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| 1 | Dietary encapsulated essential oils and organic acids mixture improves gut health in broiler chickens challenged with necrotic enteritis显示文摘Background:The poultry industry is in need of effective antibiotic alternatives to control outbreaks of necrotic enteritis(NE)due to Clostridium perfringens.In the present study,we investigated the effects of dietary supplementation with a blend of encapsulated essential oils and organic acids(BLJ)on growth performance and gut health using a coinfection model of NE in broiler chickens.Methods:Two hundred and eighty-eight one-day-old male Arbor Acres broiler chicks were randomly assigned using a 2×2 factorial design into two groups fed either 0 or 500 mg/kg dietary BLJ and co-challenged(or not challenged for the control)with Eimeria spp./C.perfringens.Results:Infected birds fed the BLJ-supplemented diet exhibited an improved feed conversion ratio throughout the trial(P<0.01),a higher villus height and villus height/crypt depth ratio,and reduced intestinal C.perfringens counts,liver C.perfringens carriage,gut lesion scores and serum fluorescein isothiocyanate dextran(FITC-D)concentrations at 7 d postinfection compared with those of birds without BLJ supplementation(P<0.05).NE-infected birds fed BLJ exhibited significantly upregulated claudin-1 and IGF-2 mRNA levels(P<0.05),increased A20 mRNA expression and significantly downregulated TRAF-6,TNFSF15 and TOLLIP mRNA levels in the jejunum at 7 d post-infection compared with those in birds without BLJ supplementation(P<0.05).Compared with the uninfected and untreated birds,the uninfected birds fed BLJ displayed increased relative abundances of Lactobacillus and Coprococcus but reduced Rikenellaceae levels.Compared with the unsupplemented NE-challenged birds,infected birds fed BLJ showed an increased relative abundance of Unclassified_Lachnospiraceae and a significantly decreased relative abundance of Erysipelotrichaceae.Conclusion:BLJ supplementation improved growth performance and gut health in NE-infected broiler chickens by strengthening the intestinal barrier function,positively modulating the gut microbiota community and differentially regulating intestinal immune responses.Our results also suggested that adding BLJ effectively controlled NE infections after experimental Eimeria and Clostridium perfringens coinfection. | Van Hieu Pham Liugang Kan Jinyu Huang Yanqiang Geng Wenrui Zhen Yuming Guo Waseem Abbas Zhong Wang | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 8 |
| 2 | CO_2 methanation over TiO_2–Al_2O_3 binary oxides supported Ru catalysts显示文摘TiO_2 modified Al_2O_3 binary oxide was prepared by a wet-impregnation method and used as the support for ruthenium catalyst. The catalytic performance of Ru/TiO_2–Al_2O_3catalyst in CO_2 methanation reaction was investigated. Compared with Ru/Al_2O_3 catalyst, the Ru/TiO_2–Al_2O_3catalytic system exhibited a much higher activity in CO_2 methanation reaction. The reaction rate over Ru/TiO_2–Al_2O_3 was 0.59 mol CO_2·(g Ru)1·h-1, 3.1 times higher than that on Ru/Al_2O_3[0.19 mol CO_2·(gRu)-1·h-1]. The effect of TiO_2 content and TiO_2–Al_2O_3calcination temperature on catalytic performance was addressed. The corresponding structures of each catalyst were characterized by means of H_2-TPR, XRD, and TEM. Results indicated that the averaged particle size of the Ru on TiO_2–Al_2O_3support is 2.8 nm, smaller than that on Al_2O_3 support of 4.3 nm. Therefore, we conclude that the improved activity over Ru/TiO_2–Al_2O_3catalyst is originated from the smaller particle size of ruthenium resulting from a strong interaction between Ru and the rutile-TiO_2 support, which hindered the aggregation of Ru nanoparticles. | Jinghua Xu Qingquan Lin Xiong Su Hongmin Duan Haoran Geng Yanqiang Huang | 2016 | Chinese Journal of Chemical Engineering2016，24，1： | 4 |
| 3 | Multi-site anchoring of single-molecule for efficient and stable perovskite solar cells with lead shielding显示文摘The emergence of perovskite solar cells(PSCs) has greatly promoted the progress of photovoltaic technologies.The rapid development of PSCs has been driven by the advances in optimizing perovskite films and their adjacent interfaces.However,the polycrystalline perovskite layers in most highly efficient PSCs still contain various defects that greatly limit photovoltaic performance and stability of the devices.Herein,we introduce a multifunctional additive ethylene diamine tetra methylene phosphonic sodium(EDTMPS) with multiple anchor points into the precursor of perovskite to improve the efficiency and stability of PSCs and provide in-situ protection of lead leakage.The addition of EDTMPS acts as a crystal growth controller and passivation agent for perovskite films,thereby slowing down the crystallization rate of the film and obtaining high-quality perovskite films.Our study also provides an insight into how the modifier modulate the interfacial energy level arrangement as well as affect transfer of charge carriers and their recombination under photoinduced excitation.As a result,the power conversion efficiency(PCE) of single subcell with a working area of 0.255 cm^(2) increases significantly from 20.03% to 23.37%.Moreover,we obtained a PCE of 19.16% for the 25 cm^(2) module.Importantly,the unencapsulated EDTMP-modified PSCs exhibit better operational and thermal stability,as well as in-situ absorption of leaked lead ions. | Zhengyan He Shufang Zhang Yushuang Gao Quanming Geng Xiangrui Jia Shuo Yang Zhiqiang Zhang Yanpu Zheng Yanqiang Hu Changlin Yao Qi Zhang | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 4 | Lithium chloride alleviates MPTP-induced neurotoxicity in PD by activating the PI3K/Akt显示文摘Dopamine replacement therapy is the most effective treatment to reduce motor symptoms in Parkinson's disease(PD).However,chronic L-Dopa treatment results in abnormal involuntary movements along with the prolongation of course of the disease and therapeutic time.Recent studies have shown that lithium has the potential for the treatment of neurodegenerative disorders.We tested whether lithium Chloride(LiCl)can reduce the progression of MPTP-induced damage by measuring weight and behavioral tests,further explored whether this is related to the PI3K/Akt signaling pathway using immunohistochemistry and WB.Our results showed that lithium chloride significantly improved motor function and increased body weight and the expression of PI3K,p-Akt Ser473,and p-caspase 3 were significantly increased,Bax/Bcl-2 ratio and the level of p-caspase 3 were decreased. | Li Xuerwei Lyu E Pang Meng Li Jian Geng Jianhong Wang Yanqiang | 2021 | 解剖学杂志2021，44，S01： | 0 |
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