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| 1 | A Risk Prediction Model for Ischemic Stroke in Southern Chinese Population:Impact of Multiple Genetic Variants and Clinical/Lifestyle Factors显示文摘With a global prevalence of 7.7 million,ischemic stroke(IS)is one of the leading causes of death and disability worldwide.In China,IS alone contributed to 69.6%of stroke events and accounted for 37.1%of the mortality/disability rate[1].IS is a complex disease that is known to be associated with various genetic variants and clinical and lifestyle risk factors[2].Genome-wide association studies(GWAS)provided evidence for the occurrence of more than 160 IS-associated single nucleotide polymorphisms(SNPs).In terms of clinical risk factors,patients with a history of chronic diseases like hypertension,dyslipidemia,and diabetes mellitus,display a higher risk of developing IS.Among the various lifestyle components,leading a sedentary lifestyle,smoking,and having an unhealthy diet are known to be associated with the risk of IS.Thus,integration of various genetic,clinical,and lifestyle variables might prove to be highly beneficial in the prediction and prevention of IS at the individual level[3]. | YE Cheng Yin LI Jin Mei WU Jing Hua LI Zheng XIAO Juan YIN Xiao Yu WANG Da Hui XU Guo Zhang YANG Lei | 2021 | Biomedical and Environmental Sciences2021，34，8： | 2 |
| 2 | Genomic analyses reveal distinct genetic architectures and selective pressures in Chinese donkeys显示文摘Donkey(Equus asinus)is an important livestock animal in China because of its draft and medicinal value.After a long period of natural and artificial selection,the variety and phenotype of donkeys have become abundant.We clarified the genetic and demographic characteristics of Chinese domestic donkeys and the selection pressures by analyzing 78 whole genomes from 12 breeds.According to population structure,most Chinese domestic donkeys showed a dominant ancestral type.However,the Chinese donkeys still represented a significant geographical distribution trend.In the selective sweep,gene annotation,functional enrichment,and differential expression analyses between large and small donkey groups,we identified selective signals,including NCAPG and LCORL,which are related to rapid growth and large body size.Our findings elucidate the evolutionary history and formation of different donkey breeds and provide theoretical insights into the genetic mechanism underlying breed characteristics and molecular breeding programs of donkey clades. | Jiafei Shen Jie Yu Xuelei Da Mei Li Gang Wang Ningbo Chen Hong Chen Chuzhao Lei Ruihua Dang | 2021 | Journal of Genetics and Genomics2021，48，8： | 2 |
| 3 | Lattice Boltzmann method for 3-D flows with curved boundary 显示文摘 | Mei Rui Wei Shi Yu Da | 2000 | J Comput Phys2000，161，： | 1 |
| 4 | Rare 5-connected BN topology in homochiral Cd (11) camphorate with 2-(4- pyridyl) benzimidazole Inorg显示文摘 | Fei Li Yao Kang Yu Mei Da | 2011 | Chem Commun2011，14，12： | 1 |
| 5 | 中国软件学院国际合作项目类型探析(英文)显示文摘在全球化和软件行业需求的双重影响下,中国的软件学院与国外高校开展了形式多样的国际合作项目,包括体验式项目、学位项目以及联合合作项目。文章分析各类国际合作项目的特点,并根据这些特点探索出适合中国软件学院开展国际合作项目的方法。 | Siyao Gong Da Li Nan Yin Mei Li Ruiyun Yu | 2016 | 计算机教育2016，，8： | 1 |
| 6 | Photocatalytic C-H Bonds Activation:Ambient Carbonylation of Cyclohexane by Co(acac)_2 Under Ultraviolet Irradiation显示文摘A high turnover number was achieved in the photocatalytic carbonylation of C - H bonds of cyclohexane catalyzed by Co (acac)2 under ambient conditions (1 atm,25℃) to give mainly cyclohexanecarboxaldehyde. | Da Bin GAo Jing Mei YIN Ming GUO Yuan YU(Departemnt of Chemistry & Chemical Engineering, Dalian University, Dalian 116622)Yong An MA(National Marine Environmental Monitoring Center, Institute of Marine Environmental Protection, State Oceanic Administrat | 1997 | Chinese Chemical Letters1997，8，9： | 0 |
| 7 | 基于个体化机器学习的原发性免疫性血小板减少症危重出血预测模型:一项全国前瞻性队列研究显示文摘原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者致命出血事件的预测模型。本研究首次采用国际血栓与止血学会新提出的ITP致命出血标准,利用大样本数据开发了首个基于机器学习的在线应用,用于预测ITP患者的致命出血.研究中,我们使用中国各地大型多中心数据进行开发,并对全国39家医疗中心进行为期一年的外部测试,得到了较好的训练、验证和测试数据集预测能力该基于新算法的便捷网络工具能够快速识别ITP患者的出血风险,辅助临床决策,有望未来降低不良事件的发生。 | Zhuo-Yu An Ye-Jun Wu Yu Hou Heng Mei Wei-Xia Nong Wen-Qian Li Hu Zhou Ru Feng Jian-Ping Shen Jun Peng Hai Zhou Yi Liu Yong-Ping Song Lin-Hua Yang Mei-Yun Fang Jian-Yong Li Yun-Feng Cheng Peng Liu Ya-Jing Xu Zhao Wang Yi Luo Zhen Cai Hui Liu Jing-Wen Wang Juan Li Xi Zhang Zi-Min Sun Xiao-Yu Zhu Xin Wang Rong Fu Liang Huang Shao-Yuan Wang Tong-Hua Yang Li-Ping Su Liang-Ming Ma Xie-Qun Chen Dai-Hong Liu Hong-Xia Yao Jia Feng Hong-Yu Zhang Ming Jiang Ze-Ping Zhou Wen-Sheng Wang Xu-Liang Shen Yangjin Baima Yue-Ying Li Qian-Fei Wang Qiu-Sha Huang Hai-Xia Fu Xiao-Lu Zhu Yun He Qian Jiang Hao Jiang Jin Lu Xiang-Yu Zhao Ying-Jun Chang Tao Wu Yao-Zhu Pan Lin Qiu Da Gao A-Rong Jin Wei Li Su-Jun Gao Lei Zhang Ming Hou Xiao-Jun Huang Xiao-Hui Zhang on behalf of the National Cooperative ITP Working Group | 2023 | Science Bulletin2023，68，18： | 0 |
| 8 | HIV-1 Subtype Diversity and Factors Affecting Drug Resistance among Patients with Virologic Failure in Antiretroviral Therapy in Hainan Province,China,2014–2020显示文摘Objective This study aimed to determine the HIV-1 subtype distribution and HIV drug resistance(HIVDR)in patients with ART failure from 2014 to 2020 in Hainan,China.Methods A 7-year cross-sectional study was conducted among HIV/AIDS patients with ART failure in Hainan.We used online subtyping tools and the maximum likelihood phylogenetic tree to confirm the HIV subtypes with pol sequences.Drug resistance mutations(DRMs)were analyzed using the Stanford University HIV Drug Resistance Database.Results A total of 307 HIV-infected patients with ART failure were included,and 241 available pol sequences were obtained.Among 241 patients,CRF01_AE accounted for 68.88%,followed by CRF07_BC(17.00%)and eight other subtypes(14.12%).The overall prevalence of HIVDR was 61.41%,and the HIVDR against non-nucleoside reverse transcriptase inhibitors(NNRTIs),nucleotide reverse transcriptase inhibitors(NRTIs),and protease inhibitors(PIs)were 59.75%,45.64%,and 2.49%,respectively.Unemployed patients,hypoimmunity or opportunistic infections in individuals,and samples from 2017 to 2020 increased the odd ratios of HIVDR.Also,HIVDR was less likely to affect female patients.The common DRMs to NNRTIs were K103N(21.99%)and Y181C(20.33%),and M184V(28.21%)and K65R(19.09%)were the main DRMs against NRTIs.Conclusion The present study highlights the HIV-1 subtype diversity in Hainan and the importance of HIVDR surveillance over a long period. | YU De E XU Yu Jun LI Mu YANG Yuan LIANG Hua Yue ZHONG Shan Mei QIN Cai LAN Ya Nan LI Da Wei YU Ji Peng PANG Yuan QIN Xue Qiu LIANG Hao ZHU Kao Kao YE Li LIANG Bing Yu | 2023 | Biomedical and Environmental Sciences2023，36，9： | 0 |
| 9 | Phases confirmation of cloudy Silwet L-77 aqueous solution by dielectric relaxation spectroscopy显示文摘The phase transition of Silwet L-77 (a kind of siloxane surfactant) dilute aqueous solution with temperature was investigated by dielectric relaxation spectroscopy. In the initial heating process, a dielectric relaxation was found at about 106 Hz, which was considered as the interface polarization ascribed to the interface between water and liquid phases (Wand L1). With the temperature increasing further, a new dielectric relaxation was observed at about 104 Hz, which was assigned to the appearance of liquid crystal phase (Lα). According to the dielectric parameters fitted by Cole-Cole equation, the coexistence temperature of W, L1 and Lα was determined at about 37.0℃. | Wei Zhou Wei Da Xu Yu Mei Sun Ya Wen Zhou | 2010 | Chinese Chemical Letters2010，21，6： | 0 |
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