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	题名	作者	年代	出处	被引量
1	Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins显示文摘In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs. However, the administration of therapeutic peptides/proteins is mainly limited in parenteral approach. Oral therapy which was hampered by harsh gastrointestinal environment and poorly penetrating epithelial barriers often results in low bioavailability(less than 1%–2%). Therefore, delivery systems that are rationally designed to overcome these challenges in gastrointestinal tract and ameliorate the oral bioavailability of therapeutic peptides/proteins are seriously promising. In this review, we summarized various multifunctional delivery systems, including lipid-based particles, polysaccharide-based particles, inorganic particles, and synthetic multifunctional particles that achieved effective oral delivery of therapeutic peptides/proteins.	Ying Han Zhonggao Gao Liqing Chen Lin Kang Wei Huang Mingji Jin Qiming Wang You Han Bae	2019	Acta Pharmaceutica Sinica B2019，9，5：	5
2	Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer显示文摘	Sae‐Won Han Hyun‐Jung Lee Jeong Mo Bae Nam‐Yun Cho Kyung‐Hun Lee Tae‐Yong Kim Do‐Youn Oh Seock‐Ah Im Yung‐Jue Bang Seung‐Yong Jeong Kyu Joo Park Jae‐Gahb Park Gyeong Hoon Kang Tae‐You Kim	2012	Int J Cancer2012，，9：	2
3	Polymer- ic micelle for tumor pH and folate-mediated targeting显示文摘	EUN SEONG LEE KUN NA YOU HAN BAE	2003	Journal of Control Release2003，91，12：	1
4	Albumin loaded microsphere of amphiphilic poly (ethylene glycol)/poly (α- ester) multiblock copolymer显示文摘	Kim Jong-Ho You Han Bae	2004	European Journal of Pharmaceutical Sciences2004，23，：	1
5	Poly( l -histidine)–PEG block copolymer micelles and pH-induced destabilization显示文摘	Eun Seong Lee Hyun Joon Shin Kun Na You Han Bae	2003	Journal of Controlled Release2003，，3：	1
6	Super pH-sensitive multifunctional polymeric micelle显示文摘	Eun Seong Lee Kun Na You Han Bae		0，，：	1
7	Saccharide effect on the lower critical solution temperature of thermosensitive polymers 显示文摘	Yong- Hee Kim Ick Chan Kwon You Han Bae	1995	Macromolecules1995，28，：	1
8	Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer显示文摘	Sae‐Won Han Hyun‐Jung Lee Jeong Mo Bae Nam‐Yun Cho Kyung‐Hun Lee Tae‐Yong Kim Do‐Youn Oh Seock‐Ah Im Yung‐Jue Bang Seung‐Yong Jeong Kyu Joo Park Jae‐Gahb Park Gyeong Hoon Kang Tae‐You Kim	2012	Int. J. Cancer2012，，9：	1
9	Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N isopropylacrylamide copolymers显示文摘	Herman Feil You Han Bae Jan Feijen	1993	Macromolecules1993，26，10：	1
10	pH-sensitivity and pH-dependent interior structural change of self-assembled hydrogel nanoparticles of pullulan acetate/oligo-sulfonamide conjugate 显示文摘	Kun N Lee Kwang Hee Bae You Han	2004	Journal of Controlled Release2004，97，3：	1
11	Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N-isopropylacrylamide copolymers 显示文摘	Herman Feil You Han Bae Jan Feijen	1993	Macromolecules1993，26，10：	1
12	Polymeric micelle for tumor pH and folate-mediated targeting显示文摘	Eun Seong Lee Kun Na You Han Bae	2003	Journal of Controlled Release2003，，1：	1
13	A Biodegradable pH-sensitive Micelle System for Targeting Acidic Solid Tumors显示文摘	Vijay A. Sethuraman Myung Cheon Lee You Han Bae	2008	Pharmaceutical Research2008，，3：	1
14	Adriamycin loaded pullulan acetate/sulfonamide conjugate nanoparticles responding to tumor pH: pH-dependent cell interaction, internalization and cytotoxicity in vitro显示文摘	Kun Na Eun Seong Lee You Han Bae	2002	Journal of Controlled Release2002，，1：	1
15	The performance of gadolinium diethylene triamine pentaacetate-pullulan hepatocyte-specific T1 contrast agent for MRI显示文摘	Hyeona Yim Su-Geun Yang Yong Sun Jeon In Suh Park Mina Kim Don Haeng Lee You Han Bae Kun Na	2011	Biomaterials2011，，22：	1
16	Thermosensitive sol–gel reversible hydrogels显示文摘	Byeongmoon Jeong Sung Wan Kim You Han Bae	2002	Advanced Drug Delivery Reviews2002，，：	1
17	Doxorubicin Loaded pH-sensitive Micelle: Antitumoral Efficacy against Ovarian A2780/DOXR Tumor显示文摘	Dongin Kim Eun Seong Lee Kyeongsoon Park Ick Chan Kwon You Han Bae	2008	Pharmaceutical Research2008，，9：	1
18	Enhanced Intercellular Retention Activity of Novel pH-sensitive Polymeric Micelles in Wild and Multidrug Resistant MCF-7 Cells显示文摘	Ghazal Mohajer Eun Seong Lee You Han Bae	2007	Pharmaceutical Research2007，，9：	1
19	A sulfonamide based glucose-responsive hydrogel with covalently immobilized glucose oxidase and catalase显示文摘	Seong Il Kang You Han Bae	2002	Journal of Controlled Release2002，，1：	1
20	Enhanced Intercellular Retention Activity of Novel pH-sensitive Polymeric Micelles in Wild and Multidrug Resistant MCF-7 Cells显示文摘	Ghazal Mohajer Eun Seong Lee You Han Bae	2007	Pharmaceutical Research2007，，9：	1

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