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| 1 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 2 | Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design显示文摘Varicella-zoster virus(VZV)is a highly infectious agent responsible for both varicella and herpes zoster disease.Despite high efficacy,there remain safety and accessibility concerns with the licensed vaccines.Here,we sought to produce a VZV g E immunogen using an E.coli expression system.We found that the soluble expression and yield of g E protein could be enhanced via C-terminal truncations to the protein,thereby facilitating a robust and scalable purification process for the purpose of vaccine manufacturing.The lead truncated g E(aa 31–358),hereafter referred to as tg E,was a homogenous monomer in solution and showed excellent antigenicity.Finally,we assessed and compared the immunogenicity of tg E with commercial v Oka LAV and Shingrix vaccine.We found that aluminum-adjuvanted tg E was immunogenic as compared with v Oka LAV.When adjuvanted with AS01B,a two-dose immunization of tg E showed comparable or better potency in antibody responses and cell-mediated immunity with those of the Shingrix vaccine at the same dosage,especially in terms of the proportion of IFN-γ-expressing CD4^(+)T cells.In conclusion,this method of E.coli-mediate tg E expression offers a cost-effective and scalable strategy to generate an ideal VZV g E immunogen for the development of both varicella and zoster vaccines. | Tingting Chen Jie Sun Sibo Zhang Tingting Li Liqin Liu Wenhui Xue Lizhi Zhou Siting Liang Zhili Yu Qingbing Zheng Hai Yu Tong Cheng Jun Zhang Ying Gu Shaowei Li Ningshao Xia | 2023 | Science China(Life Sciences)2023，66，4： | 1 |
| 3 | Tensile behavior of 3D woven composites by using different fabric structures 显示文摘 | Huang Gu Zhong Zhili | 2002 | Materials and Design2002，23，7： | 1 |
| 4 | The fracture processes of the Tangshan earthquake and its mechanical analysis 显示文摘 | Zhang Zhili Li Qinzu Gu Jicheng | 1980 | Acta Seismologica Sinica1980，2，2： | 1 |
| 5 | Tensile behavior of 3D woven composites by using different fabric structures显示文摘 | Gu H Zhili Z | 2002 | Materi als and Design2002，23，7： | 1 |
| 6 | Tensile behavior of 3D woven composites by using different fabric structures显示文摘 | Zhong Zhili | 2002 | Materials and Design2002，23，7： | 1 |
| 7 | From atom to monatomic wire:an ab initio study of magnetism in 3d transition metals显示文摘A systematic ab initio study on magnetism of the 3d transition metals(TM) from atom to monoatomic wire within density functional theory with generalized gradient approximation(GGA) was performed.The results show that the spin coupling has strong intraatomic exchange strengths about 1 eV for isolated 3d TM atoms.The magnetic moments are distinctly lower than those of free atoms for all dimers except Mn 2 .All the 3d TM elements exhibit magnetic ground states in the linear wire structure. | Zhili ZHU Jinhua GU Yu JIA Xing HU | 2010 | Acta Metallurgica Sinica(English Letters)2010，23，3： | 0 |
| 8 | First principle study on the possibilities of magnetism in one-dimensional In and Tl atomic wires with the full-potential linearized augmented plane wave method显示文摘Using ab initio total energy calculations with the full-potential linearized augmented plane wave method,the possibilities of magnetism in one-dimensional In and Tl wires were explored and their properties as the function of geometric structures were studied.The results suggest that the linear In and Tl wires show magnetization at the equilibrium bond distance with magnetic moments of 0.71 and 0.67 μB/atom,respectively.Allowing ions to relax,the wires were deformed as zigzag structures,but no dimerization occurs.The zigzag wires also exhibit spontaneous magnetization,although the magnetic moments are lower than those of straight wires. | Zhili ZHU Jinhua GU Yu JIA Xing HU | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，2： | 0 |
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