|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Magnetic resonance susceptibility weighted imaging in detecting intracranial calcification and hemorrhage显示文摘背景计算断层摄影术(CT ) 在检测 intracranial 石灰化比平淡的磁性的回声成像(MRI ) 好。试图估计在 intracranial 石灰化和 hemorrhage.Methods 的察觉和区别的加权的成像(SWI ) 在这研究注册了的先生危险性的价值的这研究是包括 CT 表明的石灰化的 13 个盒子和 intracerebral 出血的 22 个盒子的 35 个病人。在所有这些题目使用的先生序列包括了轴的 T1WI, T2WI 和 SWI。SWI 上的石灰化和出血的阶段移动(PS ) 被计算,他们的信号在改正的阶段图象上展示被比较。在检测 intracranial 石灰化和出血的 T1WI, T2WI 和 SWI 的敏感是为头部的石灰化的 SWI 的察觉率是的分析 statistically.Results 98.2% ,比 T1 Wl 和 T2WI 的显著地高。它不与 CT 的显著地不同(P > 0.05 ) 。在不同阶段有 49 出血性的损害检测 n SWI, 30 在 T2WI 上并且 18 在 T1WI 上。石灰化和出血的平均 PS 是在检测的 +0.734han 常规 MRI 微出血, SWI 可以在区分与石灰化或出血联系的服的疾病起一个重要作用。 | ZHU Wen-zhen QI Jian-pin ZHAN Chuan-jia SHU Hong-ge ZHANG Lin WANG Cheng-yuan XIA Li-ming HU Jun-wu FENG Ding-yi | 2008 | Chinese Medical Journal2008，，20： | 26 |
| 2 | Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line显示文摘曙光 A kinase, serine/threonine 蛋白质 kinase,是潜在的 oncogene。扩大并且在人的肿瘤的几种类型在曙光 A 的表示上被发现了,包括的食道的有鳞的房间癌(ESCC ) 。在表示曙光 A 上的房间对导致 cisplatin 的 apoptosis 更抵抗,这被表明了。然而,调停的分子的机制这些效果仍然保持大部分未知。在这份报告,我们证明在通过在人的 ESCC KYSE150 的 pEGFP-Aurora-A 的稳定的 transfection 的曙光 A 的表示上,房间显著地支持了房间增长并且禁止了 cisplatin- 或紫外导致照耀的 apoptosis。caspase-3 并且 poly 的劈开(自动数据处理核糖) 在在表示房间上的曙光 A 的聚合酶(PARP ) 实质地在 cisplatin 或紫外处理以后被减少。而且,我们发现有 siRNA 的内长的曙光 A kinase 的那 silencing 实质地提高了敏感到导致 cisplatin 或在人的 ESCC EC9706 房间的紫外导致 apoptosis。在平行,在曙光 A 的表示上 potently 起来调整了 Bcl-2 的表示。而且,由废除的 siRNA 的 Bcl-2 击倒 Aurora-A 禁止 apoptosis 上的效果。总起来说,这些数据提供证据在支持房间增长并且禁止 apoptosis 的表示上的那曙光 A,建议是的新奇机制仔细与恶意的显型和 ESCC 房间的反癌症药抵抗有关。 | Xiao Xia Wang Rong Liu Shun Qian Jin Fei Yue Fan Qi Min Zhan | 2006 | Cell Research2006，16，4： | 24 |
| 3 | Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure显示文摘AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a'tonifying qi and detoxification'('TQD')group(72 patients);and(3)a'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the'TQD'group were given a TCM formula'tonifying qi and detoxification'and general internal medicine treatment;patients in the'TTK'group were given a TCM formula of'TTK'and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,'TQD',and'TTK'groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the'TTK'group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the'TQD'group and'TTK'group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the'TQD'group and one case of gastrointestinal side effect in the'TTK'group.CONCLUSION:Treatment with'TTK'improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored. | Han-Min Li Zhi-Hua Ye Jun Zhang Xiang Gao Yan-Ming Chen Xin Yao Jian-Xun Gu Lei Zhan Yang Ji Jian-Liang Xu Ying-He Zeng Fan Yang Lin Xiao Guo-Guang Sheng Wei Xin Qi Long Qing-Jing Zhu Zhao-Hong Shi Lian-Guo Ruan Jia-Yao Yang Chang-Chun Li Hong-Bin Wu Sheng-Duo Chen Xin-La Luo | 2014 | World Journal of Gastroenterology2014，20，48： | 20 |
| 4 | Impact of meteorological factors on the incidence of childhood hand,foot,and mouth disease(HFMD)analyzed by DLNMs-based time series approach显示文摘Background:Hand,foot,and mouth disease(HFMD)has become an emerging infectious disease in China in the last decade.There has been evidence that meteorological factors can influence the HFMD incidence,and understanding the mechanisms can help prevent and control HFMD.Methods:HFMD incidence data and meteorological data in Minhang District,Shanghai were obtained for the period between 2009 and 2015.Distributed lag non-linear models(DLNMs)were utilized to investigate the impact of meteorological factors on HFMD incidence after adjusting for potential confounders of long time trend,weekdays and holidays.Results:There was a non-linear relationship between temperature and HFMD incidence,the RR of 5th percentile compared to the median is 0.836(95%CI:0.671-1.042)and the RR of 95th percentile is 2.225(95%CI:1.774-2.792),and the effect of temperature varied across age groups.HFMD incidence increased with increasing average relative humidity(%)(RR=1.009,95%CI:1.005-1.015)and wind speed(m/s)(RR=1.197,95%CI:1.118-1.282),and with decreasing daily rainfall(mm)(RR=0.992,95%CI:0.987-0.997)and sunshine hours(h)(RR=0.966,95%CI:0.951-0.980).Conclusions:There were significant relationships between meteorological factors and childhood HFMD incidence in Minhang District,Shanghai.This information can help local health agencies develop strategies for the control and prevention of HFMD under specific climatic conditions. | Hongchao Qi Yue Chen Dongli Xu Hualin Su Longwen Zhan Zhiyin Xu Ying Huang Qianshan He Yi Hu Henry Lynn Zhijie Zhang | 2018 | Infectious Diseases of Poverty2018，7，1： | 17 |
| 5 | Biomechanical and biological responses of periodontium in orthodontic tooth movement:up-date in a new decade显示文摘Nowadays,orthodontic treatment has become increasingly popular.However,the biological mechanisms of orthodontic tooth movement(OTM)have not been fully elucidated.We were aiming to summarize the evidences regarding the mechanisms of OTM.Firstly,we introduced the research models as a basis for further discussion of mechanisms.Secondly,we proposed a new hypothesis regarding the primary roles of periodontal ligament cells(PDLCs)and osteocytes involved in OTM mechanisms and summarized the biomechanical and biological responses of the periodontium in OTM through four steps,basically in OTM temporal sequences,as follows:(1)Extracellular mechanobiology of periodontium:biological,mechanical,and material changes of acellular components in periodontium under orthodontic forces were introduced.(2)Cell strain:the sensing,transduction,and regulation of mechanical stimuli in PDLCs and osteocytes.(3)Cell activation and differentiation:the activation and differentiation mechanisms of osteoblast and osteoclast,the force-induced sterile inflammation,and the communication networks consisting of sensors and effectors.(4)Tissue remodeling:the remodeling of bone and periodontal ligament(PDL)in the compression side and tension side responding to mechanical stimuli and root resorption.Lastly,we talked about the clinical implications of the updated OTM mechanisms,regarding optimal orthodontic force(OOF),acceleration of OTM,and prevention of root resorption. | Yuan Li Qi Zhan Minyue Bao Jianru Yi Yu Li | 2021 | International Journal of Oral Science2021，13，2： | 15 |
| 6 | Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger显示文摘Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. | YIN Zhi Na WU Wen Jia SUN Chong Zhen LIU Hui Fan CHEN Wen Bo ZHAN Qi Ping LEI Zhuo Gui XIN Xuan MA Juan Juan YAO Kun MIN Tian ZHANG Meng Meng WU Hui | 2019 | Biomedical and Environmental Sciences2019，32，1： | 14 |
| 7 | Tumor necrosis factor-α mediates JNK activation response to intestinal ischemia-reperfusion injury显示文摘AIM:To investigate whether tumor necrosis factor-α(TNF-α)mediates ischemia-reperfusion(I/R)-induced intestinal mucosal injury through c-Jun N-terminal kinase(JNK)activation.METHODS:In this study,intestinal I/R was induced by 60-min occlusion of the superior mesenteric artery in rats followed by 60-min reperfusion,and the rats were pretreated with a TNF-α inhibitor,pentoxifylline,or the TNF-α antibody infliximab.After surgery,part of the intestine was collected for histological analysis.The mucosal layer was harvested for RNA and protein extraction,which were used for further real-time polymerase chain reaction,enzyme-linked immunosorbent assay and Western blotting analyses.The TNF-α expression,intestinal mucosal injury,cell apoptosis,activation of apoptotic protein and JNK signaling pathway were analyzed.RESULTS:I/R significantly enhanced expression of mucosal TNF-α at both the mRNA and protein levels,induced severe mucosal injury and cell apoptosis,activated caspase-9/caspase-3,and activated the JNK signaling pathway.Pretreatment with pentoxifylline markedly downregulated TNF-α at both the mRNA and protein levels,whereas infliximab pretreatment did not affect the expression of TNF-α induced by I/R.However,pretreatment with pentoxifylline or infliximab dramatically suppressed I/R-induced mucosal injury and cell apoptosis and significantly inhibited the activation of caspase-9/3 and JNK signaling.CONCLUSION:The results indicate there was a TNFα-mediated JNK activation response to intestinal I/R injury. | Qi Yang Feng-Ping Zheng Ya-Shi Zhan Jin Tao Si-Wei Tan Hui-Ling Liu Bin Wu | 2013 | World Journal of Gastroenterology2013，19，30： | 9 |
| 8 | Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation显示文摘Vascular dementia(VD)is the second most common dementia disease after Alzheimer’s diseases(AD)in the world.Donepezil is used to treat mild to moderate AD,and it has been shown to treat cognitive impairment and memory deficits caused by VD.However,the action mechanism of donepezil against VD has not been clarified.In this study,a bilateral common carotid artery occlusion(BCCAO)model was established in rats to simulate the pathology of VD.Two weeks after the surgery,the rats were administered donepezil(10 mg·kg^−1·d^−1,ig)for 3 weeks,and then subjected to behavioral tests.We showed that donepezil treatment significantly improved the performance of BCCAO rats in Morris Water Mazes test and Step-down test.Furthermore,we showed that donepezil treatment significantly attenuated neurodegeneration and restored the synapse dendritic spines density in cortex and hippocampus.We revealed that donepezil treatment significantly increased BDNF expression in cortex and hippocampus.Interestingly,donepezil treatment significantly decreased nuclear translocation of HDAC6 and the binding between HDAC6 and BDNF promoter IV in cortex,but not in the hippocampus.The attenuated neurodegeneration by donepezil in cortex and hippocampus might due to the reduced ROS levels and increased phosphorylation of AMPK,whereas increased phosphorylation of AKT was only detected in cortex.In conclusion,our results demonstrate that donepezil attenuates neurodegeneration in cortex and hippocampus via increasing BDNF expression;the regulation of donepezil on HDAC6 occurred in cortex,but not in the hippocampus.This study further clarifies the pharmacological mechanism of donepezil,while also emphasizes the promising epigenetic regulation of HDAC6. | Wen-xuan Jian Zhao Zhang Jia-hong Zhan Shi-feng Chu Ye Peng Ming Zhao Qi Wang Nai-hong Chen | 2020 | Acta Pharmacologica Sinica2020，41，5： | 9 |
| 9 | Effect of tempering temperature on the microstructure and properties of ultrahigh-strength stainless steel显示文摘The microstructure, precipitation and mechanical properties of Ferrium S53 steel, a secondary hardening ultrahigh-strength stainless steel with 10% Cr developed by QuesTek Innovations LLC, upon tem pering were studied by scanning electron microscopy (SEM), transm ission electron microscopy (TEM), X-ray diffraction (XRD), and tensile and impact tests. Based on these results, the influence of the tem pering temperature on the microstructure and properties was discussed. The results show th at decom position occurred when the retained austenite was tem pered above 440 ℃ and that the hardening peak at 482 ℃ was caused by the joint strengthening of the precipitates and martensite transformation. Due to the high Cr content, the trigonal M7C3 carbide precipitated w hen the steel was tem pered at 400 ℃, and M7C3 and M2C (5 -10 nm in size) coexisted w hen it was tem pered at 482 ℃. When the steel was tem pered at 630 ℃, M2C and M23C6 carbides precipitated, and the sizes w ere greater than 50 nm and 500 nm, respectively, but no M7C3 carbide formed. When the tempering tem perature was above 540 ℃, austenitization and large-size precipitates w ere the main factors affecting the strength and toughness. | Yangpeng Zhang Dongping Zhan Xiwei Qi Zhouhua Jiang | 2019 | Journal of Materials Science & Technology2019，35，7： | 9 |
| 10 | Enhanced methane production in an anaerobic digestion and microbial electrolysis cell coupled system with co-cultivation of Geobacter and Methanosarcina显示文摘The anaerobic digestion(AD)and microbial electrolysis cell(MEC)coupled system has been proved to be a promising process for biomethane production.In this paper,it was found that by co-cultivating Geobacter with Methanosarcina in an AD–MEC coupled system,methane yield was further increased by 24.1%,achieving to 360.2 m L/g-COD,which was comparable to the theoretical methane yield of an anaerobic digester.With the presence of Geobacter,the maximum chemical oxygen demand(COD)removal rate(216.8 mg COD/(L·hr))and current density(304.3 A/m_3)were both increased by 1.3 and 1.8 fold compared to the previous study without Geobacter,resulting in overall energy efficiency reaching up to 74.6%.Community analysis demonstrated that Geobacter and Methanosarcina could coexist together in the biofilm,and the electrochemical activities of both were confirmed by cyclic voltammetry.Our study observed that the carbon dioxide content in total gas generated from the AD reactor with Geobacter was only half of that generated from the same reactor without Geobacter,suggesting that Methanosarcina may obtain the electron transferred from Geobacter for the reduction of carbon dioxide to methane.Taken together,Geobacter not only can improve the performance of the MEC system,but also can enhance methane production. | Qi Yin Xiaoyu Zhu Guoqiang Zhan Tao Bo Yanfei Yang Yong Tao Xiaohong He Daping Li Zhiying Yan | 2016 | Journal of Environmental Sciences2016，28，4： | 9 |
| 11 | Dissecting the Genetic Basis of Grain Shape and Chalkiness Traits in Hybrid Rice Using Multiple Collaborative Populations显示文摘 | Junyi Gong Jiashun Miao Yan Zhao Qiang Zhao Qi Feng Qilin Zhan Benyi Cheng Junhui Xia Xuehui Huang Shihua Yang Bin Han | 2017 | Molecular Plant2017，10，10： | 8 |
| 12 | Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China显示文摘Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China. | Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li | 2022 | Journal of Genetics and Genomics2022，49，1： | 7 |
| 13 | Induction of cytotoxic T lymphocyte respones in vivo after immunotherapy with dendritic cells in patients with nasopharyngeal carcinoma显示文摘The aim of the present study was to determine the efficacy of immunotherapy with dendritic cells to elicit EBV-specific CTL-immunity in advanced cases of EBV-positive patients with nasopharyngeal carcinoma (NPC) and to determine the safety and toxicity of this preparation. Nine cases of histologically confirmed patients with NPC undergoing treatment with radiological therapy were enrolled in this study. Dendritic cells, generated in vitro from blood monocytes of patients were cultured and matured with cytokines and then infected with recombinant adenovirus vaccine containing EBV-latent membrane protein-2 (Ad-LMP2). On 9 days' cultivation of cells, the matured DCs were harvested, irradiated with Co and then injected intradermally to patients with NPC. The injections were performed 3 times totally. After immunization, the CTL responses were assayed by means of cytotoxicity and epitope-specific IFN-γproduction. The results of this trial showed that all patients could tolerate this kind of treatment without any side effect, during which marked increase of LMP2-specific CTL-responses could be demonstrated in 5 patients of this group. And the level of IgA/VCA antibody decreased in 8 of 9 patients, thus accounting for a better prognosis for these patients. All patients will be followed up for another one year. At least, the present work shows that intradermal vaccination with autologous DCs infected with recombinant Ad-LMP2 adenovirus is a safe procedure in NPC patients, in which this procedure can enhance the LMP2-specific CTL responses in patients. These data are encouraging to develop more effective vaccine strategies for the treatment of nasopharyngeal carcinoma. | JIAN MIN ZUO LING ZHOU ZHI JIAN CHEN DE RUI LI QI WANG JIONG YU CHEN ZHAN WANG SI-IU QING WE YI ZENG | 2006 | Journal of Microbiology and Immunology2006，4，1： | 7 |
| 14 | Adsorption of thorium(IV) on magnetic multi-walled carbon nanotubes显示文摘The influences of pH, contact time, solid-liquid ratio, temperature and C60(C(COOH)2)n on Th(IV) adsorption onto the magnetic multi-walled carbon nanotubes(MMWCNTs) were studied by batch technique. The dynamic process showed that the adsorption of Th(IV) onto MMWCNTs could reach equilibrium in 40 h and matched the pseudo-second-order kinetics model. The adsorption of Th(IV) onto MMWCNTs was significantly dependent on pH values, the adsorption ratio increased markedly at pH 3.0–5.0, and then maintained a steady state as pH values increased. At low pH, different C60(C(COOH)2)n content could enhance the adsorption content of Th(IV) onto MMWCNTs, but restrained it at higher pH. Through simulating the adsorption isotherms by Langmuir, Freundlich and Dubini-Radushkevich models, it could be seen respectively that the adsorption pattern of Th(IV) onto MMWCNTs was mainly surface complexation, and that the adsorption process was endothermic and irreversible. | LIU Peng QI Wei DU YaoFang LI Zhan WANG Jing BI JuanJuan WU WangSuo | 2014 | Science China Chemistry2014，57，11： | 7 |
| 15 | Review of CHINARE chemical oceanographic research in the Southern Ocean during 1984–2016显示文摘Between 1984 and 2016, China executed 33 Antarctic cruises with the icebreaker R/V Xuelong, which have provided opportunities for Chinese scientists to investigate the status and changes of the Southern Ocean. Research in chemical oceanography constitutes one of the primary missions of the Chinese National Antarctic Research Expedition(CHINARE). This paper reviews nearly 30 years of Chinese Antarctic expeditions, focusing on the major progress achieved in chemical oceanographic research. Specifically, the sea-surface distributions and air–sea fluxes of CO_2 and N_2O are considered, and the transport, flux, and budget of organic matter are investigated based on isotopes in the Southern Ocean, especially in Prydz Bay. In addition, the nutrient distribution and deep-water particle export in Prydz Bay and the study of aerosol heavy metal characteristics are considered. Finally, the prospects for future Chinese Antarctic chemical oceanographic research are outlined. | CHEN Liqi CHEN Min ZHAN Liyan QI Di GAO Zhongyong WANG Jianjun XU Suqing CHEN Kui ZENG Jian ZHANG Run | 2017 | Advances in Polar Science2017，28，2： | 6 |
| 16 | Microstructure Variation and Hardness Diminution During Low Cycle Fatigue of 55NiCrMoV7 Steel显示文摘The influence of temperature and hardness level on the cyclic behavior of 55NiCrMoV7 steel, and the microstructure variation and hardness diminution during low cycle fatigue behavior were investigated. By means of SEM and XRD, the modality of carbides and the full-width half-maximum (FWHM) of martensite (211) [M(211)] of X-ray diffraction spectrum in fatigue specimen were studied. The results showed that the cyclic stress response behavior generally showed an initial exponential softening for the first few cycles, followed by a gradual softening without cyclic softening saturation. The fatigue behavior of the steel is closely related to the hardness level. The hardness diminution and the variation of half-width M(211) are remarkably influenced by the interaction between the cyclic plastic deformation and the thermal loading when the fatigue temperature exceeds the tempering temperature of the steel. | ZHANG zhan ping QI Yu-hong DELAGNES Denis BERNHART Gerard | 2007 | Journal of Iron and Steel Research(International)2007，14，6： | 6 |
| 17 | The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation显示文摘Interleukin(IL)17-producing T helper(Th17)cells play critical roles in the clearance of extracellular bacteria and fungi as well as the pathogenesis of various autoimmune diseases,such as multiple sclerosis,psoriasis,and ulcerative colitis.Although a global transcriptional regulatory network of Th17 cell differentiation has been mapped recently,the participation of epigenetic modifications in the differentiation process has yet to be elucidated.We demonstrated here that histone H3 lysine-27(H3K27)demethylation,predominantly mediated by the H3K27 demethylase Jmjd3,crucially regulated Th17 cell differentiation.Activation of naı¨ve CD41 T cells immediately induced high expression of Jmjd3.Genetic depletion of Jmjd3 in CD41 T cells specifically impaired Th17 cell differentiation both in vitro and in vivo.Ectopic expression of Jmjd3 largely rescued the impaired differentiation of Th17 cells in vitro in Jmjd3-deficientCD41 T cells.Importantly,Jmjd3-deficient mice were resistant to the induction of experimental autoimmune encephalomyelitis(EAE).Furthermore,inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppressed Th17 cell differentiation in vitro.At the molecular level,Jmjd3 directly bound to and reduced the level of H3K27 trimethylation(me3)at the genomic sites ofRorc,which encodes the masterTh17 transcription factorRorgt,and Th17 cytokine genes such as Il17,Il17f,and Il22.Therefore,our studies established acritical role of Jmjd3-mediatedH3K27demethylation inTh17 cell differentiation andsuggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses. | Zhi Liu Wei Cao Longxia Xu Xi Chen Yu Zhan Qian Yang Sanhong Liu Pengfei Chen Yuhang Jiang Xiaohua Sun Yu Tao Yiming Hu Cuifeng Li Qi Wang Ying Wang Charlie Degui Chen Yufang Shi Xiaoren Zhang | 2015 | Journal of Molecular Cell Biology2015，7，6： | 6 |
| 18 | Preparation of Polyimide/BaTiO_3/Ag Nanocomposite Films via in situ Technique and Study of Their Dielectric Behavior显示文摘Triphase polyimide nanocomposite films were fabricated using barium titanate(BaTiO3) with high dielectric constant and silver(Ag) with high conductivity as fillers. In situ method was utilized to obtain the homogeneous dispersion of nanoparticles. The in situ polymerization of polyimide precursor-poly(amic acid) was performed in the presence of BaTiO3 particles. Silver compound 1,1,1-trifluoro-2,4-pentadionato silver(I) was added into the BaTiO3 containing poly(amic acid) solution to achieve silver nanoparticles via in situ self metallization technique. The thermally induced reduction converted silver(I) to metallic silver with concomitant imidization of poly(amic acid) to polyimide. Both BaTiO3 and silver nanoparticles were uniformly dispersed in the polyimide substrate. The dependence of dielectric behavior on the BaTiO3 and Ag contents was studied. The incorporation of small amount of silver nanoparticles greatly increased dielectric constant of composite films. | Jia-yu Zhan Guo-feng Tian Zhan-peng Wu Sheng-li Qi 武德珍 | 2014 | Chinese Journal of Polymer Science2014，32，4： | 5 |
| 19 | AN OVERVIEW ON THE URBAN-RURAL INTERACTION IN THE PAST 50 YEARS IN CHINA显示文摘China is a country with a long history of agricultural development,the tr adition of bureaucratic administra-tion and economic management system s for the social development.In its t ransition from traditional society to modern soci-ety during the past 50years,the rela tions between rural areas and urban a reas have been kept abnormal if considered from the point of view of the modernized co untries.Today,China still has its more than 70percent of population,bu t limited capital,lower technology and underdeveloped culture,in the rural areas.This unbalance forms not only the o bstacles to China’s modernization of social development,but also the barriers to th e society,economy and environment sustainable devel-opment.This paper focuses on the dis cussion about the coordinate develo pment of the relations between rural and urban in the past 50years,and the authors hold that only has the abnormal relation between the two areas been corrected,could China’s future development of natio nal economy be successful. | Qi Lu Jin-yan Zhan Kang-won Lee | 2001 | Chinese Geographical Science2001，11，3： | 4 |
| 20 | TfR1 Extensively Regulates the Expression of Genes Associated with Ion Transport and Immunity显示文摘Transferrin receptor 1(TfR1),encoded by the TFRC gene,is the gatekeeper of cellular iron uptake for cells.A variety of molecular mechanisms are at work to tightly regulate TfR1 expression,and abnormal TfR1 expression has been associated with various diseases.In the current study,to determine the regulation pattern of TfR1,we cloned and overexpressed the human TFRC gene in HeLa cells.RNA-sequencing(RNA-seq)was used to analyze the global transcript levels in overexpressed(OE)and normal control(NC)samples.A total of 1669 differentially expressed genes(DEGs)were identified between OE and NC.Gene ontology(GO)analysis was carried out to explore the functions of the DEGs.It was found that multiple DEGs were associated with ion transport and immunity.Moreover,the regulatory network was constructed on basis of DEGs associated with ion transport and immunity,highlighting that TFRC was the node gene of the network.These results together suggested that precisely controlled TfR1 expression might be not only essential for iron homeostasis,but also globally important for cell physiology,including ion transport and immunity. | Nan HUANG Lei-Lei ZHAN Yi CHENG Xiao-long WANG Ya-xun WEI Qi WANG Wen-jing LI | 2020 | Current Medical Science2020，40，3： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员