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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | Occurrence of mycotoxins in feed ingredients and complete feeds obtained from the Beijing region of China显示文摘Background:The current study was carried out to provide a reference for the control of mycotoxin contamination in feed ingredients and complete feeds for swine.Methods:A total of 55 feed ingredients,including 14 corn,13 wheat bran,11 soybean meal and 17 dried distillers grains with solubles(DDGS) as well as 76 complete swine feeds including 7 creep feeds,14 starter feeds,14 grower feeds,18 grower-finisher feeds,10 gestating sow feeds,and 13 lactating sow feeds were randomly collected from15 swine farms located in the Beijing region of China from July to August 2011.Immunoaffinity clean-up,using High-Performance Liquid Chromatography(HPLC) in combination with UV or Fluorescence Detection,was used for quantitative analysis of aflatoxin B,(AFB,),deoxynivalenol(DON),zearalenone(ZEA) and ochratoxin A(OTA) in the ingredients and complete feeds.Results:DON and ZEA were the most prevalent mycotoxins found.DON was detected at percentages of 93,92,54,100 and 97%with a mean level of 1.01,0.44,0.05,1.36 and 0.65 ppm in the samples of corn,wheat bran,soybean meal,DDGS and complete feeds,respectively.The detected percentages of ZEA were 100,100,54,100 and 100 with mean levels of 109.1,14.9,9.2,882.7 and 58.9 ppb in the same samples.In the wheat bran and soybean meal samples,the content of all four mycotoxins were below the maximum limits set by Chinese regulations while the percentage of samples that exceeded regulatory limits were 7,57 and 7%for corn,and 7,14 and 3%for the complete feeds for AFB,,DON and OTA respectively.DDGS showed the most serious mycotoxin contamination and the percentage of samples that exceeded regulatory limits were 6,88 and 41%,for AFB,,DON and ZEA,respectively.Conclusions:This paper is the first to present data on the natural occurrence of AFB,,DON,ZEA and OTA in ingredients and complete feeds obtained from swine farms in China's Beijing region.The data shows that feed ingredients and complete swine feeds obtained from these farms are most often contaminated with DON followed by contamination with AFB,and ZEA. | Xiaoying Li Lihong Zhao Yu Fan Yaxiong Jia Lei Sun Shanshan Ma Cheng Ji Qiugang Ma Jianyun Zhang | 2014 | Journal of Animal Science and Biotechnology2014，5，4： | 7 |
| 3 | Development and validation of a nomogram for predicting the survival of patients with non-metastatic nasopharyngeal carcinoma after curative treatment显示文摘Background: The TNM staging system is far from perfect in predicting the survival of individual cancer patients because only the gross anatomy is considered. The survival rates of the patients who have the same TNM stage disease vary across a wide spectrum. This study aimed to develop a nomogram that incorporates other clinicopathologic factors for predicting the overall survival(OS) of non-metastatic nasopharyngeal carcinoma(NPC) patients after curative treatments.Methods: We retrospectively collected the clinical data of 1520 NPC patients who were diagnosed histologically between November 2000 and September 2003. The clinical data of a separate cohort of 464 patients who received intensity-modulated radiation therapy(IMRT) between 2001 and 2010 were also retrieved to examine the extensibility of the model. Cox regression analysis was used to identify the prognostic factors for building the nomogram. The predictive accuracy and discriminative ability were measured using the concordance index(c-index).Results: We identiied and incorporated 12 independent clinical factors into the nomogram. The calibration curves showed that the prediction of OS was in good agreement with the actual observation in the internal validation set and IMRT cohort. The c-index of the nomogram was statistically higher than that of the 7th edition TNM staging system for predicting the survival in both the primary cohort(0.69 vs. 0.62) and the IMRT cohort(0.67 vs. 0.63).Conclusion: We developed and validated a novel nomogram that outperformed the TNM staging system in predicting the OS of non-metastatic NPC patients who underwent curative therapy. | Wenhua Liang Guanzhu Shen Yaxiong Zhang Gang Chen Xuan Wu Yang Li Anchuan Li Shiyang Kang Xi Yuan Xue Hou Peiyu Huang Yan Huang Hongyun Zhao Ying Tian Chong Zhao Li Zhang | 2016 | Chinese Journal of Cancer2016，35，12： | 6 |
| 4 | Carbon emission trading system of China: a linked market vs. separated markets显示文摘中国政府打算升级它在 2015 交换飞行员到一个全国性的计划的当前的省的碳排放。这研究调查二种情形:分开的省的市场和一个连接内部省的市场。分开并且连接的市场的碳消退效果基于一个可计算出来的一般平衡模型用湖北和广东的二个飞行员省被比较称为的 Sino-TERMCo2。模拟结果证明连接市场能与分开的市场相比为国家以及为湖北广东团体改进社会福利和还原剂碳排放紧张。然而,联合系统也更不均匀的散布福利并且因此增加社会不公正。在政策地面上,当前的结果建议与足够的福利转移政策补充的一个构造得好的、全国性的碳市场能被采用代替当前的自顶向下的消退目标崩溃实践。 | Yu LIU Shenghao FENG Songfeng Yaxiong ZHANG Xiang ZHOU Yanbin CHEN Zhanming CHEN | 2013 | Frontiers of Earth Science2013，7，4： | 5 |
| 5 | Liensinine induces gallbladder cancer apoptosis and G2/M arrest by inhibiting ZFX-induced PI3K/AKT pathway显示文摘Gallbladder carcinoma (GBC) is the most comm on and aggressive can cer of the biliary tract. Liensinine has been proved to have hypotensive effect. However, the effect of liensinine on GBC is still unknown. The aim of this study is to investigate the effect and mechanism of liensinine in human GBC cells. Cell viability assay and colony formation assay were performed to assess cell growth and proliferation. Flow cytometry analysis was used to investigate cell cycle apoptosis in vitro. Hoechst 33342 staining was also used to evaluate cell apoptosis. Western blot analysis was used to determine the expression of proteins corresponding to the related cell cycle and apoptosis.The effect of liensinine treatment in vivo was experimented with xenografted tumors. We found that liensinine significantly inhibited the growth of GBC cells both in vivo and in vitro. In vitro, cell growth and proliferation were significantly suppressed by liensinine in a dose- and time-dependent manner. In vivo, liensinine inhibited tumor growth. Liensinine could induce GBC cells G2/M phase arrest by up-regulating the levels of Cyclin B1 and CDK1 proteins. Liensinine also affected GBC cell cycle progress!on and induced apoptosis by down-regulating phosphorylated protein kinase B (AKT), phosphorylated protein kinase B (p-AKT), phosphatidylinositol 3-kinase (PI3K), and Zinc finger X-chromosomal protein (ZFX) proteins. Liensinine induced G2/M arrest and apoptosis in gallbladder cancer, suggest!ng that liensinine might represent a novel and effective agent against gallbladder cancer. | Yitong Shen Rui Bian Yaxiong Li Yuan Gao Yingbin Liu Yuzhen Xu Xiaoling Song Yijian Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 4 |
| 6 | A graphene rheostat for highly durable and stretchable strain sensor显示文摘Strain sensors for human health monitoring are of paramount importance in wearable medical diagnostics and personal health monitoring.Despite extensive studies,strain sensors with both high durability and stretchability are still desired,particularly with the stability for different environmental conditions.Here,we report a series of strain sensors possessing the graphene network with a high density of intermittent physical interconnections,which produces the relative resistance change by varying the overlap area between the neighboring graphene sheets under stretching and releasing,analogous to the slide rheostat working in electronics.Our in-situ transmission electron microscope observation reveals the full recoverability of the structure from large deformation upon unloading for ensuring the exceptional cycle stability of our material on monitoring full-range body movements.The stable response is also demonstrated over wide temperature range and frequency range,because the peculiar dynamic structure can be maintained through the self-adjustment to the thermal expansion of the bulk material.Based on the working mechanism of graphene“slide rheostat,”the sensing properties of the strain sensor are tailored by tuning the graphene network structure with different mass densities using different concentrations of graphene oxide dispersion,while the stretchability and sensitivity can be separately optimized for different application requirements. | Jing Ren Wenjun Zhang Yubo Wang Yaxiong Wang Jun Zhou Liming Dai Ming Xu | 2019 | InfoMat2019，1，3： | 4 |
| 7 | Photodynamic therapy accelerates skin wound healing through promoting re-epithelialization显示文摘Background:Epidermal stem cells(EpSCs)that reside in cutaneous hair follicles and the basal layer of the epidermis are indispensable for wound healing and skin homeostasis.Little is known about the effects of photochemical activation on EpSC differentiation,proliferation and migration during wound healing.The present study aimed to determine the effects of photodynamic therapy(PDT)on wound healing in vivo and in vitro.Methods:We created mouse full-thickness skin resection models and applied 5-aminolevulinic acid(ALA)for PDT to the wound beds.Wound healing was analysed by gross evaluation and haematoxylin–eosin staining in vivo.In cultured EpSCs,protein expression was measured using flow cytometry and immunohistochemistry.Cell migration was examined using a scratch model;apoptosis and differentiation were measured using flow cytometry.Results:PDT accelerated wound closure by enhancing EpSC differentiation,proliferation and migration,thereby promoting re-epithelialization and angiogenesis.PDT inhibited inflammatory infiltration and expression of proinflammatory cytokines,whereas the secretion of growth factors was greater than in other groups.The proportion of transient amplifying cells was significantly greater in vivo and in vitro in the PDT groups.EpSC migration was markedly enhanced after ALAinduced PDT.Conclusions:Topical ALA-induced PDT stimulates wound healing by enhancing re-epithelialization,promoting angiogenesis as well as modulating skin homeostasis.This work provides a preliminary theoretical foundation for the clinical administration of topical ALA-induced PDT in skin wound healing. | Zengjun Yang Xiaohong Hu Lina Zhou Yaxiong He Xiaorong Zhang Jiacai Yang Zhenyu Ju Yih-Cherng Liou Han-Ming Shen Gaoxing Luo Michael R.Hamblin Weifeng He Rui Yin | 2021 | Burns & Trauma2021，9，1： | 3 |
| 8 | Transferrin plays a central role in coagulation balance by interacting with clotting factors显示文摘Coagulation balance is maintained through fine-tuned interactions among clotting factors,whose physiological concentrations vary substantially.In particular,the concentrations of coagulation proteases(pM to nM)are much lower than their natural inactivator antithrombin(AT,〜3μM),suggesting the existence of other coordinators.In the current study,we found that transferrin(norm plasma concentration〜40 μM)interacts with fibrinogen,thrombin,factor Xlla(FXlla),and AT with different affinity to maintain coagulation balance.Normally,transferrin is sequestered by binding with fibrinogen(normal plasma concentration〜10 μM)at a molar ratio of 4:1.In atherosclerosis,abnormally up-regulated transferrin interacts with and potentiates thrombin/FXlla and blocks ATs inactivation effect on coagulation proteases by binding to AT,thus inducing hypercoagulability.In the mouse model,transferrin overexpression aggravated atherosclerosis,whereas transferrin inhibition via shRNA knockdown or treatment with antitransferrin antibody or designed peptides interfering with transferrin-thrombin/FXlla interactions alleviated atherosclerosis.Collectively,these findings identify that transferrin is an important clotting regulator and an adjuster in the maintenance of coagulation balance and modifies the coagulation cascade. | Xiaopeng Tang Zhiye Zhang Mingqian Fang Yajun Han Gan Wang Sheng Wang Min Xue Yaxiong Li Li Zhang Jian Wu Biqing Yang James Mwangi Qiumin Lu Xiaoping Du Ren Lai | 2020 | Cell Research2020，30，2： | 2 |
| 9 | Novel human H7N9 influenza virus in China显示文摘Outbreaks of H7N9 avian influenza in humans in 5 provinces and 2 municipalities of China have reawakened concern that avian influenza viruses may again cross species barriers to infect the human population and thereby initiate a new influenza pandemic.Evolutionary analysis shows that human H7N9 influenza viruses originated from the H9N2,H7N3 and H11N9 avian viruses,and that it is as a novel reassortment influenza virus.This article reviews current knowledge on 11 subtypes of influenza A virus from human which can cause human infections. | Chengmin WANG Jing LUO Jing WANG Wen SU Shanshan GAO Min ZHANG Li XIE Hua DING Shelan LIU Xiaodong LIU Yu CHEN Yaxiong JIA Hongxuan HE | 2014 | Integrative Zoology2014，9，3： | 2 |
| 10 | Effect of pore size on CH4/N2 separation using activated carbon显示文摘In this paper,a model of activated carbon was established by molecular simulation and the separation performance of N2 and CH4 on activated carbon was studied.In order to evaluate the adsorption selectivity and diffusion selectivity of N2 and CH4,Grand Canonical Monte Carlo and molecular dynamic methods were used to obtain equilibrium adsorption isotherms and mean square displacements of N2 and CH4 on activated carbon with different pore sizes.Research results showed that the difference in adsorption isosteric heat of N2 and CH4 at the pore size of 0.46 nm is the largest,which is 5.759 and 7.03 kcal·mol^-1(1 cal=4.184 J),respectively.Activated carbon with pore size of 0.46 nm has the best N2 and CH4 adsorption selectivity,while its diffusion selectivity is not obvious. | Gaofei Chen Yaxiong An Yuanhui Shen Yayan Wang Zhongli Tang Bo Lu Donghui Zhang | 2020 | Chinese Journal of Chemical Engineering2020，28，4： | 2 |
| 11 | Which is false: Oxaliplatin or fluoropyrimidine? An analysis of patients with KRAS wild‐type metastatic colorectal cancer treated with first‐line epidermal growth factor receptor monoclonal antibody显示文摘 | Feng Wen Ruilei Tang Yaxiong Sang Meng Li Qiancheng Hu Zedong Du Yi Zhou Pengfei Zhang Xiaofeng He Qiu Li | 2013 | Cancer Sci2013，，10： | 2 |
| 12 | Aqueous Zn-MnO_(2) battery: Approaching the energy storage limit with deep Zn^(2+) pre-intercalation and revealing the ions insertion/extraction mechanisms显示文摘Rechargeable aqueous zinc ion batteries(AZIBs)were considered as one of the most promising candidates for large-scale energy storage due to the merits of high safety and inexpensiveness.As AZIBs cathode material,Mn O_(2)possesses great merits but was greatly hindered due to the sluggish diffusion kinetic of Zn^(2+) during electrochemical operations.Herein,deep Zn^(2+) ions intercalatedδ-Mn O_(2)(Zn-Mn O_(2))was achieved by the in situ electrochemical deposition route,which significantly enhanced the diffusion ability of Zn^(2+) due to the synergistic effects of Zn^(2+) pillars and structural H;O.The resultant Zn-Mn O_(2)based AZIBs delivers a record capacity of 696 m Ah/g(0.5 m Ah/cm^(2))based on the initial mass loading,which is approaching the theoretical capacity of Mn O_(2)with a two-electrons reaction.In-situ Raman studies reveal highly reversible Zn^(2+)ions insertion/extraction behaviors and here the Zn-Mn O_(2)plays the role of a container during the charge–discharge process.Further charge storage mechanism investigations point out the insertion/extraction of Zn^(2+) and H^(+) coincides,and such process is significantly facilitated results from superior interlayered configurations of Zn-Mn O_(2)The excellent electrochemical performance of Zn-Mn O_(2)achieved in this work suggests the deep ions pre-intercalation strategy may aid in the future development of advanced cathodes for AZIBs. | Yaxiong Zhang Xiaosha Cui Yupeng Liu Situo Cheng Peng Cui Yin Wu Zhenheng Sun Zhipeng Shao Jiecai Fu Erqing Xie | 2022 | Journal of Energy Chemistry2022，31，4： | 2 |
| 13 | Improved filtered mesoscale interphase heat transfer model显示文摘Mesoscale structures that form in gas-solid flows considerably affect interphase heat transfer.A filtered interphase heat transfer model accounts for the effects of unresolved mesoscale structures is required in coarse-grid simulations.In the literature,researchers obtain the filtered interphase heat transfer coefficient using a correction(Q)to the microscopic interphase heat transfer coefficient.Available models are based on filtered data in the range 01 is non-negligible.This percentage can reach approximately 20%when the dimensionless filter size is smaller than 1.028(66.7×the particle diameter).We proposed an improved filtered interphase heat transfer model by considering the data in the range Q<0 and Q>1.We evaluated the predictive power of our model in an a priori test.Our model has much better performance than other models when the dimensionless filter size△<8.222. | Yu Li Yaxiong Yu Chi Zhang Zheqing Huang Qiang Zhou | 2021 | Particuology2021，19，4： | 1 |
| 14 | An improved QSPR method based on support vector machine applying rational sample data selection and genetic algorithm-controlled training parameters optimization显示文摘 | Zhang Yaxiong | 2014 | Chemometrics and Intelligent Laboratory Systems2014，134，： | 1 |
| 15 | Impact of Smoking Status on EGFR-TKI Efficacy for Advanced Non–Small-Cell Lung Cancer in EGFR Mutants: A Meta-analysis显示文摘 | Yaxiong Zhang Shiyang Kang Wenfeng Fang Shaodong Hong Wenhua Liang Yue Yan Tao Qin Yanna Tang Jin Sheng Li Zhang | 2014 | Clinical Lung Cancer2014，，： | 1 |
| 16 | High-performance magnesium ion asymmetric Ppy@FeOOH//Mn3O4 micro-supercapacitor显示文摘Micro-supercapacitors(MSCs)are attractive electrochemical energy storage devices owing to their high power density and extended cycling stability.However,relatively low areal energy density still hinders their practical applications.Here,an asymmetric Mg ion MSC with promising high energy density is fabricated.Firstly,indium tin oxide(ITO)NWs were synthesized by chemical vapor deposition as the excellent current collector.Subsequently,nanostructured Mn_(3)O_(4)and Ppy@FeOOH were deposited on the laser-engraved interdigital structure ITO NWs electrodes as the positive and negative electrodes,respectively.Beneficial from the hierarchical micro-nano structures of active materials,high conductive electron transport pathways,and charge-balanced asymmetric electrodes,the obtained MSC possesses a high potential window of 2.2 V and a high areal capacitance of 107.3 mF cm^(-2)at 0.2 mA cm^(-2).The insitu XRD,VSM,and ex-situ XPS results reveal that the primary energy storage mechanism of Mg ions in negative FeOOH electrode is Mg ions de-/intercalation and phase transition reaction of FeOOH.Furthermore,the MSC exhibits a high specific energy density of 71.18μWh cm^(-2)at a power density of 0.22 mWh cm^(-2)and capacitance retention of 85%after 5000 cycles with unvaried Coulombic efficiency.These results suggest promising applications of our MSC in miniaturized energy storage devices. | Xueliang Lv Yaxiong Zhang Xijuan Li Zhiye Fan Guo Liu Wenjian Zhang Jinyuan Zhou Erqing Xie Zhenxing Zhang | 2022 | Journal of Energy Chemistry2022，31，9： | 1 |
| 17 | SJES14110700479122显示文摘 | Song Wang Tingting Zheng Ming Xie Yaxiong Wang Jiming Zhang | 2014 | Rare Metal Materials and Engineering2014，，4： | 1 |
| 18 | Artificial neural networks based on genetic input selection for quantification in overlapped capillary electrophoresis peaks显示文摘 | ZHANG Yaxiong LI Hua HOU Aixia | 2005 | Talanta2005，65，： | 1 |
| 19 | Patientswith exon 19 deletion were associated with longer pro-gression-free survival compared to those with L858H mu-tation after first-line EGFR-TKIs for advanced non-smallcell lung cancer: a meta-analysis 显示文摘 | Zhang Yaxiong Sheng Jin Zhang Li | 2014 | PLoS One2014，9，07： | 1 |
| 20 | Aberrant activation of Wnt/13-catenin signaling pathway contributes to the sequential progression of DMBA-induced HBP carcinomas显示文摘 | David Yee Yaxiong Tang Zhang boLiu | 2012 | Oral Oncology2012，48，1： | 1 |
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