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| 1 | Adsorption-energy-based activity descriptors for electrocatalysts in energy storage applications显示文摘Energy storage technologies, such as fuel cells, ammonia production and lithium–air batteries, are important strategies for addressing the global challenge of energy crisis and environmental pollution.Taking overpotential as a direct criterion, we illustrate in theory and experiment that the adsorption energies of charged species such as Li^++e^-and H^++e^-are a central parameter to describe catalytic activities related to electricity-in/electricity-out efficiencies. The essence of catalytic activity is revealed to relate with electronic coupling between catalysts and charged species. Based on adsorption energy, some activity descriptors such as d-band center, e_g-electron number and charge-transfer capacity are further defined by electronic properties of catalysts that directly affect interaction between catalysts and charged species. The present review is helpful for understanding the catalytic mechanisms of these electrocatalytic reactions and developing accurate catalytic descriptors, which can be employed to screen high-activity catalysts in future high-throughput calculations and experiments. | Youwei Wang Wujie Qiu Erhong Song Feng Gu Zhihui Zheng Xiaolin Zhao Yingqin Zhao Jianjun Liu Wenqing Zhang | 2018 | National Science Review2018，5，3： | 8 |
| 2 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
| 3 | Regulation of the cellular uptake of nanopartides by the orientation of helical polypeptides显示文摘Controlling the cellular interactio n and internal izatio n of polymer-modified nan oparticles (NPs) is of central importa nee to the developme nt of promisi ng nano medici nes. Here, we describe the use of synthetic polypeptides for NP surface coati ng and regulati on of their cellular uptake behaviors by simply switching the conformation and anchoring orientation. Our results show that gold NPs (AuNPs) coated with a helical poly(Y-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)esteryl「glutamate)(L-P(EG3Glu)5o) from the C-terminus ((L-C)-AuNPs) exhibit greater zeta potential and more cellular uptake (2.0-5.5 fold higher) than those coated with the same polypeptide but anchored from the N-terminus ((L-N)-AuNPs), or from both the C- and N-terminus at a 1/1 molar ratio ((L-C/L-N)-AuNPs). A similar orientation-regulated cellular internalization pattern is observed in D-P(EG3Glu)50 but not the unstructured DL-P(EG3Glu)5o-rnodified AuNPs, suggesting an important and universal role of the helix-derived macrodipole in cellular uptake. Moreover, this orientation-governed internalization is successfully reproduced in P(EG3Glu)50-coated gold nano rods (AuNRs), and applied to the desig n of doxorubici reloaded polypeptide micelles. Simulation study offers time-resolved in sights regarding the NP-membrane in teracti ons and membrane remodeling. Thus, our study provides a delicate way of regulating the surface chemistry of NPs and the subsequent NP-cell interactions. Moreover, the results highlight the uniqueness of polypeptides in NP surface engineering, and urge a more careful consideration on the polymer orientation effect. | Chong Zhang Jianhua Lu Falin Tian Lindong Li Yingqin Hou Yaoyi Wang Lingdong Sun Xinghua Shi Hua Lu | 2019 | Nano Research2019，12，4： | 4 |
| 4 | The character of the weather and climate in West Kunlun mountains area in summer,1987 显示文摘 | Kang Xingcheng Xie Yingqin | 1989 | Bulletin of Glacier Research1989，6，： | 1 |
| 5 | The coordinated control of SVC and excitation of generators in power systems with nonlinear loads显示文摘 | Ruan Yingqin Wang Jie | 2005 | International Journal of Electrical Power and Energy Systems2005，27，8： | 1 |
| 6 | The coordinated control of SVC and excitation of generators in power systems with nonlinear loads显示文摘 | RUAN Yingqin WANG Jie | 2005 | Electrical Power and Energy Systems2005，27，8： | 1 |
| 7 | Recent advances in molecularly imprinted polymers in food analysis显示文摘 | Xingliang Song Shoufang Xu Lingxin Chen Yingqin Wei Hua Xiong | 2014 | J. Appl. Polym. Sci2014，，16： | 1 |
| 8 | Least squares based iterative parameter estimation algorithm for multivariable con- trolled ARMA system modeling with nite measurement data 显示文摘 | BAO Bo XUE Yingqin SHENG Jie | 2011 | Mathematical & Computer Modelling2011，53，4： | 1 |
| 9 | From Boundary Spanning to Creolization: A Study of ChineseSoftware and Services Outsourcing Vendors显示文摘 | PAMELA ABBOTT ZHENG YINGQIN DU RONG | 2013 | The Journal of Strategic Information Systems2013，，2： | 1 |
| 10 | Tailoring Cationic Helical Polypeptides for Efficient Cytosolic Protein Delivery显示文摘Protein delivery is of central importance for both diagnostic and therapeutic applications.However,protein delivery faces challenges including poor endosomal escape and thus limited efficiency.Here,we report the facile construction and screening of a small library of cationic helical polypeptides for cytosolic protein delivery.The library is based on a random copolymer poly(γ-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}esteryl-L-glutamate)-randompoly(γ-6-chlorohexyl-L-glutamate)[P(EG3-r-ClC6)Glu],which is then modified with various pyridine derivatives and alkyl thiols.Flow Cytometry,confocal laser scanning microscopy,and viability assay collaboratively identify two leading polymers,showing efficient delivery of enhanced green fluorescent protein(eGFP)and low cytoto-xicity.This finding is further validated by the cytosolic delivery of RNase A and cytochrome C(Cyt C)to HeLa cells in the viability assay.Together,this work demonstrates that high-throughput screening is an effective and viable approach to the selection of cationic helical polypeptides for the cytosolic delivery of functional proteins. | WANG Ruijue SHENG Kai HOU Yingqin SUN Jialing LU Hua | 2020 | Chemical Research in Chinese Universities2020，36，1： | 1 |
| 11 | 信息系统外包绩效影响因素实证研究显示文摘在三年来对从事离岸IT外包服务企业调查的基础上,对北京中关村软件园、上海浦东软件园和西安软件园内20多家外包企业的信息系统部门项目小组成员进行问卷调查,并对回收到的293份有效问卷运用SPSS16.0和AMOS17.0进行统计分析,得出文化相似性、关系规范、创新能力、知识共享之间的相互影响关系以及它们对外包绩效的影响作用,解释了边界跨越在文化相似性、关系规范、创新能力、知识共享对信息系统外包绩效的影响关系中所起的调节作用,并给予了管理建议。 | 杜荣 艾时钟 厉敏 Pamela Abbott Yingqin Zheng | 2012 | 信息资源管理学报2012，2，1： | 1 |
| 12 | Contextual factors, knowledge processes and performance in global sourcing of IT services: an investigation in China显示文摘 | Du Rong Ai Shizhong Abbott P Zheng Yingqin | 2011 | Journal of Global Information Management2011，19，2： | 1 |
| 13 | Internal and contextual factors, knowledge processes and performance: from the chinese provider's perspective 显示文摘 | Ai Shizhong Du Rong Abbott P Zheng Yingqin | 2012 | Expert Systems With Applications2012，39，4： | 1 |
| 14 | The character of the weather and climate in the West Kunlun Mountains area in summer显示文摘 | Kang Xincheng Xie Yingqin | 1987 | Bulletin of Glacier Research1987，7，： | 1 |
| 15 | Analytical Solutions to the Fundamental Frequency of Arbitrary Laminated Plates under Various Boundary Conditions显示文摘在最近的年里,当合成把压成薄片的盘子广泛地在工程被使用,练习例如设计的太空,水兵和大楼,合成把压成薄片的盘子的颤动问题正在变得越来越重要。频率,特别基本频率,处于颤动问题被看作了一个重要因素。在这份报纸,在各种各样的边界条件下面的任意的把压成薄片的盘子的基本频率的一个计算方法被建议。颤动把压成薄片的盘子的微分方程在这份报纸的开始被建立,特长 orthotropic 的频率公式在各种各样的边界条件和反对称的角度厚度下面把盘子压成薄片有简单地支持的边的把压成薄片的盘子被调查。他们被证明正确。为在各种各样的边界条件下面的多层的反对称、任意的把压成薄片的盘子的基本频率的简单算法被一系列典型例子学习。从联合的观点,什么时候把压成薄片的盘子层 N 的数字 > 810,对基本频率的一些联合影响能被忽视。orthotropic 与一样的厚度,但是少些把盘子压成薄片,对使用特长合理计算把压成薄片的盘子的相应基本频率的层。几个例子被进行证明这个结论的正确性。在这份报纸的结束, orthotropic 在基本频率上把压成薄片的特长的层的选择数字的影响被调查。精确性和复杂性被层的数字决定。它对特殊 orthotropic 的层的合适的数字与一样的厚度把压成薄片处于不同边界条件模仿基本频率的使用必要。 | Yingqin Luo Ming Hong Yuan Liu | 2015 | Journal of Marine Science and Application2015，14，1： | 1 |
| 16 | Distribution of biomarkers in lacustrine sediments of the Linxia Basin, NE Tibetan Plateau, NW China: Significance for climate change显示文摘 | Yongli Wang Xiaomin Fang Tongwei Zhang Yuanmao Li Yingqin Wu Daxiang He Yuan Gao Pei Meng Youxiao Wang | 2011 | Sedimentary Geology2011，，： | 1 |
| 17 | Inequality of what? Social exclusion in the E-society as capability deprivation 显示文摘 | ZHENG Yingqin WALSHAM G | 2008 | Information Technology & People2008，21，3： | 1 |
| 18 | Inequality of What? SocialExclusion in the E -Society as Capability Deprivation 显示文摘 | ZHENG YINGQIN WALSHAM GEOFF | 2008 | Information Technology & People2008，21，3： | 1 |
| 19 | Co-delivery of Cisplatin and Chlorin e6 by Poly(phosphotyrosine)for Synergistic Chemotherapy and Photodynamic Therapy显示文摘Nanoscale drug delivery systems(NDDSs)have emerged as promising carriers for combinational therapy by co-delivery of multiple drugs and modalities.However,most co-delivery systems require the use of complicated materials and formulations.Herein,we report the single use of a polymeric material,namely mPEG-block-poly(phosphotyrosine)(mPEG-b-PpY),as a multi-functional carrier for the facile fabrication of NDDS Pt/Ce6@mPEG-b-PpY(PtCeNP)for the co-delivery of cisplatin and photosensitizer chlorin e6(Ce6)via phosphato-platinum coordination andπ-πstacking,respectively.PtCeNP improves the solubility,cellular uptake,and bioavailability of both parental drugs,and showed strong synergistic antitumor efficacy both in vitro and in vivo through combined chemo-photodynamic therapy.Our results indicate that PpY is a biocompatible,multifunctional,and promising carrier material suitable for a variety of drugs and may simplify the design for co-delivery systems. | Haisen Zhou Yaoyi Wang Yingqin Hou Zhengkui Zhang Qi Wang Xiaodong Tian Hua Lu | 2022 | Chinese Journal of Chemistry2022，40，20： | 1 |
| 20 | Distributed decision fusion with a random-access channel for sensor network applications 显示文摘 | Yingqin Y Kam M | 2004 | Instrumentation and Measurement2004，53，4： | 1 |
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