge in practice.This paper presents a time division duplex(TDD)-based 128-antenna massive MIMO prototype system from theory to reality.First,an analytical signal model is provided to facilitate the setup of a feasible massive MIMO prototype system.Second,a link-level simulation consistent with practical TDDbased massive MIMO systems is conducted to guide and validate the massive MIMO system design.We design and implement the TDDbased 128-antenna massive MIMO prototype system with the guidelines obtained from the link-level simulation.Uplink real-time video transmission and downlink data transmission under the configuration of multiple single-antenna users are achieved.Comparisons withstate-of-the-art prototypes demonstrate the advantages of the proposed system in terms of antenna number,bandwidth,latency,and throughput.The proposed system is also equipped with scalability,which makes the system applicable to a wide range of massive scenarios. | Xi Yang Wenjun Lu Ning Wang Karl Nieman Chao-Kai Wen Chuan Zhang Shi Jin Xiaomin Mu Ian Wong Yongming Huang Xiaohu You | 2017 | China Communications2017,14,12: | 3 |
| 10 | Full-spectrum cell-free RAN for 6G systems:system design and experimental results显示文摘With distributed transceivers and scalable cooperative transmission,cell-free massive multipleinput multiple-output(CF-mMIMO)technology eliminates the“cells”of traditional mobile communications,thereby significantly improving the performance of wireless networks.CF-mMIMO is considered as a major technical tool for achieving the key performance indicators of sixth generation(6G)mobile communication systems.In this paper,a scalable implementation architecture for CF-mMIMO is proposed,based on which potential key technologies such as channel information acquisition,transceiver design,dynamic user and access point association,and novel duplexing are introduced.Finally,based on low-cost commercial access points,a CF-mMIMO testbed with 64 transmit and receive antennas is developed,and the performance of the distributed receiver design is evaluated. | Dongming WANG Xiaohu YOU Yongming HUANG Wei XU Jiamin LI Pengcheng ZHU Yanxiang JIANG Yang CAO Xinjiang XIA Ziyang ZHANG Qingji JIANG Pan WANG Dongjie LIU Kang ZHENG Mengting LOU Jing JIN Qixing WANG Jiangzhou WANG | 2023 | Science China(Information Sciences)2023,66,3: | 3 |
| 11 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://bencao.bmicc.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023,66,10: | 2 |
| 12 | A parallel ant colonies approach to de novo prediction of protein backbone in CASP8/9显示文摘Predicting the three-dimensional structure of proteins from amino acid sequences with only a few remote homologs,or de novo prediction,remains a major challenge in computational biology.The modeling of the protein backbone represents the initial phase of a protein structure prediction process.Using a parallel ant colony optimization based on sharing one pheromone matrix,this report proposes a parallel approach to predict the structure of a protein backbone.The parallel approach combines various sources of energy functions and generates protein backbones with the lowest energies jointly determined by the various energy functions.All free modeling targets in CASP8/9 are used to evaluate the performance of the method.For 13 targets in CASP8,two out of the predicted model1s selected by our approach are the best of the published CASP8 results,and seven out of the model1s are ranked in the top 10.For 29 targets in CASP9,20 out of the best models from our predictions are ranked in the top 10,and 11 out of the model1s are ranked in the top 10. | LV Qiang WU HongJie WU JinZhen HUANG Xu LUO XiaoHu QIAN PeiDe | 2013 | Science China(Information Sciences)2013,56,10: | 2 |
| 13 | Research Progress of Grassland Feed-animal Balance at Home and Abroad显示文摘Feed-animal balance is the key technique on the grassland ecosystem management,and attracts widespread attention in the world.Many studies have been conducted by former researchers,and most of their efforts were intended to keep the balance of feed-animal.However,there are still much more issue needed to be studied in details on the face of grassland degeneration and animal husbandry sustainable development.The author analyzed the feed-animal balance research progress,including the concept of stocking rate and its practical management techniques,especially on the stocking rate calculation methods.In addition,the social and economy effects on feed-animal balance were also discussed during the progress of improving the development of pastoral economy.In order to achieve feed-animal balance more effectively,it was concluded that the focus must be shift from only on animal number to the grassland quality,and it's necessary to strengthen market tax control. | Xiaohu MAI Yujuan ZHANG Yingjun ZHANG Shangli SHI Ding HUANG Yajun ZHANG | 2013 | Asian Agricultural Research2013,5,12: | 2 |
| 14 | Production of non-mosaic genome edited porcine embryos by injection of CRISPR/Cas9 into germinal vesicle oocytes显示文摘Genetically modified pigs represent a great promise for generating models of human diseases and producing new breeds.Generation of genetically edited pigs using somatic cell nuclear transfer(SCNT)or zygote cytoplasmic microinjection is a tedious process due to the low developmental rate or mosaicism of the founder(FO).Herein,we developed a method termed germinal vesicle oocyte gene editing(GVGE)to produce non-mosaic porcine embryos by editing maternal alleles during the GV to MII transition.Injection of Cas9 mRNA and X-linked Dmd gene-specific gRNA into GV oocytes did not affect their developmental potential.The MII oocytes edited during in vitro maturation(IVM)could develop into blastocysts after parthenogenetic activation(PA)or in vitro fertilization(IVF).Genotyping results indicated that the maternal gene X-linked Dmd could be efficiently edited during oocyte maturation.Up to81.3% of the edited IVF embryos were non-mosaic Dmd gene mutant embryos.In conclusion,GVGE might be a valuable method for the generation of non-mosaic maternal allele edited FO embryos in a short simple step. | Xiaohu Su Wei Chen Qingqing Cai Puping Liang Yaosheng Chen Peiqing Cong Junjiu Huang | 2019 | Journal of Genetics and Genomics2019,46,7: | 2 |
| 15 | Supermodulus effect by grain-boundary wetting in nanostructured multilayers显示文摘The effect of thermal treatments on mechanical properties was systematically investigated in Ni/Mo multilayers with a constant modulation period(160 nm)prepared by magnetron sputtering deposition.A supermodulus effect was found in the annealed multilayers as compared to the as-deposited state.A large tensile stress development was observed in the multilayers.The evolution of grain-boundary(GB)wetting was observed at the interfaces of the multilayers,which results in an enhanced modulus based on the mechanism of GB-wetting-induced interfacial stress/strain.The GB wetting phenomenon was further supported by a thermodynamic calculation.The results not only bring clear evidence of the important role of interfacial structures in governing the elastic behavior of metallic multilayers,but also allow designing the multilayers with special properties through atomic diffusion and wetting at the interfaces based on the thermodynamic calculation. | Jing Wang Lu Han Xiaohu Li Dongguang Liu Laima Luo Yuan Huang Yongchang Liu Zumin Wang | 2021 | Journal of Materials Science & Technology2021,,6: | 1 |
| 16 | 显示文摘 | Yang Youwen Li Liang Huang Xiaohu | 2006 | Materials Letters2006,60,4: | 1 |
| 17 | Single-cell RNA sequencing identifies novel cell types in Drosophila blood显示文摘Drosophila has been extensively used to model the human blood-immune system,as both systems share many developmental and immune response mechanisms.However,while many human blood cell types have been identified,only three were found in flies:plasmatocytes,crystal cells and lamellocytes.To better understand the complexity of fly blood system,we used single-cell RNA sequencing technology to generate co mprehensive gene expression profiles for Drosophila circulating blood cells.In addition to the known cell types,we identified two new Drosophila blood cell types:thanacytes and primocytes.Thanacytes,which express many stimulus response genes,are involved in distinct responses to different types of bacteria.Primocytes,which express cell fate commitment and signaling genes,appear to be involved in keeping stem cells in the circulating blood.Furthermore,our data revealed four novel plasmatocyte subtypes(Ppn+,CAH7^+,Lsp^+and reservoir plasmatocytes),each with unique molecular identities and distinct predicted functions.We also identified cross-species markers from Drosophila hemocytes to human blood cells.Our analysis unveiled a more complex Drosophila blood system and broadened the scope of using Drosophila to model human blood system in development and disease. | Yulong Fu Xiaohu Huang Peng Zhang Joyce van de Leemput Zhe Han | 2020 | Journal of Genetics and Genomics2020,47,4: | 1 |
| 18 | A polymer electrolyte with a thermally induced interfacial ion-blocking function enables safety-enhanced lithium metal batteries显示文摘Lithium metal batteries(LMBs)have recently been revitalized as one of the most promising electrochemical energy storage systems,owing to the ultrahigh specific capacity(3860 mAh g^(-1))and ultralow potential(-3.04 V vs.standard hydrogen electrode)of lithium metal anodes.However,safety hazards originating from lithium dendrite growth and pulverization during cycling and thermal stimulation present significant challenges to the practical application of LMBs.To address this issue,we have developed an in situ polymer electrolyte with thermally induced interfacial ion-blocking ability.We demonstrate that the repolymerization and deposition of residual vinylene carbonate in the as-prepared electrolyte under thermal abuse predominantly results in thermally induced ion blocking at the solid electrolyte interface,thus achieving superior LMB safety.The developed polymer electrolyte also yields superior cyclability in LMBs.This design philosophy provides a good paradigm for improving the safety of LMBs. | Huanrui Zhang Lang Huang Hantao Xu Xiaohu Zhang Zhou Chen Chenhui Gao Chenglong Lu Zhi Liu Meifang Jiang Guanglei Cui | 2022 | eScience2022,2,2: | 1 |
| 19 | Fabrication of InSb- core/alumina- sheath nanocables显示文摘 | Youwen Yang Liang Li Xiaohu Huang | 2006 | Materials Letters2006,60,: | 1 |
| 20 | Recent development of nanomaterials for carbon dioxide electroreduction显示文摘Electrochemical CO_(2) reduction reaction(CO_(2)RR)to produce value‐added products has received tremendous research attention in recent years.With research efforts across the globe,remarkable advancement has been achieved,including the improvement of selectivity for the reduction products,the realization of efficient reduction beyond two electrons,and the delivery of industrially relevant current densities.In this review,we introduce the recent development of nanomaterials for CO_(2)RR,including the zero‐dimensional graphene quantum dots,two‐dimensional materials such as metal chalcogenides and metal/covalent organic framework,singleatom catalysts,and nanostructured metal catalysts.The engineering of materials into three‐dimensional structure will also be discussed.Finally,we will provide a summary of the catalytic performance and perspectives on future development. | Jianjun Su Yong Liu Yun Song Libei Huang Weihua Guo Xiaohu Cao Yubing Dou Le Cheng Geng Li Qiushi Hu Ruquan Ye | 2022 | SmartMat2022,3,1: | 1 |