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| 1 | Fabrication and characterization of biodegradable Mg-Zn-Y-Nd-Ag alloy:Microstructure,mechanical properties,corrosion behavior and antibacterial activities显示文摘Magnesium(Mg),a potential biodegradable material,has drawn wide attention in the bone reconstruction field.However,Mg alloys,served as the bone graft substitution,remain a clinical challenge,the antibacterial activity of which is required to be enhanced.Here,we prepared biodegradable magnesium Mg-Zn-Y-Nd-Ag and then had it been further densified by extruding.The microstructure evolution of the as-cast and as-extruded Mg-Zn-Y-Nd-Ag was characterized using optical microscope and X-ray diffraction analyses(XRD).The results showed that the microstructure of the as-cast alloys was mainly dendrites,between which,the second phase was mainly distributed;with the increase of Ag additions,grain structure was further refined as well as the increase of amount of the second phase.After the extrusion,the grains were further refined.Microhardness tests indicated that both of the increase of Ag content and the extrusion process improved the microhardness of the alloys,specially the later.A systematic investigation of the in vivo antibacterial capability of Staphylococcus aurous and Escherichia coli was performed,and the results of which indicated that all Mg-Zn-Y-N-xAg(x?0.2,0.4,0.6,0.8)alloys exhibited certain antibacterial property,which would increased with the increase of Ag content.Taken all together,the antimicrobial property of the as-extruded alloy containing 0.4 wt%Ag exhibited the relatively better antimicrobial properties and mechanical property with the relatively small loss in corrosion resistance,which suggested the potential utility of as-extruded Mg-Zn-Y-N-0.4Ag in treating orthopedic infections. | Yashan Feng Shijie Zhu Liguo Wang Lei Chang Yachen Hou Shaokang Guan | 2018 | Bioactive Materials2018，3，3： | 7 |
| 2 | Characterization and corrosion property of nano-rod-like HA on fluoride coating supported on Mg-Zn-Ca alloy×显示文摘The poor corrosion resistance of biodegradable magnesium alloys is the dominant factor that limits theirclinical application. In this study, to deal with this challenge, fluoride coating was prepared on MgeZneCa alloy as the inner coating and then hydroxyapatite (HA) coating as the outer coating was depositedon fluoride coating by pulse reverse current electrodeposition (PRC-HA/MgF2). As a comparative study,the microstructure and corrosion properties of the composite coating with the outer coating fabricatedby traditional constant current electrodeposition (TED-HA/MgF2) were also investigated. Scanningelectron microscopy (SEM) images of the coatings show that the morphology of PRC-HA/MgF2 coating isdense and uniform, and presents nano-rod-like structure. Compared with that of TED-HA/MgF2, thecorrosion current density of Mg alloy coated with PRC-HA/MgF2 coatings decreases from 5.72× 10^-5 A/cm2 to 4.32× 10^-7 A/cm^2, and the corrosion resistance increases by almost two orders of magnitude. Inimmersion tests, samples coated with PRC-HA/MgF2 coating always show the lowest hydrogen evolutionamount, and could induce deposition of the hexagonal structure-apatite on the surface rapidly. Theresults show that the corrosion resistance and the bioactivity of the coatings have been improved byadopting double-pulse current mode in the process of preparing HA on fluoride coating, and the PRC-HA/MgF2 coating is worth of further investigation. | Yashan Feng Shijie Zhu Liguo Wang Lei Chang Bingbing Yan Xiaozhe Song Shaokang Guan | 2017 | Bioactive Materials2017，2，2： | 6 |
| 3 | Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation显示文摘Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis.Recent studies reported that reactive oxygen species(ROS)-mediated ferroptosis plays a critical role in the development of heart diseases.Therefore,we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac injury.Herein,we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles(MMPP)improves myocardial function by inhibiting ROS-related ferroptosis signaling pathway.In LPS-induced murine sepsis model,after a single dose intravenously injection of MMPP treatment,MMPP markedly alleviated the myocardial injury including cardiac function and heart structure disorder through suppressing iron-accumulation induced ferroptosis.In vitro,MMPP inhibited cardiomyocyte death by attenuating oxidative stress,inflammation and maintaining mitochondrial homeostasis.Collectively,our findings demonstrated that MMPP protected heart against sepsis-induced myocardial injury via inhibiting ferroptosis and inflammation,which might be a novel therapeutic approach in future. | Chang Liu Quan Zou Huixin Tang Jia Liu Shiqi Zhang Caihong Fan Junwei Zhang Ruiqing Liu Yashan Liu Ruiyan Liu Yan Zhao Qiang Wu Zhi Qi Yanna Shen | 2023 | Bioactive Materials2023，，6： | 5 |
| 4 | A case of scalp avulsion with prolonged ischemic time:indocyanine green angiography can aid in predicting replant survival显示文摘Background:Microsurgical replantation has become the most favorable treatment option for scalp avulsion.However,the accurate prediction of postoperative replant viability remains challenging.Case presentation:In this article,we showed that(indocyanine green angiography,ICGA)can provide a much more precise prediction of replant necrosis than conventional clinical assessment in a rare case of complete scalp avulsion with prolonged ischemia time.Conclusion:Clinical assessment of replant survival may be misleading in cases of complex tissue injuries and prolonged ischemic stress.This case provides insight into the promising utility of ICGA as an important adjuvant tool to better assess tissue perfusion and viability in scalp avulsion and possibly other types of replantation. | Xin Huang Zhichao Wang Caiyue Liu Shuchen Gu Yashan Gao Xiangwen Xu Tao Zan | 2019 | Burns & Trauma2019，7，1： | 2 |
| 5 | Inertia friction welding of 1100 aluminium to type 316 stainless steel显示文摘 | YASHAN D TSANG S JOHNS W L | 1987 | Welding Journal1987，66，8： | 1 |
| 6 | High - speed counter-current chromatography separation and purification of resveratrol and piceid from Polygonum cuspidatum 显示文摘 | Lei Chen Yashan Han Fuquan Yang | 2001 | Journal of Chromatography A2001，907，： | 1 |
| 7 | Current control fordual three-phase permanent magnet synchronous motorsaccounting for current unbalance and harmonics 显示文摘 | Hu Yashan Zhu Ziqiang Liu Kan | 2014 | IEEE Journal of Emerging and Selected Topics in PowerElectronics2014，2，2： | 1 |
| 8 | Three-dimensional thermo-rheological structure of the lithosphere in the North China Craton determined by integrating multiple observations: Implications for the formation of rifts显示文摘The lithosphere of the North China Craton(NCC)has experienced significant destruction and deformation since the Mesozoic,a notable feature of which is the widespread extensional structure and lithospheric thinning in the eastern NCC.Since the thermo-rheological structure of the lithosphere is one of the main factors controlling these dynamic processes,a threedimensional thermo-rheological model of the present lithosphere in the NCC was developed based on a geophysical-petrological method using a variety of data,and its relationship with the extensional structures and the formation of rifts was further analyzed.Our results show that the western NCC is characterized by thick lithosphere,low Moho temperature(TMoho<600°C),as well as high lithospheric strength and mantle-crust strength ratio(Sm/Sc>1).The deformation of the western narrow rift is consistent with the localized deformation dominated by the strength of lithospheric mantle.On the other hand,the lithosphere in the eastern NCC is characterized by extensive thinning(with lithospheric thickness of about 80–110 km).However,the decrease of lithospheric strength is not uniform,with high strength(10×1012 Pa m)observed in some areas(such as the Bohai Bay Basin and Hehuai Basin).Most of the eastern lithosphere is characterized by high TMoho(600–750°C)and low Sm/Sc(<1),which is inconsistent with the widespread extensional structure in the eastern NCC.Incorporating results from palaeo-geothermal and petrological studies,we developed a thermo-rheological structure model of the lithosphere at different evolutionary stages of the NCC,and suggested that the eastern NCC had a significantly thinned and weakened lithosphere in the early stages of the formation of the rift,leading to a regional distributed extension deformation dominated by crustal strength,which eventually evolved into a series of wide rifts.However,the cooling and accretion of the lithosphere in the subsequent stages significantly increased the strength of the lithospheric mantle,resulting in the inconsistency between the present thermo-rheological structure of the lithosphere and the extensional structure formed in the past. | Kai WANG Xiong XIONG Yuming ZHOU Yashan FENG | 2020 | Science China Earth Sciences2020，63，7： | 1 |
| 9 | Inertia friction welding of 1100 aluminum to type 316 stainless steel 显示文摘 | Yashan D Tsang S Johns W L | 1987 | Welding Journal1987，66，8： | 1 |
| 10 | Inertia friction welding of 1100 aluminum to type 316 stainless stee显示文摘 | Yashan D Tsang S Johns W L | 1987 | Welding Journal1987，66，8： | 1 |
| 11 | Screening and characterization of astaxanthin-hyperproducing mutants of Haematococcus pluvialis显示文摘 | Yong Chen Defa Li Wenqing Lu Jianjun Xing Bodi Hui Yashan Han | 2003 | Biotechnology Letters2003，，7： | 1 |
| 12 | Current Control for Dual three- phase Permanent Magnet Synchronous Motors Ac-counting for CurrentUnbalance and Harmonics 显示文摘 | Hu Yashan Zhu Ziqing Liu Kan | 2014 | IEEE Journal of Emerging and Se- lected Topics in Power Elec-tronies2014，2，2： | 1 |
| 13 | Novel urchin-like CuO synthesized by a facile reflux method with efficient olefin epo- xidation catalytic performance 显示文摘 | Xu Linping Sithambaram S Zhang Yashan | 2009 | Chemistry of Materials2009，21，7： | 1 |
| 14 | Novel urchin-like Cu O synthesized by a facile reflux method with efficient olefin epoxidation catalytic performance显示文摘 | Xu Linping Sithambaram S Zhang Yashan | 2009 | Chemical of Materials2009，21，7： | 1 |
| 15 | Advances in Cotton Tolerance to Heavy Metal Stress and Applications to Remediate Heavy Metal-Contaminated Farmland Soil显示文摘Heavy metal-contaminated soil is one of the major environmental pollution problems of agricultural production and human health in the world.Remediation of heavy metals in soil is one of the most popular research subjects.Different remediation strategies have been reported to remove heavy metals from contaminated soil,among which phytoremediation is the most important one.Compared with other major crops,cotton shows the strongest and most widespread resistance to abiotic stresses,such as heavy metals.Although heavy metal stress adversely affects the growth and development of cotton,cotton possesses a set of sophisticated stress-resistance strategies.As the main product of cotton is nonedible fibers,which have a large biomass and strong heavy metal absorption and enrichment capacities,cotton is an ideal crop to restore heavy metal-contaminated soils and has unique advantages in terms of both ecological and economic benefits,with great application prospects.In this review,based on domestic and foreign research results in recent years,the effects of heavy metals on cotton growth and product quality were analyzed,the heavy metal absorption,accumulation,translocation and enrichment characteristics of cotton plants were summarized,and the adaptation and tolerance mechanisms of cotton to heavy metals were explored.Furthermore,the view that cotton is an effective crop to remediate heavy metal pollution in farmland soil has been proposed,and popularization and application suggestions for planting cotton to repair heavy metal pollution have been put forward to provide a reference for the comprehensive evaluation of the economic feasibility of cotton to repair heavy metal pollution in farmland soil. | Ling Li Xuyu Yan Juan Li Yashan Tian Pan Ren | 2021 | Phyton-International Journal of Experimental Botany2021，90，1： | 1 |
| 16 | Coulomb stress changes due to the 2021 MS7.4 Maduo Earthquake and expected seismicity rate changes in the surroundings显示文摘On May 22 nd,2021,an MS7.4 earthquake occurred near the Maduo county of the Qinghai Province,China,within the Bayan Har Block.Seismic activities have been intense in this block,thus whether the Maduo Earthquake will bring subsequent seismic hazards to its surrounding regions raises wide concerns.In this paper,we first calculated the Coulomb failure stress changes caused by the Maduo Earthquake on nearby faults,and estimated how much these faults are brought closer or further from their next failures based on their stressing rates.Next,we combined the Coulomb failure stress changes with the rate-state frictional law to estimate the seismicity rate in the study region in the next decade.A declustered catalogue before the Maduo Earthquake was adopted to calculate background seismicity rate,and rate-state parameters are constrained by fault slip rates.Our results show that the Maduo Earthquake increases stress accumulations in the northwestern portion of the Qingshuihe fault(0.02 MPa at maximum),the two ends of the Kunlun Mountain Pass-Jiangcuo fault(0.01 MPa at maximum),and the northwestern portion of the Maduo-Gande fault(on average~0.09 MPa),and seismicity rates are expected to increase near these faults.What is especially worth noting is the seismic hazard in the region extending from the eastern end of the Kunlun Mountain Pass-Jiangcuo fault to the Maqin-Maqu seismic gap on the Eastern Kunlun fault,which is calculated to have experienced a maximum stress increase of 0.67 MPa after the Maduo Earthquake.On the other hand,stress accumulations are reduced in the southern end of the Elashan fault,the Eastern Kunlun fault segment to the west of Maduo,and the northwestern portion of the Dari fault.Seismic hazards are expected to be low in these regions.For the study region as a whole,the probability of an M≥6 earthquake taking place in the next decade is estimated to be 59%,about twice the value calculated for the time period before the Maduo Earthquake. | Yashan FENG Xiong XIONG Bin SHAN Chengli LIU | 2022 | Science China Earth Sciences2022，65，4： | 1 |
| 17 | 显示文摘 | Qiu Guohong Saminda Dharmarathna Zhang Yashan | 2012 | Phys Chem C2012，116，1： | 1 |
| 18 | Screening and characterization of astaxanthin-hyperproducing mutants of Haematococcus pluvialis显示文摘 | Yong Chen Defa Li Wenqing Lu Jianjun Xing Bodi Hui Yashan Han | 2003 | Biotechnology Letters2003，，7： | 1 |
| 19 | Evolution of prisoner's dilemma strategies on scale -free networks 显示文摘 | Chen Yashan Lin Hai Wtt Chenxu | 2007 | Physica A - Statistical Mechanics and its Applications2007，385，： | 1 |
| 20 | The role of macrophages in the formation of hypertrophic scars and keloids显示文摘Numerous studies have shown that macrophages can orchestrate the microenvironment from the early stage of wound healing to the later stages of scar formation.However,few reviews have highlighted the significance of macrophages during the formation of abnormal scars.The purpose of this reviewwas to outline the polarization of macrophages from early to late stage of pathological scar formation,focusing on spatiotemporal diversity of M1 and M2 macrophages.In this review,the role of macrophages in the formation of hypertrophic scars and keloids is summarized in detail.First,an increased number of M2 cells observed before injuries are significantly associated with susceptibility to abnormal scar pathogenesis.Second,decreased expression of M1 at the early stage and delayed expression of M2 at the late stage results in pathological scar formation.Third,M2 cells are highly expressed at both the margin and the superficial region,which is consistent with the invasive property of keloids.Finally,this review helps to characterize strategies for the prediction and prevention of pathological scar formation. | Xiangwen Xu Shuchen Gu Xin Huang Jieyi Ren Yihui Gu Chengjiang Wei Xiang Lian Haizhou Li Yashan Gao Rui Jin Bin Gu Tao Zan Zhichao Wang | 2020 | Burns & Trauma2020，8，1： | 0 |
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