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| 1 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 2 | Phototriggered targeting of nanocarriers for drug delivery显示文摘 | Yafei Li Yarning Zhang Weiping Wang | 2018 | Nano Research2018，11，10： | 4 |
| 3 | Chatter suppression via an oscillating cutter显示文摘 | Yarn F Zhang B Yu J | 1999 | ASME Journal of Manufacturing Science and Engineering1999，121，1： | 1 |
| 4 | A 280-GHz schottky diode detector in 130-nm digital cMOS 显示文摘 | Ruonan Han Yarning Zhang | 2011 | IEEE JSSC2011，46，11： | 1 |
| 5 | Cycleoxygenase - 2 genetic vari- ants are associated with survival in urtresectable locally advanced non- 'small cell lung cancer显示文摘 | Bi N Yarn M Zhang L | 2010 | Clinical cancer research2010，16，8： | 1 |
| 6 | Photo-triggered nucleus targeting for cancer drug delivery显示文摘Here,we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting ability under a spatiotemporal control.The nanoparticles were constructed through self-assembly of photoresponsive prodrugs and free drugs.By incorporating a nucleus localization sequence in the system,drug nanoparticles could be delivered into nuclei upon visible light irradiation.The drug nanoparticles showed high drug loading capacity and specific nucleus-targeting ability,which efficiently killed cancer cells.This self-assembly strategy could be applied to other hydrophobic drugs and targeting ligands for photo-controlled organelle-targeted drug delivery. | Yafei Li Wen Lv Lang Wang Yarning Zhang Lipeng Yang Tianyi Wang Linyong Zhu Yufeng Wang Weiping Wang | 2021 | Nano Research2021，14，8： | 1 |
| 7 | 'An Anti-compressionWatermarking Scheme for Vector Map Based on ImprovedDouglas-Peucker Algorithm '显示文摘 | ZHANG Zuoli WANG Yarning | 2009 | First InternationalWorkshop on Education Technology and Computer Science2009，，2： | 1 |
| 8 | Palladium-Catalyzed Desulfitative Cross-Coupling of Sodium Arylsulfinates with Aryl Bromides and Chlorides: An Alternative Convenient Synthesis of Biaryls显示文摘为 biaryls 的合成的一个其他的方法通过 Pd 被开发了有芳基溴化物和氯化物的钠 arylsulfinates 的催化 desulfitative 联合反应。过程容忍例如 cyano,许多功能的组甲酰,乙酰, chloro, methoxy, trifluoromethyl 和 heteroaromatic 单位。需要的产品被获得在对在没有添加剂,底或合作催化剂的相对温和的反应条件下面的优秀收益中等。 | Chao Zhou Yarning Li Yang Lu Rong Zhang Kun Jin Xinmei Fu Chunying Duan | 2013 | Chinese Journal of Chemistry2013，31，10： | 1 |
| 9 | Research on dynamic load balance model of distributed storage system in digital gas fields显示文摘 | Li YarN Jian Zhang Xinyu Gen Xiedong Cao | 2011 | Computer Research and Development (ICCRD)2011，4，2： | 1 |
| 10 | A biepitope,adjuvant-free,self-assembled influenza nanovaccine provides cross-protection against H3N2 and H1N1 viruses in mice显示文摘Currently,the incorporation of multiple epitopes into vaccines is more desirable than the incorporation of a single antigen for universal influenza vaccine development.However,epitopes induce poor immune responses.Although the use of adjuvants can overcome this obstacle,it may raise new problems.Effective antigen delivery vehicles that can function as both antigen carriers and intrinsic adjuvants are highly desired for vaccine development.Here,we report a biepitope nanovaccine that provides complete protection in mice against H3N2 virus as well as partial protection against H1N1 virus.This vaccine(3MCD-f)consists of two conserved epitopes(matrix protein 2 ectodomain(M2e)and CDhelix),and these epitopes were presented on the surface of ferritin in a sequential tandem format.Subcutaneous immunization with 3MCD-f in the absence of adjuvant induces robust humoral and cellular immune responses.These results provide a proof of concept for the 3MCD-f nanovaccine that might be an ideal candidate for future influenza pandemics. | Yongbo Qiao YaXin Zhang Jie Chen Shenghui Jin Yarning Shan | 2022 | Nano Research2022，15，9： | 0 |
| 11 | A multi-parameter data acquisition system for the collision research platform at Shanghai EBIT显示文摘In this work we describe a multi-parameter data acquisition system(DAQ)which has been developed for the Shanghai EBIT.This system is operated at the collision research platform which includes a recoil-ion momentum spectrometer(RIMS).We have employed DAQ based on the VME system,which is a very fast developing system within the RIMS community,and with which we can reach data transfer rates of up to 160 Mb·s- 1.The software developed for DAQ based on UnisDX-XP is also described. | WANG Xincheng WEI Baoren YANG Yang SHEN Yang XIAO Jun ZHANG Xuemei ZOU Yarning | 2009 | Nuclear Science and Techniques2009，20，1： | 0 |
| 12 | Cytoskeleton-a crucial key in host cell for coronavirus infection显示文摘The emerging coronavirus(CoV)pandemic is threatening the public health all over the world.Cytoskeleton is an intricate network involved in controlling cell shape,cargo transport,signal transduction,and cell division.Infection biology studies have illuminated essential roles for cytoskeleton in mediating the outcome of host-virus interactions.In this review,we discuss the dynamic interactions between actin filaments,microtubules,intermediate filaments,and CoVs.In one round of viral life cycle,CoVs surf along filopodia on the host membrane to the entry sites,utilize specific intermediate filament protein as co-receptor to enter target cells,hijack microtubules for transportation to replication and assembly sites,and promote actin filaments polymerization to provide forces for egress.During CoV infection,disruption of host cytoskeleton homeostasis and modification state is tightly connected to pathological processes,such as defective cytokinesis,demyelinating,cilia loss,and neuron necrosis.There are increasing mechanistic studies on cytoskeleton upon CoV infection,such as viral protein-cytoskeleton interaction,changes in the expression and post-translation modification,related signaling pathways,and incorporation with other host factors.Collectively,these insights provide new concepts for fundamental virology and the control of CoV infection. | Zeyu Wen Yue Zhang Zhekai Lin Kun Shi Yarning jiu | 2020 | Journal of Molecular Cell Biology2020，12，12： | 0 |
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