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| 1 | The modulation of radiation-induced cell death by genistein in K562 cells:Activation of thymidine kinase 1显示文摘Ionizing radiation is one of the most effective tools in cancer therapy. In a previous study, we reported that protein tyrosine kinase (PTK) inhibitors modulate the radiation responses in the human chronic myelogenous leukemia (CML)cell line K562. The receptor tyrosine kinase inhibitor, genistein, delayed radiation-induced cell death, while non-recepter tyrosine kinase inhibitor, herbimycin A (HMA) enhances radiation-induced apoptosis. In this study, we focused on the modulation of radiation-induced cell death by genistein and performed PCR-select suppression subtractive hybridization(SSH) to understand its molecular mechanism. We identified human thymidine kinase 1 (TK1), which is cell cycle regulatory gene and confirmed expression of TK1 mRNA by Northern blot analysis. Expression of TK1 mRNA and TK 1enzymatic activity were parallel in their increase and decrease. TK1 is involved in G1-S phase transition of cell cycle progression. In cell cycle analysis, we showed that radiation induced G2 arrest in K562 cells but it was not able to sustain. However, the addition of genistein to irradiated cells sustained a prolonged G2 arrest up to 120 h. In addition,the expression of cell cycle-related proteins, cyclin A and cyclin B 1, provided the evidences of G1/S progression and G2-arrest, and their relationship with TK1 in cells treated with radiation and genistein. These results suggest that the activation of TK1 may be critical to modulate the radiation-induced cell death and cell cycle progression in irradiated K562 cells. | Min Ho JEONG Young Hee JIN Eun Young KANG Wol Soon JO Hwan Tae PARK Jae Dong LEE Yeo Jin YOO Soo Jin JEONG | 2004 | Cell Research2004，14，4： | 10 |
| 2 | Online Predictive Monitoring and Prediction Model for a Periodic Process Through Multiway Non-Gaussian Modeling显示文摘一新为周期的生物过程的联机预兆的监视和预言模型被建议用多方法 non-Gaussian 建模。这条途径的基本想法是多使用方法 non-Gaussian 当模特儿在一个周期的过程从每日的正常操作数据提取某主导的关键组分,并且随后把这些部件与预兆的统计过程监视相结合技术。建议预兆的监视方法被使用了在生物废水处理过程指责察觉和诊断,它基于强壮日报特征。结果显示出力量和优点连续法的建议预兆的监视用多方法预兆监视概念,它因此能为一个每日的监视过程并且也给很有用的概念的结果比另外的传统的监视方法启用过程差错的更快速的察觉。 | Changkyoo Yoo Minhan Kim Sunjin Hwang Yongmin Jo Jongmin Oh | 2008 | Chinese Journal of Chemical Engineering2008，16，1： | 3 |
| 3 | Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network显示文摘The healthcare industry is in dire need of rapid microbial identification techniques for treating microbial infections.Microbial infections are a major healthcare issue worldwide,as these widespread diseases often develop into deadly symptoms.While studies have shown that an early appropriate antibiotic treatment significantly reduces the mortality of an infection,this effective treatment is difficult to practice.The main obstacle to early appropriate antibiotic treatments is the long turnaround time of the routine microbial identification,which includes time-consuming sample growth.Here,we propose a microscopy-based framework that identifies the pathogen from single to few cells.Our framework obtains and exploits the morphology of the limited sample by incorporating three-dimensional quantitative phase imaging and an artificial neural network.We demonstrate the identification of 19 bacterial species that cause bloodstream infections,achieving an accuracy of 82.5%from an individual bacterial cell or cluster.This performance,comparable to that of the gold standard mass spectroscopy under a sufficient amount of sample,underpins the effectiveness of our framework in clinical applications.Furthermore,our accuracy increases with multiple measurements,reaching 99.9%with seven different measurements of cells or clusters.We believe that our framework can serve as a beneficial advisory tool for clinicians during the initial treatment of infections. | Geon Kim Daewoong Ahn Minhee Kang Jinho Park DongHun Ryu YoungJu Jo Jinyeop Song Jea Sung Ryu Gunho Choi Hyun Jung Chung Kyuseok Kim Doo Ryeon Chung In Young Yoo Hee Jae Huh Hyun-seok Min Nam Yong Lee YongKeun Park | 2022 | Light(Science & Applications)2022，11，7： | 2 |
| 4 | Highly reliable processes for embedding discrete passive components into organic substrates显示文摘 | Han Seo Cho Sukhyeon Cho Jihong Jo Haenam Seo Byongmoon Kim Jegwang Yoo | 2008 | Microelectronics Reliability2008，，5： | 1 |
| 5 | The control of neural cell-to-cell interactions through non- contact electrical field stimulation using graphene electrodes显示文摘 | Heo C Yoo J Lee S Jo A Jung S Yoo H Lee Y H Suh M | 2011 | Biomaterials2011，32，： | 1 |
| 6 | Compositional prediction of creep rupture life of single crystal Ni base super alloy by Bayesian neural network显示文摘 | Yoo Y S Jo C Y Jones C N | 2002 | Materials Science and Engineering A2002，336，1： | 1 |
| 7 | A secure and efficient SIP authentication scheme for converged VoIP networks显示文摘 | Eun-Jun Yoon Kee-Young Yoo Cheonshik Kim You-Sik Hong Minho Jo Hsiao-Hwa Chen | 2010 | Computer Communications2010，，14： | 1 |
| 8 | A comparative study on thermomechanical and low cycle fatigue failures of a single crystal nickel-based superalloy显示文摘 | H.U. Hong J.G. Kang B.G. Choi I.S. Kim Y.S. Yoo C.Y. Jo | 2011 | International Journal of Fatigue2011，，12： | 1 |
| 9 | CO 2 capture characteristics of dry sorbents in a fast fluidized reactor显示文摘 | Chang-Keun Yi S.H. Jo Y. Seo S.D. Park K.H. Moon J.S. Yoo J.B. Lee C.K. Ryu | 2006 | Studies in Surface Science and Catalysis2006，，： | 1 |
| 10 | Synchronous elevation of soluble intercelleular adhesion molecule-1(ICAM-1)and vascular cell adhesion molecule-1(VCAM-1) correlates with gastric cancer progression显示文摘 | Chung HC Park JO | 1998 | Yonsei Med J1998，39，1： | 1 |
| 11 | Synchronous elevation of sICAM-1 and sVCAM-1 correlates with gastric cancer progression显示文摘 | Yoo NC Chung HC Park JO | 1998 | Yonsei Med J1998，39，1： | 1 |
| 12 | Efect of mobile phase composition on henry' s constants of 2-amino-3-phenyl-propanoic acid, 2-amino-3-(3-indolyl)-propanoic acid, and 2-amino-3-(d-hydroxyphenyl)-propanoic acid in a capcell pak C ls chromatography显示文摘 | Hart Q Yoo C G Jo S H | 2008 | J Chem Eng Data2008，53，： | 1 |
| 13 | Diffusionless-Like Transformation Unlocks Pseudocapacitance with Bulk Utilization: Reinventing Fe_(2)O_(3) in Alkaline Electrolyte显示文摘Energy density can be substantially raised and even maximized if the bulk of an electrode material is fully utilized.Transition metal oxides based on conversion reaction mechanism are the imperative choice due to either constructing nanostructure or intercalation pseudocapacitance with their intrinsic limitations.However,the fully bulk utilization of transition metal oxides is hindered by the poor understanding of atomic-level conversion reaction mechanism,particularly it is largely missing at clarifying how the phase transformation(conversion reaction)determines the electrochemical performance such as power density and cyclic stability.Herein,α-Fe_(2)O_(3) is a case provided to claim how the diffusional and diffusionless transformation determine the electrochemical behaviors,as of its conversion reaction mechanism with fully bulk utilization in alkaline electrolyte.Specifically,the discharge productα-FeOOH diffusional from Fe(OH)2 is structurally identified as the atomic-level arch criminal for its cyclic stability deterioration,whereas the counterpartδ-FeOOH is theoretically diffusionless-like,unlocking the full potential of the pseudocapacitance with fully bulk utilization.Thus,such pseudocapacitance,in proof-of-concept and termed as conversion pseudocapacitance,is achieved via diffusionless-like transformation.This work not only provides an atomic-level perspective to reassess the potential electrochemical performance of the transition metal oxides electrode materials based on conversion reaction mechanism but also debuts a new paradigm for pseudocapacitance. | Taowen Dong Wencai Yi Ting Deng Tingting Qin Xianyu Chu He Yang Lirong Zheng Seung Jo Yoo Jin-Gyu Kim Zizhun Wang Yan Wang Wei Zhang Weitao Zheng | 2023 | Energy & Environmental Materials2023，6，1： | 1 |
| 14 | Electmspinning mechanism for producing nanosc:e polymer fibers 显示文摘 | Kong C S Yoo W S Jo N G | 2010 | Journal of Macromolecular Science Part B: Physics2010，49，1： | 1 |
| 15 | New insights into the mechanisms for photodynamic therapy-induced cancer cell death显示文摘 | Yoo JO Ha KS | 2012 | Int Rev Cell Mol Biol2012，295，： | 1 |
| 16 | Compositional prediction of creep rupture life of single crystal Ni base superalloy by Bayesian neural network显示文摘 | YOO Y S JO C Y | 2002 | Materials Science & Engineering2002，336，12： | 1 |
| 17 | EFFECT OF CARBON AND BORON ON MICROSTRUCTURE AND MECHANICAL PROPERTIES OF A SINGLE CRYSTAL SUPERALLOY RR 2072显示文摘Carbon and boron have been considered to strengthen grain boundaries that might form during single crystal casting.In this study the effect of boron on solidification behavior and creep properties of the carbon aoped single crystal RR 2072 has been investigated.In order to understand solidification behavior with boron addition, the solid/liquid interface morphology and solidification microstructure were examined with solidification rate.The relationship between microstructural evolution and creep properties of the carbon and boron modified single crystal has been also investigated. | D.H.Kim D.H. Ye J.H. Lee Y.S. Yoo C.Y. Jo | 2005 | Acta Metallurgica Sinica(English Letters)2005，18，1： | 1 |
| 18 | Palliative treatment of malignant gastroduodenal obstruction with metallic stent: prospective comparison of covered and uncovered stents显示文摘 | Kee Myung Lee Sang Jo Choi Sung Jae Shin Jae Chul Hwang Sun Gyo Lim Jae Yeon Jung Byung Moo Yoo Sung Won Cho Jin Hong Kim | 2009 | Scandinavian Journal of Gastroenterology2009，，7： | 1 |
| 19 | lncreasing incidence of medial meniscal tears in nonoperativly ryeated anterior cruciate ligament insafficjency patients docu-Mented by serial magnatie resortarice imagfng studies显示文摘 | Yoo JO Ahn JH Lee SH | 2009 | Am J Sports Med2009，57，： | 1 |
| 20 | Irradiation effect on a-and ?easeins of milk and Queso Blanco cheese determined by capillary electrophoresis显示文摘 | HAM J S JEONG S G LEE S G HAN G S CHAE H S YOO Y M KIM D H LEE W K JO C | 2009 | Radiat Phys Chem2009，78，2： | 1 |
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