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| 1 | Synthesis and properties of phosphorus-containing bio-based epoxy resin from itaconic acid显示文摘A phosphorus-containing bio-based epoxy resin(EADI)was synthesized from itaconic acid(IA)and 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide(DOPO).As a matrix,its cured epoxy network with methyl hexahydrophthalic anhydride(MHHPA)as the curing agent showed comparable glass-transition temperature and mechanical properties to diglycidyl ether in a bisphenol A(DGEBA)system as well as good flame retardancy with UL94 V-0 grade during a vertical burning test.As a reactive flame retardant,its flame-resistant effect on DGEBA/MHHPA system as well as its influence on the curing behavior and the thermal and mechanical properties of the modified epoxy resin were investigated.Results showed that after the introduction of EADI,not only were the flame retardancy determined by vertical burning test,LOI measurement,and thermogravimetric analysis significantly improved,but also the curing reactivity,glass transition temperature(T g),initial degradation temperature for 5%weight loss(T d(5%)),and flexural modulus of the cured system improved as well.EADI has great potential to be used as a green flame retardant in epoxy resin systems. | MA SongQi LIU XiaoQing JIANG YanHua FAN LiBo FENG JianXiang ZHU Jin | 2014 | Science China Chemistry2014，57，3： | 33 |
| 2 | A novel miR167a-OsARF6-OsAUX3 module regulates grain length and weight in rice显示文摘Grain size is one of the most important factors that control rice yield,as it is associated with grain weight(GW).To date,dozens of rice genes that regulate grain size have been isolated;however,the regulatory mechanism underlying GW control is not fully understood.Here,the quantitative trait locus qGL5 for grain length(GL)and GW was identified in recombinant inbred lines of 9311 and Nipponbare(NPB)and fine mapped to a candidate gene,OsAUX3.Sequence variations between 9311 and NPB in the OsAUX3 promoter and loss of function of OsAUX3 led to higher GL and GW.RNA sequencing,gene expression quantification,dual-luciferase reporter assays,chromatin immunoprecipitation-quantitative PCR,and yeast one-hybrid assays demonstrated that OsARF6 is an upstream transcription factor regulating the expression of OsAUX3.OsARF6 binds directly to the auxin response elements of the OsAUX3 promoter,covering a single-nucleotide polymorphism site between 9311 and NPB/Dongjin/Hwayoung,and thereby controls GL by altering longitudinal expansion and auxin distribution/content in glume cells.Furthermore,we showed that miR167a positively regulate GL and GW by directing OsARF6 mRNA silencing.Taken together,our study reveals that a novel miR167a-OsARF6-OsAUX3 module regulates GL and GW in rice,providing a potential target for the improvement of rice yield. | Jiyue Qiao Hongzhen Jiang Yuqing Lin Lianguang Shang Mei Wang Dongming Li Xiangdong Fu Markus Geisler Yanhua Qi Zhenyu Gao Qian Qian | 2021 | Molecular Plant2021，14，10： | 8 |
| 3 | Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China显示文摘Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China. | Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li | 2022 | Journal of Genetics and Genomics2022，49，1： | 7 |
| 4 | Diversity of root-associated fungi of Vaccinium mandarinorum along a human disturbance gradient in subtropical forests,China显示文摘Aims Ericaceous plant species can host diverse fungi in their roots,including ericoid mycorrhizal fungi(ERMF),endophytes,pathogens and some species with unknown functions.However,how this diversity of fungi responds to different human disturbances is not well understood.Methods In this study,we examined the effects of different human disturbance on fungal diversity in hair roots of Vaccinium mandarinorum,an ericaceous plant.Fungal DNA was extracted from hair roots of V.mandarinorum and high-throughput sequencing was applied to detect the diversity of root-associated fungi along a human disturbance gradient in subtropical forests in Gutianshan National Nature Reserve(GNNR)in East China.The four forest types with different disturbance regime were:old growth forest(OGF),secondary forest with once cut(SEC I),secondary forest with twice cut(SEC II)and Cunninghamia lanceolata plantation(PLF).Important Findings The results showed that:(i)diverse fungal operational units(OTUs)were detected in hair roots of V.mandarinorum in the four types of forests,covering fungal phyla of Ascomycota,Basidiomycota,Chytridiomycota,Glomeromycota and Zygomycota;(ii)Community composition of root-associated fungi of V.mandarinorum in PLF was distinct from those in the other three forest types,and two types of secondary forests had similar fungal community composition;(iii)Different fungal families respond differently to human disturbances:fungal families with significant preference to OGF were ectomycorrhizal or saprophytic fungi while fungal families with higher relative abundance in PLF were plant pathogenic or saprophytic fungi;(iv)The first principal component(PC1)of plant community had a significant effect on composition of root-associated fungal community,while edaphic parameters showed no significant effect on fungal community composition in roots of V.mandarinorum.Our results help to better understand the responses of both ericaceous plants and their fungal partners to human disturbances and forest managements. | Yanhua Zhang Jian Ni Fangping Tang Lifen Jiang Tianrong Guo Kequan Pei Lifu Sun Yu Liang | 2017 | Journal of Plant Ecology2017，10，1： | 6 |
| 5 | An Attribute-Based Signature Scheme from Lattice Assumption显示文摘Inspired by the framework of Boyen, in this paper, an attribute-based signature(ABS) scheme from lattice assumption is proposed. In this attribute-based signature scheme, an entity's attributes set corresponds to the concatenation of a lattice matrix with the sum of some random matrices, and the signature vector is generated by using the Preimage Sampling algorithm. Compared with current attribute-based signature schemes, this scheme can resist quantum attacks and enjoy shorter public-key, smaller signature size and higher efficiency. | ZHANG Yanhua HU Yupu JIANG Mingming | 2015 | Wuhan University Journal of Natural Sciences2015，20，3： | 4 |
| 6 | Synthesis of multifunctional monomers from rosin for the properties enhancement of soybean-oil based thermosets显示文摘Two kinds of rosin derivatives,(2-hydroxy-3-(methacryloyloxy)propyl 7-isopropyl-l,4a-dimethyl-1,2,3,4,4a,4b,5,6,10,10adecahydrophenanthrene-1-carboxylate)(HMPIDDC) and(((7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-l-yl)methyl)azanediyl)bis(2-hydroxypropane-3,l-diyl)bis(2-methylacrylate)(IDOMAHM) were synthesized under mild and easy to implement conditions.The two derivatives were employed as the rigid monomers to copolymerize with acrylated epoxidized soybean oil(AESO),as so to improve the performance of the cured resins.The chemical structures of HMPIDDC and IDOMAHM were confirmed by nuclear magnetic resonance(NMR) and Fourier Transform Infrared(FT-IR) before copolymerization.The curing behaviors of pristine AESO,AESO/HMPIDDC blend,and AESO/IDOMAHM blend were monitored by differential scanning calorimetry(DSC).Moreover,the thermal and mechanical properties of the cured resins were evaluated by universal mechanical testing,dynamic mechanical analysis(DMA) and thermogravimetric analysis(TGA).The results demonstrated that after the introduction of HMPIDDC and IDOMAHM,the glass transition temperature and mechanical properties of the copolymerized resin were significantly increased.In one word,HMPIDDC and IDOMAHM showed dramatic potential to be used as bio-based compounds to improve the properties of soybean-oil based thermosets. | LIU Yuan LI Chao DAI JinYue JIANG YanHua LIU XiaoQing ZHU Jin | 2017 | Science China(Technological Sciences)2017，60，9： | 3 |
| 7 | ETCM v2.0:An update with comprehensive resource and rich annotations for traditional Chinese medicine显示文摘Existing traditional Chinese medicine(TCM)-related databases are still insufficient in data standardization,integrity and precision,and need to be updated urgently.Herein,an Encyclopedia of Traditional Chinese Medicine version 2.0(ETCM v2.0,http://www.tcmip.cn/ETCM2/front/#/)was constructed as the latest curated database hosting 48,442 TCM formulas recorded by ancient Chinese medical books,9872 Chinese patent drugs,2079 Chinese medicinal materials and 38,298 ingredients.To facilitate the mechanistic research and new drug discovery,we improved the target identification method based on a two-dimensional ligand similarity search module,which provides the confirmed and/or potential targets of each ingredient,as well as their binding activities.Importantly,five TCM formulas/Chinese patent drugs/herbs/ingredients with the highest Jaccard similarity scores to the submitted drugs are offered in ETCM v2.0,which may be of significance to identify prescriptions/herbs/ingredients with similar clinical efficacy,to summarize the rules of prescription use,and to find alternative drugs for endangered Chinese medicinal materials.Moreover,ETCM v2.0 provides an enhanced Java Script-based network visualization tool for creating,modifying and exploring multi-scale biological networks.ETCM v2.0 may be a major data warehouse for the quality marker identification of TCMs,the TCM-derived drug discovery and repurposing,and the pharmacological mechanism investigation of TCMs against various human diseases. | Yanqiong Zhang Xin Li Yulong Shi Tong Chen Zhijian Xu Ping Wang Meng Yu Wenjia Chen Bing Li Zhiwei Jing Hong Jiang Lu Fu Wenjing Gao Yanhua Jiang Xia Du Zipeng Gong Weiliang Zhu Hongjun Yang Haiyu Xu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 3 |
| 8 | Solid-state intramolecular motions in continuous fibers driven by ambient humidity for fluorescent sensors显示文摘One striking feature of molecular rotors is their ability to change conformation with detectable optical signals through molecular motion when stimulated.However,due to the strong intermolecular interactions,synthetic molecular rotors have often relied on fluid environments.Here,we take advantage of the solid-state intramolecular motion of aggregation-induced emission(AIE)molecular rotors and one-dimensional fibers,developing highly sensitive optical fiber sensors that respond to ambient humidity rapidly and reversibly with observable chromatic fluorescence change.Moisture environments induce the swelling of the polymer fibers,activating intramolecular motions of AIE molecules to result in red-shifted fluorescence and linear response to ambient humidity.In this case,polymer fiber provides a process-friendly architecture and a physically tunable medium for the embedded AIE molecules to manipulate their fluorescence response characteristics.Assembly of sensor fibers could be built into hierarchical structures,which are adaptive to diverse-configuration for spatial-temporal humidity mapping,and suitable for device integration to build light-emitting sensors as well as touchless positioning interfaces for intelligence systems. | Yunmeng Jiang Yanhua Cheng Shunjie Liu Haoke Zhang Xiaoyan Zheng Ming Chen Michidmaa Khorloo Hengxue Xiang Ben Zhong Tang Meifang Zhu | 2021 | National Science Review2021，8，4： | 3 |
| 9 | Rationale for the use of multifunctional drugs as neuroprotective agents for glaucoma显示文摘Glaucoma, the leading cause globally of irreversible blindness, is a neurodegenerative disease characterized by progressive retinal ganglion cell death. To date, no drug has been shown to prevent the retinal ganglion cell loss associated with glaucoma. Multiple mechanisms lead to ganglion cell death in glaucoma, suggesting that a neuroprotectant that has a single mode of action, like memantine, would have a limited positive effect at slowing down ganglion cell death. Conversely, simultaneously targeting several factors may be the best therapeutic approach to improve outcomes. Multifunctional drugs are fast gaining acceptance as a strategy for the treatment of complex disor-ders of the central nervous system, such as Parkinson's disease, Alzheimer's disease and other progressive neurodegenerative diseases. In this paper, we review the current literature on multi-functional drugs and propose a rationale for the use of multifunctional drugs in glaucomatous optic neuropathy. | Jiahua Fang Fagang Jiang Jingbo Li Yanhua Zhu | 2012 | Neural Regeneration Research2012，7，4： | 3 |
| 10 | Lattice-based sequential aggregate signatures with lazy verification显示文摘This paper proposes the first lattice-based sequential aggregate signature(SAS) scheme with lazy verification that is provably secure in the random oracle model. As opposed to large integer factoring and discrete logarithm based systems, the security of the construction relies on worst-case lattice problem, namely, under the small integer solution(SIS) assumption. Generally speaking, SAS schemes enable any group of signers ordered in a chain to sequentially combine their signatures such that the size of the aggregate signature is much smaller than the total size of all individual signatures. Unlike prior such proposals, the new scheme does not require a signer to retrieve the keys of other signers and verify the aggregate-so-far before adding its own signature, and the signer can add its own signature to an unverified aggregate and forward it along immediately, postponing verification until load permits or the necessary public keys are obtained. Indeed, the new scheme does not even require a signer to know the public keys of other signers. | Zhang Yanhua Hu Yupu Jiang Mingming Xue Lili | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，6： | 3 |
| 11 | A NEW PUBLIC-KEY ENCRYPTION SCHEME BASED ON LUCAS SEQUENCE显示文摘Investigated the properties of LUCas sequence(LUC), the paper proposed a new variant of (probabilistic) public-key encryption scheme. Security analysis of the proposed encryption schemes shows that its one-wayness is equivalent to partial LUC discrete logarithm problem in ZN, and for the proposed probabilistic encryption scheme, its semantic security is equivalent to decisional LUC Diffie-Hellman problem in ZN. At last, the efficiency of the proposed schemes is briefly analyzed. | Jiang Zhengtao Hao Yanhua Wang Yumin | 2005 | Journal of Electronics(China)2005，22，5： | 2 |
| 12 | Combating climate change calls for a global technological cooperation system built on the concept of ecological civilization显示文摘Climate change has been considered as the most paramount global environmental problem and the biggest externality throughout the history of human development. Accordingly, the world is facing unprecedented technological innovation and collaborative demands to deal with climate change. In the 2015 Paris Agreement, a long-term vision of technology development and transfer implementation was proposed, and policy and financial support for technological innovation in the area of climate change was advocated. These terms aim to enable developing countries to acquire the necessary technology in the early stage of the technology cycle to address climate change challenge. However, the traditional technological innovation and cooperation mode based on industrial civilization can hardly meet the technical demands of global climate protection. To ensure the continuous development and deployment of technology in a required scale and pace, a new global technical cooperation system is proposed to develop based on the philosophy of ecological civilization. The core contents of this system are supposed be as follows:to implement all-win cooperation targets, adhering to cooperation principles of Eco-man, adopt cooperation content that reflects synergy, pursue cooperation based on mutual trust, encourage participation of multiple actors, and promote sharing of cooperative outputs. | Jiani Jiang Wentao Wang Can Wang Yanhua Liu | 2017 | Chinese Journal of Population,Resources and Environment2017，15，1： | 2 |
| 13 | Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis显示文摘环境暗示和细胞内部的 bioenergetic 状态深刻地影响细胞内部的 pH (pHi ) 。一个房间怎么对 pHi 变化作出回应维持 bioenergetic 动态平衡,留下逃犯。这里,我们显示出那 Smad5,发信号的形态基因的蛋白质(BMP ) 回答到 pHi 的骨头的一个描绘得好的下游的部件变化。冷、基本或张力亢进的条件增加 pHi,它接着在 Smad5 的 MH1 域以内声言不赞成控告的氨基酸簇,推动它到细胞质的从原子核的重定位。在另一方面,加热,酸或张力减退的条件减少 pHi,堵住 Smad5 的原子出口,并且因此引起它的原子累积。环境变化和 pHi 变化导致的 Smad5 的活跃 nucleocytoplasmic shuttling 独立于 BMP 发信号, carboxyl 终点 phosphorylation 和 Smad4。另外, Smad5 的脱离引起在区别识别了的神经发展过程人的 pluripotent 干细胞建模的细胞的 bioenergetic 动态平衡和破坏正常的长期、不可逆的 dysregulation。重要地,在 Smad5 缺乏的房间的这些新陈代谢、发展的赤字能仅仅由细胞质的 Smad5 被救。细胞质的 Smad5 身体上与 hexokinase 交往 1 并且加速 glycolysis。一起,我们的调查结果显示 Smad5 充当一个 pHi 送信人并且由调整细胞质的新陈代谢的机械维持房间的 bioenergetic 动态平衡。 | Yujiang Fang Zhongliang Liu Zhenyu Chen Xiangjie Xu Mengtao Xiao Yanyan Yu Yuanyuan Zhang Xiaobai Zhang Yanhua Du Cizhong Jiang Yuzheng Zhao Yiran Wang Beibei Fan Daniel Terheyden-Keighley Yang Liu Lei Shi Yi Hui Xin Zhang Bowen Zhang Hexi Feng Lin Ma Quanbin Zhang Guohua Jin Yi Yang Bin Xiang Ling Liu Xiaoqing Zhang | 2017 | Cell Research2017，27，9： | 2 |
| 14 | All-trans retinoic acid(ATRA)inhibits insufficient radiofrequency ablation(IRFA)-induced enrichment of tumor-initiating cells in hepatocellular carcinoma显示文摘Objective:Local recurrence of hepatocellular carcinoma(HCC)after radiofrequency ablation(RFA)treatment remains a serious problem.Tumor-initiating cells(TICs)are thought to be responsible for tumor relapse.Here,we investigated the effect of the TIC differentiation inducer,all-trans retinoic acid(ATRA),on RFA and explored the potential molecular mechanisms.Methods:The proportions of CD133+and epithelial cell adhesion molecule(Ep CAM);TICs in recurrent HCC after RFA and primary HCC were first determined in clinic.Then,the effect of heat intervention or insufficient RFA(IRFA)on the malignant potential of HCC cells,including cell migration,sphere formation ability,tumor growth,the proportion of CD133+and Ep CAM+TICs and expression of stem cell-related genes,was evaluated in vitro and in vivo.Finally,the effect of ATRA on the tumor growth and the proportion of TICs was evaluated.Results:In clinical data,a higher proportion of CD133+and Ep CAM+TICs was found in recurrent tumors than in primary tumors.In vitro heat intervention promoted the cell migration and sphere formation ability.Additionally,it increased the proportion of CD133+and Ep CAM+TICs and the expression of stem cell-related genes.In addition,after IRFA the residual tumors in xenografts grew faster and had more TICs than untreated tumors.ATRA remarkably inhibited residual tumor growth after IRFA by elimination of TICs though the PI3 K/AKT pathway.Combination treatment with ATRA resulted in longer survival outcomes in mouse xenografts than RFA alone.Conclusions:ATRA,as a TIC differentiation inducer,could help to improve the effect of RFA treatment,which was partially attributed to its effect against TICs.The data indicated its potential as an alternative drug in the development of better therapeutic strategies for use in combination with RFA. | Song Wang Jingtao Liu Hao Wu Anna Jiang Kun Zhao Kun Yan Wei Wu Haibo Han Yanhua Zhang Wei Yang | 2021 | Chinese Journal of Cancer Research2021，33，6： | 2 |
| 15 | H3K27me3 Signal in the Cis Regulatory Elements Reveals the Differentiation Potential of Progenitors During Drosophila Neuroglial Development显示文摘Drosophila neural development undergoes extensive chromatin remodeling and precise epigenetic regulation.However,the roles of chromatin remodeling in establishment and maintenance of cell identity during cell fate transition remain enigmatic.Here,we compared the changes in gene expression,as well as the dynamics of nucleosome positioning and key histone modifications between the four major neural cell types during Drosophila neural development.We find that the neural progenitors can be separated from the terminally differentiated cells based on their gene expression profiles,whereas nucleosome distribution in the flanking regions of transcription start sites fails to identify the relationships between the progenitors and the differentiated cells.H3K27me3 signal in promoters and enhancers can not only distinguish the progenitors from the differentiated cells but also identify the differentiation path of the neural stem cells(NSCs)to the intermediate progenitor cells to the glial cells.In contrast,H3K9ac signal fails to identify the differentiation path,although it activates distinct sets of genes with neuron-specific and glia-related functions during the differentiation of the NSCs into neurons and glia,respectively.Together,our study provides novel insights into the crucial roles of chromatin remodeling in determining cell type during Drosophila neural development. | Xiaolong Chen Youqiong Ye Liang Gu Jin Sun Yanhua Du Wen-Ju Liu Wei Li Xiaobai Zhang Cizhong Jiang | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 1 |
| 16 | Micro or nano:Evaluation of biosafety and biopotency of magnesium metal organic framework-74 with different particle sizes显示文摘In recent years,various particulate materials have played important roles in medical applications.However,nano-and micron-sized particles of the same material could exhibit distinct properties due to different particle sizes.This finding provided a simple and effective way to improve the biological applications of particulate materials.Therefore,as a highly promising member,the effect of the particle size change of the magnesium metal organic framework-74(Mg-MOF74)was well worth evaluating.Here we firsth assessed the in vitro and in vivo toxicity of micron/nanoscale Mg-MOF74(m-Mg-MOF74/n-Mg-MOF74)in detail.Our in vitro study revealed that compared to micron-sized subjects,n-Mg-MOF74 provided a wider range of safe concentrations.Furthermore,both micron/nanoscale Mg-MOF74 showed good biocompatibility and allowed all the rats under the treatment to survive through the expected experimental periods,with n-Mg-MOF74 still showing lower cardiotoxicity.These advantages of nanoscale Mg-MOF74might benefit from its sustainable and balanced release of Ma^2+both inside and outside the cells.Based on the biosafety evaluation,advanced bio-functional assessments of m/n-Mg-MOF74 including early osteogenesis and angiogenesis were alsoperformed.Similarly,the suitable dose groups of n-Mg-MOF74 achieved optimal early osteogenic promotion and angiogenic stimulation effects.Overall,our combined data delineated the toxicity and biological behaviors of Ma-MOF74 of different scales,and sugqested nanoscale Mg-MOF74 as a better choice for future applications.This result revealed that particle size reductior might be a viable strategy to improve and expand medical applications of MOFs or other particulate materials. | Zhou Zhu Shaokang Jiang Yanhua Liu Xiaomeng Gao Shanshan Hu Xin Zhang Chao Huang Qianbing Wan Jian Wang Xibo Pei | 2020 | Nano Research2020，13，2： | 1 |
| 17 | Spatiotemporal cortical activation underlying self-referencial processing evoked by self-hand显示文摘 | Yanhua Su Antao Chen Huazhan Yin Jiang Qiu Jieyu Lv Dongtao Wei Fang Tian Shen Tu Ting Wang | 2010 | Biological Psychology2010，，2： | 1 |
| 18 | Obstetric care quality defects cause and the prevention countermeasures 显示文摘 | Yanhua jiang | 2013 | Chinese and foreign medical research2013，，4： | 1 |
| 19 | Reduced order modeling of the upper tropical pacific ocean model using proper orthogonal decomposition显示文摘 | Cao Yanhua Zhu Jiang Luo Zhendong | 2006 | Comput Math2006，52，89： | 1 |
| 20 | Experimental study and numerical simulation on bonding behavior of the new HB-FRP strengthening technology 显示文摘 | Guan Yanhua Jiang Binsong Song Xiuguang | 2011 | Journal of Per- formance of Constructed Facilities2011，26，2： | 1 |
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