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| 1 | The Genome of Dendrobium officinale Illuminates the Biology of the Important Traditional Chinese Orchid Herb显示文摘 | Liang Yan Xiao Wang Hui Liu Yang Tian Jinmin Lian Ruijuan Yang ShumeiHao Xuanjun Wang Shengchao Yang Qiye Li Shuai Qi Ling Kui Moses Okpekum Xiao Ma Jiajin Zhang Zhaoli Ding Guojie Zhang Wen Wang Yang Dong Jun Sheng | 2015 | Molecular Plant2015，8，6： | 64 |
| 2 | Whole-Genome Sequencing and Analysis of the Chinese Herbal Plant Panax notoginseng显示文摘 | Wei Chen Ling Kui Guanghui Zhang Shusheng Zhu Jing Zhang Xiao Wang Min Yang Huichuan Huang Yixiang Liu Yong Wang Yahe Li Lipin Zeng Wen Wang Xiahong He Yang Dong Shengchao Yang | 2017 | Molecular Plant2017，10，6： | 21 |
| 3 | Endoplasmic reticulum oxidoreductin 1α mediates hepatic endoplasmic reticulum stress in homocysteine-induced atherosclerosis显示文摘Endoplasmic 蜂窝胃(嗯) 应力作为不同病理学的过程的一个重要调节的人并且作为贡献导致的 homocysteine (Hcy ) 的机制正在出现 hepar 损害。然而,分子的事件导致 Hcy 嗯在在动脉粥样硬化背景下面的 hepar 的应力当前是未知的。Endoplasmic 蜂窝胃 oxidoreductin (ERO1 ) 1 在维持起一个关键作用嗯压力功能。在这研究,我们在 hepacytes 在 hyperhomocysteinemia 和 ERO1 的效果在 hepar 决定了 ERO1 的表示嗯应力面对 Hcy。HHcy 模型被在 apolipoprotein-E-deficient (ApoE-/-) 喂蛋氨酸食谱建立老鼠,和 hepatocytes 与 Hcy 的叶酸、不同的集中被孵化。我们的结果证明 Hcy 被触发嗯应力描绘了由一调整葡萄糖的蛋白质的增加的内容 78 (GRP78 ) ,蛋白质 kinase 象 RNA 一样嗯 kinase (津贴) ,激活抄写因素(ATF ) 6 并且 X 盒子有约束力的 protein-1 (XBP-1 ) 。在 HHcy 老鼠和对待 Hcy 的 hepatocytes 的 ERO1 表情在 ApoE-/- 组和控制 hepacytes 与那些相比被减少(P < 0.05 ) 分别地。有小介入的 RNA 的 ERO1 的表示显著地扩充了的敲门下面导致 Hcy 嗯应力。同时,表情嗯压力相关的因素包括 GRP78,津贴, ATF6 和 XBP-1,当 ERO1 基因在 hepacytes 是过去表示的时,显著地被减少。我们的结果建议 ERO1 可以涉及导致 Hcy 的 hepar 嗯 ERO1 表示的应力,和抑制能加速这进程。 | Xiaoling Yang Hua Xu Yinju Hao Li Zhao Xin Cai Jue Tian Minghao Zhang Xuebo Han Shengchao Ma Jun Cao Yideng Jiang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 14 |
| 4 | Genome of Plant Maca (Lepidium meyenil) Illuminates Genomic Basis for High-Altitude Adaptation in the Central Andes显示文摘Maca (Lepidium meyenii Walp, 2n = 8x = 64 ) ,属于 Brassicaceae 家庭,经济植物在秘鲁(4000-4500 m ) 在中央安第斯山脉岭被栽培。认为快速中央安第斯山脉高举发生 5-10 百万年以前(妈) ,一个进化问题关于象 maca 那样的植物怎么在一个短地质的时期以内获得高高度的改编产生。这里,我们报导 maca 的高质量的染色体集会,在里面它二仔细 spaced maca 特定的整个染色体的复制(WGD;6.7 妈) 被识别。在 maca 和密切相关的 Brassicaceae 种类之间的比较 genomic 分析揭示了经由 WGD 涉及不能生活的压力反应,荷尔蒙发信号小径,和第二等的代谢物生合成的 maca 基因和基因家庭的扩大。保留和许多复制基因的随后的功能的分叉可以说明词法、生理的变化(即,小叶形状和自我富饶) 在在高高度的环境的 maca。另外,一些复制 maca 基因在词法改编与功能被识别(即,叶卷应答) 并且不能生活的压力反应(即, GLYCINE 富有的 RNA 有约束力的蛋白质和 DNA-DAMAGE-REPAIR/TOLERATION 2 ) 在积极选择下面。一起, maca 染色体提供有用信息在安第斯山脉在植物的高高度的改编理解 WGD 的重要角色。 | Jing Zhang Yang Tian Liang Yan GuanghuiZhang Xiao Wang Yan Zeng Jiajin Zhang Xiao Ma Yuntao Tan Ni Long Yangzi Wang Yujin Ma Yuqi He Yu Xue Shumei Hao Shengchao Yang Wen Wang Liangsheng Zhang Yang Dong Wei Chen Jun Sheng | 2016 | Molecular Plant2016，9，7： | 9 |
| 5 | Response spectra for nuclear structures on rock sites considering the near-fault directivity effect显示文摘Near-fault ground motions, potentially with large amplitude and typical velocity pulses, may signifi cantly impact the performance of a wide range of structures.The current study is aimed at evaluating the safety implications of the near-fault effect on nuclear power plant facilities designed according to the Chinese code.To this end, a set of near-fault ground motions at rock sites with typical forward-directivity effect is examined with special emphasis on several key parameters and response spectra.Spectral comparison of the selected records with the Chinese and other code design spectra was conducted.The bi-normalized response spectra in terms of different corner periods are utilized to derive nuclear design spectra.It is concluded that nuclear design spectra on rock sites derived from typical rupture directivity records are significantly influenced both by the earthquake magnitude and the rupture distance.The nuclear design spectra specified in the code needs to be adjusted to reflect the near-fault directivity effect of large earthquakes. | Xu Longjun Yang Shengchao Xie Lili | 2010 | Earthquake Engineering and Engineering Vibration2010，9，3： | 9 |
| 6 | Enhanced selective catalytic reduction of NO with NH3 via porous micro-spherical aggregates of Mn–Ce–Fe–Ti mixed oxide nanoparticles显示文摘We rationally designed a high performance denitration(De-NOx) catalyst based on a micrometer-sized spherical Mn–Ce–Fe–Ti(CP-SD)catalyst for selective catalytic reduction(SCR). This was prepared by a co-precipitation and spray drying(CP-SD) method. The catalyst was systematically characterized, and its morphological structure and surface properties were identified. Compare with conventional Mn–Ce–Fe–Ti(CP) catalysts, the Mn–Ce–Fe–Ti(CP-SD) catalyst had superior surface-adsorbed oxygen leading to enhanced 'fast NH3-SCR' reaction. The asobtained Mn–Ce–Fe–Ti(CP-SD) catalyst offered excellent NO conversion and N2 selectivity of 100.0% and 84.8% at 250℃, respectively, with a gas hourly space velocity(GHSV) of 40,000 h-1. The porous micro-spherical structure provides a larger surface area and more active sites to adsorb and activate the reaction gases. In addition, the uniform distribution and strong interaction of manganese, iron, cerium, and titanium oxide species improved H2O and SO2 resistance. The results showed that the Mn–Ce–Fe–Ti(CP-SD) catalyst could be used prospectively as a denitration(De-NOx) catalyst. | Junqi Tian Ke Zhang Wei Wang Fu Wang Jianming Dan Shengchao Yang Jinli Zhang Bin Dai Feng Yu | 2019 | Green Energy & Environment2019，4，3： | 4 |
| 7 | RNA-seq analysis of Paris polyphylla var.yunnanensis roots identified candidate genes for saponin synthesis显示文摘Paris polyphylla Smith var.yunnanensis(Franch.) Hand.-Mazz.is a rhizomatous,herbaceous,perennial plant that has been used for more than a thousand years in traditional Chinese medicine.It is facing extinction due to overharvesting.Steroids are the major therapeutic components in Paris roots,the commercial value of which increases with age.To date,no genomic data on the species have been available.In this study,transcriptome analysis of an 8-year-old root and a 4-year-old root provided insight into the metabolic pathways that generate the steroids.Using Illumina sequencing technology,we generated a high-quality sequence and demonstrated de novo assembly and annotation of genes in the absence of prior genome information.Approximately 87,577 unique sequences,with an average length of 614 bases,were obtained from the root cells.Using bioinformatics methods,we annotated approximately 65.51% of the unique sequences by conducting a similarity search with known genes in the National Center for Biotechnology Information's non-redundant database.The unique transcripts were functionally classified using the Gene Ontology hierarchy and the Kyoto Encyclopedia of Genes and Genomes database.Of 3082 genes that were identified as significantly differentially expressed between roots of different ages,1518(49.25%) were upregulated and 1564(50.75%) were downregulated in the older root.Metabolic pathway analysis predicted that 25 unigenes were responsible for the biosynthesis of the saponins steroids.These data represent a valuable resource for future genomic studies on this endangered species and will be valuable for efforts to genetically engineer P.polyphylla and facilitate saponin-rich plant development. | Tao Liu Xiaoxian Li Shiqing Xie Ling Wang Shengchao Yang | 2016 | Plant Diversity2016，38，3： | 4 |
| 8 | Metallogenetic model of Jiaodong-type gold deposits,eastern China显示文摘The genesis of giant gold provinces is an international scientific frontier,in which the source of a huge amount of gold and the drive for mineralization are key challenges.The mineralization intensity of the Jiaodong gold province in eastern China is a rare occasion in the world,because it owns gold reserves of~5500 tons within an area of less than 10,000 km^(2).The Jiaodong gold province formed in the superimposed domain of diverse tectonic regimes in an intracontinental setting.Paleoproterozoic regional peak metamorphism and Triassic continental collision are followed by the tectonic transition and gold mineralization at ca.120 Ma with time intervals of 1.9 billion years and about 100 million years,respectively.The Jiaodong gold deposits are different from orogenic and intrusion-related gold deposits in terms of the tectonic background,types of host rocks,and oreforming mechanism.These gold deposits show close spatial-temporal and genetic relationships to mafic igneous rocks,implying the derivation of ore-forming fluids from the metasomatic mantle domains.Mafic dykes in Jiaodong have negativeε_(Hf)(t)values of-29.9 to-9.1,Os content of 0.002-0.16 ppb,heavyδ^(18)O up to 8.23‰,and high initial^(187)Os/^(188)Os ratios of 0.1352-0.8858.These indicate that the lithospheric mantle was metasomatized by ancient crust-derived components.The lithospheric mantle in the western Jiaodong shows generally more enriched isotope features than that in the eastern part,which is explained to be an important reason for its huge gold resources.The mafic dykes show lighter Mg isotope characteristics(averageδ^(26)Mg of-0.33‰,n=50)and high Ca O content(overall greater than 6.5 wt%),indicating that the lithospheric mantle would also record the metasomatism by the carbonate rocks from the subducting oceanic slab.Under the background of the rollback of the subducting paleo-Pacific slab and the destruction of the North China Craton,partial melting of the lower crust would produce granitic magmas that led to the enrichment of gold in the residual crust.The syn-mineralization asthenosphere upwelling would promote the recycling of the lower crust and the partial melting of the metasomatic mantle domains.Basic magmas,produced by the partial melting,and the mantle itself would degas to form ore fluids.The ore fluids would further leach gold in the lower crust to increase its fertility.The auriferous fluids were transported to the middle to upper crust along the detachment and strike-slip faults.Water-rock interaction and fluid immiscibility,which occurred in and above the ductile-brittle transition zone to induce gold precipitation,formed the Jiaodong gold deposits.Given the unique geological features and genetic model of the Jiaodong gold deposits,they can be defined as“Jiaodong-type”gold deposits. | Jun DENG Qingfei WANG Liang ZHANG Shengchao XUE Xuefei LIU Lin YANG Liqiang YANG Kunfeng QIU Yayun LIANG | 2023 | Science China Earth Sciences2023，66，10： | 2 |
| 9 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 10 | Overwhelming electrochemical oxygen reduction reaction of zinc-nitrogen-carbon from biomass resource chitosan via a facile carbon bath method显示文摘Developing high efficiency and low cost electrocatalysts is critical for the enhancement of oxygen reduction reaction(ORR),which is the fundamental for the development and commercialization of renewable energy conversion technology.Herein,zinc-nitrogen-carbon(Zn-N-C)was prepared by using biomass resource chitosan via a facile carbon bath method.The obtained Zn-N-C delivered a high specific surface area(794.7 cm^2/g)together with pore volume(0.49 cm^3/g).During the electrochemical evaluation of oxygen reduction reaction(ORR),Zn-N-C displayed high activity for ORR with an onset pote ntial E0=0.96 VRHE and a half wave potential E1/2=0.86 VRHE,which were more positive than those of the comme rcial 20 wt%Pt/C benchmark catalyst(E0=0.96 VRHE and E1/2=0.81 VRHE).In addition,the ZnN-C catalyst also had a better stability and methanol tolerance than those of the Pt/C catalyst. | Libing Hu Feng Yu Fu Wang Shengchao Yang Banghua Peng Long Chen Gang Wang Juan Hou Bin Dai Zhi-Qun Tian | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 11 | Extracellular-superoxide dismutase DNA methylation promotes oxidative stress in homocysteine-induced atherosclerosis显示文摘In the present study,we investigate the effect of homocysteine(Hcy)on extracellular-superoxide dismutase(ECSOD)DNA methylation in the aorta of mice,and explore the underlying mechanism in macrophages,trying to identify the key targets of Hcy-induced EC-SOD methylation changes.ApoE--mice are fed different diets for 15 weeks,EC-SODand DNAmethyltransferase1(DNMT1)expression levels aredetected byRT-PCRandwestern blot analysis.EC-SOD methylation levels are assessed by ntMS-PCR.After EC-SOD overexpression or knockdown in macrophages,following the transfection of macrophages with pEGFP-N1-DNMT1,the methylation levels of ECSOD are detected.Our data show that the concentrations of Hcy and the area of atherogenic lesions are significantly increased in ApoE--mice fed with a high-methionine diet,and have a positive correlation with the levels of superoxide anions,which indicates that Hcy-activated superoxide anions enhance the development of atherogenic lesions.EC-SOD expression is suppressed by Hcy,and the content of superoxide anion is increased when EC-SOD is silenced by RNAi in macrophages,suggesting that EC-SOD plays a major part in oxidative stress induced by Hcy.Furthermore,the promoter activity of EC-SOD is increased following transfection with the-1/-110o fragment,and EC-SOD methylation level is significantly suppressed by Hcy,and more significantly decreased upon DNMT1 overexpression.In conclusion,Hcy may alter the DNA methylation status and DNMT1 acts as the essential enzyme in the methyl transfer process to disturb the status of EC-SOD DNA methylation,leading to decreased expression of Ec-sODandincreasedoxidativestressandatherosclerosis. | Shengchao Ma Guanjun Lu Qing Zhang Ning Ding Yuzhen Jie Hui Zhang Lingbo Xu Lin Xie Xiaoling Yang Huiping Zhang Yideng Jiang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 1 |
| 12 | Submergence induced changes of molecular species in membrane lipids in Arabidopsis thaliana显示文摘The composition of membrane lipids is sensitive to environmental stresses.Submergence is a type of stress often encountered by plants.However,how the molecular species of membrane lipids respond to submergence has not yet been characterised.In this study,we used a lipidomic approach to profile the molecular species of membrane lipids in whole plants of Arabidopsis thaliana that were completely submerged for three days.The plants survived one day of submergence,after which,we found that the total membrane lipids were only subtly decreased,showing significant decreases of monogalactosyldiacylglycerol(MGDG)and phosphatidylcholine(PC)and an increase of phosphatidic acid(PA);however,the basic lipid composition was retained.In contrast,three days of submergence caused plants to die,and the membranes deteriorated via the rapid loss of 96% of lipid content together with a 229% increase in PA.The turnover of molecular species from PG and MGDG to PA indicated that submergenceinduced lipid changes occurred through PA-mediated degradation.In addition,molecular species of extraplastidic PG degraded sooner than plastidic ones,lyso-phospholipids exhibited various patterns of change,and the double-bond index(DBI)remained unchanged until membrane deterioration.Our results revealed the unique changes of membrane lipids upon submergence and suggested that the major cause of the massive lipid degradation could be anoxia. | Mulan Wang Yunmei Shen Faqing Tao Shengchao Yang Weiqi Li | 2016 | Plant Diversity2016，38，3： | 1 |
| 13 | All-optical modulation of quantum states by nonlinear metasurface显示文摘Metasurfaces have proven themselves an exotic ability to harness light at nano-scale,being important not only for classical but also for quantum optics.Dynamic manipulation of the quantum states is at the heart of quantum information processing;however,such function has been rarely realized with metasurfaces so far.Here,we report an all-optical dynamic modulation of the photonic quantum states using the nonlinear metasurface.The metasurface consists of a metallic nanostructure combined with a photoisomerizable azo layer.By tuning the plasmonic resonance through optically switching the azo molecules between their binary isomeric states,we have realized dynamic control of transmission efficiencies of orthogonally polarized photons and also the phase delay between them,thereby an entangled state was efficiently controlled.As an illustration,a quantum state distillation has been demonstrated to recover a Bell state from a non-maximally entangled one to that with fidelities higher than 98%.Our work would enrich the functions of the metasurface in the quantum world,from static to dynamic modulation,making the quantum metasurface going practical. | Di Zhang Yang Chen Shengchao Gong Wei Wu Wei Cai Mengxin Ren Xifeng Ren Shuang Zhang Guangcan Guo Jingjun Xu | 2022 | Light(Science & Applications)2022，11，3： | 1 |
| 14 | The Blue-emitting long afterglow photoluminescence phosphor 显示文摘 | YANG Zhiping ZHU Shengchao GUO Zhi | 2002 | Proc SPIE2002，4918，： | 1 |
| 15 | Metabolic engineering of Yarrowia lipolytica for scutellarin production显示文摘Scutellarin related drugs have superior therapeutic effects on cerebrovascular and cardiovascular diseases.Here,an optimal biosynthetic pathway for scutellarin was constructed in Yarrowia lipolytica platform due to its excellent metabolic potential.By integrating multi-copies of core genes from different species,the production of scutellarin was increased from 15.11 mg/L to 94.79 mg/L and the ratio of scutellarin to the main by-product was improved about 110-fold in flask condition.Finally,the production of scutellarin was improved 23-fold and reached to 346 mg/L in fed-batch bioreactor,which was the highest reported titer for de novo production of scutellarin in microbes.Our results represent a solid basis for further production of natural products on unconventional yeasts and have a potential of industrial implementation. | Yina Wang Xiaonan Liu Bihuan Chen Wei Liu Zhaokuan Guo Xiangyu Liu Xiaoxi Zhu Jiayu Liu Jin Zhang Jing Li Lei Zhang Yadi Gao Guanghui Zhang Yan Wang MIqbal Choudhary Shengchao Yang Huifeng Jiang | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 1 |
| 16 | HMOD: An Omics Database for Herbal Medicine Plants显示文摘 | Xiao Wang Jiajin Zhang Simei He Yuanni Gao Xiaoqin Ma Yun Gao Guanghui Zhang Ling Kui Wen Wang Ying wang Shengchao Yang Yang Dong | 2018 | Molecular Plant2018，11，5： | 1 |
| 17 | A Comprehensive Porosity Prediction Model for the Upper Paleozoic Tight Sandstone Reservoir in the Daniudi Gas Field, Ordos Basin显示文摘This paper investigated the porosity controlling factors for tight sandstone reservoir in the Daniudi gas field, Ordos Basin based on an integrated petrographic, petrophysical and geostatistical analyses, and proposed a comprehensive prediction model for reservoir porosity. Compaction was found to be a key factor for causing reservoir densification. The degree of sandstone compaction appears to be affected by grain sizes and sorting. Under normal compaction conditions(e.g., cement content less than 6%, and with no dissolution), the variation in reservoir porosity with burial depth can be well correlated with grain compositions, grain sizes, and sorting. Based on qualitative examination of the controlling factors for reservoir porosities, geostatistics were used to quantify the effects of various geological parameters on reservoir porosities. A statistical model for comprehensive prediction of porosity was then established, on the assumption that the present reservoir porosity directly relates to both normal compaction and diagenesis. This model is easy to use, and has been validated with measured porosity data. The porosity controlling factors and the comprehensive porosity prediction can be used to quantify effects of the main controlling factors and their interaction on reservoir property evolution, and may provide a reference model for log interpretation. | Longwei Qiu Shengchao Yang Changsheng Qu Ningning Xu Qingsong Gao Xiangjin Zhang Xugang Liu Donghui Wang | 2017 | Journal of Earth Science2017，28，6： | 1 |
| 18 | Analysis of changes in the Panax notoginseng glycerolipidome in response to long-term chilling and heat显示文摘Long-term moderately high or low temperatures can damage economically important plants.In the present study,we treated Panax notoginseng,an important traditional Chinese medicine,with temperatures of 10,20,and 30℃for 30 days.We then investigated P.notoginseng glycerolipidome responses to these moderate temperature stresses using an ESI/MS-MS-based lipidomic approach.Both long-term chilling(LTC,10℃)and long-term heat(LTH,30℃)decreased photo pigment levels and photosynthetic rate.LTH-induced degradation of photo pigments and glycerolipids may further cause the decline of photosynthesis and thereafter the senescence of leaves.LTC-induced photosynthesis decline is attributed to the degradation of photo synthetic pigments rather than the degradation of chloroplastidic lipids.P.notoginseng has an especially high level of lysophosphatidylglycerol,which may indicate that either P.notoginseng phospholipase A acts in a special manner on phosphatidylglycerol(PG),or that phospholipase B acts.The ratio of sulfoquinovosyldiacylglycerol(SQDG)to PG increased significantly after LTC treatment,which may indicate that SQDG partially substitutes for PG.After LTC treatment,the increase in the degree of unsaturation of plastidic lipids was less than that of extraplastidic lipids,and the increase in the unsaturation of PG was the largest among the ten lipid classes tested.These results indicate that increasing the level of unsaturated PG may play a special role in maintaining the function and stability of P.notoginseng photosystems after LTC treatment. | Tao Liu Jia Chen Furong Xu Xiahong He Shengchao Yang Youyong Zhu Weiqi Li Guowei Zheng | 2020 | Plant Diversity2020，42，2： | 1 |
| 19 | LncRNA FPASL suppresses fibroblast proliferation through its DNA methylation via DNMT3b in hypertrophic scar显示文摘Long noncoding RNAs(lncRNAs)are increasingly being implicated as key regulators of cell proliferation,apoptosis,and differentiation.However,the molecular mechanisms of specific lncRNAs in the context of hypertrophic scar remain largely unclear.Here,we find that the lncRNA FPASL(fibroblast proliferation-associated LncRNA)is downregulated in HS,and FPASL reduces fibroblast proliferation and colony formation and blocks cell cycle progression.Using GO annotation enrichment analysis along with AZC(a specific inhibitor of DNA methylation),we identify that DNA methylation is responsible for downregulating FPASL in hypertrophic scar.Subsequent studies demonstrate that high expression of DNMT3b inhibits FPASL expression in HS.Mechanistic study reveals a significant increase in fibroblast proliferation after transfection with LNA-FPASL,which is further inhibited by knockdown of DNMT3b.Thus,our study reveals that DNMT3b mediates hypermethylation of the lncRNA FPASL promoter and the downregulation of lncRNA FPASL promotes fibroblast proliferation in hypertrophic scar. | Kai Wu Fang Ma Jiangyong Shen Hui Zhang Yu Wan Xi He Anning Yang Jiantuan Xiong Yun jiao Zhigang Bai Shengchao Ma Yideng Jiang Huiping Zhang Yinju Hao | 2022 | Acta Biochimica et Biophysica Sinica2022，54，12： | 0 |
| 20 | The stochastic semantics and verification for periodic control systems显示文摘Periodic control systems(PCS) are widely used in the embedded industry like aerospace and automotive.Such systems usually run periodic tasks and respond to the external signals.Based on our previous work on Mode diagram modeling(MDM) notations for specifying the periodic control system,we present the stochastic semantics for MDM in this paper.The stochastic semantics of MDM is based on the Markov chain.The semantics proposed here provides the basis for the satisfaction of formulae of the interval temporal logic(ITL) based specification language that is aimed to specify the properties of PCS.To verify whether the system satisfies the ITL-based properties,we apply the statistical model checking technique to efficiently estimate the probability of the system satisfying the given property with a desired level of confidence.The empirical experiments show that our approach is both effective and efficient. | YANG MengFei WANG Zheng PU GeGuang Qin ShengChao GU Bin HE JiFeng | 2012 | Science China(Information Sciences)2012，55，12： | 0 |
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