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| 1 | Role of Wnt/β‐catenin signaling pathway in epithelial‐mesenchymal transition of human prostate cancer induced by hypoxia‐inducible factor‐1α显示文摘 | Yong‐GuangJiang YongLuo Da‐linHe XiangLi Lin‐linZhang TaoPeng Ming‐ChuanLi Yun‐HuaLin | 2007 | International Journal of Urology2007，，11： | 2 |
| 2 | The analysis of deregulated expression and methylation of the PER2 genes in gliomas显示文摘 | Wang Fan Xiaowei Chen Caiyan Li Yongluo Lvan Chen Pingfei Liu Zhijun Chen | 2014 | Journal of Cancer Research and Therapeutics2014，，3： | 1 |
| 3 | A novel preparation method of ZnO/MCM-41 for hydrogenation of methyl benzoate显示文摘 | Weijing Lu GuanzhongLu YongLuo etal | 2002 | Journal of Molecular Catalysis A:Chemical2002，188，： | 1 |
| 4 | Friction and wear behavior of three-dimensional braided carbon fiber/epoxy composites under lubricated sliding conditions显示文摘 | Wan Yizhi Luo Hengliang Wang Yongluo | 2005 | J Mater Sci2005，40，17： | 1 |
| 5 | Localization and identification of parapharyngeal metastases from differentiated thyroid carcinoma by 131I‐SPECT/CT显示文摘 | Zhong‐LingQiu Yan‐HongXu Hong‐JunSong Quan‐YongLuo | 2011 | Head Neck2011，，： | 1 |
| 6 | The Abundance of Strange Attractor in the Families of Nearby Singular Diffeomorphism | Cao Yongluo (Department of Mathematics,Suzhou University,Suzhou 215006,China) | 1997 | Acta Mathematica Sinica,English Series1997，13，1： | 0 |
| 7 | SINAI BOWEN RUELLE MEASURE AND THE STRUCTURE OF STRANGE ATTRACTORS IN THE LAUWERIER MAP显示文摘In this paper,the Lauwerier map F a,b (x,y)=(bx(1-2y)+y,ay(1-y)) is considered for a=4 . This map possesses a nontrivial topologically transitive attractor Λ which is the closure of the unstable set of some hyperbolic fixed point. Periodic points are dense in Λ and all of them are hyperbolic with eigenvalues uniformly bounded away from 1 in norm. Moreover,any two periodic points are heteroclinically related (transversal intersection of their stable and unstable sets). The Sinai Bowen Ruelle measure supported on the attractor is constructed and its properties are studied. | Wang Yi\ Cao Yongluo Dept. of Math., Suzhou Univ., Suzhou 215006. | 2001 | Applied Mathematics(A Journal of Chinese Universities)2001，16，1： | 0 |
| 8 | Discussion on the Geometrie Structure of Strange Attractor显示文摘We discuss the tr&nsversal heteroclinic cycle formed by hyperbolic periodic points of diffeomorphism on the differential manifold.We point out that every possible kind of transversal heteroclinic cycle has the Smsdehorse property and the unstable manifolds of hyperbolic periodic points have the closure relation mutually.Therefore the strange attractor may be the closure of unstable manifolds of a countable number of hyperbolic periodic points.The Henon mapping is used as an example to show that the conclusion is reasonable. | LIU Zengrong CAO Yongluo | 1991 | Chinese Physics Letters1991，8，10： | 0 |
| 9 | The burgeoning importance of PIWI-interacting RNAs in cancer progression显示文摘PIWI-interacting RNAs(pi RNAs)are a class of small noncoding RNA molecules that specifically bind to piwi protein family members to exert regulatory functions in germ cells.Recent studies have found that pi RNAs,as tissue-specific molecules,both play oncogenic and tumor suppressive roles in cancer progression,including cancer cell proliferation,metastasis,chemoresistance and stemness.Additionally,the atypical manifestation of pi RNAs and PIWI proteins in various malignancies presents a promising strategy for the identification of novel biomarkers and therapeutic targets in the diagnosis and management of tumors.Nonetheless,the precise functions of pi RNAs in cancer progression and their underlying mechanisms have yet to be fully comprehended.This review aims to examine current research on the biogenesis and functions of pi RNA and its burgeoning importance in cancer progression,thereby offering novel perspectives on the potential utilization of pi RNAs and piwi proteins in the management and treatment of advanced cancer. | Xinpei Deng Tianle Liao Jindong Xie Da Kang Yiwei He Yuying Sun Zhangling Wang Yongluo Jiang Xuan Miao Yixuan Yan Hailin Tang Lewei Zhu Yutian Zou Peng Liu | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
| 10 | Analysis on appendicitis of 2000 patients in clinical anatomy显示文摘 | JianCao BinMeng BoZhang YingquanLi RuiWang MingzhiCheng WeiTao JunHu BoLiang DishengMeng DaweiLi YongLuo GeyangXu | 2004 | 中国组织化学与细胞化学杂志2004，13，3： | 0 |
| 11 | Solubility of disulfide-bonded proteins in the cytoplasm of Escherichia co/i and its “oxidizing” mutant显示文摘AIM: To study the influence of redox environment of Escherichia coli ( E. coli) cytoplasm on disulfide bond formation of recombinant proteins.METHODS: Bovine fibroblast growth factor (BbFGF) was selected as a model of simple proteins with a single disulfide bond and free cysteines. Anti-HBsAg single-chain Fv (HBscFv), an artificial multidomain protein, was selected as the model molecule of complex protein with 2 disulfide bonds. A BbFGF-producing plasmid, pJN-BbFGF,and a HBscFv producing-plasmid, pQE-HBscFv, were constructed and transformed into E. coli strains BL21(DE3)and M15[pREP4]respectively. At the same time, both plasmids were transformedinto a reductase-deficient host strain, E. coli Origami(DE3). The 4 recombinant E. coli strains were cultured and the target proteins were purified. Solubility and bioactivity of recombinant BbFGF and HBscFv produced in different host strains were analyzed and compared respectively.RESULTS: All recombinant E. colistrains could efficiently produce target proteins. The level of BbFGF in BL21(DE3)was 15-23% of the total protein, and was 5-10% in Origami (DE3). In addition, 65% of the BbFGF produced in BL21(DE3) formed into inclusion body in the cytoplasm,and all the target proteins became soluble in Origami (DE3). The bioactivity of BbFGF purified from Origami(DE3)was higher than its counterpart from BL21(DE3). The ED50of BbFGF from Origami(DE3) and BL21(DE3) was 1.6 μg/L and 2.2 μg/L, respectively. Both HBscFv formed into inclusion body in the cytoplasm of M15[pQE-HBscFv] or Origami[pQE-HBscFv]. But the supernatant of Origami[pQE-HBscFv] lysate displayed weak bioactivity and its counterpart from M15[pQE-HBscFv] did not display any bioactivity. The soluble HBscFv in Origami[pQE-HBscFv]was purified to be 1-2 mg/L and its affinity constant was determined to be 2.62×107 mol/L. The yield of native HBscFv refolded from indusion body in M15[pQE-H Fv] was30-35 mg/L and the affinity constant was 1.98×107 mol/L.There was no significant difference between the bioactivity of HBscFvs refolded from the inclusion bodies produced in different host strains.CONCLUSION: Modification of the redox environment of E. coli cytoplasm can significantly improve the folding of recombinant disulfide-bonded proteins produced in it. | ShengXiong Yi-FeiWang Xiang-RongPen BingLi Mei-YingZhang YongLuo LingZhang Qiu-LingXie Kuan-YuanSu | 2005 | World Journal of Gastroenterology2005，11，7： | 0 |
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