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| 1 | Effects of Yishengukang decoction on expression of bone-specific alkaline phosphatase,carboxyterminal propeptide of typeⅠprocollagen,and carboxyterminal cross-linked telepeptide of typeⅠcollagen in malignant tumor patients with bone metastasis显示文摘OBJECTIVE: To investigate the effect of Yishengukang decoction on the expression of the metabolic bone markers, bone-specific alkaline phosphatase(BAP), carboxyterminal propeptide of type Ⅰ procollagen(PICP), and carboxyterminal cross-linked telepeptide of type Ⅰ collagen(ICTP), in cancer patients with bone metastasis.METHODS: Patients(n = 180) were divided into three groups:(a) bone metastasis patients treated with Yishengukang and pamidronate disodium injection(treatment group, n = 60);(b) bone metastasis patients treated with pamidronate disodium injection alone(control group, n = 60);(c) cancer patients without metastatic bone lesion(non-bone metastasis group, n = 60). Serum levels of the metabolic markers BAP, PICP, and ICTP were detected by enzyme-linked immunosorbent assay pre- and post-therapy.RESULTS: A significant decrease in serum BAP level was observed in the treatment group compared with the control group. However there were no significant differences in serum levels of PICP and ICTP before or after treatment compared with the control group.CONCLUSION: Yishengukang decoction combined with pamidronate disodium injection reduced serum BAP level to a greater extent that pamidronate disodium injection alone. Furthermore, the combined therapy was more beneficial in regulating imbalanced bone metabolism after bone metastasis,and may represent the molecular mechanism underpinning the effects of Yishengukang decoction. | Yin Yukun Feng Li Zhou Lei Li Jie Gao Yin Wang Ningjun Yu Jianhua Jiang Zhenglong He Shengqi Lu Dianrong Wang Fang Du Yanlin | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 6 |
| 2 | Plant diversity-productivity patterns in the alpine steppe environment of the Central Tianshan Mountains显示文摘The biodiversity-productivity relationship is an important topic in the research of bio- diversity and ecosystem function. The plant diversity-productivity pattern is commonly unimodal and positively correlated. This paper researches the characteristics of plant diversity-productivity patterns in the Bayanbuluk alpine steppe in the central Tianshan Mountains, Xinjiang, China, and analyzes the effects of environmental factors on the distribution of plant communities, species composition, plant diversity and productivity in the steppe. The results show a positive correlation between plant diversity and productivity. DCCA (detrended canonical correspondence analysis) ordination reveals a significant relationship between the effects of air temperature, soil moisture content, available soil nitrogen, relative humidity and pH value on the distribution and composition of plant communities. There are significant correlations between the soil moisture content, relative humidity, pH value, air temperature and species richness and the aboveground biomass of Gramineae and Cyperaceae, and also significant correlations between the relative humidity, pH values and the total aboveground biomass of plant communities. | Hu, YuKun Li, KaiHui Gong, YanMing Yin, Wei | 2009 | Journal of Arid Land2009，1，1： | 3 |
| 3 | Interface electronic engineering of molybdenum sulfide/MXene hybrids for highly efficient biomimetic sensors显示文摘Interface regulation plays a key role in the electrochemical performance for biosensors.By controlling the interfacial interaction,the electronic structure of active species can be adjusted effectively at micro and nano-level,which results in the optimal reaction energy barrier.Herein,we propose an interface electronic engineering scheme to design a strongly coupled 1T phase molybdenum sulfide(1T-MoS2)/MXene hybrids for constructing an efficient electrocatalytic biomimetic sensor.The local electronic and atomic structures of the 1T-MoS2/Ti3C2TX are comprehensively studied by synchrotron radiation-based X-ray photoelectron spectroscopy(XPS),as well as X-ray absorption spectroscopy(XAS)at atomic level.Experiments and theoretical calculations show that there are interfacial stresses,atomic defects and adjustable bond-length between MoS2/MXene nanosheets,which can significantly promote biomolecular adsorption and rapid electron transfer to achieve excellent electrochemical activity and reaction kinetics.The 1T-MoS2/Ti3C2TX modified electrode shows ultra high sensitivity of 1.198μA/μM for dopamine detection with low limit of 0.05μM.We anticipate that the interface electronic engineering investigation could provide a basic idea for guiding the exploration of advanced biosensors with high sensitivity and low detection limit. | Pengfei Wu Tingting You Qingyuan Ren Hongyan Xi Qingqing Liu Fengjuan Qin Hongfei Gu Yu Wang Wensheng Yan Yukun Gao Wenxing Chen Penggang Yin | 2023 | Nano Research2023，16，1： | 0 |
| 4 | Quantitative Characterization and Genesis Analysis of Complex Modals of Pore Structure in Alluvial-Fan Sandy Conglomerate Reservoirs显示文摘新疆油田冲积扇砂砾岩储层岩石类型多样,颗粒大小混杂,分选极差,储层孔隙结构具有典型的多种模态特征,即单模态、双模态与复模态等。利用铸体薄片、压汞、恒速压汞资料定量表征了七东1区砂砾岩储层复杂模态孔隙特征以及连通特征,利用多元回归分析法建立复杂模态孔隙结构储层的识别模型。以此为基础,分析了冲积扇砂砾岩储层孔隙结构复杂模态成因机制。研究表明:单模态储层主要以Ⅰ类储层为主,双模态储层以Ⅱ、Ⅲ类储层为主,复模态储层以Ⅲ类储层为主。从单模态类型到复模态孔喉组合类型,孔隙发育由好变差,由连通较好的网状到连通较差的星点状,面孔率降低,平均孔径减小,孔喉配位数减小。利用已有147块样品统计发现,七东1区下克拉玛依组储层中单模态储层占19%、双模态储层占48%、复模态储层占33%。由此提出不同模态判断标准,建立了储层孔隙结构预测模型,揭示了储层构型、成岩后作用及注水(聚)开发中后期的系列变化等多因素是导致形成复杂模态的原因。 | Senlin Yin Juan Chen Yukun Chen Xiaoguang Wang Xuzhuang Zhu | 2017 | 石油天然气学报2017，39，3： | 0 |
| 5 | LITTIP/Lgr6/HnRNPK complex regulates cementogenesis via Wnt signaling显示文摘Orthodontically induced tooth root resorption(OIRR)is a serious complication during orthodontic treatment.Stimulating cementum repair is the fundamental approach for the treatment of OIRR.Parathyroid hormone(PTH)might be a potential therapeutic agent for OIRR,but its effects still lack direct evidence,and the underlying mechanisms remain unclear.This study aims to explore the potential involvement of long noncoding RNAs(lncRNAs)in mediating the anabolic effects of intermittent PTH and contributing to cementum repair,as identifying lncRNA-disease associations can provide valuable insights for disease diagnosis and treatment.Here,we showed that intermittent PTH regulates cell proliferation and mineralization in immortalized murine cementoblast OCCM-30 via the regulation of the Wnt pathway.In vivo,daily administration of PTH is sufficient to accelerate root regeneration by locally inhibiting Wnt/β-catenin signaling.Through RNA microarray analysis,lncRNA LITTIP(LGR6 intergenic transcript under intermittent PTH)is identified as a key regulator of cementogenesis under intermittent PTH.Chromatin isolation by RNA purification(ChIRP)and RNA immunoprecipitation(RIP)assays revealed that LITTIP binds to mRNA of leucine-rich repeatcontaining G-protein coupled receptor 6(LGR6)and heterogeneous nuclear ribonucleoprotein K(HnRNPK)protein.Further cotransfection experiments confirmed that LITTIP plays a structural role in the formation of the LITTIP/Lgr6/HnRNPK complex.Moreover,LITTIP is able to promote the expression of LGR6 via the RNA-binding protein HnRNPK.Collectively,our results indicate that the intermittent PTH administration accelerates root regeneration via inhibiting Wnt pathway.The lncRNA LITTIP is identified to negatively regulate cementogenesis,which activates Wnt/β-catenin signaling via high expression of LGR6 promoted by HnRNPK. | Tiancheng Li Han Wang Yukun Jiang Shuo Chen Danyuan Huang Zuping Wu Xing Yin Chenchen Zhou Yuyu Li Shujuan Zou | 2023 | International Journal of Oral Science2023，15，3： | 0 |
| 6 | Architectural Model of a Dryland Gravel Braided River,based on 3D UAV Oblique Photogrammetric Data:A Case Study of West Dalongkou River in Eastern Xinjiang,China显示文摘Three-dimensional unmanned aerial vehicle(UAV)oblique photogrammetric data were used to infer mountainous gravel braided river lithofacies,lithofacies associations and architectural elements.Hierarchical architecture and lithofacies associations with detailed lithofacies characterizations were comprehensively described to document the architectural model,architectural element scale and gravel particle scale.(1)Nine lithofacies(i.e.,Gmm,Gcm,Gcc,Gci,Gcl,Ss,Sm,Fsm and Fl)were identified and classified as gravel,sand and fine matrix deposits.These are typical depositional features of a mountainous dryland gravel-braided river.(2)Three architectural elements were identified,including channel(CH),gravel bar(GB)and overbank(OB).CH can be further divided into flow channel and abandoned channel,while GB consists of Central Gravel bar(CGB)and Margin Gravel bar(MGB).(3)The gravel bar is the key architectural element of the gravel braided river,with its geological attributes.The dimensions of GBs and their particles are various,but exhibit good relationships with each other.The grain size of GB decreases downstream,but the dimensions of GB do not.The bank erosion affects the GB dimensions,whereas channel incision and water flow velocity influence the grain size of GB.The conclusions can be applied to the dryland gravel braided river studies in tectonically active areas. | YIN Senlin ZHU Baiyu GUO Haiping XU Zhenhua LI Xiaoshan WU Xiaojun CHEN Yukun JIANG Zhibin | 2023 | Acta Geologica Sinica(English Edition)2023，97，1： | 0 |
| 7 | Peroxidase-like single Fe atoms anchored on Ti_(3)C_(2)T_(x)MXene as surface enhanced Raman scattering substrate for the simultaneous discrimination of multiple antioxidants显示文摘Single-atom nanozymes(SAzymes)are emerging as promising alternatives to mimic natural enzyme,which is due to high atomic utilization efficiency,well-defined geometric,and unique electronic structure.Herein,Fe single atoms supported on Ti_(3)C_(2)T_(x)(Fe-SA/Ti_(3)C_(2)T_(x))with intrinsic peroxidase activity is developed,further constructing a sensitive Raman sensor array for sensing of five antioxidants.Fe-SA/Ti_(3)C_(2)T_(x)shows excellent peroxidase-like performance in catalyzing the oxidation of 3,3',5,5'-tetramethylbenzidine(TMB)with colorimetric reactions.X-ray adsorption fine structure(XAFS)reveals that the electron transport between the Ti_(3)C_(2)T_(x)and Fe atoms occurs along Fe-O-Ti ligands,meanwhile the density functional theory(DFT)calculations confirm the spontaneous dissociation of H_(2)O_(2)and the formation of OH radicals.Furthermore,the peroxidase-like Fe-SA/Ti_(3)C_(2)T_(x)was used as surface enhanced Raman scattering(SERS)substrate of oxidized TMB(TMB+)and achieved satisfied signal amplification performance.Using the blocking effects of free radical reactions,one-off identification of 5 antioxidants,including ascorbic acid(AA),uric acid(UA),glutathione(GSH),melatonin(Mel),and tea polyphenols(TPP),could be realized with this high identifiable catalytic property.This principle could realize 100%distinguish accuracy combined with linear discriminant analysis(LDA)and heat map data analysis.A wide detection concentration ranges from 10^(-8)to 10^(-3)M for five antioxidants was also achieved. | Hongyan Xi Hongfei Gu Yurui Han Tingting You Pengfei Wu Qingqing Liu Lirong Zheng Shuhu Liu Qiang Fu Wenxing Chen Yukun Gao Yuting Wang Penggang Yin | 2023 | Nano Research2023，16，7： | 0 |
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