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| 1 | The influence on liver parenchymal function and complications of radiofrequency ablation or the combination with transcatheter arterial embolization for hepatocellular carcinoma显示文摘 | Masahiko Koda Masaru Ueki Yoshiko Maeda Ken-Ichi Mimura Kinya Okamoto Yoshiko Matsunaga Manri Kawakami Keiko Hosho Yoshikazu Murawaki | 2004 | Hepatology Research2004，，1： | 2 |
| 2 | Stanniocalcin 1 stimulates osteoblast differentiation in rat calvaria cell cultures显示文摘 | Yoshiko Y Maeda N Aubin JE | 2003 | Endocrinology2003，144，： | 1 |
| 3 | Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro显示文摘 | Wang H Yoshiko Y Yamamoto R Minamizaki T Kozai K Tanne K Aubin JE Maeda N | | 0，，6： | 1 |
| 4 | Qualitative assessment of tumor vascularity in hepatocellular carcinoma by contrast-enhanced coded ultrasound: comparison with arterial phase of dynamic CT and conventional color/power Doppler ultrasound显示文摘 | Masahiko Koda Yoshiko Matsunaga Masaru Ueki Yoshiko Maeda Ken-ichi Mimura Kinya Okamoto Keiko Hosho Yoshikazu Murawaki | 2004 | European Radiology2004，，6： | 1 |
| 5 | Osteoblast autonomous Pi regulation via Pitl plays a role in bone Mineralization显示文摘 | Yoshiko Y Candeliere GA Maeda N | 2007 | Mol Cell Biol2007，27，12： | 1 |
| 6 | Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios alone or combined with prostate-specific antigen for the diagnosis of prostate cancer and clinically significant prostate cancer显示文摘Objective:We evaluated whether the blood parameters before prostate biopsy can diagnose prostate cancer(PCa)and clinically significant PCa(Gleason score[GS]7)in our hospital.Methods:This study included patients with increased prostate-specific antigen(PSA)up to 20 ng/mL.The associations of neutrophil-to-lymphocyte ratio(NLR)and platelet-tolymphocyte ratio(PLR)alone or with PSA with PCa and clinically significant PCa were analyzed.Results:We included 365 patients,of whom 52.9%(193)had PCa including 66.8%(129)with GS of≥7.PSA density(PSAD)and PSA had better the area under the curve(AUC)of 0.722 and 0.585,respectively with pZ0.001 for detecting PCa compared with other blood parameters.PSA combined with PLR(PsPLR)and PSA with NLR(PsNLR)had better AUC of 0.608 and 0.610,respectively with p<0.05,for diagnosing GS≥7 population,compared with PSA,free/total PSA,NLR,PLR,and PsNPLR(PSA combined with NLR and PLR).NLR and PLR did not predict PCa on multivariate analysis.For GS≥7 cancer detection,in the multivariate analysis,separate models with PSA and NLR(Model 1:PsNLRþbaseline parameters)or PSA and PLR(Moder 2:PsPLRþbaseline parameters)were made.Baseline parameters comprised age,digital rectal exam-positive lesions,PSA density,free/total PSA,and magnetic resonance imaging.Model 2 containing PsPLR was statistically significant(odds ratio:2.862,95% confidence interval:1.174-6.975,p=0.021)in finding aggressive PCa.The predictive accuracy of Model 2 was increased(AUC:0.734,p<0.001)than that when only baseline parameters were used(AUC:0.693,p<0.001).Conclusion:NLR or PLR,either alone or combined with PSA,did not detect PCa.However,the combined use of PSA with PLR could find the differences between clinically significant and insignificant PCa in our retrospective study limited by the small number of samples. | Sat Prasad Nepal Takehiko Nakasato Takashi Fukagai Yoshio Ogawa Yoshihiro Nakagami Takeshi Shichijo Jun Morita Yoshiko Maeda Kazuhiko Oshinomi Tsutomu Unoki Tetsuo Noguchi Tatsuki Inoue Ryosuke Kato Satoshi Amano Moyuru Mizunuma Masahiro Kurokawa Yoshiki Tsunokawa Sou Yasuda | 2023 | Asian Journal of Urology2023，10，2： | 1 |
| 7 | Hepatocellular carcinoma with sarcomatous change arising after radiofrequency ablation for well-differentiated hepatocellular carcinoma显示文摘 | Masahiko Koda Yoshiko Maeda Yoshiko Matsunaga Ken-ichi Mimura Yoshikazu Murawaki Yasushi Horie | 2003 | Hepatology Research2003，，2： | 1 |
| 8 | Differentiation in C2C12 muobtasts depends on the expression of endogenous IGFs and not serum depletion 显示文摘 | Yuji Yoshiko Keita Hirao Norihiko Maeda | 2002 | Am J Phusiol Cell Physiol2002，283，： | 1 |
| 9 | Low-dose non-enhanced CT versus full-dose contrast-enhanced CT in integrated PET/CT scans for diagnosing ovarian cancer recurrence显示文摘 | Kazuhiro Kitajima Yoshiko Ueno Kayo Suzuki Masato Kita Yasuhiko Ebina Hideto Yamada Michio Senda Tetsuo Maeda Kazuro Sugimura | 2012 | European Journal of Radiology2012，，： | 1 |
| 10 | Differentiation in C2C12 myoblasts depends on IGFs and not serum depletion 显示文摘 | Yoshiko Y Hirao K Maeda N | 2002 | Am J Physiol Cell Physiol2002，283，4： | 1 |
| 11 | Macroglial Plasticity and the Origins of Reactive Astroglia inExperimental Autoimmune Encephalomyelitis显示文摘 | Fuzheng Guo Yoshiko Maeda Joyce Ma | | 0，，33： | 1 |
| 12 | Evidence for Stanniocalcin Gene Expression in Mammalian Bone 显示文摘 | Yoshiko Y Son A Maeda S | 1999 | Endocrinology1999，140，4： | 1 |
| 13 | Osteoblasl au- tonomous Pi regulation via Pitl plays a role in bone mineruliz:li:n 显示文摘 | YOSHIKO Y CANDELIERE G A MAEDA N | 2007 | Mol Cell Biol2007，27，12： | 1 |
| 14 | Clinical prediction of complicated appendicitis:A case-control study utilizing logistic regression显示文摘BACKGROUND Since high-quality evidence on conservative treatment of acute appendicitis using antibiotics has increased,differentiation of patients with complicated appendicitis(CA)from those with simple appendicitis(SA)has become increasingly important.Previous studies have revealed that male gender,advanced age,comorbid conditions,prehospital delay,fever,and anorexia are risk factors of perforated appendicitis.Elevated serum C-reactive protein(CRP)level and hyponatremia have also been reported as predictive biomarkers of CA.However,confounding between various factors is problematic because most previous studies were limited to univariate analysis.AIM To evaluate non-laboratory and laboratory predictive factors of CA using logistic regression analyses.METHODS We performed an exploratory,single-center,retrospective case-control study that evaluated 198 patients(83.9%)with SA and 38 patients(16.1%)with CA.Diagnoses were confirmed by computed tomography images for all cases.We compared age,sex,onset-to-visit interval,epigastric/periumbilical pain,right lower quadrant pain,nausea/vomiting,diarrhea,anorexia,medical history(of previous non-surgically treated appendicitis,diabetes,hypertension,dyslipidemia,liver cirrhosis,hemodialysis,chronic lung diseases,malignant tumors,immunosuppressant use,and antiplatelet use),vital signs,physical findings,and laboratory data to select the explanatory variates for logistic regression.Based on the univariate comparisons,we performed logistic regression for clinical differentiation between CA and SA using only nonlaboratory factors and also including both non-laboratory and laboratory factors.RESULTS The 236 eligible patients consisted of 198 patients(83.9%)with SA and 38 patients(16.1%)with CA.The median ages were 34 years old[interquartile ranges(IR),24-45 years]in the SA group and 49 years old(IR,35-63 years)in the CA group(P<0.001).The median onset-to-visit interval was 1 d(IR,0-1)and 1 d(IR,1-2)in the SA and CA groups,respectively(P<0.001).Heart rate,body temperature,and serum CRP level in the CA group were significantly higher than in the SA group;glomerular filtration rate and serum sodium were significantly lower in the CA group.Anorexia was significantly more prevalent in the CA group.The regression model including age,onset-to-visit interval,anorexia,tachycardia,and fever as non-laboratory predictive factors of CA(Model 1)showed that age≥65 years old,longer onset-to-visit interval,and anorexia had significantly high odds ratios.The logistic regression for prediction of CA including age,onset-to-visit interval,anorexia,serum CRP level,hyponatremia(serum sodium<135 mEq/L),and glomerular filtration rate<60 mL/min/1.73 m2(Model 2)showed that only elevated CRP levels had significantly high odds ratios.Under the curve values of receiver operating characteristics curves of each regression model were 0.74 for Model 1 and 0.87 for Model 2.CONCLUSION Our logistic regression analysis on differentiating factors of CA from SA showed that high CRP level was a strong dose-dependent predictor of CA. | Yosuke Sasaki Fumiya Komatsu Naoyasu Kashima Takeshi Suzuki Ikutaka Takemoto Sho Kijima Tadashi Maeda Taito Miyazaki Yoshiko Honda Hiroaki Zai Nagato Shimada Kimihiko Funahashi Yoshihisa Urita | 2020 | World Journal of Clinical Cases2020，8，11： | 0 |
| 15 | Clinical differentiation of acute appendicitis and right colonic diverticulitis: A case-control study显示文摘BACKGROUND Acute right colonic diverticulitis (ARCD) is an important differential diagnosis of acute appendicitis (AA) in Asian countries because of the unusually high prevalence of right colonic diverticula. Due to qualitative improvement and the high penetration rate of computed tomography (CT) scanning in Japan, differentiation of ARCD and AA mainly depends on this modality. But cost, limited availability, and concern for radiation exposure make CT scanning problematic. Differential findings of ARCD from AA are based on several small studies that used univariate comparisons from Korea and Taiwan. Previous studies on clinical and laboratory differences between AA and ARCD are limited. AIM To determine clinical differences between AA and ARCD for differentiation of these two diagnoses by creating a logistic regression model. METHODS We performed an exploratory single-center retrospective case-control study evaluating 369 Japanese patients (age ≥ 16 years), 236 (64.0%) with AA and 133 (36.0%) with ARCD, who were hospitalized between 2012 and 2016. Diagnoses were confirmed by CT images. We compared age, sex, onset-to-visit interval, epigastric/periumbilical pain, right lower quadrant (RLQ) pain, nausea/vomiting, diarrhea, anorexia, medical history, body temperature, blood pressure, heart rate, RLQ tenderness, peritoneal signs, leukocyte count, and levels of serum creatinine, serum C-reactive protein (CRP), and serum alanine aminotrans-ferase. We subsequently performed logistic regression analysis for differentiating AA from ARCD based on the results of the univariate analyses.RESULTS In the AA and ARCD groups, median ages were 35.5 and 41.0 years, respectively (p=0.011);median onset-to-visit intervals were 1 [interquartile range (IQR): 0-1] and 2 (IQR: 1-3) days, respectively (P < 0.001);median leukocyte counts were 12600 and 11500/mm3, respectively (P = 0.002);and median CRP levels were 1.1 (IQR: 0.2-4.1) and 4.9 (IQR: 2.9-8.5) mg/dL, respectively (P < 0.001). In the logistic regression model, odds ratios (ORs) were significantly high in nausea/vomiting (OR: 3.89, 95%CI: 2.04-7.42) and anorexia (OR: 2.13, 95%CI: 1.06-4.28). ORs were significantly lower with a longer onset-to-visit interval (OR: 0.84, 95%CI: 0.72- 0.97), RLQ pain (OR: 0.28, 95%CI: 0.11-0.71), history of diverticulitis (OR: 0.034, 95%CI: 0.005-0.20), and CRP level > 3.0 mg/dL (OR: 0.25, 95%CI: 0.14-0.43). The regression model showed good calibration, discrimination, and optimism. CONCLUSION Clinical findings can differentiate AA and ARCD before imaging studies;nausea/vomiting and anorexia suggest AA, and longer onset-to-visit interval, RLQ pain, previous diverticulitis, and CRP level > 3.0 mg/dL suggest ARCD. | Yosuke Sasaki Fumiya Komatsu Naoyasu Kashima Takahiro Sato Ikutaka Takemoto Sho Kijima Tadashi Maeda Takamasa Ishii Taito Miyazaki Yoshiko Honda Nagato Shimada Yoshihisa Urita | 2019 | World Journal of Clinical Cases2019，7，12： | 0 |
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