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您的检索式：作者名="Yangzi Tian"
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| 1 | Genome of Plant Maca (Lepidium meyenil) Illuminates Genomic Basis for High-Altitude Adaptation in the Central Andes显示文摘Maca (Lepidium meyenii Walp, 2n = 8x = 64 ) ,属于 Brassicaceae 家庭,经济植物在秘鲁(4000-4500 m ) 在中央安第斯山脉岭被栽培。认为快速中央安第斯山脉高举发生 5-10 百万年以前(妈) ,一个进化问题关于象 maca 那样的植物怎么在一个短地质的时期以内获得高高度的改编产生。这里,我们报导 maca 的高质量的染色体集会,在里面它二仔细 spaced maca 特定的整个染色体的复制(WGD;6.7 妈) 被识别。在 maca 和密切相关的 Brassicaceae 种类之间的比较 genomic 分析揭示了经由 WGD 涉及不能生活的压力反应,荷尔蒙发信号小径,和第二等的代谢物生合成的 maca 基因和基因家庭的扩大。保留和许多复制基因的随后的功能的分叉可以说明词法、生理的变化(即,小叶形状和自我富饶) 在在高高度的环境的 maca。另外,一些复制 maca 基因在词法改编与功能被识别(即,叶卷应答) 并且不能生活的压力反应(即, GLYCINE 富有的 RNA 有约束力的蛋白质和 DNA-DAMAGE-REPAIR/TOLERATION 2 ) 在积极选择下面。一起, maca 染色体提供有用信息在安第斯山脉在植物的高高度的改编理解 WGD 的重要角色。 | Jing Zhang Yang Tian Liang Yan GuanghuiZhang Xiao Wang Yan Zeng Jiajin Zhang Xiao Ma Yuntao Tan Ni Long Yangzi Wang Yujin Ma Yuqi He Yu Xue Shumei Hao Shengchao Yang Wen Wang Liangsheng Zhang Yang Dong Wei Chen Jun Sheng | 2016 | Molecular Plant2016，9，7： | 9 |
| 2 | SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation显示文摘Melanoma is the most lethal type of skin cancer,originating from the malignant transformation of melanocyte.While the development of targeted therapy and immunotherapy has gained revolutionary advances in potentiating the therapeutic effect,the prognosis of patients with melanoma is still suboptimal.During tumor progression,melanoma frequently encounters stress from both endogenous and exogenous sources in tumor microenvironment.SIRT7 is a nuclear-localized deacetylase of which the activity is highly dependent on intracellular nicotinamide adenine dinucleotide(NAD+),with versatile biological functions in maintaining cell homeostasis.Nevertheless,whether SIRT7 regulates tumor cell biology and tumor immunology in melanoma under stressful tumor microenvironment remains elusive.Herein,we reported that SIRT7 orchestrates melanoma progression by simultaneously promoting tumor cell survival and immune evasion via the activation of unfolded protein response.We first identified that SIRT7 expression was the most significantly increased one in sirtuins family upon stress.Then,we proved that the deficiency of SIRT7 potentiated tumor cell death under stress in vitro and suppressed melanoma growth in vivo.Mechanistically,SIRT7 selectively activated the IRE1α-XBP1 axis to potentiate the pro-survival ERK signal pathway and the secretion of tumorpromoting cytokines.SIRT7 directly de-acetylated SMAD4 to antagonize the TGF-β-SMAD4 signal,which relieved the transcriptional repression on IRE1αand induced the activation of the IRE1α-XBP1 axis.Moreover,SIRT7 up-regulation eradicated anti-tumor immunity by promoting PD-L1 expression via the IRE1α-XBP1 axis.Additionally,the synergized therapeutic effect of SIRT7 suppression and anti-PD-1 immune checkpoint blockade was also investigated.Taken together,SIRT7 can be employed as a promising target to restrain tumor growth and increase the effect of melanoma immunotherapy. | Xiuli Yi Huina Wang Yuqi Yang Hao Wang Hengxiang Zhang Sen Guo Jianru Chen Juan Du Yangzi Tian Jingjing Ma Baolu Zhang Lili Wu Qiong Shi Tianwen Gao Weinan Guo Chunying | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
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