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| 1 | Strength properties and evolution laws of cracked sandstone samples in re-loading tests显示文摘To study the strength properties and evolution laws of cracked sandstone samples in re-loading tests,strength and damage evolution properties of intact sandstone samples were first analyzed through the triaxial compression tests carried on TAW-2000 microcomputer control electro-hydraulic servo rock triaxial test system.Damage evolution models were established based on dilatancy properties realizing the real-time and quantitative evaluation of samples damage state in loading process.On this basis,samples with different damage were obtained by pre-peak,peak point,post-peak and residual strength stage unloading tests in the loading process of intact samples.The characteristics of the stress-strain curves and strength evolution laws were studied through the re-loading tests of samples with different damage under different stress states.The experimental results showed that the slope of stress-strain curves,peak strength and residual strength of cracked samples increased linearly with confining pressure and decreased linearly with damage.The equivalent cohesion decreased with damage in the exponential decay curves.The mechanics properties of samples transformed from strain softening to strain hardening with damage. | Yijiang Zong Lijun Han Qinbin Meng Yingchao Wang | 2020 | International Journal of Mining Science and Technology2020，30，2： | 3 |
| 2 | Short-term Effect of Hydroxyapatite Nanoparticles on Cancer Cells显示文摘 | Ingo W. Bauer Yingchao Han Shipu Li | 2006 | Journal of US-China Medical Science2006，3，3： | 3 |
| 3 | Effect of Hydroxyapatitc Nanoparticles on K562 Cells in vitro显示文摘稳定、分散单人赛的 hydroxyapatite (幸运) nanoparticles 与超声帮助方法被综合。幸运 nanoparticles 被动态轻散布, XRD (X 光检查衍射) 和 TEM (传播电子显微镜学) 描绘。K562 人的骨髓内产生的白血病房间线上的幸运 nanoparticles 的效果被 MTT 试金和房间计数测试调查,并且机制通过房间周期和超微结构的变化被学习。结果证明幸运 nanoparticles 在 vitro 戏剧性地禁止了 K562 房间的增长。幸运 nanoparticles 进入了 K562 房间的细胞质,这样,房间在 G2/M 阶段被逮捕房间直接死了。 | CHEN Pei DAI Honglian HAN Yingchao YIN Meizhen LI Shipu | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，2： | 2 |
| 4 | A New Type of Nanogel Carrier based on Mixed Pluronic Loaded with Low-Dose Antitumor Drugs显示文摘To design a new type of antitumor nanodrug carrier with good biocompatibility, a drug delivery system with a 2.19% drug-loading rate, measured by high-performance liquid chromatography(HPLC), was prepared by membrane hydration using a mixed polymer: Pluronic■ F-127, which binds folic acid(FA), Pluronic■ F-68 and triptolide(TPL)(FA-F-127/F-68-TPL). As a control, another drug delivery system based on a single polymer(FA-F-127-TPL) with a 1.90% drug-loading rate was prepared by substituting F-68 with F-127. The average particle sizes of FA-F-127/F-68-TPL and FA-F-127-TPL measured by a particle size analyzer were 30.7 nm and 31.6 nm, respectively. Their morphology was observed by atomic force microscopy(AFM). The results showed that FA-F-127-TPL self-assembled into nanomicelles, whereas FA-F-127/F-68-TPL self-assembled into nanogels. An MTT assay showed that a very low concentration of FA-F-127/F-68-TPL or FA-F-127-TPL could significantly inhibit the proliferation of multidrug-resistant(MDR) breast cancer cells(MCF-7/ADR cells) and induce cell death. The effects were significantly different from those of free TPL(P < 0.01). Using the fluorescent probe Nile red(Nr) as the drug model, FA-F-127/F-68-Nr nanogels and FAF-127-Nr nanomicelles were prepared and then incubated with human hepatocarcinoma(HepG2) and MCF-7/ADR cells, and the fluorescence intensity in the cells was measured by a multifunctional microplate reader. The results indicated that both FA-F-127/F-68-Nr and FA-F-127-Nr had sustained release in the cells, but HepG2 and MCF-7/ADR cells exhibited significantly higher endocytosis of FA-F-127/F-68-Nr than that of FA-F-127-Nr(P < 0.01). A nude mice transplanted tumor model was prepared to monitor FA-F-127/F-68-Nr in the tumor tissue and organs by whole-body fluorescent imaging. The results showed that FA-F-127/F-68-Nr targeted tumor tissues. The prepared nanogels had small particle size, were easy to swallow, exhibited slow release property,targeted tumor cells, and could improve the antitumor effects of TPL;hence, they are ideal carriers for low-dose antineoplastic drugs. | 尹美珍 SU Zhenhong CUI Bingcun HAN Yingchao DAI Honglian 喻昕 | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，4： | 2 |
| 5 | Synthesis and sintering of nanocrystalline hydroxyapatite powders by citric acid sol-gel combustion method显示文摘 | Han Yingchao Li Shipu Wang Xinyu | 2004 | Materials Research Bulletin2004，39，： | 1 |
| 6 | Flexible inorganic bioelectronics显示文摘Flexible inorganic bioelectronics represent a newly emerging and rapid developing research area.With its great power in enhancing the acquisition,management and utilization of health information,it is expected that these flexible and stretchable devices could underlie the new solutions to human health problems.Recent advances in this area including materials,devices,integrated systems and their biomedical applications indicate that through conformal and seamless contact with human body,the measurement becomes continuous and convenient with yields of higher quality data.This review covers recent progresses in flexible inorganic bio-electronics for human physiological parameters’monitoring in a wearable and continuous way.Strategies including materials,structures and device design are introduced with highlights toward the ability to solve remaining challenges in the measurement process.Advances in measuring bioelectrical signals,i.e.,the electrophysiological signals(including EEG,ECoG,ECG,and EMG),biophysical signals(including body temperature,strain,pressure,and acoustic signals)and biochemical signals(including sweat,glucose,and interstitial fluid)have been summarized.In the end,given the application property of this topic,the future research directions are outlooked. | Ying Chen Yingchao Zhang Ziwei Liang Yu Cao Zhiyuan Han Xue Feng | 2020 | npj Flexible Electronics2020，4，1： | 1 |
| 7 | Synthesis and Sintering of Nanocrystalline Hydroxyapatite Powders by Citric Acid Sol-gel Combustion Method显示文摘 | Han Yingchao Li Shipu Wang Xinyu | 2004 | Materials Research Bulletin2004，39，1： | 1 |
| 8 | Hyperbolic white noise functional solutions of Wick-type stochastic compound Kdv-Burgers equations显示文摘 | Han Xiu Xie Yingchao | 2009 | Chaos Solitions and Fractals2009，39，4： | 1 |
| 9 | Effects of the Interaction between Hydroxyapatite Nanoparticles and Hepatoma Cells显示文摘To gain a better understanding of the anticancer effects of hydroxyapatite(HAP) nanoparticles in vivo and in vitro, the effects of the interaction of HAP nanoparticles with hepatoma cells were explored. HAP nanoparticles were prepared by homogeneous precipitation and characterized by laser particle analysis and transmission electron microscopy(TEM). HAP nanoparticles were observed to be uniformly distributed, with rod-like shapes and diameters in the range of 42.1-87.1 nm. Overnight attached, suspended, and proliferating Bel-7402 cells were incubated with HAP nanoparticles. Inverted microscopy observation revealed that HAP nanoparticles with a cell membrane showed good adsorption. TEM demonstrated that HAP nanoparticles were present on the surface of cells, continuously taken up by cells through endocytosis, and transported in vesicles close to the nucleus. Fluorescence microscopy showed that the concentrations of intracellular Ca2+ labeled with Fluo-3 calcium fluorescent probe were significantly enhanced. In addition, inverted microscopy observation revealed that suspended cells treated with HAP nanoparticles did not adhere to the culture bottle, resulting in cell death. After the overnight attached cells were treated with HAP nanoparticles for 96 h with increasing doses of HAP nanoparticles, inverted microscopy observation revealed that cell proliferation was slowed and cell–cell adhesion was weakened. Feulgen staining and image analysis indicated that the nuclear DNA content of the cells was markedly reduced, and argyrophilic nucleolar organizer region(AgNOR) staining and image analysis indicated that the number of AgNORs was signifi cantly decreased. Therefore, hepatoma cells brought about the adsorption, uptake, transport and degradation of HAP nanoparticles. In addition, HAP nanoparticles affected hepatoma cells with regard to cell–cell adhesion, cell and extracellular matrix adhesion, and DNA and protein synthesis; thus inhibiting cell proliferation. This understanding of the effects of interaction between HAP nanoparticles and hepatoma cells is useful for further study of the anticancer mechanisms of HAP nanoparticles. | 尹美珍 XU Weiguo CUI Bingcun 戴红莲 HAN Yingchao YIN Yixia LI Shipu | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，3： | 1 |
| 10 | Evaluation of pharmaceutical activities of G-protein coupled receptor targeted pharmaceuticals in Chinese wastewater effluent显示文摘The occurre nce of biologically active pharmaceuticals in aquatic enviro nments raised the potential risks to aquatic species.Among these marketed biological active pharmaceuticals,it has been estimated that40%of them target G-protein-coupled receptors(GPCRs).We have illustrated pharmaceutical activities of GPCR targeted pharmaceuticals in English and Japanese wastewater by the in vitro transforming growth factor-α(TGFα)shedding assay.However,as the most important producer and consumer of pharmaceuticals,the occurrence of GPCR targeted pharmaceuticals in China had remained unclear.In this study,we investigated the pharmaceutical activities of GPCR targeted pharmaceuticals in secondary effluents of Chinese wastewater treatment plants.We discovered antagonistic activities against angiotensin(AT1)receptor at up to 7.2×102 ng-valsartan-equivalent quantity/L in Chinese wastewater for the first time as well as agonistic activities against dopamine(D2)receptor.Furthermore,in parallel with the assay,we determined concentrations of GPCR targeted pharmaceuticals in target wastewater by liquid chromatography coupled with tandem mass spectrometry(LC-MS/MS).Through the comparison of predicted antagonistic activities calculated by concentrations and potency values from the assay,we found that the measured antagonistic activities against AT1 receptor from the assay were higher than the predicted AT1 activities from valsartan,irbesartan,and losartan,indicating the potential existence of other unknown AT1 antagonists in wastewater. | Han Zhang Yingchao Lin Zhengyu Men Masaru Ihara Weizun Li Kai He | 2020 | Chinese Chemical Letters2020，31，10： | 1 |
| 11 | Synthesis and sintering of nanocrystallinehydroxyapatite powders by citric acid Sol-gel combustion method显示文摘 | Han Yingchao Li Shipu Wang Xinyu | 2004 | Materials ResearchBulletin2004，39，1： | 1 |
| 12 | 显示文摘 | Yin Meizhen Han Yingchao Ingo | 2006 | Biomedical Materials2006，1，： | 1 |
| 13 | Hyperbolic white noise functional solutions of Wick-type stochastic compound Kdv-Burgers equations显示文摘 | Han Xiu Xie Yingchao | | Chaos Solitions & Fractals0，，： | 1 |
| 14 | 显示文摘 | Han Yingchao Li Shipu Wang Xinyu | 2004 | Mater Res Bull2004，39，： | 1 |
| 15 | Visualizing the melting processes in ultrashort intense laser triggered gold mesh with high energy electron radiography显示文摘High-energy electron radiography(HEER)is a promising diagnostic tool for high-energy-density physics,as an alternative to tools such as X/γ-ray shadowgraphy and high-energy proton radiography.Impressive progress has been made in the development and application ofHEER in the past fewyears,and its potential for high-resolution imaging of static opaque objects has been proved.In this study,by taking advantage of the short pulse duration and tunable time structure of high-energy electron probes,time-resolved imaging measurements of high-energy-density gold irradiated by ultrashort intense laser pulses are performed.Phenomena at different time scales frompicoseconds to microseconds are observed,thus proving the feasibility of this technique for imaging of static and dynamic objects. | Zheng Zhou Yu Fang Han Chen Yipeng Wu Yingchao Du Zimin Zhang Yongtao Zhao Ming Li Chuanxiang Tang Wenhui Huang | 2019 | Matter and Radiation at Extremes2019，4，6： | 1 |
| 16 | Synthesis and luminescence of Eu 3+ doped hydroxyapatite nanocrystallines: Effects of calcinations and Eu 3+ content显示文摘 | Yingchao Han Xinyu Wang Honglian Dai Shipu Li | 2013 | Journal of Luminescence2013，，： | 1 |
| 17 | The influence of nano-apatite onc-myc andp53 gene in the hepatocellular carcinoma显示文摘 | Chen Jun Cao Xianying Li Shipu Han Yingchao Zhang Ran | 2005 | Journal of Wuhan University of Technology - Mater Sci Ed2005，，2： | 1 |
| 18 | 一种设计的抗癌多肽调控p53的两种翻译后修饰显示文摘文章简介蛋白质的翻译后修饰可能对蛋白质的表达和功能产生影响,同时也是重要的药物靶标。现有的方法通常只调控单一类型的翻译后修饰。本研究报道了一种同时调控两种翻译后修饰的多肽。 | 梁纶熙 王焕彬 Hubing Shi Zhaoli Li Han Yao Zhigao Bu Ningning Song Chushu Li Dabin Xiang Yao Zhang Jilin Wang Ye Hu Qi Xu Yanlei Ma Zhongyi Cheng Yingchao Wang Shuliang Zhao Jin Qian Yingxuan Chen Jing-Yuan Fang 许杰 | 2019 | 科学新闻2019，0，2： | 0 |
| 19 | 社交学习时嗅觉记忆中僧帽细胞依赖胰岛素样生长因子的突触可塑性显示文摘工作与资助文章简介在食物偏好的社交传递(STFP)中,小鼠能对社交伙伴带来的食物气味形成长时程记忆。传统观点认为,记忆的形成和维持发生在海马和大脑皮层。课题组应用分子遗传学和膜片钳电生理技术,发现小鼠的社交学习记忆依赖于嗅觉神经元释放的类胰岛素生长因子(IGF1)。 | Zhihui Liu Zijun Chen Congping Shang Fei Yan Yingchao Shi Jiajing Zhang Baole Qu Hailin Han Yanying Wang Dapeng Li Thomas C.Südhof 曹鹏 | 2018 | 科学新闻2018，0，4： | 0 |
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