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| 1 | miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines显示文摘化疗是为 colorectal 腺癌癌症的重要治疗;然而, colorectal 腺癌房间经常开发抵抗到化学疗法的药,导致恶化和差的耐心的预后。药抵抗的发展经常是一个 multifactor 过程,它包含了几基因和细胞的机制。microRNAs 是否定地在 post-transcriptional 水平调整基因表示的内长的小非编码的 RNA。在现在的学习,我们在调整 colorectal 腺癌房间 SW620 和 SW480 的药敏感调查了 microRNAs 的可能的角色。使用 microRNA 表达式数组和我们发现了房间展出了的那 SW620 的量的反向的 transcriptase (RT )-PCR, 与 SW480 房间相比提高了 miR-20a 表示。另外,这二房间行显示了不同敏感到化学疗法的药氟尿嘧啶, oxaliplatin,和 teniposide。miR-20a 的调整改变了 SW620 和 SW480 房间的敏感到这些药;miR-20a 击倒敏化的 SW620 房间到化学疗法的代理人,而在 SW480 房间的 miR-20a 的 overexpression 导致了 chemoresistance。内长的 BNIP2 mRNA 和 BNIP2 蛋白质层次是相反地由量的 RT-PCR 和西方的污点分析与是的 miR-20a 层次有关检测了。荧光记者试金显示出在 miR-20a 和 BNIP2 3UTR 之间的一个直接相互作用。一起拿,我们的调查结果建议 miR-20a 可以在 colorectal 腺癌癌症房间药抵抗起一个作用并且可以是对在 colorectal 腺癌的化疗药抵抗的一个治疗学的目标。 | Huijuan Chai Min Liu Ruiqing Tian Xin Li Hua Tang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 18 |
| 2 | Effect of catgut implantation at acupoints on GABA_B and mGluR1 expressions in brain stem of rats with spasticity after stroke显示文摘OBJECTIVE: To investigate the effect of catgut implantation at acupoints on the expressions of γ-amino butyric acid B receptor(GABAB ) and metabotropic glutamate receptor 1(mGluR1) in the brain stem of rats with spasticity after stroke.METHODS: In total, 60 male Sprague-Dawley rats were randomly divided into three groups: a sham group(n=10), a model group(n=25) and a treatment group(n=25). The rats in both the model group and the treatment group were subjected to middle cerebral artery occlusion to establish a model of focal cerebral ischemia. Rats with limb-spasm met the inclusion criteria. Only the left carotid artery was isolated in sham group rats. Three days after modeling, the treatment group was subjected to catgut implantation at Dazhui(GV 14), Guanyuan(CV 4), and Zhongwan(CV 12). Neurological deficit symptoms were assessed with the Zea-Longa neurological deficit score. The Modified Ashworth Scale(MAS), and isolated muscle tone were used to evaluate spasticity before and after treatment. Immunohistochemistry was applied to determine the expression of GABAB and mGluR1 in the rat brain stem after treatment.RESULTS: After treatment, neural impairment symptoms had significantly improved in the treatment group when compared to the model group(P<0.05). Both MAS and isolated muscle tone in the treatment group were significantly decreased when compared with the model group(P<0.05),and were also lower than before treatment. GABAB expression was significantly higher and mGluR1 was lower in the treatment group when compared with the model group(P<0.01 and P<0.05, respectively).CONCLUSION: Catgut implantation at Dazhui(GV 14), Guanyuan(CV 4), and Zhongwan(CV 12), can relieve limb spasticity by increasing the expression of GABAB and reducing the expression of mGluR1 in the brain stem of rats after stroke. | Chengmei Liu Ruiqing Li Xiaolei Song Xiaodong Feng | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 14 |
| 3 | LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation显示文摘天生的免疫系统为清除感染是批评的,并且紧被调整避免过多的织物损坏。Nod1/2-Rip2 发信号,它为开始天生的有免疫力的反应到细菌的感染是必要的并且嗯应力,服从于许多规章的机制。在这研究,我们发现了那 LRRK2,由基因编码了在 Crohns 疾病,败坏和家庭 Parkinsons 疾病含有,调制由提高 Rip2 phosphorylation 发信号的 Nod1/2-Rip2 的力量。LRRK2 缺乏显著地由 muramyl dipeptide (MDP ) 在 Nod2 激活之上在巨噬细胞减少 cytokine 生产,由 D-gamma-Glu-meso-diaminopimelic 酸(即弹跳) 的 Nod1 激活或嗯应力。我们的生物化学的学习证明 LRRK2 的存在为在 Nod2 激活之上的 Rip2 的最佳的 phosphorylation 是必要的。因此,这研究表明 LRRK2 是 Rip2 的一个新积极管理者并且支持通过 Nod1/2-Rip2 小径感应的煽动性的 cytokine。 | Ruiqing Yan Zhihua Liu | 2017 | Protein & Cell2017，8，1： | 6 |
| 4 | Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation显示文摘Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis.Recent studies reported that reactive oxygen species(ROS)-mediated ferroptosis plays a critical role in the development of heart diseases.Therefore,we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac injury.Herein,we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles(MMPP)improves myocardial function by inhibiting ROS-related ferroptosis signaling pathway.In LPS-induced murine sepsis model,after a single dose intravenously injection of MMPP treatment,MMPP markedly alleviated the myocardial injury including cardiac function and heart structure disorder through suppressing iron-accumulation induced ferroptosis.In vitro,MMPP inhibited cardiomyocyte death by attenuating oxidative stress,inflammation and maintaining mitochondrial homeostasis.Collectively,our findings demonstrated that MMPP protected heart against sepsis-induced myocardial injury via inhibiting ferroptosis and inflammation,which might be a novel therapeutic approach in future. | Chang Liu Quan Zou Huixin Tang Jia Liu Shiqi Zhang Caihong Fan Junwei Zhang Ruiqing Liu Yashan Liu Ruiyan Liu Yan Zhao Qiang Wu Zhi Qi Yanna Shen | 2023 | Bioactive Materials2023，，6： | 5 |
| 5 | Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases显示文摘DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal cells.However,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately regulated.STING is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA sensing.Here,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for degradation.Knockout of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory cytokines.Ccdc50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with HSV-1.Remarkably,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune disease.CCDC50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE patients.CCDC50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE serum.Thus,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 6 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 7 | Chance Constrained Integer Programming and Stochastic Simulation Based Genetic Algorithm | ZHAO Ruiqing College of Mechanical Engineering,Shijiazhuang 050003,China Kakuzo Iwamura Department of Mathematics, Josai University,Sakado,Saitama 350-02,Japan LIU Baoding Department of Applied Mathematics,Tsinghua University,Beijing 100084,China | 1998 | Systems Science and Systems Engineering1998，8，1： | 3 |
| 8 | Small-angle X-ray scattering investigation of aging behavior of Al-Cu-Mg-Ag alloys using synchrotron radiation显示文摘The aging behavior of Al-Cu-Mg-Ag alloys with high Cu/Mg was studied by transmission electron microscopy (TEM) and small-angle X-ray scattering (SAXS) using synchrotron radiation. TEM study reveals that the major strengthening phases of the alloy after aging at 160?C for 10 h are Ω and less θ′. SAXS study shows that the scattering patterns are composed of several concentric circles at the beginning of aging process, which is replaced by the butterfly-wings scattering patterns with the increase of aging time. The butterfly-wings scattering patterns are composed of several branches. The angles between the branches are roughly equal to that between the habit planes of precipitates. The evolution of Guinier radius with aging time indicates the good coarsening resistance of the precipitates. The evolution of integrated intensity is consistent with the classical two-step precipitation process. | Zhang Jianbo Zhang Yongan Zhu Baohong Liu Ruiqing Li Zhihui Li Xiwu | 2012 | Rare Metals2012，31，6： | 2 |
| 9 | Ecosystem service valuation of bays in East China Sea and its response to sea reclamation activities显示文摘Ecosystem service values(ESVs)of bays and their response to sea reclamation are of great practical importance for forming bay eco-compensation policy and extension of blue economic space.Based on land use information of bays collected during the period of 1990–2015,the spatiotemporal evolution of ESVs of 12 main bays in East China Sea and their response to sea reclamation activities over the past 25 years were quantitatively analyzed.The analysis results indicate that ESVs of bays in East China Sea showed a continuous downward trend and the whole ecosystem was continuously degraded,in which the degradation degree of ESV in the southern bays was higher than that in the northern bays.Spatial zoning of ESVs of bays in East China Sea was remarkable,showing a continuous downward trend from low-value to high-value zone.Spatial variation of ESVs of each bay was also significant,expanding from a city and from inland to the coast,which suggests that human activities,mainly reclamation,have become main agents for ESV evolution of bays in East China Sea.ESVs of bays have a significant response to sea reclamation,manifested as a significant negative correlation between ESV and reclamation intensity.The correlation in the southern bays was stronger than that in the northern bays,which was caused by different effects of sea reclamation modes on ESV evolution of muddy and bedrock bays.A negative effect of sea reclamation activities on bay ecosystem was hysteretic.Therefore,an attention should be paid to dynamic monitoring and early warning of development status in offshore areas,ecosystem-level reclamation control policy,and coastal wetland reserves planning.Moreover,the spatial coupling mechanism study between bay ecosystem service demand and its service supply capacity should be strengthened to realize systematic regulation of bay ecological security pattern. | LIU Ruiqing XU Hao LI Jialin PU Ruiliang SUN Chao CAO Luodan JIANG Yimei TIAN Peng WANG Lijia GONG Hongbo | 2020 | Journal of Geographical Sciences2020，30，7： | 2 |
| 10 | Recent developments in CVD growth and applications of 2D transition metal dichalcogenides显示文摘Two-dimensional(2D)transition metal dichalcogenides(TMDs)with fascinating electronic energy band structures,rich valley physical properties and strong spin–orbit coupling have attracted tremendous interest,and show great potential in electronic,optoelectronic,spintronic and valleytronic fields.Stacking 2D TMDs have provided unprecedented opportunities for constructing artificial functional structures.Due to the low cost,high yield and industrial compatibility,chemical vapor deposition(CVD)is regarded as one of the most promising growth strategies to obtain high-quality and large-area 2D TMDs and heterostructures.Here,state-of-the-art strategies for preparing TMDs details of growth control and related heterostructures construction via CVD method are reviewed and discussed,including wafer-scale synthesis,phase transition,doping,alloy and stacking engineering.Meanwhile,recent progress on the application of multi-functional devices is highlighted based on 2D TMDs.Finally,challenges and prospects are proposed for the practical device applications of 2D TMDs. | Hui Zeng Yao Wen Lei Yin Ruiqing Cheng Hao Wang Chuansheng Liu Jun He | 2023 | Frontiers of physics2023，18，5： | 2 |
| 11 | Symptom clustering in chronic gastritis based on spectral clustering显示文摘OBJECTIVE: Apply spectral clustering to analyze the patterns of symptoms in patients with chronic gastritis(CG).METHODS: Based on 919 CG subjects, we applied mutual information feature selection to choose the positively correlated symptoms with each pattern.Then, we used the Shi and Malik spectral clustering algorithm to select the top 20 correlated symptoms.RESULTS: We ascertained the results of six patterns.There were three categories for the pattern of accumulation of damp heat in the spleen-stomach(0.00332). There were six categories for the pattern of dampness obstructing the spleen-stomach(0.02466). There were two categories for the pattern of spleen-stomach Qi deficiency(0.013 89).There were three categories for the pattern of spleen-stomach deficiency cold(0.009 15). There were five categories for the pattern of liver-Qistagnation(0.01910).There were four categories for the pattern of stagnant heat in the liver-stomach(0.00585).CONCLUSION: Most of the spectral clustering results of the symptoms of CG patterns were in accordance with clinical experience and Traditional Chinese Medicine theory. Most categories suggested the nature and/or location of the disease. | Wenhua Zhu Zhaoxiang Fan Guoping Liu Jianjun Yan Tao Zhong Wu Zheng Ruiqing Wang Chunying Wang | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 2 |
| 12 | Implementation method of Oil and Gas Geologic Information System with ArcGIS Engine显示文摘ComGIS is the mainstream of developing GIS currently.Developing Geographic Information System with the technology of components can reduce the difficulties of developing,improving the developing efficiency and enhancing the flexibility and opening of system.ArcObjects(AO) is based on the technology of COM,and ArcGIS Engine(AE) is a set of embedded AO which can extend to various platforms.Compared with AO,ArcGIS Engine can shorten the period of developing and improve the efficiency greatly.Having introduced the techniques of ArcObjects and ArcGIS Engine,we offer the method of developing GIS with Visual Basic and ArcGIS Engine with Oil and Gas Geologic Information System. | Chunyan DENG Yunliang YU Shixiang LIU Ruiqing QIE Zhiguo ZHOU | 2007 | Global Geology2007，10，1： | 2 |
| 13 | 查看详情显示文摘 | Luo YP Liu H Q RuiQ Tian Y | | 0，，08： | 1 |
| 14 | Renewal process with fuzzy interarrival times and rewards 显示文摘 | Zhao Ruiqing Liu Baoding | 2003 | International Journal of Uncertainty Fuzziness and Knowledge-Based Systems2003，11，5： | 1 |
| 15 | Self-extinguishing and transparent epoxy resin modified by a phosphine oxide-containing bio-based derivative显示文摘A phosphine oxide-containing bio-based curing agent was synthesized by addition reaction between furan derivatives and diphenylphosphine oxide.The molecular structure of the as-prepared bio-based curing agent was confirmed by Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy.Dynamic mechanical analysis results indicated that with the increase of bio-based curing agent content,the glass transition temperature of epoxy/bio-based curing agent composites decreased,which was related to the steric effect of diphenylphosphine oxide species that possibly hinder the curing reaction as well as the reduction in the cross-linking density by mono-functional N-H.By the addition of 7.5 wt-%bio-based curing agent,the resulting epoxy composite achieved UL-94 V-0 rating,in addition to limiting oxygen index of 32.0 vol-%.With the increase of content for the bio-based curing agent,the peak of heat release rate and total heat release of the composites gradually decreased.The bio-based curing agent promoted the carbonization of the epoxy matrix,leading to higher char yield with good thermal resistance.The high-quality char layer served as an effective barrier to retard the diffusion of decomposition volatiles and oxygen between molten polymers and the flame.This study provides a renewable strategy for fabricating flame retardant and transparent epoxy thermoset. | Gang Tang Ruiqing Zhao Dan Deng Yadong Yang Depeng Chen Bing Zhang Xinliang Liu Xiuyu Liu | 2021 | Frontiers of Chemical Science and Engineering2021，15，5： | 1 |
| 16 | A Photo-responsive Catalytic Vesicle with GPx Activity显示文摘谷胱甘肽 peroxidase (GPx ) 是涉及反应的氧种类的减小的重要抗氧化剂酶并且保护房间免受氧化损坏的伤害。因而庞大的努力被奉献给与 GPx 功能开发人工的催化剂。而且,关于提高 GPx 的催化活动的研究模仿,聪明的 GPx 模型的设计和构造也启发了大兴趣。此处,一个新奇相片应答的包含硒的小囊的 GPx 模型成功地被构造由超分子有通过在水的媒介的恐水病、静电的相互作用的 benzeneseleninic 酸(PhSeO2H ) 的 cationic 表面活化剂 PyC10AzoC10Py 自己组装。这包含硒的小囊的催化剂显示出显著象 GPx 一样活动,它由 4-nitrobenzenethiol (NBT ) 是比为 cumene hydroperoxide (CUOOH ) 的减小的 PhSeO2H 更有效的 692 次。有趣地,当 CD 的 equimolar 数量被增加时,催化的泡的象 GPx 一样活动面对 CD 由于泡崩溃显著地衰退。而 biomimetic 系统被紫外光在 365 nm 照耀,催化的泡再被形成,象 GPx 一样活动恢复了。 | Ruiqing Xiao Lipeng Zhou Zeyuan Dong Yuzhou Gao Junqiu Liu | 2014 | Chinese Journal of Chemistry2014，32，1： | 1 |
| 17 | Redundancy Optimization Problems with Uncertainty of Combining Randomness and Fuzziness 显示文摘 | Ruiqing Zhao Liu B | 2002 | European Journal of Operational Research (S0377-2217)2002，11，： | 1 |
| 18 | GL9 from Oryza glumaepatula controls grain size and chalkiness in rice显示文摘Grain size is a key factor influencing grain yield and appearance quality in rice.We identified twelve quantitative trait loci(QTL)for grain length(GL),nine for grain width(GW),and nine for 1000-kernel weight(TKW)using GLU-SSSLs,which are single-segment substitution lines with Oryza glumaepatula as donor parent and Huajingxian 74(HJX74)as recipient parent.Among the QTL,qGL1-2,qGL1-4,qGL9-2,qGW2-2,qGW9-1 and qTKW9-2 contributed to high grain yield.GL9 was identified as a candidate gene for qGL9-2 by map-based cloning and sequencing,and is a novel allele of GS9.The kernel of NIL-gl9was slenderer and longer than that of HJX74,and the TKW and grain yield per plant of NIL-gl9 were higher than those of HJX74.The proportion of grain chalkiness of NIL-gl9 was much lower than that of HJX74.Thus,gl9 increased grain yield and appearance quality simultaneously.Three pyramid lines,NIL-gs3/gl9,NIL-GW7/gl9 and NIL-gw8/gl9,were developed and the kernel of each was longer than that of the corresponding recipient parent lines.The gl9 allele may be beneficial for breeding rice varieties with high grain yield and good appearance quality. | Shaojun Lin Zupei Liu Kui Zhang Weifeng Yang Penglin Zhan Quanya Tan Yajun Gou Shuaipeng Ma Xin Luan Chubing Huang Zhili Xiao Yuanyuan Liu Bihuang Zhu Ruiqing Liang Wenqi Zhou Haitao Zhu Suhong Bu Guifu Liu Guiquan Zhang Shaokui Wang | 2023 | The Crop Journal2023，11，1： | 1 |
| 19 | Interpretation of remote sensing of geological structures and prediction of gold mineralization in Mohe area and its adjacent region显示文摘The authors took the ETM+ multi-spectra data as the data information and correlation coefficient for each band and carried out their information volume statistics.According to certain criteria,the authors also determined the optimum band-combined image.The image clarity is improved by various enhancements and fusions method.Based on remote sensing geological interpretation in detail,the relationship between remote sensing geological characters and gold mine were analyzed systemically.Using all kinds of remote sensing structure information,combining other research data,the authors determined mainly ore-controlling ore structure.Several prospective areas of gold ores were determined and furthermore significant finding mine target areas was confirmed. | Ruiqing QIE Linfu XUE Shixiang LIU Yunliang YU | 2007 | Global Geology2007，10，1： | 1 |
| 20 | Field Evaluation of a Duplex RT-RAA Assay for Rapid Detection of SARS-CoV-2--Hebei Province,China,January 2021显示文摘Introduction:Recently,a local cluster epidemic has occurred in Shijiazhuang City,Hebei Province.Failure to promptly identify patients with fever in rural areas was the major reason for this epidemic.Methods:We presented the field evaluation of a new real-time reverse transcription recombinase-aided amplification(RT-RAA)kit incorporating an endogenous internal control in a single-tube format,completed at the Hebei CDC from January 17,2021 to January 27,2021.Results:We evaluated the diagnostic performance of RT-RAA assay using automatic extracted RNA of 808 clinical samples.Compared with reverse transcriptase real-time quantitative PCR(qRT-PCR),RT-RAA kit achieved 92.41%sensitivity,98.78%specificity and a 96.29%coincidence rate,demonstrating an excellent agreement between the RTRAA assay and qRT-PCR assay.Furthermore,58 samples were extracted using a manual extraction method within 5 minutes,but only samples with high nucleic acid concentration(cycle threshold value not higher than 32)could be stably detected.Discussion:The RT-RAA is more suitable to meet the needs of rapid,sensitive,and accurate detection in community-level medical institutions. | Ruiqing Zhang Shunxiang Qi Jiandong Li Shiyou Liu Guangyue Han Xinxin Shen Qi Li Wenbo Xu Xuejun Ma | 2022 | China CDC weekly2022，4，23： | 1 |
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