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| 1 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 2 | Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity显示文摘Histone deacetylase 6 (HDAC6 ) ,主要细胞质的蛋白质 deacetylase,通过它的 deacetylase 活动参予大量细胞的过程。然而, HDAC6 的多样的功能不能充分与它的已知的底层被阐明。在一次尝试到探索 HDAC6 的底层差异,我们执行了量的 proteomic 分析响应 HDAC6 在许多蛋白质离氨酸 acetylation 监视变化缺乏。我们在 HDAC6 猛烈老鼠的肝与提高的 acetylation 识别了 107 蛋白质。三细胞质的蛋白质,包括肌浆球蛋白重链 9 (MYH9 ) ,热吃惊血缘的蛋白质 70 (Hsc70 ) ,并且 dnaJ 相当或相同的事物亚科 A 成员 1 (DNAJA1 ) ,被验证与 HDAC6 交往。这些蛋白质的 acetylation 层次被 HDAC6 否定地在老鼠肝并且在有教养的房间调整。功能的研究表明调停 HDAC6 的 deacetylation 调制在 Hsc70 和 DNAJA1 之间的 MYH9 和相互作用的肌动朊绑定能力。这些调查结果巩固 HDAC6 以协调各种各样的细胞的功能的能力作为蛋白质 acetylation 的一个批评管理者供给的观点。 | Linlin Zhang Shanshan Liu Ningning Liu Yong Zhang Min Liu Dengwen Li Edward Seto Tso-PangYao Wenqing Shui J-un Zhou | 2015 | Protein & Cell2015，6，1： | 1 |
| 3 | The 2007 water crisis in Wuxi, China: Analysis of the origin显示文摘 | Xiao-jian Zhang Chao Chen Jian-qing Ding Aixin Hou Yong Li Zhang-bin Niu Xiao-yan Su Yan-juan Xu Edward A. Laws | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 4 | The SARS-CoV-2 spike L452R-E484Q variant in the Indian B.1.617 strain showed significant reduction in the neutralization activity of immune sera显示文摘To assess the impact of the key non-synonymous amino acid substitutions in the RBD of the spike protein of SARS-CoV-2 variant B.1.617.1(dominant variant identified in the current India outbreak)on the infectivity and neutralization activities of the immune sera,L452R and E484Q(L452R-E484Q variant),pseudotyped virus was constructed(with the D614G background).The impact on binding with the neutralizing antibodies was also assessed with an ELISA assay.Pseudotyped virus carrying a L452R-E484Q variant showed a comparable infectivity compared with D614G.However,there was a significant reduction in the neutralization activity of the immune sera from non-human primates vaccinated with a recombinant receptor binding domain(RBD)protein,convalescent patients,and healthy vaccinees vaccinated with anmRNA vaccine.In addition,there was a reduction in binding of L452R-E484Q-D614G protein to the antibodies of theimmune sera fromvaccinated nonhuman primates.These results highlight the interplay between infectivity and other biologic factors involved in the natural evolution of SARS-CoV-2.Reduced neutralization activities against the L452R-E484Q variant will have an impact on health authority planning and implications for the vaccination strategy/newvaccine development. | Gen Li Zhongcheng Zhou Peng Du Meixing Yu Ning Li Xinxin Xiong Hong Huang Zhihai Liu Qinjin Dai Jie Zhu Chengbin Guo ShanyunWu Daniel T.Baptista-Hon Man Miao LamWai Ming Yong Wu Fanxin Zeng Charlotte L.Zhang Edward D.Zhang Haifeng Song Jianghai Liu Johnson Yiu-Nam Lau Andy P.Xiang Kang Zhang | 2021 | Precision Clinical Medicine2021，4，3： | 0 |
| 5 | Multi-omics analysis reveals the evolutionary origin of diterpenoid alkaloid biosynthesis pathways in Aconitum显示文摘Diterpenoid alkaloids(DAs) have been often utilized in clinical practice due to their analgesic and anti-infammatory properties. Natural DAs are prevalent in the family Ranunculaceae, notably in the Aconitum genus. Nevertheless, the evolutionary origin of the biosynthesis pathway responsible for DA production remains unknown.In this study, we successfully assembled a highquality, pseudochromosome-level genome of the DA-rich species Aconitum vilmorinianum(A.vilmorinianum)(5.76 Gb). An A. vilmorinianumspecific whole-genome duplication event was discovered using comparative genomic analysis,which may aid in the evolution of the DA biosynthesis pathway. We identified several genes involved in DA biosynthesis via integrated genomic, transcriptomic, and metabolomic analyses. These genes included enzymes encoding target ent-kaurene oxidases and aminotransferases, which facilitated the activation of diterpenes and insertion of nitrogen atoms into diterpene skeletons, thereby mediating the transformation of diterpenes into DAs. The divergence periods of these genes in A. vilmorinianum were further assessed, and it was shown that two major types of genes were involved in the establishment of the DA biosynthesis pathway. Our integrated analysis offers fresh insights into the evolutionary origin of DAs in A.vilmorinianum as well as suggestions for engineering the biosynthetic pathways to obtain desired DAs. | Dake Zhao Ya Zhang Huanxing Ren Yana Shi Ding Dong Zonghang Li Guanghong Cui Yong Shen Zongmin Mou Edward JKennelly Luqi Huang Jue Ruan Suiyun Chen Diqiu Yu Yupeng Cun | 2023 | Journal of Integrative Plant Biology2023，65，10： | 0 |
| 6 | Ablation of Venusian oxygen ions by unshocked solar wind显示文摘As an Earth-like planet Venus probably had a primordial dipole field for several million years after formation of the planet.Since this dipole field eventually vanished the ionosphere of Venus has been exposed to the solar wind.The solar wind is shocked near Venus,and then scavenges the ionospheric particles through the magnetosheath and the magnetotail.The escape rate of oxygen ions(O^+)estimated from spacecraft observations over the past several decades has manifested its importance for the evolution of planetary habitability,considering the accumulated effect over the history of Venus.However,all the previous observations were made in the shocked solar wind and/or inside the wake,though some simulations showed that unshocked solar wind can also ablate O^+ions.Here we report Venus Express observations of O^+ions in the unshocked solar wind during the solar minimum.The observations suggest that these O^+ions are accelerated by the unshocked solar wind through pickup processes.The estimated O^+escape rate,2.1×10^(24) ions/s,is comparable to those measured in the shocked solar wind and the wake.This escape rate could result in about 2 cm global water loss over 4.5 billion years.Our results suggest that the atmospheric loss at unmagnetized planets is significantly underestimated by previous observations,and thus we can emphasize the importance of an Earth-like dipole for planetary habitability. | Yong Wei Markus Fraenz Edward Dubinin Weixing Wan Tielong Zhang Zhaojin Rong Lihui Chai Jun Zhong Rixiang Zhu Yoshifumi Futaana Stas Barabash | 2017 | Science Bulletin2017，62，24： | 0 |
| 7 | Fine-mapping and characterisation of genes on barley(Hordeum vulgare)chromosome 2H for salinity stress tolerance during germination显示文摘Salinity causes a detrimental impact on plant growth,particularly when the stress occurs during germination and early development stages.Barley is one of the most salt-tolerant crops;previously we mapped two quantitative trait loci(QTL)for salinity tolerance during germination on the short arm of chromosome 2 H using a CM72/Gairdner doubled haploid(DH)population.Here,we narrowed down the major QTL to a region of 0.341 or 0.439 Mb containing 9 or 24 candidate genes belonging to 6 or 20 functional gene families according to barley reference genomes v1 and v3 respectively,using two DH populations of CM72/Gairdner and Skiff/CM72,F_(2)and F;generations of CM72/Gairdner/;Spartacus CL,Two Receptorlike kinase 4(RLPK4)v1 or Receptor-like kinase(RLK)v3 could be the candidates for enhanced germination under salinity stress because of their upregulated expression in salt-tolerant variety CM72.Besides,several insertion/deletion polymorphisms were identified within the 3 rd exon of the genes between CM72 and Gairdner.The sequence variations resulted in shifted functional protein domains,which may be associated with differences in salinity tolerance.Two molecular markers were designed for selecting the locus with receptor-like protein kinase 4,and one was inside HORVU2 Hr1 G111760.1 or HORVU.MOREX.r3.2 HG0202810.1.The diagnostic markers will allow for pyramiding of 2 H locus in barley varieties and facilitate genetic improvement for saline soils.Further,validation of the genes to elucidate the mechanisms involved in enhancing salinity tolerance at germination and designing RLPK4 specific markers is proposed.For this publication,all the analysis was based on barley reference genome of2017(v1),and it was used throughout for consistence.However,the positions of the markers and genes identified were updated according to new genome(v3)for reference. | Edward Mwando Yong Han Tefera Angessa Xiao-Qi Zhang Chengdao Li | 2022 | The Crop Journal2022，10，3： | 0 |
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