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| 1 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 2 | Thermal behaviors and heavy metal vaporization of phosphatized tannery sludge in incineration process显示文摘The high concentration of heavy metal (Cu, Cr, Zn, Pb) in tannery sludge causes severe heavy metal emissions in the process of incineration. In the present investigation, the tannery sludge was treated with 85% phosphoric acid before the incineration process in the tube furnace to control the heavy metal emissions. The thermal behavior and heavy metal vaporization of pre-treated tannery sludge were investigated, and X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis were also implemented to elucidate the chemical mechanisms responsible for the thermal behavior and weakening of heavy metal vaporization of pre-treated tannery sludge. The results obtained show that the differences in thermal behaviors between untreated and pre-treated tannery sludge are caused by the reaction of phosphoric acid and calcium carbonate. The vaporization percentage of heavy metal decreased efficiently with the increasing volumes of H3PO4, which indicated the important thermal stability of the water-insoluble metallic phosphates (Ca18Cu3(PO4)14, Ca9Cr(PO4)7, Ca19Zn2(PO4)14, PbMgP2O7) formed during tannery sludge phosphatation. | TANG, Ping ZHAO, Youcai XIA, Fengyi | 2008 | Journal of Environmental Sciences2008，20，9： | 11 |
| 3 | Structure of the Upper Mantle and Transition Zone Beneath the South China Block Imaged by Finite Frequency Tomography显示文摘We applied the finite frequency tomography method to S wave data recorded by 350 broadband stations beneath the South China Block(SCB) and its surroundings from earthquakes occurring between July 2007 and July 2010,to better understand upper mantle deformation.Differential travel-times in the pair of stations with appropriate weighting for each station are used in the inversion.Our results are consistent with previous tomography that show a high velocity anomaly beneath the Sichuan basin and a high velocity anomaly in the transition zone beneath the Yangtze Craton.However,the resolution of mantle heterogeneity provides new insight into the tectonic framework of subduction of Burmese lithosphere in the west part of the study region and subduction of oceanic lithosphere in the east.In the subduction realm,west of 107°E,a significant fast S-wave anomaly is located on the southeast of Sichuan Basin.East of 107°E,and two narrow and discontinuous fast S-wave anomalies occur at a depth of 400-600 km beneath the middle of the South China block overlain by the pronounced low S-wave anomalies at a depth of 100 and 400 km.If the fast anomalies located in the mantle transition zone represent stagnant slabs,their fragmented nature may suggest that they could be produced by different episodes of subduction beneath western Pacific island and the above slow velocity anomaly may associated with the back-arc regions of ongoing subduction.In addition,tomography also reveals an anomalously high S-wave velocity continental root extends eastward to a depth 400 km beneath the eastern Sichuan Basin.This anomaly may be related to eastern extrusion of Indian lithosphere associated with the collision of India and Eurasia.Moreover,our results also show large slow anomalies beneath the Red River fault region connected to deeper anomalies beneath the South China Fold Belt and South China Sea.AH these observations are consistent with the scenario that the South China block has been built by both of subduction of Paleopacific plate and eastward subduction of Burma microplate. | SUN Ya LIU Jianxin TANG Youcai CHEN Jiawei ZHOU Keping CHEN Bo | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 8 |
| 4 | Crust and upper mantle structures beneath Northeast China from receiver function studies显示文摘P-wave and S-wave receiver function analyses have been performed along a profile consisted of 27broadband seismic stations to image the crustal and upper mantle discontinuities across Northeast China.The results show that the average Moho depth varies from about37 km beneath the Daxing'anling orogenic belt in the west to about 33 km beneath the Songliao Basin,and to about35 km beneath the Changbai mountain region in the east.Our results reveal that the Moho is generally flat beneath the Daxing'anling region and a remarkable Moho offset(about 4 km) exists beneath the basin-mountain boundary,the Daxing'anling-Taihang Gravity Line.Beneath the Tanlu faults zone,which seperates the Songliao Basin and Changbai region,the Moho is uplift and the crustal thickness changes rapidly.We interpret this feature as that the Tanlu faults might deeply penetrate into the upper mantle,and facilitate the mantle upwelling along the faults during the Cenozoic era.The average depth of the lithosphereasthenosphere boundary(LAB) is *80 km along the profile which is thinner than an average thickness of a continental lithosphere.The LAB shows an arc-like shape in the basin,with the shallowest part approximately beneath the center of the basin.The uplift LAB beneath the basin might be related to the extensive lithospheric stretching in theMesozoic.In the mantle transition zone,a structurally complicated 660 km discontinuity with a maximum 35 km depression beneath the Changbai region is observed.The35 km depression is roughly coincident with the location of the stagnant western pacific slab on top of the 660 km discontinuity revealed by the recent P wave tomography. | Zhen Guo Yuliang Cao Xianguang Wang Y.John Chen Jieyuan Ning Weiguang He Youcai Tang Yongge Feng | 2014 | Earthquake Science2014，27，3： | 6 |
| 5 | Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids显示文摘Epigenetic modifications have been proved to be a powerful way to activate silent gene clusters and lead to diverse secondary metabolites in fungi. Previously, inactivation of a histone H3 deacetylase in Calcarisporium arbuscula had led to pleiotropic activation and overexpression of more than 75% of the biosynthetic genes and isolation of ten compounds. Further investigation of the crude extract of C. arbuscula Δhda A strain resulted in the isolation of twelve new diterpenoids including three cassanes(1-3), one cleistanthane(4), six pimaranes(5-10), and two isopimaranes(11 and 12) along with two know cleistanthane analogues. Their structures were elucidated by extensive NMR spectroscopic data analysis. Compounds 2 and 4 showed potent inhibitory effects on the expression of MMP1 and MMP2(matrix metalloproteinases family) in human breast cancer(MCF-7) cells. | Jian Bai Rong Mu Man Dou Daojiang Yan Bingyu Liu Qian Wei Jun Wan Yi Tang Youcai Hu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 5 |
| 6 | Doppler effect of the rupture process of the great M_W7.9 Wenchuan earthquake显示文摘In this study we performed a classical spectrum analysis of seismic waveforms recorded at far field stations of the great MW7.9 Wenchuan earthquake to observe the shifts of the corner frequency with azimuth due to the Doppler effect.Our results show that this damaging great earthquake had a dominating rupture propagation direction of 64.0°.The equivalent radius of the fault rupture surface was estimated to be 33 km,yielding the rupture area of about 3 500 km2.Thus the length of the rupture fault surface is about 230 km if the depth(or width) extent is 15 km.The computer program developed in this study can quickly provide the information about the source of a future large(damaging) earthquake,which could be very useful for predicting aftershocks and planning the rescue operations. | Ge Jin Youcai Tang Shiyong Zhou Yongshun John Chen | 2010 | Earthquake Science2010，23，6： | 2 |
| 7 | 打 Collectivization 和传统的农村家庭的结构的转变显示文摘本文使用年龄在70岁以上的农村老年人的口述史资料,分析他们在20世纪50年代中期土地集体化之前、50-70年代的土地集体化时期与70年代末期后家庭联产承包责任制时期的农村家庭生产与生活情况,以及这三个时期农村家庭结构的变化。研究发现,中国传统大家庭向小家庭的转型并不是由西方传统意义的工业化促成的。作为1949年后国家早期工业化策略的农村土地集体化,彻底改变了传统家庭生产与生活的组织方式,改变了父权制度下的代际关系与结构,进而启动了家庭结构转型的历史进程。这一解释有别于经典的家庭变迁的“现代化理论”。 | Wang Tianfu Wang Fei Tang Youcai | 2016 | Social Sciences in China2016，37，3： | 2 |
| 8 | A cascade of redox reactions in the biosynthesis of the protein phosphatase-2A inhibitor rubratoxin A显示文摘Subject Code:H30 With the support by the National Natural Science Foundation of China,a collaborative study by the research groups led by Prof.Hu Youcai(胡友财),Prof.Yu Shishan(庾石山)and Prof.Tang Yi(唐奕)from the State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute | Hu Youcai (胡友财) Yu Shishan (庾石山) Tang Yi (唐奕) | 2017 | Science Foundation in China2017，25，2： | 0 |
| 9 | cGAS regulates the DNA damage response to maintain proliferative signaling in gastric cancer cells显示文摘The activation of some oncogenes promote cancer cell proliferation and growth,facilitate cancer progression and metastasis by induce DNA replication stress,even genome instability.Activation of the cyclic GMP-AMP synthase(cGAS)mediates classical DNA sensing,is involved in genome instability,and is linked to various tumor development or therapy.However,the function of cGAS in gastric cancer remains elusive.In this study,the TCGA database and retrospective immunohistochemical analyses revealed substantially high cGAS expression in gastric cancer tissues and cell lines.By employing cGAS high-expression gastric cancer cell lines,including AGS and MKN45,ectopic silencing of cGAS caused a significant reduction in the proliferation of the cells,tumor growth,and mass in xenograft mice.Mechanistically,database analysis predicted a possible involvement of cGAS in the DNA damage response(DDR),further data through cells revealed protein interactions of the cGAS and MRE11-RAD50-NBN(MRN)complex,which activated cell cycle checkpoints,even increased genome instability in gastric cancer cells,thereby contributing to gastric cancer progression and sensitivity to treatment with DNA damaging agents.Furthermore,the upregulation of cGAS significantly exacerbated the prognosis of gastric cancer patients while improving radiotherapeutic outcomes.Therefore,we concluded that cGAS is involved in gastric cancer progression by fueling genome instability,implying that intervening in the cGAS pathway could be a practicable therapeutic approach for gastric cancer. | BIN LIU HAIPENG LIU FEIFEI REN HANGFAN LIU IHTISHAM BUKHARI YUMING FU WANQINGWU MINGHAI ZHAO SHAOGONG ZHU HUI MO FAZHAN LI MICHAEL B.ZHENG YOUCAI TANG PENGYUAN ZHENG YANG MI | 2021 | Oncology Research2021，29，2： | 0 |
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