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| 1 | Permian Alkaline Granites in Central Inner Mongolia and Their Geodynamic Significance显示文摘Alkaline granites (Rb-Sr ages 276-286 Ma)occurring in the Bayan Ul-East Ujimqin belt at the southern margin of the Siberian plate originated in a tensional tectonic environment about 60 Ma earlier than the Late Devonian to Early Carboniferous collision between the Siberian and Sino-Korean plates. They belong to post-orogenic A-type granites and may be used as an indicator of the end of the orogeny. At the northern margin of the Sino-Korean plate, however, only late-orogenic calc-alkaline granites occurred during the late Caboniferous-Permian, and alkaline syenites did not appear until the Late Triassic. The asymmetric magmatism at the margins of the two neighbouring plates might be controlled by the differences in size and mass of the two plates. | Hong Dawei, Huang Huaizeng, Lithosphere Research Center, Chinese Academy of Geological Sciences, BeijingXiao Yijun, Institute of Geology, Chinese Academy of Geological Sciences, BeijingXu Haiming,Institute of Mineral Deposits, Chinese Academy of Geological Sciences, Beijingand Jin M anyuanTianjin Geological Academy, Ministry of Metallurgical Industry, Tianjin Fei Zhenbi | 1995 | Acta Geologica Sinica(English Edition)1995，69，1： | 40 |
| 2 | BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders显示文摘Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey embryos. These monkeys showed higher nocturnal locomotion and reduced sleep, which was further exacerbated by a constant light regimen. Physiological circadian disruption was reflected by the markedly dampened and arrhythmic blood hormonal levels. Furthermore, BMAL1-deficient monkeys exhibited anxiety and depression, consistent with their stably elevated blood cortisol, and defective sensory processing in auditory oddball tests found in schizophrenia patients. Ablation of BMAL1 up-regulated transcriptional programs toward inflammatory and stress responses, with transcription networks associated with human sleep deprivation, major depressive disorders, and aging. Thus, BMAL1 knockout monkeys are potentially useful for studying the physiological consequences of circadian disturbance, and for developing therapies for circadian and psychiatric disorders. | Peiyuan Qiu Jian Jiang Zhen Liu Yijun Cai Tao Huang Yan Wang Qiming Liu Yanhong Nie Fang Liu Jiumu Cheng Qing Li Yun-Chi Tang Mu-ming Poo Qiang Sun Hung-Chun Chang | 2019 | National Science Review2019，6，1： | 21 |
| 3 | Low-frequency E-field Detection Array(LFEDA)-Construction and preliminary results显示文摘In recent years, locating total lightning at the VLF/LF band has become one of the most important directions in lightning detection. The Low-frequency E-field Detection Array(LFEDA) consisting of nine fast antennas was developed by the Chinese Academy of Meteorological Sciences in Guangzhou between 2014 and 2015. This paper documents the composition of the LFEDA and a lightning-locating algorithm that applies to the low-frequency electric field radiated by lightning pulse discharge events(LPDEs). Theoretical simulation and objective assessment of the accuracy and detection efficiency of LFEDA have been done using Monte Carlo simulation and artificial triggered lightning experiment, respectively. The former results show that having a station in the network with a comparatively long baseline improves both the horizontal location accuracy in the direction perpendicular to the baseline and the vertical location accuracy along the baseline. The latter results show that detection efficiencies for triggered lightning flashes and return strokes are 100% and 95%, respectively. The average planar location error for return strokes of triggered lightning flashes is 102 m. By locating LPDEs in thunderstorms, we find that LPDEs are consistent with convective regions as indicated by strong reflectivity columns, and present a reasonable distribution in the vertical direction.In addition, the LFEDA can reveal an image of lightning development through mapping the channels of lightning. Based on three-dimensional locations, the vertical propagation speed of the preliminary breakdown and the changing trend of the leader's speed in an intra-cloud and a cloud-to-ground flash are investigated. The research results show that the LFEDA has the capability for three-dimensional location of lightning, which provides a new technique for researching lightning development characteristics and thunderstorm electricity. | SHI DongDong ZHENG Dong ZHANG Yang ZHANG YiJun HUANG ZhiGang LU WeiTao CHEN ShaoDong YAN Xu | 2017 | Science China Earth Sciences2017，60，10： | 10 |
| 4 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 5 | Nanolubricant additives: A review显示文摘Using nanoadditives in lubricants is one of the most effective ways to control friction and wear,which is of great significance for energy conservation,emission reduction,and environmental protection.With the scientific and technological development,great advances have been made in nanolubricant additives in the scientific research and industrial applications.This review summarizes the categories of nanolubricant additives and illustrates the tribological properties of these additives.Based on the component elements of nanomaterials,nanolubricant additives can be divided into three types:nanometal-based,nanocarbon-based,and nanocomposite-based additives.The dispersion stabilities of additives in lubricants are also discussed in the review systematically.Various affecting factors and effective dispersion methods have been investigated in detail.Moreover,the review summarizes the lubrication mechanisms of nanolubricant additives including tribofilm formation,micro-bearing effect,self-repair performance,and synergistic effect.In addition,the challenges and prospects of nanolubricant additives are proposed,which guides the design and synthesis of novel additives with significant lubrication and antiwear properties in the future. | Jun ZHAO Yiyao HUANG Yongyong HE Yijun SHI | 2021 | Friction2021，9，5： | 9 |
| 6 | Fast multipole boundary element analysis of 2D viscoelastic composites with imperfect interfaces显示文摘A fast multipole boundary element method(FMBEM)is developed for the analysis of 2D linear viscoelastic composites with imperfect viscoelastic interfaces.The transformed fast multipole formulations are established using the time domain method. To simulate the viscoelastic behavior of imperfect interfaces that are frequently encountered in practice,the Kelvin type model is introduced.The FMBEM is further improved by incorporating naturally the interaction among inclusions as well as eliminating the phenomenon of material penetration.Since all the integrals are evaluated analytically,high accuracy and fast convergence of the numerical scheme are obtained.Several numerical examples,including planar viscoelastic composites with a single inclusion or randomly distributed multi-inclusions are presented.The numerical results are compared with the developed analytical solutions,which illustrates that the proposed FMBEM is very efficient in determining the macroscopic viscoelastic behavior of the particle-reinforced composites with the presence of imperfect interfaces.The laboratory measurements of the mixture creep compliance of asphalt concrete are also compared with the prediction by the developed model. | ZHU XingYi 1 ,CHEN WeiQiu 2 ,HUANG ZhiYi 1* &LIU YiJun 3 1 Department of Civil Engineering,Zhejiang University,Zijingang Campus,Hangzhou 310058,China 2 Department of Engineering Mechanics,Zhejiang University,Yuquan Campus,Hangzhou 310027,China 3Department of Mechanical Engineering,University of Cincinnati,Cincinnati,Ohio 45221-0072,USA | 2010 | Science China(Technological Sciences)2010，53，8： | 7 |
| 7 | Proteomic analysis of long-term salinity stress-responsive proteins in Thellungiella halophila leaves显示文摘Salinity is one of the most severe environmental factors that may impair crop productivity. A proteomic study based on two-dimensional gel electrophoresis is performed in order to analyze the long-term salinity stress response of Thellungiella halophila, an Arabidopsis-related halophyte. Four-week-old seedlings are exposed to long-term salinity treatment. The total crude proteins are extracted from leaf blades, separated by 2-DE, stained with Coomassie Brilliant Blue, and differentially displayed spots are identified by MALDI-TOF MS or QTOF MS/MS. Among 900 protein spots reproducibly detected on each gel, 30 spots exhibit significant change and some of them are identified. The identified proteins include not only some previously characterized stress-responsive proteins such as TIR-NBS-LRR class disease resistance protein, ferritin-1, and pathogenesis-related protein 5, but also some proteins related to energy pathway, metabolism, RNA processing and protein degradation, as well as proteins with unknown functions. The possible functions of these proteins in salinity tolerance of T. halophila are discussed and it is suggested that the long-term salinity tolerance of T. halophila is achieved, at least partly, by enhancing defense system, adjusting energy and metabolic pathway and maintaining RNA structure. | GAO Fei ZHOU YiJun HUANG LingYun HE DaChengt ZHANG GenFa | 2008 | Chinese Science Bulletin2008，53，22： | 6 |
| 8 | A reappraisal of the relationship between metatarsus adductus and hallux valgus显示文摘 | Chen Li Wang Chen Wang Xu Huang Jiazhang Zhang Chao Zhang Yijun Ma Xin | 2014 | Chinese Medical Journal2014，，11： | 4 |
| 9 | Numerical simulation of 23 June 2016 Yancheng City EF4 tornadic supercell and analysis of lightning activity显示文摘Based on the Weather Research Forecasting(WRF) model that features charging and discharging parameterization,relationships between tornado, hail and lightning were investigated for a tornado-producing(EF4 intensity) supercell thunderstorm over Yancheng City in Jiangsu Province, China, on 23 June 2016. Based on a sounding at 0800, there was a low lifting condensation level, substantial convective available potential energy(CAPE), and strong vertical wind shear near Yancheng City, which promote supercell development. At 1400, observations revealed that hail production and a dramatic increase of positive cloud-to-ground flash rates occurred simultaneously, maximizing five minutes later. The tornado occurred 30 min after the hail production. The time of minimum positive cloud-to-ground flash rates was 15 min later. The simulation indicated that the tornadic supercell moved eastward and that positive cloud-to-ground flash rates increased dramatically at 1400, the same as observed, but their maximum was 5 min later than observed. The simulated updraft volume peaked at 1425 and the simulated downdraft volume maximized5 min later, when the mesocyclone formed. Simulated reflectivities showed no hook echo and horizontal winds for different height at mid-low levels had a different cyclonic shear at 1430, favorable to mesocyclone formation. Based on the simulated results,the region of positively charged graupel ascended resulting from the region of high liquid water content was lifted by the strong updraft, forming a mid-level strong positive charge region. A lower negative charge region formed by the inductive charging mechanism of collisions between graupel and droplets at the bottom of the cloud, conducive to positive cloud-to-ground flashes. | GUO FengXia LI Yang HUANG ZhaoChu WANG ManFei ZENG FanHui LIAN ChunHao MU YiJun | 2017 | Science China Earth Sciences2017，60，12： | 3 |
| 10 | Nanovilli electrode boosts hydrogen evolution:A surface with superaerophobicity and superhydrophilicity显示文摘Although tremendous efforts have been paid on electrocatalysts toward efficient electrochemical hydrogen generation,breakthrough is still highly needed in the design and synthesis of wonderful non-precious-metal electrocatalyst.Herein,a nanovilli Ni2P electrode,which with superaerophobic and superhydropholic can significantly facilitate the mass and electron transfer was constructed via a facial morphology control strategy.Meanwhile,the substitution of sluggish oxygen evolution with urea oxidation,lowering the two-electrode cell voltage to only 1.48 volts to achieve a current density of 10 mA·cm^(-2).Thus,the as-constructed electrode achieves the operation of hydrogen generation by an AA battery.This work sheds new light on the exploration of other high-efficient electrocatalysts for hydrogen generation by using intermittent clean energy. | Yijun Yin Yan Tan Qiuyuan Wei Shucong Zhang Siqi Wu Qin Huang Feilong Hu Yan Mi | 2021 | Nano Research2021，14，4： | 3 |
| 11 | A Physical Layer Algorithm for Estimation of Number of Tags in UHF RFID Anti-Collision Design显示文摘A priori knowledge of the number of tags is crucial for anti-collision protocols in slotted UHF RFID systems.The number of tags is used to decide optimal frame length in dynamic frame slotted ALOHA(DFSA)and to adjust access probability in random access protocols.Conventional researches estimate the number of tags in MAC layer based on statistics of empty slots,collided slots and successful slots.Usually,a collision detection algorithm is employed to determine types of time slots.Only three types are distinguished because of lack of ability to detect the number of tags in single time slot.In this paper,a physical layer algorithm is proposed to detect the number of tags in a collided slot.Mean shift algorithm is utilized,and some properties of backscatter signals are investigated.Simulation results verify the effectiveness of the proposed solution in terms of low estimation error with a high SNR range,outperforming the existing MAC layer approaches. | Zhong Huang Jian Su Guangjun Wen Wenxian Zheng Chu Chu Yijun Zhang Yibo Zhang | 2019 | Computers, Materials & Continua2019，，7： | 2 |
| 12 | The decay kinetics of residual chlorine in cooling seawater simulation experiments显示文摘To find out the decay character of residual chlorine (RC) in the sea water, the concentration of RC was analyzed by N, N-diethyl-p-phenylenediamine (DPD) method under different simulation experimental conditions, in which salinity, temperature, and Chemical Oxygen Demand (COD) were selected. The water used in the experiment was the mixture of aging ocean water, coastal water and extracting solution of coastal sediment at appropriate level. Results are shown as follows: (1) Piecewise function can well reffect the decay dynamics of RC in the cooling seawater. Concretely, the decay dynamics of first 1 min is too rapid to ascertain using a specific kinetic function, and that of the time from 1 to 30 min is fit for the first-order kinetic model. (2) The results could be the foundation of the chemical behavior of RC in seawater, and be used as not only the guidance of the coastal power plants production and sea water desalting companies, but also the establishment of the correlative trade standard. | ZENG Jiangning JIANG Zhibing CHEN Quanzhen ZHENG Ping HUANG Yijun | 2009 | Acta Oceanologica Sinica2009，28，2： | 2 |
| 13 | Biochar-based slow-release of fertilizers for sustainable agriculture:A mini review显示文摘Increasing global population and decreasing arable land pose tremendous pressures to agricultural production.The application of conventional chemical fertilizers improves agricultural production,but causes serious environmental problems and significant economic burdens.Biochar gains increasing interest as a soil amendment.Recently,more and more attentions have been paid to biochar-based slowrelease of fertilizers(SRFs)due to the unique properties of biochar.This review summarizes recent advances in the development,synthesis,application,and tentative mechanism of biochar-based SRFs.The development mainly undergoes three stages:(i)soil amendment using biochar,(ii)interactions between nutrients and biochar,and(iii)biochar-based SRFs.Various methods are proposed to improve the fertilizer efficiency of biochar,majorly including in-situ pyrolysis,co-pyrolysis,impregnation,encapsulation,and granulation.Considering the distinct features of different methods,the integrated methods are promising for fabricating effective biochar-based SRFs.The in-depth understanding of the mechanism of nutrient loading and slow release is discussed based on current knowledge.Additionally,the perspectives and challenges of the potential application of biochar-based SRFs are described.Knowledge surveyed from this review indicates that applying biochar-based SRFs is a viable way of promoting sustainable agriculture. | Chongqing Wang Dan Luo Xue Zhang Rong Huang Yijun Cao Gonggang Liu Yingshuang Zhang Hui Wang | 2022 | Environmental Science and Ecotechnology2022，，2： | 2 |
| 14 | Simultaneous determination of four Sudan dyes in rat blood by UFLC–MS/MS and its application to a pharmacokinetic study in rats显示文摘A rapid and sensitive method based on ultrafast liquid chromatography–tandem mass spectrometry was developed and validated for simultaneous determination of Sudan I, Sudan II, Sudan III, and Sudan IV levels in rat whole blood. Cleanert C18 mixed-mode polymeric sorbent was used for effective solid-phase extraction cleanup. Separation was carried out on a reversed-phase C18column(100 mm 2.1 mm,1.8 μm) using 0.1%(v/v) formic acid in water/0.1%(v/v) formic acid in acetonitrile as the mobile phase in gradient elution. Quanti fi cation was performed by an electrospray ionization source in the positive multiple reaction monitoring mode using D5-Sudan I as the internal standard. Calibration curves showed good linearity between 0.2 and 20.0 μg/L, with correlation coef fi cients higher than 0.9990. The average recovery rates were between 93.05% and 114.98%. The intra- and inter-day relative standard deviations were within 6.2%. The lower limit of quanti fi cation was 0.2 μg/L. All the analytes were found to be stable in a series of stability studies. The proposed method was successfully applied to a pharmacokinetic study of four Sudan dyes after oral administration to rats. | Hao Zhu Yijun Chen Changshun Huang Yangyang Han Yiwei Zhang Shucan Xie Xiaohong Chen Micong Jin | 2015 | Journal of Pharmaceutical Analysis2015，5，4： | 1 |
| 15 | FXR ligands protect against hepatocellular inflammation via SOCS3 induction显示文摘 | Zhizhen Xu Gang Huang Wei Gong Peng Zhou Yuanyin Zhao Yan Zhang Yijun Zeng Min Gao Zhisheng Pan Fengtian He | 2012 | Cellular Signalling2012，，8： | 1 |
| 16 | Let-7 regulates self renewal and tumorigenicity of breast cancer cells 显示文摘 | Fengyan Yu Herui Yao Pengcheng Zhu Xiaoqin Zhang Qiuhui Pan Chang Gong Yijun Huang Xiaoqu Hu Fengxi Su Judy Lieberman and Erwei Song | 2007 | Cell 20072007，，： | 1 |
| 17 | Thermal properties of an epoxy cresol-formaldehyde novolac/diaminodiphenyl sulfone system modified by bismaleimide containing tetramethylbiphenyl and aromatic ether structures显示文摘 | Zhou Boxuan Huang Yijun Zhang Xinghong | 2009 | Polymer Engineering&Science2009，49，8： | 1 |
| 18 | Insight into the microstructural evolution of anthracite during carbonization-graphitization process from the perspective of materialization显示文摘Materialization of coal is one of effective and clean pathways for its utilization. The microstructures of coal-based carbon materials have an important influence on their functional applications. Herein, the microstructural evolution of anthracite in the temperature range of 1000–2800 ℃ was systematically investigated to provide a guidance for the microstructural regulation of coal-based carbon materials.The results indicate that the microstructure of anthracite undergoes an important change during carbonization-graphitization process. As the temperature increases, aromatic layers in anthracite gradually transform into disordered graphite microcrystals and further grow into ordered graphite microcrystals, and then ordered graphite microcrystals are laterally linked to form pseudo-graphite phase and eventually transformed into highly ordered graphite-like sheets. In particular, 2000–2200 ℃ is a critical temperature region for the qualitative change of ordered graphite crystallites to pseudo-graphite phase,in which the relevant structural parameters including stacking height, crystallite lateral size and graphitization degree show a rapid increase. Moreover, both aromaticity and graphitization degree have a linear positive correlation with carbonization-graphitization temperature in a specific temperature range.Besides, after initial carbonization, some defect structures in anthracite such as aliphatic carbon and oxygen-containing functional groups are released in the form of gaseous low-molecular volatiles along with an increased pore structure, and the intermediates derived from minerals could facilitate the conversion of sp^(3) amorphous carbon to sp^(2) graphitic carbon. This work provides a valuable reference for the rational design of microstructure of coal-based carbon materials. | Huihui Zeng Baolin Xing Yijun Cao Bing Xu Lei Hou Hui Guo Song Cheng Guangxu Huang Chuanxiang Zhang Qi Sun | 2022 | International Journal of Mining Science and Technology2022，32，6： | 1 |
| 19 | Stem-like Cancer Cells Are Inducible by Increasing Genomic Instability in Cancer CeUs显示文摘 | Yi Liang Zhendong Zhong Yijun Huang | 2010 | J Biol Chem2010，285，7： | 1 |
| 20 | Potential prebiotic effects of nonabsorptive components of Keemun and Dianhong black tea:an in vitro study显示文摘Black tea is a healthy and popular tea beverage.However,its main bioactive compounds(theaflavins and thearubigins)are not easily absorbed.The aim of this study was to investigate the modulation of intestinal microbiota by the nonabsorptive components of Keemun black tea(KBT)and Dianhong black tea(DBT),and fructooligosaccharide(FOS)was selected for use in the control group.KBT,DBT,and FOS significantly increased total short-chain acid production.Specifically,FOS treatment predominantly increased the production of acetic acids and black tea treatments increased the production of acetic,propionic,and butyric acids at similar rates.Moreover,FOS exerted a strong bifidogenic effect after 24 h of fermentation;KBT and DBT increased the abundance of the beneficial genus Bacteroides and Roseburia.In summary,the nonabsorptive components of KBT and DBT could serve as novel prebiotics,the underlying mechanisms of which are quite different from those of FOS. | Wenjing Liao Wenjiao Li Suyu Liu Dong Tang Yunxi Chen Yijun Wang Zhongwen Xie Jinbao Huang | 2022 | Food Science and Human Wellness2022，11，3： | 1 |
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