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| 1 | FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers显示文摘forkhead 盒子抄写因素 A2 (FOXA2 ) 是在动物开发和身体动态平衡的一个重要管理者。然而, FOXA2 是否涉及转变生长因素尾 1 (TGF-尾 1 ) ,调停了 epithelial-to-mesenchymal 转变(EMT ) 和肿瘤转移仍然保持未知。现在的学习证明在人的肺癌症房间线,许多 FOXA2 断然与上皮的显型相关并且否定地与房间的间充质的显型相关,并且 TGF-尾 1 治疗减少了 FOXA2 蛋白质水平。一致地, FOXA2 击倒肺癌症房间的支持的 EMT 和侵略,而 FOXA2 的 overexpression 减少了侵略并且压制了 TGF- ,尾 1 导致了 EMT。另外, FOXA2 击倒禁止的 FOXA2 的导致的蛞蝓表示,和宫外的表示猛击抄写。而且,我们鉴别 FOXA2 能绑通过一个保存有约束力的地点猛击倡导者,并且 FOXA2 的 DNA 有约束力的区域和 transactivation 区域 II 为蛞蝓倡导者的压抑被要求。这些数据证明 FOXA2 由 EMT 的抑制作为肿瘤转移的 suppressor 工作。 | Yunneng Tang Guangwen Shu Xinwang Yuan Naihe Jing Jianguo Song | 2011 | Cell Research2011，21，2： | 27 |
| 2 | Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4显示文摘histone H3 离氨酸的 Dimethylations 9 和离氨酸 27 是与抄写压抑联系的重要 epigenetic 标记。这里,我们作为为这二个镇压标记特定的新奇 histone demethylase 识别了 KIAA1718 (KDM7A ) 。用老鼠胚胎的干细胞,我们证明那 KIAA1718 表情在神经区别的早阶段增加了。基因击倒堵住的神经区别和效果被野类型的人的基因,并且不由催化地不活跃的异种救。另外, KIAA1718 的 overexpression 加速了神经区别。我们提供 KDM7A 的支持 neural 区别效果通过 FGF4 的直接 transcriptional 激活被调停的证据,一个信号分子在神经区别含有。因此,我们的学习识别了通过 FGF4 调整神经区别的双特性的 histone demethylase。 | Chengyang Huang Yang Xiang Yanru Wang Xia Li Longyong Xu Ziqi Zhu Ting Zhang Qingqing Zhu Kejing Zhang Naihe Jing Charlie Degui Chen | 2010 | Cell Research2010，20，2： | 15 |
| 3 | Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome显示文摘PRKAG2 心脏的症候群正染色体的主导的继承疾病在编码 γ 的 PRKAG2 基因从变化被结果;激活安培的蛋白质 kinase 的 2 规章的子单元。影响病人通常开发室的 tachyarrhythmia 并且经历对医疗倔强并且要求心脏的移植的进步的心失败。在这研究,我们与家庭 Wolff-Parkinson-White 症候群从病人在 PRKAG2 识别一个 H530R 变化。由产生转基因的 H530R PRKAG2 和敲门在里面老鼠,我们证明两个模型包括心脏的肥大和肝糖存储概括人的症状,证实 H530R 变化是有原因地与 PRKAG2 有关心脏的症候群。我们进一步联合联系 adeno 的 virus-9 (AAV9 ) 和 CRISPR/Cas9 编辑基因的系统当让野类型的等位基因未经触动时,破坏编码 H530R 的变异的 PRKAG2 等位基因。在出生后的白天的 AAV9-Cas9/sgRNA 的单个全身的注射 4 或白天 42 实质地在转基因的 H530R PRKAG2 和敲门在里面鼠标恢复心的形态学和函数。一起,我们的工作建议在 vivo CRISPR/Cas9,染色体编辑由有选择地破坏引起疾病的变化是在 PRKAG2 心脏的症候群和另外的主导的继承心脏病的治疗的一个有效工具。 | Chang Xie Ya-Ping Zhang Lu Song Jie Luo Wei Qi Jialu Hu Danbo Lu Zhen Yang Jian Zhang Jian Xiao Bin Zhou Jiu-Lin Du Naihe Jing Yong Liu Yan Wang Bo-Liang Li Bao-Liang Song Yan Yan | 2016 | Cell Research2016，26，10： | 12 |
| 4 | MicroRNA expression profiling during neural differentiation of mouse embryonic carcinoma P19 cells显示文摘MicroRNAs (或 miRNAs ) 是涉及与房间的发展和区别有关的大量活动的小非编码的 RNA (2125 核苷酸) 。区分的神经干细胞的有那些的鼠标 P19 胚胎的癌房间的 miRNA 表达式侧面的比较证明表达式在区别以后 65 铺平改变的 miRNAs (2 褶层) 。MiR-124a 是戏剧性地起来调整的(超过 20 褶层) 当在 miR-290295 簇的 miR-302 家庭和那些的 miRNAs 是强烈下面调整的时。进一步的分析表明象 Oct4 和 Sox2 那样的一些重要因素看起来涉及这些 miRNAs 的规定。这些结果可以在早老鼠胚胎贡献调整 miRNA 的神经区别的更好的理解。 | Bing Huang Wei Li Botao Zhao Caihong Xia Ruqiang Liang Kangcheng Ruan Naihe Jing Youxin Jin | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 5 |
| 5 | Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages显示文摘 | Xianfa Yang Boqiang Hu Yu Hou Yunbo Qiao Ran Wang Yingying Chen Yun Qian Su Feng Jun Chen Chang Liu Guangdun Peng Fuchou Tang Naihe Jing | 2018 | Cell Research2018，28，5： | 5 |
| 6 | CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development显示文摘学习必要基因的早功能是在发展生物学的一个重要、挑战性的问题。这里,我们为很快在二房间的阶段胚胎的一个分裂球导致 CRISPR-Cas9-mediated 变化建立了一个方法,称为的 2 房间 embryo-CRISPR-Cas9 注射(2CC ) ,学习在里面必需品的 vivo 功能(或未知) 在创始人的基因妄想的鼠标。由注射指向兴趣的基因进的 Cre mRNA 和 CRISPR-Cas9 荧光灯记者老鼠, 2CC 方法能在不同发展阶段跟踪野类型、变异的房间,为变异的房间的 phenotypic 分析的出现内部控制。用这个方法,我们在在发展中的鼠标调整有刺激性、禁止的 synaptic 传播识别了必要基因 Tet3 的新奇函数服的外皮。由产生妄想的变异的老鼠, 2CC 方法允许在多重纸巾和房间的基因功能的快速的屏蔽录入妄想的老鼠创始人,显著地扩展基因工具的当前的一套设备。 | Wang, Lingbo Li, Min-Yin Qu, Chao Miao, Wan-Ying Yin, Qi Liao, Jiaoyang Cao, Hua-Teng Huang, Min Wang, Kai Zuo, Erwei Peng, Guangdun Zhang, Shu-Xin Chen, Guodong Li, Qing Tang, Ke Yu, Qian Li, Zhoujie Wong, Catherine C. L. Xu, Guoliang Jing, Naihe Yu, Xiang Li, Jinsong | 2017 | Cell Research2017，27，6： | 5 |
| 7 | TGF-β signaling pathway in early mouse development and embryonic stem cells显示文摘TGF- 总科发信号小径实质上包括胚胎的 patterning,房间命运决心和动态运动贡献早发展的事件的宽广光谱。在这评论,我们首先介绍了要求发信号显示出这些小径的基本重要性的 TGF- 的一些关键发展过程。然后,我们讨论他们的活动怎么被调整,并且关于的新调查结果 TGF- 总科 ligands 绑在染色质在胚胎开发期间调整抄写。 | Chang Liu Guangdun Peng Naihe Jing | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 4 |
| 8 | Mitochondrial replacement in macaque monkey offspring by first polar body transfer显示文摘Dear Editor,Mitochondrial DNA(mtDNA)mutations are materally inherited to the offspring and mitochondrial replacement therapy(MRT)provides.a promising approach for preventing mtDNA-related 1,2 diseases.First polar body transfer(PB1T)has been used for mitochondrial replacement to generate mouse offspring and normal human embryos that yield embryonic stem cells.However,generation of primate offspring using PB1T has not been reported.Here,we show that PB1T-based mitochondrial replacement could generate healthy macaque monkey(Macaca fascicularis),a useful non-human primate model for evaluating methods that may improve the efficiency and safety of PB1T for MRT. | Zhanyang Wang Yuzhuo Li Xianfa Yang Yan Wang Yanhong Nie Yuting Xu Xiaotong Zhang Yong Lu Tikui Zhang Qiming Liu Naihe Jing Zhen Liu Qiang Sun | 2021 | Cell Research2021，31，2： | 4 |
| 9 | Comments on ‘Molecular architecture of lineage allocation and tissue organization in early mouse embryo’显示文摘Single-cell RNA-seq,with its capability to align cells of continuously changed status by pseudo-time reconstruction,has greatly revolutionized the understanding of cell fate transition during embryo development(Shapiroetal.,2013;Hoppeetal.,2014). | Guizhong Cui Naihe jing Guangdun Peng | 2019 | Journal of Molecular Cell Biology2019，11，11： | 4 |
| 10 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 11 | AP2γ regulates neural and epidermal development down- stream of the BMP pathway at early stages of ectodermal patterning显示文摘骨头形态基因的蛋白质(BMP ) 禁止神经说明并且在 ectodermal patterning 期间导致表皮的区别。然而,这个过程的机制很好没被理解。这里,我们显示出那 AP2γ,一个抄写因素使活跃之物蛋白质(AP )-2 家庭成员,在 pluripotent 干细胞的神经区别期间是由 BMP4 的 upregulated。AP2γ 击倒;便于老鼠胚胎的干细胞(转换字符) 神经命运决心并且损害表皮的区别,而 AP2γoverexpression 禁止神经变换并且支持表皮的承诺。在早小鸡胚胎, AP2γ在 HH 舞台 3 前在全部 epiblast 被表示,逐渐地,到通常认为的表皮的外胚层的移动在 HH 期间上演 4。在未来神经的板 AP2γ也禁止过多的神经扩大和它在表面外胚层支持表皮的开发。而且, AP2γ在部分救的转换字符和小鸡胚胎击倒神经抑制和表皮的正式就职 BMP4 完成。机械学的研究证明 BMP4 直接调整 AP2γ通过对 AP2γ 有约束力的 Smad1 的表示;倡导者。一起拿,我们在小鸡胚胎在 ectodermal patterning 的早阶段期间建议那, AP2γBMP 小径下游地行动在未来的神经的板中限制早熟的神经扩大并且在未来开始表皮的区别表皮的外胚层。 | Yunbo Qiao Yue Zhu Nengyin Sheng Jun Chen Ran Tao Qingqing Zhu Ting Zhang Cheng Qian Naihe Jing | 2012 | Cell Research2012，22，11： | 4 |
| 12 | BMP signaling pathway and spinal cord development显示文摘针的绳索的发展是一个精确并且顺序调整的过程,它被在每个阶段表明小径和抄写因素控制。压到优势的数据显示出在这发展进程的不同阶段发信号的 BMP 的必要角色。BMP 发信号的合适的功能包括槽口, Wnt 和 retinoic 与几条另外的发信号的小径要求它的串音,也是清楚的酸(RA ) 小径。这里,我们在理解在针的绳索在神经发生,神经试管 patterning,轴突发展和 glial 区别期间发信号的 BMP 的角色加亮最近的前进,并且在这些过程期间与另外的小径强调它的集成。 | Zhihui XIE Nengyin SHENG Naihe JING | 2012 | Frontiers in Biology2012，7，1： | 3 |
| 13 | First intron of nestin gene regulates its expression during C2C12 myoblast differentiation显示文摘Nestin 是在神经祖先房间并且在锻炼骨胳的肌肉表示的中间的细丝蛋白质。Nestin 广泛地被用作一个神经祖先房间标记。在在神经祖先房间的基因的巢的特定的表示被在基因位于巢的第二内含子的神经特定的增强子授与,这很好被建立。然而,在在锻炼肌肉的表示的巢的 transcriptional 机制仍然是不清楚的。在这研究,我们识别了肌肉在在在老鼠 myoblast C2C12 房间的基因的老鼠巢的第一内含子的房间特定的增强子。我们局部性核心增强子活动到第一内含子的 291-661 区域,并且证明在核心增强子区域的二电子盒子为在区分 C2C12 房间的增强子活动是重要的。我们也证明那 MyoD 蛋白质在 C2C12 房间的 myogenic 区别在表示涉及巢的规定。 | Hua Zhong Zhigang Jin Yongfeng Chen Ting Zhang Wei Bian Xing Cui Naihe Jing | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 3 |
| 14 | Derivation of Haploid Neurons from Mouse Androgenetic Haploid Embryonic Stem Cells显示文摘Dear Editor,Haploid embryonic stem cells(ha ESCs)hold great potential for genetic screening and the analysis of recessive phenotypes.Several studies have recently reported the generation of mammalian ha ESCs through gamete manipulation,and evaluated the benefits of using them for studying functional genomics in different mammals[1–4].These ha ESCs have been shown to give rise to three | He Xu Chunmei Yue Ting Zhang Yuanyuan Li Ao Guo Jiaoyang Liao Gang Pei Jinsong Li Naihe Jing | 2017 | Neuroscience Bulletin2017，33，3： | 3 |
| 15 | Mouse knockout models reveal largely dispensable but context-dependent functions of IncRNAs during development显示文摘 | Xue Han Sai Luo Guangdun Peng Yuyang Lu Guizhong Cui Lichao Liu Pixi Yan Yafei Yin Wei Liu Ran Wang Jiejie Zhang Shanshan Ai Zai Chang Jie Na Aibin He Naihe Jing Xiaohua Shen | 2018 | Journal of Molecular Cell Biology2018，10，2： | 3 |
| 16 | TGFβ signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs显示文摘pluripotent 干细胞(PSC ) 的临床的治疗基于移植被 teratomas 或肿瘤的经常的开发在动物模型和临床的病人妨碍了。因此,在干细胞治疗澄清 carcinogenesis 的机制为减少 tumorigenicity 的风险是很重要的。这里,我们区分 Oct4-GFP 老鼠胚胎的干细胞(mESCs ) 进神经祖先房间(NPC ) 并且发现少数 Oct4+ 房间连续地以 Oct4+ 状态被支撑。这些房间能在标准转换字符媒介被充实并且增殖。有趣地,这些充实的房间的区别潜力紧与许多更高的 tumorigenic 活动被限制,它是因此定义的同样区别抵抗的转换字符(医生转换字符) 。Transcriptomic 和 epigenomic 分析证明医生转换字符被初发的细菌描绘像房间的基因签名(Dazl, Rec8, Stra8, Blimp1,等等) 并且从 mESCs 不同的特定的 epigenetic 模式。而且,医生转换字符拥有细菌房间潜力产生 Sycp3+ haploid 房间并且能居住在 busulfan 导致的没有精子的输精管。最后,我们发现 TGF 发信号是在 TGF 发信号的医生转换字符,和抑制的 overactivated 由导致医生转换字符的完整的区别消除导出 mESC 的 NPC 的 tumorigenicity。这些数据表明那像房间的医生转换字符是的这些 TGF-hyperactivated 细菌为导出转换字符的目标房间治疗的 tumorigenicity 和在导出转换字符的 NPC 移植发信号的 TGF 的那抑制的主要贡献者能急速地减少肿瘤开发的风险。 | Xianfa Yang Ran Wang Xiongjun Wang Guoqing Cai Yun Qian Su Feng Fangzhi Tan Kun Chen Ke Tang Xingxu Huang Naihe Jing Yunbo Qiao | 2018 | Journal of Molecular Cell Biology2018，10，3： | 2 |
| 17 | Hormones induce the formation of luminal-derived basal cells in the mammary gland显示文摘In the mammary gland, it is widely believed that the luminal cells are unipotent after birth, contributing only to the luminal compartment in normal development. Here, by lineage tracing, we uncovered an unexpected potential of luminal cells that can give rise to basal cells during pregnancy. These luminal-derived basal cells (LdBCs) persisted through mammary regression and gen erated more proge ny in successive rounds of preg nan cies. LdBCs express basal markers as well as estroge n receptor a (ERa). I n ovariectomized (OVX) mice, stimulation with estrogen and progesterone promoted the formation of LdBCs. In serial transplantation assays, LdBCs were able to rec on stitute new mammary glands in a hormone-depende nt manner. Tran scriptome an alysis and genetic experiments suggest that Wnt/p-catenin signaling is essential for the formation and maintenance of LdBCs. Our data uncover an unexpected bi-potency of luminal cells in a physiological context. The discovery of ERa+ basal cells, which can respond to hormones and are endowed with stem cell-like regenerative capacity in parous mammary gland, provides new insights into the association of hormones and breast cancer. | Wenqian Song Ran Wang Weimin Jiang Qi Yin Guangdun Peng Ruikai Yang Qing Cissy Yu Jianfeng Chen Jingsong Li Tom H. Cheung Naihe Jing Yi Arial Zeng | 2019 | Cell Research2019，29，3： | 2 |
| 18 | The genome-wide molecular regulation of mouse gastrulation embryo显示文摘The diverse morphologies among vertebrate species stems from the evolution of a basic body plan that is constituted by a spatially organized ensemble of tissue lineage progenitors. At gastrulation, this body plan is established through a coordinated morphogenetic process and the delineation of tissue lineages that are driven by the activity of the genome. To explore the molecular mechanisms, in a comprehensive context, it is imperative to glean an understanding of the region-and population-specific genetic activity underpinning this fundamental developmental process. In this review, we outline the recent progress and the future directions in studies of genome activity for the regulation of mouse embryogenesis at gastrulation. | Guangdun Peng Naihe Jing | 2017 | Science China(Life Sciences)2017，60，4： | 2 |
| 19 | Formative pluripotent stem cells show features of epiblast cells poised for gastrulation显示文摘The pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells(ESCs)and primed epiblast stem cells(EpiSCs),respectively.However,these two states of pluripotency may not be sufficient to reflect the full complexity and developmental potency of the epiblast during mammalian early development.Here we report the establishment of self-renewing formative pluripotent stem cells(fPSCs)which manifest features of epiblast cells poised for gastrulation.fPSCs can be established from different mouse ESCs,pre-/early-gastrula epiblasts and induced PSCs.Similar to pre-/early-gastrula epiblasts,fPSCs show the transcriptomic features of formative pluripotency,which are distinct from naïve ESCs and primed EpiSCs.fPSCs show the unique epigenetic states of E6.5 epiblast,including the super-bivalency of a large set of developmental genes.Just like epiblast cells immediately before gastrulation,fPSCs can efficiently differentiate into three germ layers and primordial germ cells(PGCs)in vitro.Thus,fPSCs highlight the feasibility of using PSCs to explore the development of mammalian epiblast. | Xiaoxiao Wang Yunlong Xiang Yang Yu Ran Wang Yu Zhang Qianhua Xu Hao Sun Zhen-Ao Zhao Xiangxiang Jiang Xiaoqing Wang Xukun Lu Dandan Qin Yujun Quan Jiaqi Zhang Ng Shyh-Chang Hongmei Wang Naihe Jing Wei Xie Lei Li | 2021 | Cell Research2021，31，5： | 2 |
| 20 | The promise of stem cells in the therapy of Alzheimer’s disease显示文摘Alzheimer’s disease(AD),a common neurodegenerative disorder associated with gradually to dramatic neuronal death,synaptic loss and dementia,is considered to be one of the most obscure and intractable brain disorders in medicine.Currently,there is no therapy clinically available to induce marked symptomatic relief in AD patients.In recent years,the proof-of-concept studies using stem cell-based approaches in transgenic AD animal models provide new hope to develop stem cell-based therapies for the effective treatment of AD.The degeneration of basal forebrain cholinergic neurons(BFCNs)and the resultant cholinergic abnormalities in the brain contribute substantially to the cognitive decline of AD patients.The approches using stem cell-derived BFCNs as donor cells need to be developed,and to provide proof of principle that this subtype-specific neurons can induce functional recovery of AD animal models.With the continuous scientific advances in both academic and industrial fields,the potentials of stem cells in cellular neuroprotection and cell replacement in vivo have been elucidated,and stem cell-based therapy for repairing degenerative brains of AD is promising. | Chunmei Yue Naihe Jing | 2015 | Translational Neurodegeneration2015，4，1： | 1 |
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