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| 1 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 2 | Enhanced CH4 selectivity in CO2 photocatalytic reduction over carbon quantum dots decorated and oxygen doping g-C3N4显示文摘Graphitic carbon nitride(g-C3N4,CN)exhibits inefficient charge separation,deficient CO2 adsorption and activation sites,and sluggish surface reaction kinetics,which have been recognized as the main barriers to its application in CO2 photocatalytic reduction.In this work,carbon quantum dot(CQD)decoration and oxygen atom doping were applied to CN by a facile one-step hydrothermal method.The incorporated CQDs not only facilitate charge transfer and separation,but also provide alternative CO2 adsorption and activation sites.Further,the oxygen-atom-doped CN(OCN),in which oxygen doping is accompanied by the formation of nitrogen defects,proves to be a sustainable H^+ provider by facilitating the water dissociation and oxidation half-reactions.Because of the synergistic effect of the hybridized binary CQDs/OCN addressing the three challenging issues of the CN based materials,the performance of CO2 photocatalytic conversion to CH4 over CQDs/OCN-x(x represents the volume ratio of laboratory-used H2O2(30 wt.%)in the mixed solution)is dramatically improved by 11 times at least.The hybrid photocatalyst design and mechanism proposed in this work could inspire more rational design and fabrication of effective photocatalysts for CO2 photocatalytic conversion with a high CH4 selectivity. | Qian Li Songcan Wang Zhuxing Sun Qijun Tang Yiqiu Liu Lianzhou Wang Haiqiang Wang Zhongbiao Wu | 2019 | Nano Research2019，12，11： | 9 |
| 3 | Cycle stability of lithium/garnet/lithium cells with different intermediate layers显示文摘The garnet-type electrolytes such as Ta-doped Li_7La_3Zr_2O_(12)(LLZTO) have been viewed as the promising electrolytes for solid-state lithium batteries, but it exhibits problem of high interfacial resistance(1960 Ω·cm^2) and short circuit when being cycled in Li/LLZTO/Li cells at the current density above 0.5 mA·cm^(-2). Introduction of intermediate layers in between lithium and LLZTO is helpful for decreasing the interfacial resistance and suppressing the growth of lithium dendrites. In this work, three kinds of intermediate layers of Au, Nb and Si with the thickness of 100 nm were prepared. Although the interfacial resistance with the Au layer decreases from 1960 to 32 Ω·cm^2, the cells can only cycle for 0.67 h at 0.5 mA·cm^(-2), related to the Au peeled off from the LLZTO. The Nb layers lead to the initial interfacial resistance of 14 Ω·cm^2, while showing extension of cycle time to 50 h with the increase in interfacial resistance due to the formation of the resistive Li–Nb–O phase. The Si layers induce the interfacial resistance as low as 5 Ω·cm^2 and the cycles as long as 120 h, which is attributed to the improvement in electrical contact between Li and electrolyte as well as the maintenance of conductive interface during cycles. | Ning Zhao Rui Fang MingHui He Cheng Chen YiQiu Li ZhiJie Bi Xiang-Xin Guo | 2018 | Rare Metals2018，37，6： | 7 |
| 4 | Assessing the global averaged sea-level budget from 2003 to 2010显示文摘A global mass balance(Greenland and Antarctica ice sheet mass loss,terrestrial water storage)and different sea-level components(observed sea-level from satellite altimetry,steric sea-level from Ishii data,and ocean mass from gravity recovery and climate experiment,GRACE)are estimated,in terms of seasonal and interannual variabilities from 2003 to 2010.The results show that a detailed analysis of the GRACE time series over the time period 2003–2010 unambiguously reveals an increase in mass loss from the Greenland ice sheet and Antarctica ice sheet.The mass loss of both ice sheets accelerated at a rate of(392.8±70.0)Gt/a during 2003–2010,which contributed(1.09±0.19)mm/a to the global mean sea-level during this time.The net terrestrial water storage(TWS)trend was negative over the 8 a time span,which gave a small positive contribution of(0.25±0.12)mm/a.The interannual variability of the global mean sea-level was at least partly caused by year-to-year variability of land water storage.Estimating GRACE-based ice sheet mass balance and terrestrial water storage by using published estimates for melting glaciers,the results further show that the ocean mass increase since 2003 has resulted half from an enhanced contribution of the polar ice sheets,and half from the combined ice sheet and terrestrial water storage loss.Taking also into account the melting of mountain glaciers(0.41 mm/a)and the small GRACE-based contribution from continental waters(0.25 mm/a),a total ocean mass contribution of(1.75±0.57)mm/a from 2003 to 2010 is found.Such a value represented 75%of the altimetry-based rate of sea-level rise over that period.The contributions to steric sea-level(i.e.,ocean thermal expansion plus salinity effects)are estimated from:(1)the difference between altimetry-based sea-level and ocean mass change and(2)the latest Ishii data.The inferred steric sea-level rate from(1)(1.41 mm/a from 2003 to 2010)did not agree well with the Ishii-based value also estimated here(0.44 mm/a from 2003 to 2010),but phase.The cause for such a discrepancy is not yet known but may be related to inadequate sampling of in situ ocean temperature and salinity measurements. | LI Juan ZUO Juncheng CHEN Meixiang TAN Wei YANG Yiqiu | 2013 | Acta Oceanologica Sinica2013，32，10： | 6 |
| 5 | Optical clocks based on stimulated emission radiation显示文摘Atomic clocks operating at microwave region,are divided into two categories according to the mode of operation,namely the passive mode,in which the standard frequency of a clock signal is locked on to a very narrow atomic spectral line such as in cesium beam | WANG YiQiu | 2009 | Chinese Science Bulletin2009，54，3： | 6 |
| 6 | A state-of-the-art review on interfacial behavior between asphalt binder and mineral aggregate显示文摘因为缺点和压力集中更容易发生在那里,在沥青文件夹和矿物质总数之间的接口直接影响人行道的服务生活。在沥青文件夹和矿物质总数之间的相互作用是形成接口的主要原因。这份报纸在测试技术和界面的相互作用的分析方法上论述广泛的评论,包括分子的动力学模拟,阶段域途径,吸收测试, rheological 方法和宏机械测试。所有清楚地在这个话题上进行的研究显示在沥青文件夹和矿物质总数之间的界面的相互作用是一个物理化学药品的过程,并且能是显微镜的技术描绘的品质上(例如 SEM 和 AFM ) ,并且也,份量上能被 rheological 方法和界面的机械测试评估。分子的动力学模拟和阶段领域途径也被表明是有效方法学习界面的行为和它的机制。 | Meng GUO Yiqiu TAN Linbing WANG Yue HOU | 2018 | Frontiers of Structural and Civil Engineering2018，12，2： | 6 |
| 7 | Prediction of China's Submerged Coastal Areas by Sea Level Rise due to Climate Change显示文摘Based on the simulation with the Ocean-Atmosphere Coupled Model CCSM and Ocean Model POP under the greenhouse gas emission scenario of the IPCC SRES A2(IPCC,2001),and on the earth crust subsidence and glacier melting data,the relative sea level change is obtained along the coast of China in the 21st century.Using the SRTM elevation data the submergence of coastal low land is calculated under the extreme water level with a 100-year return period.The total flooding areas are 98.3×103and 104.9×103km2for 2050 and 2080,respectively.For the three regions most vulnerable to extreme sea level rise,i.e.,the coast of Bohai Bay,the Yangtze River Delta together with neighboring Jiangsu Province and northern Zhejiang Province,and the Pearl River Delta,the flooded areas are 5.0×103,64.1×103and 15.3×103km2in 2050 and 5.2×103,67.8×103and 17.2×103km2in 2080,respectively. | ZUO Juncheng YANG Yiqiu ZHANG Jianli CHEN Meixiang XU Qing | 2013 | Journal of Ocean University of China2013，12，3： | 5 |
| 8 | The next detectors for gravitational wave astronomy显示文摘This paper focuses on the next detectors for gravitational wave astronomy which will be required after the current ground based detectors have completed their initial observations, and probably achieved the first direct detection of gravitational waves. The next detectors will need to have greater sensitivity, while also enabling the world array of detectors to have improved angular resolution to allow localisation of signal sources. Sect. 1 of this paper begins by reviewing proposals for the next ground based detectors,and presents an analysis of the sensitivity of an 8 km armlength detector, which is proposed as a safe and cost-effective means to attain a 4-fold improvement in sensitivity. The scientific benefits of creating a pair of such detectors in China and Australia is emphasised. Sect. 2 of this paper discusses the high performance suspension systems for test masses that will be an essential component for future detectors, while sect. 3 discusses solutions to the problem of Newtonian noise which arise from fluctuations in gravity gradient forces acting on test masses. Such gravitational perturbations cannot be shielded, and set limits to low frequency sensitivity unless measured and suppressed. Sects. 4 and 5 address critical operational technologies that will be ongoing issues in future detectors. Sect. 4 addresses the design of thermal compensation systems needed in all high optical power interferometers operating at room temperature. Parametric instability control is addressed in sect. 5. Only recently proven to occur in Advanced LIGO, parametric instability phenomenon brings both risks and opportunities for future detectors. The path to future enhancements of detectors will come from quantum measurement technologies. Sect. 6 focuses on the use of optomechanical devices for obtaining enhanced sensitivity, while sect. 7 reviews a range of quantum measurement options. | BLAIR David JU Li ZHAO ChunNong WEN LinQing MIAO HaiXing CAI RongGen GAO JiangRui LIN XueChun LIU Dong WU Ling-An ZHU ZongHong HAMMOND Giles PAIK Ho Jung FAFONE Viviana ROCCHI Alessio BLAIR Carl MA YiQiu QIN JiaYi PAGE Michael | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 3 |
| 9 | The influence of Stokes drift on oil spills:Sanchi oil spill case显示文摘Spilled oil floats and travels across the water’s surface under the influence of wind,currents,and wave action.Wave-induced Stokes drift is an important physical process that can affect surface water particles but that is currently absent from oil spill analyses.In this study,two methods are applied to determine the velocity of Stokes drift,the first calculates velocity from the wind-related formula based upon a one-dimensional frequency spectrum,while the second determines velocity directly from the wave model that was based on a twodimensional spectrum.The experimental results of numerous models indicated that:(1)oil simulations that include the influence of Stokes drift are more accurate than that those do not;(2)for medium and long-term simulations longer than two days or more,Stokes drift is a significant factor that should not be ignored,and its magnitude can reach about 2%of the wind speed;(3)the velocity of Stokes drift is related to the wind but is not linear.Therefore,Stokes drift cannot simply be replaced or substituted by simply increasing the wind drift factor,which can cause errors in oil spill projections;(4)the Stokes drift velocity obtained from the two-dimensional wave spectrum makes the oil spill simulation more accurate. | Yiqiu Yang Yan Li Juan Li Jingui Liu Zhiyi Gao Kaixuan Guo Han Yu | 2021 | Acta Oceanologica Sinica2021，40，10： | 3 |
| 10 | Conferring receptors on recipient cells with extracellular vesicles for targeted drug delivery显示文摘Triple negative breast cancer(TNBC)is a heterogeneous subset of breast cancer characterized by its lack of estrogen receptor,progesterone receptor,and human epidermal growth factor receptor 2(HER2),which altogether prevents TNBC from being treated effectively.For many years,the treatment paradigms and overall survival of patients with TNBC have remained largely stagnant.Recent attempts to convert cold tumors to hot tumors by promoting antigen presentation have shown increased T cell infiltration and significantly induced immune responses for tumor killing.Inspired by this concept,the expression of specific targetable antigens on TNBC cells may further benefit relevant targeted drug delivery.In this study,we successfully conferred sufficient HER2 on the surface of TNBC MDA-MB-231 cells via simple EV-plasma membrane fusion with HER2+extracellular vesicles(EV)derived from HER2 overexpressing BT-474 cells.Subsequently,anti-HER2 antibody conjugated paclitaxel-loaded liposomes were used for HER2-targeted drug delivery.Our findings demonstrated this HER2 grafting,in conjunction with targeted drug delivery,can improve the treatment efficacy in vitro and in vivo.This novel approach represents a facile method of altering cell membrane antigen presentation via convenient EVs uptake and may pave the way for the burgeoning wave of targeted therapy and/or immunotherapy. | Zachary Quinn Wenjun Mao Yiqiu Xia Rhea John Yuan Wan | 2021 | Bioactive Materials2021，6，3： | 3 |
| 11 | Total Variation Based Parameter-Free Model for Impulse Noise Removal显示文摘We propose a new two-phase method for reconstruction of blurred im-ages corrupted by impulse noise.In the first phase,we use a noise detector to iden-tify the pixels that are contaminated by noise,and then,in the second phase,we reconstruct the noisy pixels by solving an equality constrained total variation mini-mization problem that preserves the exact values of the noise-free pixels.For images that are only corrupted by impulse noise(i.e.,not blurred)we apply the semismooth Newton’s method to a reduced problem,and if the images are also blurred,we solve the equality constrained reconstruction problem using a first-order primal-dual algo-rithm.The proposed model improves the computational efficiency(in the denoising case)and has the advantage of being regularization parameter-free.Our numerical results suggest that the method is competitive in terms of its restoration capabilities with respect to the other two-phase methods. | Federica Sciacchitano Yiqiu Dong Martin S.Andersen | 2017 | Numerical Mathematics(Theory,Methods and Applications)2017，10，1： | 2 |
| 12 | HSP70 alleviates sepsis-induced cardiomyopathy by attenuating mitochondrial dysfunction-initiated NLRP3 inflammasome-mediated pyroptosis in cardiomyocytes显示文摘Background:Sepsis-induced cardiomyopathy(SIC)is an identified serious complication of sepsis that is associated with adverse outcomes and high mortality.Heat shock proteins(HSPs)have been implicated in suppressing septic inflammation.The aim of this study was to investigate whether HSP70 can attenuate cellular mitochondrial dysfunction,exuberated inflammation and inflammasome-mediated pyroptosis for SIC intervention.Methods:Mice with cecal ligation plus perforation(CLP)and lipopolysaccharide(LPS)-treated H9C2 cardiomyocytes were used as models of SIC.The mouse survival rate,gross profile,cardiac function,pathological changes and mitochondrial function were observed by photography,echocardiography,hematoxylin-eosin staining and transmission electron microscopy.In addition,cell proliferation and the levels of cardiac troponin I(cTnI),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)were determined by Cell Counting Kit-8,crystal violet staining and enzyme-linked immunosorbent assay.Moreover,mitochondrial membrane potential was assessed by immunofluorescence staining,and dynamin-related protein 1 and pyroptosis-related molecules[nucleotide-binding domain,leucine-rich-repeat containing family pyrin domain-containing 3(NLRP3),caspase-1,gasdermin-D(GSDMD),gasdermin-D N-terminal(GSDMD-N)]were measured by western blotting,immunoprecipitation and immunoblotting.Finally,hsp70.1 knockout mice with CLP were used to verify the effects of HSP70 on SIC and the underlying mechanism.Results:Models of SIC were successfully established,as reduced consciousness and activity with liparotrichia in CLP mice were observed,and the survival rate and cardiac ejection fraction(EF)were decreased;conversely,the levels of cTnI,TNF-αand IL-1βand myocardial tissue damage were increased in CLP mice.In addition,LPS stimulation resulted in a reduction in cell viability,mitochondrial destabilization and activation of NLRP3-mediated pyroptosis molecules in vitro.HSP70 treatment improved myocardial tissue damage,survival rate and cardiac dysfunction caused by CLP.Additionally,HSP70 intervention reversed LPS-induced mitochondrial destabiliza-tion,inhibited activation of the NLRP3 inflammasome,caspase-1,GSDMD and GSDMD-N,and decreased pyroptosis.Finally,knockout of hsp70.1 mice with CLP aggravated cardiac dysfunction and upregulated NLRP3 inflammasome activity,and exogenous HSP70 significantly rescued these changes.It was further confirmed that HSP70 plays a protective role in SIC by attenuating mitochondrial dysfunction and inactivating pyroptotic molecules.Conclusions:Our study demonstrated that mitochondrial destabilization and NLRP3 inflammasome activation-mediated pyroptosis are attributed to SIC.Interestingly,HSP70 ameliorates sepsis-induced myocardial dysfunction by improving mitochondrial dysfunction and inhibiting the acti-vation of NLRP3 inflammasome-mediated pyroptosis,and such a result may provide approaches for novel therapies for SIC. | Chenlu Song Yiqiu Zhang Qing Pei Li Zheng Meiyu Wang Youzhen Shi Shan Wu Wei Ni Xiujun Fu Yinbo Peng Wen Zhang Min Yao | 2022 | Burns & Trauma2022，10，1： | 2 |
| 13 | Ecological Characteristics of China's Key Ecological Function Areas显示文摘1 Introduction National Key Ecological Function Areas(NKEFA),which refer to regions undertaking water conservation,soil and water conservation,windbreak and sand-fixation,and biodiversity maintenance,are associated with national or regional ecological security and need to restrict extensive industrialization or urbanization.In 2010,the China’s State Council issued the National Major Function Zone Planning,which drew out 25NKEFA in restricted development zone according to two aspects including the ecological vulnerability and the ecological importance. | LI Yiqiu LU Chunxia DENG Ou CHEN Panpan | 2015 | Journal of Resources and Ecology2015，6，6： | 2 |
| 14 | Study on the cohesion and adhesion of hot-poured crack sealants显示文摘 | Meng GUO Yiqiu TAN Xuesong DU Zhaofeng LV | 2017 | Frontiers of Structural and Civil Engineering2017，11，3： | 2 |
| 15 | Chopper-modulated gas chromatography electroantennography enabled using high-temperature MEMS flow control device显示文摘We report the design,fabrication and characterization of a microelectromechanical systems(MEMS)flow control device for gas chromatography(GC)with the capability of sustaining high-temperature environments.We further demonstrate the use of this new device in a novel MEMS chopper-modulated gas chromatography-electroantennography(MEMS-GC-EAG)system to identify specific volatile organic compounds(VOCs)at extremely low concentrations.The device integrates four pneumatically actuated microvalves constructed via thermocompression bonding of the polyimide membrane between two glass substrates with microstructures.The overall size of the device is 32 mm×32 mm,and it is packaged in a 50 mm×50 mm aluminum housing that provides access to the fluidic connections and allows thermal control.The characterization reveals that each microvalve in the flow control chip provides an ON to OFF ratio as high as 1000:1.The device can operate reliably for more than 1 million switching cycles at a working temperature of 300℃.Using the MEMS-GC-EAG system,we demonstrate the successful detection of cis-11-hexadecenal with a concentration as low as 1 pg at a demodulation frequency of 2 Hz by using an antenna harvested from the male Helicoverpa Virescens moth.In addition,1μg of a green leafy volatile(GLV)is barely detected using the conventional GC-EAG,while MEMS-GC-EAG can readily detect the same amount of GLV,with an improvement in the signal-to-noise ratio(SNR)of~22 times.We expect that the flow control device presented in this report will allow researchers to explore new applications and make new discoveries in entomology and other fields that require high-temperature flow control at the microscale. | Ming-Da Zhou Muhammad Akbar Andrew J.Myrick Yiqiu Xia Waleed J.Khan Xiang Gao Thomas C.Baker Si-Yang Zheng | 2017 | Microsystems & Nanoengineering2017，3，1： | 2 |
| 16 | A new direetional weighted median filter for removal of random-valued impulse noise显示文摘 | Dong Yiqiu Xu Shufang | 2007 | IEEE Signal Proeessing Letters2007，14，3： | 1 |
| 17 | Development and testing of a heat and mass coupled snow melting model for hydronic heated pavement 显示文摘 | XU Huining TAN Yiqiu | 2012 | Transportation Research Record2012，2282，： | 1 |
| 18 | Investigation of lowtemperatureproperties of diatomite-modified asphalt mixtures显示文摘 | Tan Yiqiu Zhang Lei Zhang Xingyou | 2012 | Construction and Building Materials2012，36，78： | 1 |
| 19 | A new directional weighted me- dian filter for removal of random-valued impulse noise显示文摘 | Dong Yiqiu Xu Shufang | 2007 | IEEE Signal Processing Lett2007，14，3： | 1 |
| 20 | A new directional weighted median filter for removal of random-valued impulse noise显示文摘 | DONG Yiqiu XU Shufang | 2007 | IEEE Signal Processing Let- ters2007，14，3： | 1 |
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